19982020

Research output per year

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Personal profile

Biography

Dr Yogitha Srikhanta is a postdoctoral researcher located in the Department of Microbiology, Monash University. She has extensive expertise in bacterial pathogenesis. She obtained her PhD from the University of Queensland under the supervision of Prof Michael Jennings. During her PhD, she made an important contribution to bacterial pathogenesis through her discovery of the “phasevarion”, a novel mechanism of epigenetic gene regulation. This project used a combination transcriptomics, mutagenesis techniques and biological assays.

In 2011, she was awarded an NHMRC Fellowship based at the University of Melbourne, where she studied gene regulation in gut pathogens using a combination of transcriptomics, proteomics and in vivo models in the laboratories of Prof Roy Robins-Browne and Prof Elizabeth Hartland.

Since moving to Monash University she has worked with Prof Dena Lyras on Clostridiodies difficile sporulation related projects. These projects use a combination of mutagenesis, in vivo models, proteomics and imaging. One project lead to the identification of a compound that impacts the formation of C. difficile spores and prevents re-infection. In 2017, she was awarded an NHMRC grant for a project that studies epigenetic regulation in the cancer-causing pathogen Helicobacter pylori. Her research on these important pathogens will help in developing new strategies for treating their devastating diseases.

Research area keywords

  • Clostridium difficile
  • Sporulation
  • Gut pathogens
  • Epigenetics
  • Gene Regulation
  • Gene Knockout

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Projects

Research Output

Reply to: Caution is warranted in using cephamycin antibiotics against recurrent Clostridioides difficile infection

Lyras, D., Srikhanta, Y. & McGowan, S., Feb 2020, In : Nature Microbiology. 5, 2, p. 237-238 2 p.

Research output: Contribution to journalLetterOtherpeer-review

Advanced age promotes colonic dysfunction and gut-derived lung infection after stroke

Wen, S. W., Shim, R., Ho, L., Wanrooy, B. J., Srikhanta, Y., Prame Kumar, K., Nicholls, A. J., Shen, S., Sepehrizadeh, T., De Veer, M., Srikanth, V., Ma, H., Phan, T., Lyras, D. & Wong, C., 1 Oct 2019, In : Aging Cell. 18, 5, 13 p., e12980.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
2 Citations (Scopus)

Cephamycins inhibit pathogen sporulation and effectively treat recurrent Clostridioides difficile infection

Srikhanta, Y. N., Hutton, M. L., Awad, M. M., Drinkwater, N., Singleton, J., Day, S. L., Cunningham, B. A., McGowan, S. & Lyras, D., Dec 2019, In : Nature Microbiology. 4, p. 2237-2245 9 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Methylomic and phenotypic analysis of the ModH5 phasevarion of Helicobacter pylori

Srikhanta, Y. N., Gorrell, R. J., Power, P., Tsyganov, K., Boitano, M., Clark, T. A., Korlach, J., Hartland, E. L., Jennings, M. P. & Kwok, T., 1 Dec 2017, In : Scientific Reports. 7, 1, 14 p., 16140.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
8 Citations (Scopus)

Phasevarion-regulated virulence in the emerging pediatric pathogen Kingella kingae

Srikhanta, Y. N., Fung, K. Y., Pollock, G. L., Bennett-Wood, V., Howden, B. P. & Hartland, E. L., 2017, In : Infection and Immunity. 85, 12, 15 p., e00319-17.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)