Xiaowei Wang

Dr

20112019
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Research Output 2011 2019

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2019

Activated platelets in the tumor microenvironment for targeting of antibody-drug conjugates to tumors and metastases

Yap, M. L., McFadyen, J. D., Wang, X., Ziegler, M., Chen, Y. C., Willcox, A., Nowell, C. J., Scott, A. M., Sloan, E. K., Hogarth, P. M., Pietersz, G. A. & Peter, K., 1 Jan 2019, In : Theranostics. 9, 4, p. 1154-1169 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Targeting CD39 Toward Activated Platelets Reduces Systemic Inflammation and Improves Survival in Sepsis: A Preclinical Pilot Study

Granja, T., Körner, A., Glück, C., Hohmann, J. D., Wang, X., Köhler, D., Streißenberger, A., Nandurkar, H. H., Mirakaj, V., Rosenberger, P., Peter, K. & Straub, A., 1 May 2019, In : Critical Care Medicine. 47, 5, p. e420-e427 8 p.

Research output: Contribution to journalArticleResearchpeer-review

2018

A single-chain antibody-CD39 fusion protein targeting activated platelets protects from cardiac ischaemia/reperfusion injury

Ziegler, M., Hohmann, J. D., Searle, A. K., Abraham, M-K., Nandurkar, H. H. & Wang, X., 7 Jan 2018, In : European Heart Journal. 39, 2, p. 111-116 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Platelet-targeted dual pathway antithrombotic inhibits thrombosis with preserved hemostasis

Hanjaya-Putra, D., Haller, C., Wang, X., Dai, E., Lim, B., Liu, L., Jaminet, P., Yao, J., Searle, A., Bonnard, T., Hagemeyer, C. E., Peter, K. & Chaikof, E. L., 9 Aug 2018, In : JCI Insight. 3, 15, p. 1-18 18 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
2017

Association between MRI-detected osteophytes and changes in knee structures and pain in older adults: a cohort study

Zhu, Z., Laslett, L. L., Jin, X., Han, W., Antony, B. E., Wang, X., Lu, M., Cicuttini, F., Jones, G. & Ding, C., 1 Jul 2017, In : Osteoarthritis and Cartilage. 25, 7, p. 1084-1092 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Associations between endogenous sex hormones and MRI structural changes in patients with symptomatic knee osteoarthritis

Jin, X., Wang, B. H., Wang, X., Antony, B. E., Zhu, Z., Han, W., Cicuttini, F., Wluka, A. E., Winzenberg, T. M., Blizzard, C. L., Jones, G. & Ding, C., 1 Jul 2017, In : Osteoarthritis and Cartilage. 25, 7, p. 1100-1106 7 p.

Research output: Contribution to journalArticleResearchpeer-review

A unique recombinant fluoroprobe targeting activated platelets allows in vivo detection of arterial thrombosis and pulmonary embolism using a novel three-dimensional fluorescence emission computed tomography (FLECT) technology

Lim, B., Yao, Y., Huang, A. L. I., Yap, M. L., Flierl, U., Palasubramaniam, J., Zaldivia, M. T. K., Wang, X. & Peter, K., 2017, In : Theranostics. 7, 5, p. 1047-1061 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Cationic Nanoliposomes Meet mRNA: Efficient Delivery of Modified mRNA Using Hemocompatible and Stable Vectors for Therapeutic Applications

Michel, T., Luft, D., Abraham, M. K., Reinhardt, S., Salinas Medina, M. L., Kurz, J., Schaller, M., Avci-Adali, M., Schlensak, C., Peter, K., Wendel, H. P., Wang, X. & Krajewski, S., 15 Sep 2017, In : Molecular Therapy - Nucleic Acids. 8, p. 459-468 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Knee effusion-synovitis volume measurement and effects of vitamin D supplementation in patients with knee osteoarthritis

Wang, X., Cicuttini, F., Jin, X., Wluka, A. E., Han, W., Zhu, Z., Blizzard, L., Antony, B., Winzenberg, T., Jones, G. & Ding, C., Aug 2017, In : Osteoarthritis and Cartilage. 25, 8, p. 1304 - 1312 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Maintaining Vitamin D Sufficiency Is Associated with Improved Structural and Symptomatic Outcomes in Knee Osteoarthritis

Zheng, S., Jin, X., Cicuttini, F., Wang, X., Zhu, Z., Wluka, A., Han, W., Winzenberg, T., Antony, B., Aitken, D., Blizzard, L., Jones, G. & Ding, C., Oct 2017, In : American Journal of Medicine. 130, 10, p. 1211-1218 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Molecular imaging of activated platelets via antibody-targeted ultra-small iron oxide nanoparticles displaying unique dual MRI contrast

Ta, H. T., Li, Z., Hagemeyer, C. E., Cowin, G., Zhang, S., Palasubramaniam, J., Alt, K., Wang, X., Peter, K. & Whittaker, A. K., 1 Jul 2017, In : Biomaterials. 134, p. 31-42 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Molecular Imaging of Atherothrombotic Diseases: Seeing Is Believing

Wang, X. & Peter, K., 1 Jun 2017, In : Arteriosclerosis, Thrombosis and Vascular Biology. 37, 6, p. 1029-1040 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Platelet-targeted delivery of peripheral blood mononuclear cells to the ischemic heart restores cardiac function after ischemia-reperfusion injury

Ziegler, M., Wang, X., Lim, B., Leitner, E., Klingberg, F., Ching, V., Yao, Y., Huang, D., Gao, X. M., Kiriazis, H., Du, X. J., Haigh, J. J., Bobik, A., Hagemeyer, C. E., Ahrens, I. & Peter, K., 2017, In : Theranostics. 7, 13, p. 3192-3206 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Targeting activated platelets: A unique and potentially universal approach for cancer imaging

Yap, M. L., McFadyen, J. D., Wang, X., Zia, N. A., Hohmann, J. D., Ziegler, M., Yao, Y., Pham, A., Harris, M., Donnelly, P. S., Hogarth, P. M., Pietersz, G. A., Lim, B. & Peter, K., 2017, In : Theranostics. 7, 10, p. 2565-2574 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Transitional changes in the CRP structure lead to the exposure of proinflammatory binding sites

Braig, D., Nero, T. L., Koch, H. G., Kaiser, B., Wang, X., Thiele, J. R., Morton, C. J., Zeller, J., Kiefer, J., Potempa, L. A., Mellett, N. A., Miles, L. A., Du, X. J., Meikle, P. J., Huber-Lang, M., Stark, G. B., Parker, M. W., Peter, K. & Eisenhardt, S. U., 23 Jan 2017, In : Nature Communications. 8, 19 p., 14188.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2016

Preimplantation factor prevents atherosclerosis via its immunomodulatory effects without affecting serum lipids

Chen, Y. C., Rivera, J., Fitzgerald, M., Hausding, C., Ying, Y. L., Wang, X., Todorova, K., Hayrabedyan, S., Barnea, E. R. & Peter, K., 1 May 2016, In : Thrombosis and Haemostasis. 115, 5, p. 1010-1024 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Thrombus-targeted theranostic microbubbles: A new technology towards concurrent rapid ultrasound diagnosis and bleeding-free fibrinolytic treatment of thrombosis

Wang, X., Gkanatsas, Y., Palasubramaniam, J., Hohmann, J. D., Chen, Y. C., Lim, B., Hagemeyer, C. E. & Peter, K., 2016, In : Theranostics. 6, 5, p. 726 - 738 13 p.

Research output: Contribution to journalArticleResearchpeer-review

2015

A versatile approach for the site-specific modification of recombinant antibodies using a combination of enzyme-mediated bioconjugation and click chemistry

Alt, K. M., Paterson, B. M., Westein, E., Rudd, S., Poniger, S., Jagdale, S., Ardipradja, K., Connell, T. U., Krippner, G. Y., Nair, A. K. N., Wang, X., Tochon-Danguy, H., Donnelly, P. S., Peter, K. & Hagemeyer, C. E., 2015, In : Angewandte Chemie - International Edition. 54, 26, p. 7515 - 7519 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Multifunctional Thrombin-Activatable Polymer Capsules for Specific Targeting to Activated Platelets

Gunawan, S. T., Kempe, K., Bonnard, T. M. E., Cui, J., Alt, K. M., Law, L. S., Wang, X., Westein, E., Such, G. K., Peter, K., Hagemeyer, C. E. & Caruso, F., 2015, In : Advanced Materials. 27, 35, p. 5153-5157 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Nanoporous metal-phenolic particles as ultrasound imaging probes for hydrogen peroxide

Guo, J., Wang, X., Henstridge, D. C., Richardson, J. J., Cui, J., Sharma, A., Febbraio, M. A., Peter, K., De Haan-Klein, J. B., Hagemeyer, C. E. & Caruso, F., 2015, In : Advanced Healthcare Materials. 4, 14, p. 2170 - 2175 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Particle generation, functionalization and sortase A-mediated modification with targeting of single-chain antibodies for diagnostic and therapeutic use

Hagemeyer, C. E., Alt, K. M., Johnston, A., Such, G. K., Ta, H. T., Leung, M. K. M., Prabhu, S., Wang, X., Caruso, F. & Peter, K., 2015, In : Nature Protocols. 10, 1, p. 90 - 105 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Targeted antithrombotic protein micelles

Kim, W., Haller, C. A., Dai, E., Wang, X., Hagemeyer, C. E., Liu, D. R., Peter, K. & Chaikof, E. L., 2015, In : Angewandte Chemie - International Edition. 54, 5, p. 1461 - 1465 5 p.

Research output: Contribution to journalArticleResearchpeer-review

2014

Single-Chain antibody conjugated to a cage amine chelator and labeled with positron-emitting copper-64 for diagnostic imaging of activated platelets

Alt, K. M., Paterson, B. M., Ardipradja, K., Schieber, C., Buncic, G., Lim, B., Poniger, S., Jakoby, B., Wang, X., O'Keefe, G. J., Tochon-Danguy, H., Scott, A. M., Ackermann, U., Peter, K., Donnelly, P. S. & Hagemeyer, C. E., 2014, In : Molecular Pharmaceutics. 11, 8, p. 2855-2863 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Towards effective and safe thrombolysis and thromboprophylaxis: preclinical testing of a novel antibody-targeted recombinant plasminogen activator directed against activated platelets

Wang, X., Palasubramaniam, J., Gkanatsas, Y., Hohmann, J. D., Westein, E., Kanojia, R., Alt, K., Huang, D., Jia, F., Ahrens, I., Medcalf, R. L., Peter, K. & Hagemeyer, C. E., 2014, In : Circulation Research. 114, 7, p. 1083 - 1093 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2013

Delayed targeting of CD39 to activated platelet GPIIb/IIIa via a single-chain antibody: breaking the link between antithrombotic potency and bleeding?

Hohmann, J. D., Wang, X., Krajewski, S., Selan, C., Haller, C. A., Straub, A., Chaikof, E. L., Nandurkar, H. H., Hagemeyer, C. E. & Peter, K., 2013, In : Blood. 121, 16, p. 3067 - 3075 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2012

Amyloid plaques dissociate pentameric to monomeric C-reactive protein: a novel pathomechanism driving cortical inflammation in Alzheimer's disease?

Strang, F., Scheichl, A., Chen, Y-C., Wang, X., Htun, N-M., Bassler, N., Eisenhardt, S. U., Habersberger, J. P. & Peter, K., 2012, In : Brain Pathology. 22, 3, p. 337 - 346 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Novel single-chain antibody-targeted microbubbles for molecular ultrasound imaging of thrombosis: Validation of a unique noninvasive method for rapid and sensitive detection of thrombi and monitoring of success or failure of thrombolysis in mice

Wang, X., Hagemeyer, C. E., Hohmann, J. D., Leitner, E., Armstrong, P. CJ., Jia, F., Olschewski, M., Needles, A., Peter, K. & Ahrens, I., 2012, In : Circulation. 125, 25, p. 3117 - 3126 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2011

Enzymatic single-chain antibody tagging: A universal approach to targeted molecular imaging and cell homing in cardiovascular disease

Ta, H. T., Prabhu, S., Leitner, E., Jia, F., von Elverfeldt, D., Jackson, K. E., Heidt, T., Nair, A. K. N., Pearce, H., Von Zur Muhlen, C., Wang, X., Peter, K. & Hagemeyer, C. E., 2011, In : Circulation Research. 109, 4, p. 365 - 373 9 p.

Research output: Contribution to journalArticleResearchpeer-review