Projects per year
Personal profile
Biography
Dr. Yan Wang is an Early Career Research Fellow in the Integrative Cardiovascular Pharmacology Group, located in the Department of Pharmacology at Monash University.
Yan has more than 10 years’ experience in cardiovascular pharmacology (both in vivo and in vitro). In 2011, Yan joined Prof Widdop’s group undertaking 3rd year research (3990) project and Yan then completed her Honours Degree in 2012 with 1st class Honours in the Department of Pharmacology, Monash University. The honours results conducted by Yan directly contributed to a successful NHMRC grant (2013-2015; Cardiovascular protective effects of nonclassical angiotensin receptors). Yan was employed by Prof Widdop as a Research Assistant after her Honours year for 3 years before commencing her PhD training from 2016 to 2020.
Yan’s research has been focusing on novel treatments for cardiovascular and renal diseases, especially for end-organ damage (fibrosis) in the heart and kidney. In collaboration with Monash University colleagues, a number of novel peptides with high AT2R selectivity were synthesized and Yan’s studies have demonstrated these novel peptides exhibited marked anti-fibrotic and anti-inflammatory effects both in vitro and in diseased animal models. These results have successfully led to a patent filing in 2018, on which Yan is one of the co-inventors.
During her postdoc training, Yan has established robust high throughput cell assays for anti-fibrotic drug screening and established a new myocardial infarction (heart attack) model in Australia. She’s interested in screening and testing novel therapies for cardiac and renal disease.
Yan has been an active member of HBPRCA and ASCEPT since 2012 and has presented her work annually at both meetings. Yan’s work has been recognized and selected for Finalist Oral Presentation at HBPRCA (2017 and 2019); Finalist at ASCEPT Garth MacQueen Oral Prize (2018). Yan has also received several highly competitive awards including ASCEPT Cardiovascular Special Interest Group Poster Prize (2017); Best Poster Award at the International Society for Hypertension (ISH) meeting in Beijing (2018); HBPRCA Student Poster winner (2018); Young investigator Poster Award at the International Society of Heart Research (ISHR) meeting in Beijing (2019) and Paul Dudley White International Scholar at the Hypertension Scientific Sessions, New Orleans, USA (2019).
Yan’s long-term goal is to be an independent translational researcher to discover/test novel treatments for cardiovascular and renal diseases.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research area keywords
- Cardiovascular Disease
- Renal disease
- Fibrosis
- Inflammation
- Renin Angiotensin System
- Myocardial infarction
- Drug screening
- heart failure therapeutics
Collaborations and top research areas from the last five years
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AT2 Receptor: A novel target for ADPKD
Wang, Y. (Primary Chief Investigator (PCI)) & Widdop, R. (Associate Investigator (AI))
9/09/24 → 31/08/25
Project: Research
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Does selective angiotensin AT2 receptor stimulation protect against end organ extracellular matrix damage in diabetic hypertensives?
Widdop, R. (Primary Chief Investigator (PCI)), Del Borgo, M. (Chief Investigator (CI)), Aguilar, M. (Chief Investigator (CI)), Samuel, C. (Chief Investigator (CI)) & Wang, Y. (Chief Investigator (CI))
1/01/20 → 31/12/20
Project: Research
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Functional crosstalk between angiotensin receptors (types 1 and 2) and relaxin family peptide receptor 1 (RXFP1): Implications for the therapeutic targeting of fibrosis
Samuel, C. S., Li, Y., Wang, Y. & Widdop, R. E., Jul 2024, In: British Journal of Pharmacology. 181, 14, p. 2302-2318 17 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access5 Citations (Scopus) -
Targeting the Angiotensin AT2 Receptor to Treat Cardiac Fibrosis and Heart Failure
Wang, Y., Ferens, D., Salimova, E., Borgo, M., Aguilar, M., Gaspari, T., Nguyen, L., Zhu, L., Xu, P., Denton, K., Wang, M., Samuel, C. & Widdop, R., Aug 2024, In: Heart Lung and Circulation. 33, Supplement 4, p. S486 1 p., 783.Research output: Contribution to journal › Meeting Abstract › peer-review
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Novel AT2R agonist, β-Pro7Ang III, is cardio- and vaso-protective in diabetic spontaneously hypertensive rats
Li, M., Nguyen, L., Ferens, D., Spizzo, I., Wang, Y., Denton, K. M., Del Borgo, M., Kulkarni, K., Aguilar, M. I., Qin, C. H., Samuel, C. S., Gaspari, T. A. & Widdop, R. E., Sept 2023, In: Biomedicine & Pharmacotherapy. 165, 10 p., 115238.Research output: Contribution to journal › Article › Research › peer-review
Open Access9 Citations (Scopus) -
Preclinical rodent models of cardiac fibrosis
Wang, Y., Wang, M., Samuel, C. S. & Widdop, R. E., Mar 2022, In: British Journal of Pharmacology. 179, 5, p. 882-899 18 p.Research output: Contribution to journal › Review Article › Research › peer-review
20 Citations (Scopus) -
The Novel AT2 Receptor Agonist β-Pro7-AngIII Exerts Cardiac and Renal Anti-Fibrotic and Anti-Inflammatory Effects in High Salt-Fed Mice
Wang, Y., Yodgee, J., Del Borgo, M., Spizzo, I., Nguyen, L., Aguilar, M. I., Denton, K. M., Samuel, C. S. & Widdop, R. E., Nov 2022, In: International Journal of Molecular Sciences. 23, 22, 12 p., 14039.Research output: Contribution to journal › Article › Research › peer-review
Open Access7 Citations (Scopus)
Prizes
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Best Poster Award (ISH, Beijing, China 2018)
Wang, Yan (Recipient), 2018
Prize: Prize (including medals and awards)
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Cardiovascular Special Interest Group Prize
Wang, Yan (Recipient), 2017
Prize: Prize (including medals and awards)
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Garth McQueen student oral prize finalist (ASCEPT Adelaide, Australia 2018)
Wang, Yan (Recipient), 2018
Prize: Prize (including medals and awards)
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HBPRCA Young Investigator Travel Award (ISH Glasgow 2020)
Wang, Y. (Recipient), 2020
Prize: Prize (including medals and awards)
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High Blood Pressure Research Council of Australia (HBPRCA) Scientific Exchange Grant 2019
Wang, Y. (Recipient), 2019
Prize: Prize (including medals and awards)
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ASCEPT 2023 Annual Scientific Meeting
Yan Wang (Invited speaker)
2023Activity: Participating in or organising an event types › Contribution to conference
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Australian Cardiovascular Alliance, Cardiovascular symposium
Yan Wang (Invited speaker)
2020Activity: Participating in or organising an event types › Contribution to workshop, seminar, course
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Pharmacology (Organisational unit)
Yan Wang (Inventor)
2018 → …Activity: Industry, Government and Philanthropy Engagement and Partnerships › Patents › Patent