Projects per year
Personal profile
Biography
I obtained his PhD from the Paris Descartes University and the Freie University of Berlin working on nuclear positioning during skeletal muscle development. I then performed his post-doctoral training in the laboratory of Pura Munoz in Barcelona studying how myofibers respond to discrete injuries. In parallel, I lead the tissue engineering MyoChip team in Lisbon aimed at supplementing neurons and a vasculature to in vitro muscle culture. After a short stay at Stanford University to apply imaged-based spatial genomic techniques to muscle specimens, I began his laboratory on intercellular communication within the muscle organ at Monash University in Australia in 2023.
I am interested in seeing biology unfold infront of me. Throughout my training, I developed in vitro muscle systems to observe and manipulate cells in real time. My work focuses on complexifying in vitro systems to generate multi-cell type cultures with which we can answer fundamental biological questions and model diseases for drug screening.
I recently published a paper in which we identify a novel mechanism of muscle repair which is independent of stem cells. This finding could redefine strategies of how we preserve muscle function in exercise, muscle diseases and aging. Alongside my work on intercellular communication, I hope to decipher the mechanisms underlying this muscle self-repair program.
Research interests
Our lab is interested in understanding how cells communicate to establish the architecture of skeletal muscle. We use cell biology, tissue engineering and spatial transcriptomics to study how specialized regions such as the neuromuscular and myotendineous junctions develop and operate in exercise, disease and aging
Supervision interests
The lab is currently growing and we are recruiting at all levels. I am very keen on building an inclusive and dynamic environment for labmembers. My mentoring philosophy aims to give mentees the basic tools to perform the research they are passionate. By faciliating their scientific and personal development, I hope to empower them to pursue their aspirations their way.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Cell Biology, PhD, Doctorate
Award Date: 27 Sept 2016
Experimental Medicine, Masterof Science, Master of Science
Award Date: 30 Sept 2012
Physiology, Bachelor of Science, Bachelor of Science, McGill University
Award Date: 30 May 2009
Research area keywords
- Skeletal muscle
- Tissue engineering
- Regenerative Medicine
- Cell Biology
- Spatial Transcriptomics
Collaborations and top research areas from the last five years
Projects
- 1 Finished
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NHMRC Equipment Grant - Tergeo Plus plasma cleaner
Roman, W. (Primary Chief Investigator (PCI)), Combes, A. (Chief Investigator (CI)), Jarde, T. (Chief Investigator (CI)) & Currie, P. (Chief Investigator (CI))
1/11/23 → 31/12/24
Project: Research
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An in vitro agent-based modelling approach to optimization of culture medium for generating muscle cells
Hardman, D., Hennig, K., Gomes, E. R., Roman, W. & Bernabeu, M. O., 17 Jan 2024, In: Journal of the Royal Society Interface. 21, 210, 14 p., 20230603.Research output: Contribution to journal › Article › Research › peer-review
Open Access1 Citation (Scopus) -
Studying the impact of geometrical and cellular cues on myogenesis with a skeletal muscle-on-chip
Nguyen, M. L., Demri, N., Lapin, B., Di Federico, F., Gropplero, G., Cayrac, F., Hennig, K., Gomes, E. R., Wilhelm, C., Roman, W. & Descroix, S., 20 Jul 2024, In: Lab on a Chip. 24, 17, p. 4147-4160 14 p.Research output: Contribution to journal › Article › Research › peer-review
3 Citations (Scopus) -
Generating fast-twitch myotubes in vitro with an optogenetic-based, quantitative contractility assay
Hennig, K., Hardman, D., Barata, D. M., Martins, I. I., Bernabeu, M. O., Gomes, E. R. & Roman, W., Oct 2023, In: Life Science Alliance. 6, 10, 12 p., e202302227.Research output: Contribution to journal › Article › Research › peer-review
Open Access2 Citations (Scopus) -
Muscle is a stage, and cells and factors are merely players
Roman, W. & Muñoz-Cánoves, P., Oct 2022, In: Trends in Cell Biology. 32, 10, p. 835-840 6 p.Research output: Contribution to journal › Review Article › Other › peer-review
14 Citations (Scopus) -
A flagellate-to-amoeboid switch in the closest living relatives of animals
Brunet, T., Albert, M., Roman, W., Coyle, M. C., Spitzer, D. C. & King, N., 15 Jan 2021, In: eLife. 10, 30 p., e61037.Research output: Contribution to journal › Article › Research › peer-review
Open Access41 Citations (Scopus)
Prizes
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Donald Metcalf Prize
Roman, William (Recipient), 11 Nov 2024
Prize: Prize (including medals and awards)
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Metcalf Prize for Stem Cell Research
Roman, W. (Recipient), 11 Nov 2024
Prize: Prize (including medals and awards)