Projects per year
Personal profile
Biography
Dr Yogitha Srikhanta is a Level B postdoctoral researcher located in the Department of Microbiology, Monash University. Her research focusses on understanding the genetic and molecular basis of bacterial pathogenesis including; epigenetic-mediated gene regulation, virulence gene characterisation, identifying novel vaccine candidates and antibiotic resistance.
She obtained her PhD from the University of Queensland in October 2007 under the supervision of Prof Michael Jennings. During this time, she was the first to report on a novel bacterial epigenetic regulator and is recognised as a world leader in bacterial epigenetics.
In 2009, she was one of six recipients of a Griffith University Postdoctoral Fellowship, which she relinquished in 2011 when awarded an NHMRC Early Career Fellowship. During this fellowship (2011-2014) she was based at the University of Melbourne, investigating virulence gene regulation in Enteropathogenic Escherichia coli under the supervision of Prof Roy Robins-Browne and host-pathogen interactions under the supervision of Prof Elizabeth Hartland. She was a highly productive NHMRC Early Career Fellowship recipient with 10 publications between when her fellowship was awarded and expired. During this time (2013-2014) she developed two independent projects resulting in 2 first-author publications.
In 2015, she moved to Monash to work with Prof Dena Lyras where she leads Clostridiodies difficile sporulation and AMR related projects. Within a year of starting her first project she was awarded a Monash University Platform Access Grant. This project aresulted in a patent, commercial funding, a lead author Nature Microbiology paper and media attention.
In 2017, she was awarded an NHMRC grant as CIA which allowed her to establish her own separate research program on gut pathogen epigenetic gene regulation. In 2018, she was awarded a C. difficile AMR related ARC grant as CIB and a Monash University Platform Access Grant. In 2019, she was awarded a Monash Warwick Catalyst Grant as a co-investigator based on her C. difficile AMR work.
She has co-authored 36 papers (11 first-author) in leading high impact journals such as PNAS, Nucleic Acids Research, Nature Reviews Microbiology, Nature Communication, Nature Medicine and Nature Microbiology. She was invited by Nature Reviews Microbiology to write a first-author review in 2010.
Her responsibilities are divided between research, teaching and administration. She currently supervises 4 PhD students.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research area keywords
- Clostridium difficile
- Sporulation
- Gut pathogens
- Epigenetics
- Antibiotic resistance in bacteria
- Gene Regulation
- Gene Knockout
Collaborations and top research areas from the last five years
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New committee to guide ASM’s diversity and inclusion strategy
Srikhanta, Y., 23 Oct 2023, In: Microbiology Australia. 44, 4, p. 213 1 p.Research output: Contribution to journal › Comment / Debate › Other › peer-review
Open Access1 Citation (Scopus) -
Epigenetic Regulation of Virulence and Immunoevasion by Phase-Variable Restriction-Modification Systems in Bacterial Pathogens
Seib, K. L., Srikhanta, Y. N., Atack, J. M. & Jennings, M. P., 8 Sept 2020, In: Annual Review of Microbiology. 74, p. 655-671 17 p.Research output: Contribution to journal › Review Article › Research › peer-review
44 Citations (Scopus) -
Reply to: Caution is warranted in using cephamycin antibiotics against recurrent Clostridioides difficile infection
Lyras, D., Srikhanta, Y. & McGowan, S., Feb 2020, In: Nature Microbiology. 5, 2, p. 237-238 2 p.Research output: Contribution to journal › Letter › Other › peer-review
1 Citation (Scopus) -
Advanced age promotes colonic dysfunction and gut-derived lung infection after stroke
Wen, S. W., Shim, R., Ho, L., Wanrooy, B. J., Srikhanta, Y., Prame Kumar, K., Nicholls, A. J., Shen, S., Sepehrizadeh, T., De Veer, M., Srikanth, V., Ma, H., Phan, T., Lyras, D. & Wong, C., 1 Oct 2019, In: Aging Cell. 18, 5, 13 p., e12980.Research output: Contribution to journal › Article › Research › peer-review
Open AccessFile38 Citations (Scopus) -
Cephamycins inhibit pathogen sporulation and effectively treat recurrent Clostridioides difficile infection
Srikhanta, Y. N., Hutton, M. L., Awad, M. M., Drinkwater, N., Singleton, J., Day, S. L., Cunningham, B. A., McGowan, S. & Lyras, D., Dec 2019, In: Nature Microbiology. 4, p. 2237-2245 9 p.Research output: Contribution to journal › Article › Research › peer-review
25 Citations (Scopus)
Prizes
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Fellow of the Australian Society for Microbiology
Srikhanta, Yogi (Recipient), 2014
Prize: Election to learned society
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Griffith University Postdoctoral Fellowship
Srikhanta, Yogi (Recipient), 2009
Prize: Competitive Fellowships
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Monash Platform Access Grant - PAG21-0680869503
Srikhanta, Yogi (Recipient), 2021
Prize: Other distinction
Activities
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Monash THRIVE ECR steering group
Yogi Srikhanta (Member)
2021Activity: External Academic Engagement › Committees and working groups
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NHMRC Ideas Grant Peer Reviewer (NHMRC_GRP4B)
Yogi Srikhanta (Reviewer)
2021Activity: External Academic Engagement › Peer review panel or committee
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ARC Discovery Project Peer Reviewer
Yogi Srikhanta (Fellow)
2021Activity: External Academic Engagement › Peer review panel or committee
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Honours student
Yogi Srikhanta (Supervisor)
2021Activity: Other Teaching Engagements and non-HDR Supervisions › Other
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ASM Hour
Yogi Srikhanta (Organiser)
7 Sept 2021Activity: Participating in or organising an event types › Contribution to workshop, seminar, course
Press/Media
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Cephamycin and Vancomycin Prevent C. difficile infection (CDI) recurrence Discovered by Researchers
26/09/19
1 Media contribution
Press/Media: Blogs, Podcasts and Social Media › Social Media Mentions
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Our high-sugar diet is breeding a new superbug
18/09/19
1 item of Media coverage
Press/Media: Article/Feature
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Disarming enemy: Monash study finds way to disarm dangerous bacteria
30/08/19
1 item of Media coverage
Press/Media: Article/Feature
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Cephamycins treat spore-forming bacteria, prevent relapses
20/08/19
1 item of Media coverage
Press/Media: Article/Feature
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Researchers from Monash University have accidentally discovered an antibiotic which kills the gut-infecting bacteria called C difficile.
17/08/19
1 Media contribution
Press/Media: Other