Projects per year
Personal profile
Biography
Professor William Sievert is a clinician-scientist with dual appointments at Monash University and Monash Health as the Director of the Gastrointestinal and Liver Unit. Professor Sievert has a long-term interest in liver disease and directs an active clinical research unit comprising physician-scientists, clinical research nurses and research students.
The Clinical Research Unit has been continuously active over ten years and regularly contributes to international trials of new antiviral agents for hepatitis B and C in addition to developing and leading national investigator-initiated studies. He also directs a basic research laboratory investigating mechanisms of inflammatory liver injury and hepatic fibrogenesis, with a translational focus on identification and development of potential hepatic antifibrotic agents.
Professor Sievert is also active in medical education including the development of new undergraduate and graduate medical curricula at Monash University.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Collaborations and top research areas from the last five years
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A Phase 3 Double-blinded, Two-arm Study to Evaluate the Safety and Efficacy of Pembrolizumab (MK-3475) versus Placebo as Adjuvant Therapy in Participants with Hepatocellular Carcinoma and Complete Radiological Response after Surgical Resection of Local Ablation (KEYNOTE-937)
Braude, M. (Primary Chief Investigator (PCI)) & Sievert, W. (Chief Investigator (CI))
5/10/22 → 4/10/27
Project: Research
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Locally administered extracellular vesicles for perianal fistulising Crohn's disease
Moore, G. (Primary Chief Investigator (PCI)), Keung, C. (Chief Investigator (CI)), Lim, R. (Chief Investigator (CI)), Sievert, W. (Chief Investigator (CI)) & Nguyen, T. C. (Chief Investigator (CI))
1/06/21 → 28/02/26
Project: Research
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Therapeutic targeting of JAK-STAT pathway in a novel mouse model for gastro-intestinal cancers
Jenkins, B. (Primary Chief Investigator (PCI)), Ernst, M. R. W. (Chief Investigator (CI)), Segal, D. H. (Chief Investigator (CI)) & Sievert, W. (Chief Investigator (CI))
Project: Research
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Broadening and strengthening the health providers caring for patients with chronic hepatitis C may improve continuity of care
Clark, P. J., Valery, P. C., Strasser, S. I., Weltman, M., Thompson, A., Levy, M. T., Leggett, B., Zekry, A., Rong, J., Sinclair, M., George, J., Bollipo, S., McGarity, B., Sievert, W., MacQuillan, G., Tse, E., Nicoll, A., Wade, A., Cheng, W. & Roberts, S. K., Mar 2024, In: Journal of Gastroenterology and Hepatology. 39, 3, p. 568-575 8 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access1 Citation (Scopus) -
Baseline serum HBV RNA is associated with the risk of hepatitis flare after stopping nucleoside analog therapy in HBeAg-negative participants
Thompson, A. J., Jackson, K., Bonanzinga, S., Hall, S. A. L., Hume, S., Burns, G. S., Sundararajan, V., Ratnam, D., Levy, M. T., Lubel, J., Nicoll, A. J., Strasser, S. I., Sievert, W., Desmond, P. V., Ngu, M. C., Sinclair, M., Meredith, C., Matthews, G., Revill, P. A. & Littlejohn, M. & 8 others, , Aug 2023, In: Hepatology Communications. 7, 8, 10 p., e0188.Research output: Contribution to journal › Article › Research › peer-review
Open Access11 Citations (Scopus) -
First-in-human randomized study of RNAi therapeutic RG6346 for chronic hepatitis B virus infection
Gane, E. J., Kim, W., Lim, T. H., Tangkijvanich, P., Yoon, J. H., Sievert, W., Sukeepaisarnjaroen, W., Thompson, A. J., Pavlovic, V., Surujbally, B., Wat, C., Brown, B. D., Achneck, H. E. & Yuen, M. F., Nov 2023, In: Journal of Hepatology. 79, 5, p. 1139-1149 11 p.Research output: Contribution to journal › Article › Research › peer-review
18 Citations (Scopus) -
Global prevalence, cascade of care, and prophylaxis coverage of hepatitis B in 2022: a modelling study
The Polaris Observatory Collaborators, Oct 2023, In: The Lancet Gastroenterology & Hepatology. 8, 10, p. 879-907 29 p.Research output: Contribution to journal › Article › Research › peer-review
197 Citations (Scopus) -
Healthcare utilisation and costing for decompensated chronic liver disease hospitalisations at a Victorian network
Lovett, G. C., Ha, P., Roberts, A. T., Bell, S., Liew, D., Pianko, S., Sievert, W. & Le, S. T. T., Sept 2023, In: Internal Medicine Journal. 53, 9, p. 1581-1587 7 p.Research output: Contribution to journal › Article › Research › peer-review
5 Citations (Scopus)