Yogi Srikhanta

Dr

19982021

Research output per year

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Research Output

A biphasic epigenetic switch controls immunoevasion, virulence and niche adaptation in non-typeable Haemophilus influenzae

Atack, J. M., Srikhanta, Y. N., Fox, K. L., Jurcisek, J. A., Brockman, K. L., Clark, T. A., Boitano, M., Power, P. M., Jen, F. E. C., McEwan, A. G., Grimmond, S. M., Smith, A. L., Barenkamp, S. J., Korlach, J., Bakaletz, L. O. & Jennings, M. P., 2015, In : Nature Communications. 6, 12 p., 7828.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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49 Citations (Scopus)

Accumulation of manganese in Neisseria gonorrhoeae correlates with resistance to oxidative killing by superoxide anion and is independent of superoxide dismutase activity

Tseng, H. J., Srikhanta, Y., McEwan, A. G. & Jennings, M. P., 5 Jul 2001, In : Molecular Microbiology. 40, 5, p. 1175-1186 12 p.

Research output: Contribution to journalArticleResearchpeer-review

124 Citations (Scopus)

Advanced age promotes colonic dysfunction and gut-derived lung infection after stroke

Wen, S. W., Shim, R., Ho, L., Wanrooy, B. J., Srikhanta, Y., Prame Kumar, K., Nicholls, A. J., Shen, S., Sepehrizadeh, T., De Veer, M., Srikanth, V., Ma, H., Phan, T., Lyras, D. & Wong, C., 1 Oct 2019, In : Aging Cell. 18, 5, 13 p., e12980.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2 Citations (Scopus)

Cephamycins inhibit pathogen sporulation and effectively treat recurrent Clostridioides difficile infection

Srikhanta, Y. N., Hutton, M. L., Awad, M. M., Drinkwater, N., Singleton, J., Day, S. L., Cunningham, B. A., McGowan, S. & Lyras, D., Dec 2019, In : Nature Microbiology. 4, p. 2237-2245 9 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Characterization of an ntrX Mutant of Neisseria gonorrhoeae Reveals a Response Regulator That Controls Expression of Respiratory Enzymes in Oxidase-Positive Proteobacteria

Atack, J. M., Srikhanta, Y. N., Djoko, K. Y., Welch, J. P., Hasri, N. H. M., Steichen, C. T., Vanden Hoven, R. N., Grimmond, S. M., Pg Othman, D. S. M., Kappler, U., Apicella, M. A., Jennings, M. P., Edwards, J. L. & McEwan, A. G., Jun 2013, In : Journal of Bacteriology. 195, 11, p. 2632-2641 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
17 Citations (Scopus)

Characterization of the OxyR regulon of Neisseria gonorrhoeae

Seib, K. L., Wu, H. J., Srikhanta, Y. N., Edwards, J. L., Falsetta, M. L., Hamilton, A. J., Maguire, T. L., Grimmond, S. M., Apicella, M. A., McEwan, A. G. & Jennings, M. P., 1 Jan 2007, In : Molecular Microbiology. 63, 1, p. 54-68 15 p.

Research output: Contribution to journalArticleResearchpeer-review

69 Citations (Scopus)

Control of acid resistance pathways of enterohemorrhagic Escherichia coli strain EDl933 by PsrB, a prophage-encoded AraC-like regulator

Yang, J., Russell, T. W., Hocking, D. M., Bender, J. K., Srikhanta, Y. N., Tauschek, M. & Robins-Browne, R. M., Jan 2015, In : Infection and Immunity. 83, 1, p. 346-353 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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3 Citations (Scopus)

Control of bacterial virulence by the RalR regulator of the rabbit-specific enteropathogenic escherichia coli strain E22

Srikhanta, Y. N., Hocking, D. M., Wakefield, M. J., Higginson, E. E., Robins-Browne, R. M., Yang, J. & Tauschek, M., Nov 2013, In : Infection and Immunity. 81, 11, p. 4232-4243 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
2 Citations (Scopus)

Distinct physiological roles for the two l-asparaginase isozymes of Escherichia coli

Srikhanta, Y. N., Atack, J. M., Beacham, I. R. & Jennings, M. P., 5 Jul 2013, In : Biochemical and Biophysical Research Communications. 436, 3, p. 362-365 4 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

Distribution of the type III DNA methyltransferases modA, modB and modD among Neisseria meningitidis genotypes: Implications for gene regulation and virulence

Tan, A., Hill, D. M. C., Harrison, O. B., Srikhanta, Y. N., Jennings, M. P., Maiden, M. C. J. & Seib, K. L., 12 Feb 2016, In : Scientific Reports. 6, 11 p., 21015.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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13 Citations (Scopus)

Evaluation of Truncated NhhA Protein as a Candidate Meningococcal Vaccine Antigen

Peak, I. R., Srikhanta, Y. N., Weynants, V. E., Feron, C., Poolman, J. T. & Jennings, M. P., 6 Sep 2013, In : PLoS ONE. 8, 9, e72003.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
6 Citations (Scopus)

Genetic characterization of pilin glycosylation and phase variation in Neisseria meningitidis

Power, P. M., Roddam, L. F., Rutter, K., Fitzpatrick, S. Z., Srikhanta, Y. N. & Jennings, M. P., 1 Aug 2003, In : Molecular Microbiology. 49, 3, p. 833-847 15 p.

Research output: Contribution to journalArticleResearchpeer-review

95 Citations (Scopus)

Genetic characterization of pilin glycosylation in Neisseria meningitidis

Power, P. M., Roddam, L. F., Dieckelmann, M., Srikhanta, Y. N., Tan, Y. C., Berrington, A. W. & Jennings, M. P., 1 Jan 2000, In : Microbiology. 146, 4, p. 967-979 13 p.

Research output: Contribution to journalArticleResearchpeer-review

69 Citations (Scopus)

Haemophilus influenzae phasevarions have evolved from type III DNA restriction systems into epigenetic regulators of gene expression

Fox, K. L., Dowideit, S. J., Erwin, A. L., Srikhanta, Y. N., Smith, A. L. & Jennings, M. P., 1 Aug 2007, In : Nucleic Acids Research. 35, 15, p. 5242-5252 11 p.

Research output: Contribution to journalArticleResearchpeer-review

52 Citations (Scopus)

Identification and characterisation of a novel conserved outer membrane protein from Neisseria meningitidis

Peak, I. R. A., Srikhanta, Y., Dieckelmann, M., Moxon, E. R. & Jennings, M. P., 1 Aug 2000, In : FEMS Immunology and Medical Microbiology. 28, 4, p. 329-334 6 p.

Research output: Contribution to journalArticleResearchpeer-review

49 Citations (Scopus)

Identification of a novel gene involved in pilin glycosylation in Neisseria meningitidis

Jennings, M. P., Virji, M., Evans, D., Foster, V., Srikhanta, Y. N., Steeghs, L., Van Der Ley, P. & Moxon, E. R., 2 Sep 1998, In : Molecular Microbiology. 29, 4, p. 975-984 10 p.

Research output: Contribution to journalArticleResearchpeer-review

85 Citations (Scopus)

Manganese regulation of virulence factors and oxidative stress resistance in Neisseria gonorrhoeae

Wu, H. J., Seib, K. L., Srikhanta, Y. N., Edwards, J., Kidd, S. P., Maguire, T. L., Hamilton, A., Pan, K. T., Hsiao, H. H., Yao, C. W., Grimmond, S. M., Apicella, M. A., McEwan, A. G., Wang, A. H. J. & Jennings, M. P., 10 Mar 2010, In : Journal of Proteomics. 73, 5, p. 899-916 18 p.

Research output: Contribution to journalArticleResearchpeer-review

24 Citations (Scopus)

Methylomic and phenotypic analysis of the ModH5 phasevarion of Helicobacter pylori

Srikhanta, Y. N., Gorrell, R. J., Power, P., Tsyganov, K., Boitano, M., Clark, T. A., Korlach, J., Hartland, E. L., Jennings, M. P. & Kwok, T., 1 Dec 2017, In : Scientific Reports. 7, 1, 14 p., 16140.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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8 Citations (Scopus)

ModA2 phasevarion switching in nontypeable haemophilus influenzae increases the severity of experimental otitis media

Brockman, K. L., Jurcisek, J. A., Atack, J. M., Srikhanta, Y. N., Jennings, M. P. & Bakaletz, L. O., 1 Sep 2016, In : Journal of Infectious Diseases. 214, 5, p. 817-824 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
18 Citations (Scopus)

Origin of the diversity in DNA recognition domains in phasevarion associated modA genes of pathogenic Neisseria and Haemophilus influenzae

Gawthorne, J. A., Beatson, S. A., Srikhanta, Y. N., Fox, K. L. & Jennings, M. P., 23 Mar 2012, In : PLoS ONE. 7, 3, e32337.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
24 Citations (Scopus)

PerR controls Mn-dependent resistance to oxidative stress in Neisseria gonorrhoeae

Wu, H. J., Seib, K. L., Srikhanta, Y. N., Kidd, S. P., Edwards, J. L., Maguire, T. L., Grimmond, S. M., Apicella, M. A., McEwan, A. G. & Jennings, M. P., 1 Apr 2006, In : Molecular Microbiology. 60, 2, p. 401-416 16 p.

Research output: Contribution to journalArticleResearchpeer-review

43 Citations (Scopus)

Phase variable type III restriction-modification systems of host-adapted bacterial pathogens

Fox, K. L., Srikhanta, Y. N. & Jennings, M. P., 1 Sep 2007, In : Molecular Microbiology. 65, 6, p. 1375-1379 5 p.

Research output: Contribution to journalShort SurveyResearchpeer-review

31 Citations (Scopus)

Phase variation in meningococcal lipooligosaccharide biosynthesis genes

Berrington, A. W., Tan, Y. C., Srikhanta, Y., Kuipers, B., Van der Ley, P., Peak, I. R. A. & Jennings, M. P., 13 Dec 2002, In : FEMS Immunology and Medical Microbiology. 34, 4, p. 267-275 9 p.

Research output: Contribution to journalArticleResearchpeer-review

36 Citations (Scopus)

Phasevarion mediated epigenetic gene regulation in Helicobacter pylori

Srikhanta, Y. N., Gorrell, R. J., Steen, J. A., Gawthorne, J. A., Kwok, T., Grimmond, S. M., Robins-Browne, R. M. & Jennings, M. P., 2011, In : PLoS ONE. 6, 12, 9 p., e27569.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
51 Citations (Scopus)

Phasevarion-regulated virulence in the emerging pediatric pathogen Kingella kingae

Srikhanta, Y. N., Fung, K. Y., Pollock, G. L., Bennett-Wood, V., Howden, B. P. & Hartland, E. L., 2017, In : Infection and Immunity. 85, 12, 15 p., e00319-17.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Phasevarions mediate random switching of gene expression in pathogenic Neisseria

Srikhanta, Y. N., Dowideit, S. J., Edwards, J. L., Falsetta, M. L., Wu, H. J., Harrison, O. B., Fox, K. L., Seib, K. L., Maguire, T. L., Wang, A. H. J., Maiden, M. C., Grimmond, S. M., Apicella, M. A. & Jennings, M. P., 1 Apr 2009, In : PLoS Pathogens. 5, 4

Research output: Contribution to journalArticleResearchpeer-review

95 Citations (Scopus)

Positive autoregulation of mrkHI by the cyclic di-GMP-dependent MrkH protein in the biofilm regulatory circuit of Klebsiella pneumoniae

Tan, J. W. H., Wilksch, J. J., Hocking, D. M., Wang, N., Srikhanta, Y. N., Tauschek, M., Lithgow, T. J., Robins-Browne, R. M., Yang, J. & Strugnell, R. A., 2015, In : Journal of Bacteriology. 197, 9, p. 1659 - 1667 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
12 Citations (Scopus)

RegR virulence regulon of rabbit-specific enteropathogenic Escherichia coli strain E22

Srikhanta, Y. N., Hocking, D. M., Praszkier, J., Wakefield, M. J., Robins-Browne, R. M., Yang, J. & Tauschek, M., 2013, In : Infection and Immunity. 81, 4, p. 1078 - 1089 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
7 Citations (Scopus)

Reply to: Caution is warranted in using cephamycin antibiotics against recurrent Clostridioides difficile infection

Lyras, D., Srikhanta, Y. & McGowan, S., Feb 2020, In : Nature Microbiology. 5, 2, p. 237-238 2 p.

Research output: Contribution to journalLetterOtherpeer-review

Selection for phase variation of los biosynthetic genes frequently occurs in progression of non-typeable haemophilus influenzae infection from the nasopharynx to the middle ear of human patients

Fox, K. L., Atack, J. M., Srikhanta, Y. N., Eckert, A., Novotny, L. A., Bakaletz, L. O. & Jennings, M. P., 28 Feb 2014, In : PLoS ONE. 9, 2, 6 p., e90505.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
16 Citations (Scopus)

The genetic basis of the phase variation repertoire of lipopolysaccharide immunotypes in Neisseria meningitidis

Jennings, M. P., Srikhanta, Y. N., Moxon, E. R., Kramer, M., Poolman, J. T., Kuipers, B. & Van Der Ley, P., 1 Jan 1999, In : Microbiology. 145, 11, p. 3013-3021 9 p.

Research output: Contribution to journalArticleResearchpeer-review

113 Citations (Scopus)

The glycointeractome of serogroup B Neisseria meningitidis strain MC58

Mubaiwa, T. D., Hartley-Tassell, L. E., Semchenko, E. A., Jen, F. E. C., Srikhanta, Y. N., Day, C. J., Jennings, M. P. & Seib, K. L., 1 Dec 2017, In : Scientific Reports. 7, 1, 9 p., 5693.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
12 Citations (Scopus)

The phasevarion: Phase variation of type III DNA methyltransferases controls coordinated switching in multiple genes

Srikhanta, Y. N., Fox, K. L. & Jennings, M. P., 1 Mar 2010, In : Nature Reviews Microbiology. 8, 3, p. 196-206 11 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

109 Citations (Scopus)

The phasevarion: A genetic system controlling coordinated, random switching of expression of multiple genes

Srikhanta, Y. N., Maguire, T. L., Stacey, K. J., Grimmond, S. M. & Jennings, M. P., 12 Apr 2005, In : Proceedings of the National Academy of Sciences of the United States of America. 102, 15, p. 5547-5551 5 p.

Research output: Contribution to journalArticleResearchpeer-review

112 Citations (Scopus)

Translocation and dissemination of commensal bacteria in post-stroke infection

Stanley, D., Mason, L. J., MacKin, K. E., Srikhanta, Y. N., Lyras, D., Prakash, M. D., Nurgali, K., Venegas, A., Hill, M. D., Moore, R. J. & Wong, C. H. Y., 1 Nov 2016, In : Nature Medicine. 22, 11, p. 1277-1284 8 p.

Research output: Contribution to journalArticleResearchpeer-review

71 Citations (Scopus)