Projects per year
Personal profile
Biography
Professor William Sievert is a clinician-scientist with dual appointments at Monash University and Monash Health as the Director of the Gastrointestinal and Liver Unit. Professor Sievert has a long-term interest in liver disease and directs an active clinical research unit comprising physician-scientists, clinical research nurses and research students.
The Clinical Research Unit has been continuously active over ten years and regularly contributes to international trials of new antiviral agents for hepatitis B and C in addition to developing and leading national investigator-initiated studies. He also directs a basic research laboratory investigating mechanisms of inflammatory liver injury and hepatic fibrogenesis, with a translational focus on identification and development of potential hepatic antifibrotic agents.
Professor Sievert is also active in medical education including the development of new undergraduate and graduate medical curricula at Monash University.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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A Phase 3 Double-blinded, Two-arm Study to Evaluate the Safety and Efficacy of Pembrolizumab (MK-3475) versus Placebo as Adjuvant Therapy in Participants with Hepatocellular Carcinoma and Complete Radiological Response after Surgical Resection of Local Ablation (KEYNOTE-937)
Braude, M. (Primary Chief Investigator (PCI)) & Sievert, W. (Chief Investigator (CI))
5/10/22 → 4/10/27
Project: Research
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Application of follistatin to the resolution of liver fibrosis.
Phillips, D. (Primary Chief Investigator (PCI)), Sievert, W. (Chief Investigator (CI)) & de Kretser, D. (Chief Investigator (CI))
NHMRC - National Health and Medical Research Council (Australia)
Project: Research
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Therapeutic targeting of JAK-STAT pathway in a novel mouse model for gastro-intestinal cancers
Jenkins, B. (Primary Chief Investigator (PCI)), Ernst, M. R. W. (Chief Investigator (CI)), Segal, D. H. (Chief Investigator (CI)) & Sievert, W. (Chief Investigator (CI))
Project: Research
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A novel exosome therapy for perianal fistulas occurring in Crohn’s Disease patients
Lim, R. (Primary Chief Investigator (PCI)), Moore, G. (Chief Investigator (CI)), Keung, C. (Chief Investigator (CI)), Sievert, W. (Chief Investigator (CI)) & Chan, S. (Chief Investigator (CI))
1/06/23 → 31/03/25
Project: Research
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A Nonrandomized Pilot Study to Investigate the Acceptability and Feasibility of LivR Well: A Multifaceted 28-Day Home-Based Liver Optimization Program for Acute-on-Chronic Liver Failure
Ngu, N. L. Y., Saxby, E., Worland, T., Anderson, P., Stothers, L., Hunter, J., Elford, A. T., Ha, P., Hartley, I., Roberts, A., Seah, D., Tambakis, G., Connoley, D., Figredo, A., Ratnam, D., Liew, D., Rogers, B., Sievert, W., Bell, S. & Le, S., 2025, In: Gastro Hep Advances. 4, 2, 10 p., 100567.Research output: Contribution to journal › Article › Research › peer-review
Open Access4 Link opens in a new tab Citations (Scopus) -
Alcohol does not impact chronic hepatitis C treatment outcomes but increases risk for progressive liver disease: Findings from a prospective multicentre Australian study (OPERA-C)
Clark, P. J., Valery, P. C., Strasser, S. I., Weltman, M., Thompson, A., Levy, M. T., Leggett, B., Zekry, A., Rong, J., Sinclair, M., George, J., Sievert, W., MacQuillan, G., Tse, E., Nicoll, A., Wade, A., Cheng, W. & Roberts, S. K., Sept 2024, In: Drug and Alcohol Review. 43, 6, p. 1559-1572 14 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access1 Link opens in a new tab Citation (Scopus) -
Broadening and strengthening the health providers caring for patients with chronic hepatitis C may improve continuity of care
Clark, P. J., Valery, P. C., Strasser, S. I., Weltman, M., Thompson, A., Levy, M. T., Leggett, B., Zekry, A., Rong, J., Sinclair, M., George, J., Bollipo, S., McGarity, B., Sievert, W., MacQuillan, G., Tse, E., Nicoll, A., Wade, A., Cheng, W. & Roberts, S. K., Mar 2024, In: Journal of Gastroenterology and Hepatology. 39, 3, p. 568-575 8 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access1 Link opens in a new tab Citation (Scopus) -
High end-of-treatment hepatitis B core-related antigen levels predict hepatitis flare after stopping nucleot(s)ide analogue therapy
Hume, S. J., Wong, D. K., Yuen, M. F., Jackson, K., Bonanzinga, S., Vogrin, S., Hall, S. A. L., Burns, G. S., Desmond, P. V., Sundararajan, V., Ratnam, D., Levy, M. T., Lubel, J. S., Nicoll, A. J., Strasser, S. I., Sievert, W., Ngu, M. C., Sinclair, M., Meredith, C. & Matthews, G. & 6 others, , Oct 2024, In: Liver International. 44, 10, p. 2605-2614 10 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access13 Link opens in a new tab Citations (Scopus) -
Human Amniotic Epithelial Cell Transplantation is Safe and Well Tolerated in Patients with Compensated Cirrhosis: A First-in-Human Trial
Lim, R., Hodge, A., Warner, S., Moore, G. T., Correia, J., Krause, M., McDonald, H., Chan, S. T., Goonetilleke, M., Lyon, S. M. & Sievert, W., Jun 2024, In: Stem Cells Translational Medicine. 13, 6, p. 522-531 10 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access7 Link opens in a new tab Citations (Scopus)