Yi Tian Ting

Personal profile

Biography

Currently, Yi Tian is working with Professor Jamie Rossjohn and Dr. Hugh Reid, at Monash University, Melbourne, Australia, in collaboration with scientists at Janssen Research and Development, exploring the molecular basis behind the development of rheumatoid arthritis, with special focus on major histocompatibility complex (MHC) Class II antigen presenting molecules.

Yi Tian completed her Ph.D. studies under the supervision of Associate Professor Alexander McLellan and Professor Robert Walker, at the University of Otago, New Zealand, where she investigated the role of soluble MHC class II in kidney transplant rejection. Her first postdoctoral position was in Professor Edward Baker's laboratory at the University of Auckland, New Zealand, where she focused on protein crystallography. She has a keen interest in understanding how our immune system protects against microbial infection and also in how undesirable immune responses can lead to life- threatening conditions such as autoimmune disease and transplant rejection.

Research area keywords

Structural Biology
Autoimmunity
immunology and inflammation
Molecular Biology

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Research Output

12 Article
1 Letter
1 Review Article

A molecular basis for the T cell response in HLA-DQ2.2 mediated celiac disease

Ting, Y. T., Dahal-Koirala, S., Kim, H. S. K., Qiao, S. W., Neumann, R. S., Lundin, K. E. A., Petersen, J., Reid, H. H., Sollid, L. M. & Rossjohn, J., 11 Feb 2020, In : Proceedings of the National Academy of Sciences of the United States of America. 117, 6, p. 3063-3073 11 p.

Research output: Contribution to journal › Article › Research › peer-review

PD-L1– and calcitriol-dependent liposomal antigen-specific regulation of systemic inflammatory autoimmune disease

Galea, R., Nel, H. J., Talekar, M., Liu, X., Ooi, J. D., Huynh, M., Hadjigol, S., Robson, K. J., Ting, Y. T., Cole, S., Cochlin, K., Hitchcock, S., Zeng, B., Yekollu, S., Boks, M., Goh, N., Roberts, H., Rossjohn, J., Reid, H. H., Boyd, B. J. & 7 others, Malaviya, R., Shealy, D. J., Baker, D. G., Madakamutil, L., Richard Kitching, A., O’Sullivan, B. J. & Thomas, R., 19 Sep 2019, In : JCI Insight. 4, 18, 21 p., e126025.

Research output: Contribution to journal › Article › Research › peer-review

Open Access

File

4 Citations (Scopus)

Reply to Roudier et al. HLA-DRB1 polymorphism, anti-citrullinated protein antibodies, and rheumatoid arthritis

Ting, Y. T., Purcell, A. W., Reid, H. H. & Rossjohn, J., 1 Jan 2018, In : The Journal of Biological Chemistry. 293, 18, 1 p.

Research output: Contribution to journal › Letter › Other › peer-review

The interplay between citrullination and HLA-DRB1 polymorphism in shaping peptide binding hierarchies in rheumatoid arthritis

Ting, Y. T., Petersen, J., Ramarathinam, S. H., Scally, S. W., Loh, K. L., Thomas, R., Suri, A., Baker, D. G., Purcell, A. W., Reid, H. H. & Rossjohn, J., 2 Mar 2018, In : The Journal of Biological Chemistry. 293, 9, p. 3236-3251 16 p.

Research output: Contribution to journal › Article › Research › peer-review

Open Access

File

15 Citations (Scopus)

Molecular basis for increased susceptibility of Indigenous North Americans to seropositive rheumatoid arthritis

Scally, S. W., Law, S. C., Ting, Y. T., Heemst, J. V., Sokolove, J., Deutsch, A. J., Bridie Clemens, E., Moustakas, A. K., Papadopoulos, G. K., Woude, D. V. D., Smolik, I., Hitchon, C. A., Robinson, D. B., Ferucci, E. D., Bernstein, C. N., Meng, X., Anaparti, V., Huizinga, T., Kedzierska, K., Reid, H. H. & 5 others, Raychaudhuri, S., Toes, R. E., Rossjohn, J., El-Gabalawy, H. & Thomas, R., 1 Nov 2017, In : Annals of the Rheumatic Diseases. 76, 11, p. 1915-1923 9 p.

Research output: Contribution to journal › Article › Research › peer-review