Projects per year
Personal profile
Biography
Professor Shehabi, a senior clinician academic and experienced clinical trialist with extensive track record in leading multinational large scale RCTs, competitive NHMRC and industry collaborative grant funding, knowledge dissemination through publications in high impact journals and presentations at major critical care meetings. He is a respected opinion leader in critical care, nationally and internationally.
Since 2015, he has published and been involved in more than 45 (13 first author) peer reviewed original research, invited editorials and book chapters with 4300 citations with h-index 26 and i10-index 41 (total 48). Dr Shehabi has been an NHMRC GRP member in 2014/15/16/17/19 and 2020. He is a peer reviewer for many high impact journals including NEJM, JAMA, Am J Resp Crit Care Medicine, Crit Care Med and Inten Care Medicine.
Professor Shehabi led the Sedation Practice in Intensive Care Evaluation (SPICE) research programme from concept, design, execution, and publications. In collaboration with the Australian and Intensive Care Society Clinical Trials Group (ANZIC CTG), multiple SPICE studies have been conducted and published in leading critical care journals. SPICE I, the foundation of the SPICE program, conducted in 4 countries in 43 ICUs. It uncovered for the first time an independent association between deep sedation in the first 48 hrs of mechanical ventilation and 6 months mortality. SPICE II, a pilot trial conducted in 8 ICUs, tested a new concept of early goal directed sedation using dexmedetomidine as a candidate intervention. SPICE III, a pivotal trial of 4000 patients recruited in 74 ICUs tested the hypothesis that early sedation with dexmedetomidine may reverse early deep sedation and reduce mortality. SPICE IV is the next succession of the SPICE program in older population of ICU patients.
In collaboration with Canadian Critical Care Trials Group, Dr Shehabi assembled a team of investigators in Australia to conduct the BALANCE trial, Bacteraemia Antibiotic Length Actually Needed for Clinical Effectiveness. In collaboration with Infectious disease consultants at MU, a successful NHMRC grant was secured for the completion of the trial.
He has been the chief investigator of the randomised multicentre RCT, the ProGUARD trial, funded by the Intensive Care Foundation, in 12 ICUs in Australia, evaluating the utility of Procalcitonin in patients with undifferentiated infections in ICU. The results of which were published in the AJRCCM in 2012. Since then, he collaborated widely with international colleagues and participated in multiple publications in the Lancet Inf Dis and the Cochrane reviews on the utility of Procalcitonin in managing respiratory infections.
Through his research, Professor Shehabi is considered a national and an international authority on sedation and delirium management and on the use of dexmedetomidine in critical care and perioperative medicine. He actively participated in the Society Critical Care Medicine taskforce which composed and published the widely disseminated PADIS guidelines, published in Crit Care Med in 2018. He is part of an international delirium interest group evaluating the prevention and impact delirium in hospital and ICU patients. He has led the SaferCare Victoria sedation and delirium management plan, known as the Vic-PAD ICU. The first stage was conducted in 13 ICUs in Victoria prior to the COVID-19 pandemic.
Dr Shehabi secured over $20M funding for the SPICE program and obtained industry (Pfizer and Orion Pharma), NHMRC CIA, NZ Health Research Council, Malaysian Heart Foundation, UK NIHR portfolio funding for the SPICE-III, and NHMRC, Canadian Institute of Health Research, German Council funding and UK NIHR portfolio funding for SPICE-IV. He played leading role in securing over $25M outside the SPICE program in ANZ, Canada, USA, and Europe.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Medicine , PhD, Sedation and Delirium in Ventilated Critically Ill Patients in Australia and New Zealand Prevalence, Impact and Prevention, University of New South Wales (UNSW)
Award Date: 2 May 2016
Business Admin, Executive Masters Business Administration, By course attendance, University of Technology (UTS) Sydney
Award Date: 30 Jun 2003
External positions
Director Research, Intensive Care , Monash Health
2017 → …
Program Medical Director, Critical Care , Monash Health
2015 → 2017
Conj Professor Clinical School of Medicine , University of New South Wales (UNSW)
1 Mar 2013 → …
Director, Australia and New Zealand Intensive Care Society (ANZICS)
2005 → 2010
Court of Examiners , College of Intensive Care Medicine of Australia and New Zealand
2005 → 2017
Chair, Economics and Practice Committee , Australia and New Zealand Intensive Care Society (ANZICS)
2004 → 2010
Program Medical Director Acute Care Services, Prince of Wales Private Hospital (Randwick)
2004 → 2014
Court of Examiners , Australian and New Zealand College of Anaesthetists (ANZCA)
1998 → 2010
Director, Adult Intensive Care Services, Prince of Wales Private Hospital (Randwick)
1997 → 2012
Research area keywords
- critical illness
- Delirium
- Acute kidney injury
- Biomarkers
- antibiotic prescribing
Collaborations and top research areas from the last five years
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Continuous monitoring of ICU and CCU patients’ vancomycin levels in interstitial fluid: a pilot characterization study of a new device
Shehabi, Y. (Primary Chief Investigator (PCI))
17/03/25 → 16/03/30
Project: Research
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A randomized, placebo-controlled, double-blind, multi-center, phase III trial to assess the efficacy and safety of trimodulin (BT588) in adult hospitalized subjects with severe community-acquired pneumonia (sCAP)
Shehabi, Y. (Primary Chief Investigator (PCI))
12/06/24 → 11/06/29
Project: Research
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A Randomized, Sham Controlled, Double-blinded, Multi-center Trial to Evaluate the Efficacy of the VentFree Respiratory Muscle Stimulator to Assist Ventilator Weaning in Critically Ill Patients
Shehabi, Y. (Primary Chief Investigator (PCI))
19/12/23 → 18/12/28
Project: Research
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MEGA-dose aSCORbatE for Sepsis (MEGASCORES): An interdisciplinary research program to transform management of sepsis in intensive care units
Lankadeva, Y. R. (Primary Chief Investigator (PCI)), Plummer, M. P. (Chief Investigator (CI)), Cook, L. (Chief Investigator (CI)), Roquilly, A. (Chief Investigator (CI)), Booth, L. C. (Chief Investigator (CI)), Glassford, N. (Chief Investigator (CI)), Wen, S. W. (Chief Investigator (CI)), Wood, A. (Chief Investigator (CI)), Ow , P. C. C. (Chief Investigator (CI)), Emery, S. (Chief Investigator (CI)), Bellomo, R. (Associate Investigator (AI)), Shehabi, Y. (Associate Investigator (AI)), Reade, M. (Associate Investigator (AI)), Saxena, M. K. (Associate Investigator (AI)), Secombe, P. (Associate Investigator (AI)), May, C. (Associate Investigator (AI)), Wong, C. (Associate Investigator (AI)), See, E. (Associate Investigator (AI)), Betrie, A. H. (Associate Investigator (AI)) & Melbourne, U. (Associate Investigator (AI))
1/02/23 → 31/07/28
Project: Research
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A Randomized, Double-Blind, Placebo-Controlled, Two-Arm Parallel-Group, Multi-Center Phase 3 Pivotal Trial to Investigate the Efficacy and Safety of Recombinant Human Alkaline Phosphatase for Treatment of Patients with Sepsis- Associated Acute Kidney Injury
Shehabi, Y. (Primary Chief Investigator (PCI))
17/06/22 → 16/06/27
Project: Research
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The impact of a tailored nutrition intervention delivered for the duration of hospitalisation on daily energy delivery for patients with critical illness (INTENT): a phase II randomised controlled trial
Ridley, E. J., Bailey, M., Chapman, M. J., Chapple, L. A. S., Deane, A. M., Gojanovic, M., Higgins, A. M., Hodgson, C. L., King, V. L., Marshall, A., Miller, E. G., McGuinness, S. P., Parke, R. L., Paul, E., Udy, A. A. & The Australian, New Zealand Intensive Care Society Clinical Trials Group, 6 Jan 2025, In: Critical Care. 29, 1, 13 p., 8.Research output: Contribution to journal › Article › Research › peer-review
Open Access -
Alternative approaches to analyzing ventilator-free days, mortality and duration of ventilation in critical care research
Serpa Neto, A., Bailey, M., Shehabi, Y., Hodgson, C. L. & Bellomo, R., 2024, In: Critical Care Science. 36, 8 p., e20240246en.Research output: Contribution to journal › Article › Research › peer-review
Open Access4 Citations (Scopus) -
Ketamine analgo-sedation for mechanically ventilated critically ill adults: A rapid practice guideline from the Saudi Critical Care Society and the Scandinavian Society of Anesthesiology and Intensive Care Medicine
Amer, M., Møller, M. H., Alshahrani, M., Shehabi, Y., Arabi, Y. M., Alshamsi, F., Sigurðsson, M. I., Rehn, M., Chew, M. S., Kalliomäki, M. L., Lewis, K., Al-Suwaidan, F. A., Al-Dorzi, H. M., Al-Fares, A., Alsadoon, N., Bell, C. M., Groth, C. M., Parke, R., Mehta, S. & Wischmeyer, P. E. & 3 others, , Oct 2024, In: Acta Anaesthesiologica Scandinavica. 68, 9, p. 1161-1178 18 p.Research output: Contribution to journal › Article › Other › peer-review
Open Access -
Ketamine Analgo-sedation for Mechanically Ventilated Critically Ill Adults: A Rapid Practice Guideline from the Saudi Critical Care Society and the Scandinavian Society of Anesthesiology and Intensive Care Medicine
Amer, M., Møller, M. H., Alshahrani, M., Shehabi, Y., Arabi, Y. M., Alshamsi, F., Sigurðsson, M. I., Rehn, M., Chew, M. S., Kalliomäki, M. L., Lewis, K., Al-Suwaidan, F. A., Al-Dorzi, H. M., Al-Fares, A., Alsadoon, N., Bell, C. M., Groth, C. M., Parke, R., Mehta, S. & Wischmeyer, P. E. & 3 others, , 2024, (Accepted/In press) In: Anesthesia and Analgesia. 18 p.Research output: Contribution to journal › Article › Research › peer-review
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Procalcitonin-Guided Management and Duration of Antibiotic Therapy in Critically Ill Cancer Patients With Sepsis (Pro-Can Study): A Randomized Controlled Trial
Nazer, L. H., Awad, W., Thawabieh, H., Abusara, A., Abdelrahman, D., Addassi, A., Abuatta, O., Sughayer, M. & Shehabi, Y., 21 Oct 2024, In: Critical Care Explorations. 6, 10, 9 p., e1173.Research output: Contribution to journal › Article › Research › peer-review
Open Access