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Personal profile

Biography

Professor Shehabi, a senior clinician academic and experienced clinical trialist with extensive track record in leading multinational large scale RCTs, competitive NHMRC and industry collaborative grant funding, knowledge dissemination through publications in high impact journals and presentations at major critical care meetings. He is a respected opinion leader in critical care, nationally and internationally.

Since 2015, he has published and been involved in more than 45 (13 first author) peer reviewed original research, invited editorials and book chapters with 4300 citations with h-index 26 and i10-index 41 (total 48).  Dr Shehabi has been an NHMRC GRP member in 2014/15/16/17/19 and 2020. He is a peer reviewer for many high impact journals including NEJM, JAMA, Am J Resp Crit Care Medicine, Crit Care Med and Inten Care Medicine.

Professor Shehabi led the Sedation Practice in Intensive Care Evaluation (SPICE) research programme from concept, design, execution, and publications. In collaboration with the Australian and Intensive Care Society Clinical Trials Group (ANZIC CTG), multiple SPICE studies have been conducted and published in leading critical care journals. SPICE I, the foundation of the SPICE program, conducted in 4 countries in 43 ICUs. It uncovered for the first time an independent association between deep sedation in the first 48 hrs of mechanical ventilation and 6 months mortality. SPICE II, a pilot trial conducted in 8 ICUs, tested a new concept of early goal directed sedation using dexmedetomidine as a candidate intervention. SPICE III, a pivotal trial of 4000 patients recruited in 74 ICUs tested the hypothesis that early sedation with dexmedetomidine may reverse early deep sedation and reduce mortality. SPICE IV is the next succession of the SPICE program in older population of ICU patients.

In collaboration with Canadian Critical Care Trials Group, Dr Shehabi assembled a team of investigators in Australia to conduct the BALANCE trial, Bacteraemia Antibiotic Length Actually Needed for Clinical Effectiveness. In collaboration with Infectious disease consultants at MU, a successful NHMRC grant was secured for the completion of the trial.

He has been the chief investigator of the randomised multicentre RCT, the ProGUARD trial, funded by the Intensive Care Foundation, in 12 ICUs in Australia, evaluating the utility of Procalcitonin in patients with undifferentiated infections in ICU. The results of which were published in the AJRCCM in 2012. Since then, he collaborated widely with international colleagues and participated in multiple publications in the Lancet Inf Dis and the Cochrane reviews on the utility of Procalcitonin in managing respiratory infections.

Through his research, Professor Shehabi is considered a national and an international authority on sedation and delirium management and on the use of dexmedetomidine in critical care and perioperative medicine. He actively participated in the Society Critical Care Medicine taskforce which composed and published the widely disseminated PADIS guidelines, published in Crit Care Med in 2018. He is part of an international delirium interest group evaluating the prevention and impact delirium in hospital and ICU patients. He has led the SaferCare Victoria sedation and delirium management plan, known as the Vic-PAD ICU. The first stage was conducted in 13 ICUs in Victoria prior to the COVID-19 pandemic.

Dr Shehabi established a successful collaboration with medical pharma and device companies securing > A$ 3 million in direct and in-kind funding over the last 5 years.  

Education/Academic qualification

Medicine , PhD, University of New South Wales

Award Date: 2 May 2016

Business Admin, Executive Masters Business Administration, University of Technology Sydney

Award Date: 30 Jun 2003

External positions

Conj Professor Clinical School of Medicine , University of New South Wales

1 Mar 2013 → …

Research area keywords

  • critical illness
  • Delirium
  • Acute kidney injury
  • Biomarkers
  • antibiotic prescribing

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Projects

Research Output

Effect of Vitamin C, Hydrocortisone, and Thiamine vs Hydrocortisone Alone on Time Alive and Free of Vasopressor Support among Patients with Septic Shock: The VITAMINS Randomized Clinical Trial

Fujii, T., Luethi, N., Young, P. J., Frei, D. R., Eastwood, G. M., French, C. J., Deane, A. M., Shehabi, Y., Hajjar, L. A., Oliveira, G., Udy, A. A., Orford, N., Edney, S. J., Hunt, A. L., Judd, H. L., Bitker, L., Naorungroj, T., Yanase, F., Bates, S., McGain, F. & 9 others, Hudson, E. P., Al-Bassam, W., Dwivedi, D. B., Peppin, C., McCracken, P., Orosz, J., Bailey, M., Bellomo, R. & for the VITAMINS Trial Investigators, 4 Feb 2020, In : JAMA - Journal of the American Medical Association. 323, 5, p. 423-431 9 p.

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)

Conservative oxygen therapy for mechanically ventilated adults with sepsis: a post hoc analysis of data from the intensive care unit randomized trial comparing two approaches to oxygen therapy (ICU-ROX)

Young, P., Mackle, D., Bellomo, R., Bailey, M., Beasley, R., Deane, A., Eastwood, G., Finfer, S., Freebairn, R., King, V., Linke, N., Litton, E., McArthur, C., McGuinness, S., Panwar, R. & the ICU-ROX Investigators the Australian New Zealand Intensive Care Society Clinical Trials Group, Jan 2019, In : Intensive Care Medicine. p. 17-26 10 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Driving Simulator Performance after Administration of Analgesic Doses of Ketamine with Dexmedetomidine or Fentanyl

Hayley, A. C., Downey, L. A., Green, M., Shiferaw, B., Kenneally, M., Keane, M., Adams, M. & Shehabi, Y., 1 Sep 2019, In : Journal of Clinical Psychopharmacology. 39, 5, p. 446-454 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Duration of therapy recommended for bacteraemic illness varies widely amongst clinicians

Alwan, M., Davis, J. S., Daneman, N., Fowler, R., Shehabi, Y. & Rogers, B., 1 Aug 2019, In : International Journal of Antimicrobial Agents. 54, 2, p. 184-188 5 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Early sedation with dexmedetomidine in critically ill patients

Shehabi, Y., Howe, B. D., Bellomo, R., Arabi, Y. M., Bailey, M., Bass, F. E., Bin Kadiman, S., McArthur, C. J., Murray, L., Reade, M. C., Seppelt, I. M., Takala, J., Wise, M. P. & Webb, S. A., 27 Jun 2019, In : The New England Journal of Medicine. 380, 26, p. 2506-2517 12 p.

Research output: Contribution to journalArticleResearchpeer-review

42 Citations (Scopus)