Projects per year
Personal profile
Biography
Professor William Sievert is a clinician-scientist with dual appointments at Monash University and Monash Health as the Director of the Gastrointestinal and Liver Unit. Professor Sievert has a long-term interest in liver disease and directs an active clinical research unit comprising physician-scientists, clinical research nurses and research students.
The Clinical Research Unit has been continuously active over ten years and regularly contributes to international trials of new antiviral agents for hepatitis B and C in addition to developing and leading national investigator-initiated studies. He also directs a basic research laboratory investigating mechanisms of inflammatory liver injury and hepatic fibrogenesis, with a translational focus on identification and development of potential hepatic antifibrotic agents.
Professor Sievert is also active in medical education including the development of new undergraduate and graduate medical curricula at Monash University.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Collaborations and top research areas from the last five years
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A novel exosome therapy for perianal fistulas occurring in Crohn’s Disease patients
Lim, R., Moore, G., Keung, C. Y. Y., Sievert, W. & Chan, S.
1/06/23 → 31/03/25
Project: Research
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A Phase 3 Double-blinded, Two-arm Study to Evaluate the Safety and Efficacy of Pembrolizumab (MK-3475) versus Placebo as Adjuvant Therapy in Participants with Hepatocellular Carcinoma and Complete Radiological Response after Surgical Resection of Local Ablation (KEYNOTE-937)
5/10/22 → 4/10/27
Project: Research
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Locally administered extracellular vesicles for perianal fistulising Crohn's disease
Moore, G., Keung, C. Y. Y., Lim, R., Sievert, W. & Nguyen, T. C.
1/06/21 → 28/02/25
Project: Research
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A Phase 3 Multicenter, Randomized, Double-blinded, Active-controlled, Clinical Study to Evaluate the Safety and Efficacy of Lenvatinib (E7080/MK-7902) in Combination with Pembrolizumab (MK-3475) Versus Lenvatinib in First-line Therapy of Participants with Advanced Hepatocellular Carcinoma
24/01/20 → 23/01/25
Project: Research
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Hepatitis B Virus Flares After Nucleot(s)ide Analogue Cessation Are Associated With Activation of Toll-Like Receptor Signaling Pathways
Hall, S. A. L., Burns, G. S., Mooney, B. J., Millen, R., Morris, R., Vogrin, S., Sundararajan, V., Ratnam, D., Levy, M. T., Lubel, J. S., Nicoll, A. J., Strasser, S. I., Sievert, W., Desmond, P. V., Ngu, M. C., Angus, P., Sinclair, M., Meredith, C., Matthews, G., Revill, P. A., & 6 others , 1 Jan 2023, In: The Journal of Infectious Diseases. 227, 1, p. 123-132 10 p.Research output: Contribution to journal › Article › Research › peer-review
1 Citation (Scopus) -
Liver stiffness (Fibroscan®) is a predictor of all-cause mortality in people with non-alcoholic fatty liver disease
Braude, M., Roberts, S., Majeed, A., Lubel, J., Prompen, J., Dev, A., Sievert, W., Bloom, S., Gow, P. & Kemp, W., 2023, In: Liver International. 43, 1, p. 90-99 10 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access9 Citations (Scopus) -
A home-based, multidisciplinary liver optimisation programme for the first 28 days after an admission for acute-on-chronic liver failure (LivR well): a study protocol for a randomised controlled trial
Ngu, N. L., Saxby, E., Worland, T., Anderson, P., Stothers, L., Figredo, A., Hunter, J., Elford, A., Ha, P., Hartley, I., Roberts, A., Seah, D., Tambakis, G., Liew, D., Rogers, B., Sievert, W., Bell, S. & Le, S., 5 Sept 2022, In: Trials. 23, 1, 11 p., 744.Research output: Contribution to journal › Article › Other › peer-review
Open Access2 Citations (Scopus) -
Combination treatments including the small-interfering RNA JNJ-3989 induce rapid and sometimes prolonged viral responses in patients with CHB
Yuen, M. F., Locarnini, S., Lim, T. H., Strasser, S. I., Sievert, W., Cheng, W., Thompson, A. J., Given, B. D., Schluep, T., Hamilton, J., Biermer, M., Kalmeijer, R., Beumont, M., Lenz, O., De Ridder, F., Cloherty, G., Ka-Ho Wong, D., Schwabe, C., Jackson, K., Lai, C. L., & 2 others , Nov 2022, In: Journal of Hepatology. 77, 5, p. 1287-1298 12 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access21 Citations (Scopus) -
Determinants of Hepatitis C Virus Prevalence in People with Serious Mental Illness: A Systematic Review and Meta-Analysis
Braude, M. R., Phan, T., Dev, A. & Sievert, W., Jan 2022, In: Journal of Clinical Psychiatry. 83, 1, 15 p., 21r14079.Research output: Contribution to journal › Review Article › Research › peer-review
2 Citations (Scopus)