William Charman

Professor

1984 …2019
If you made any changes in Pure these will be visible here soon.

Research Output 1984 2019

Filter
Article
2019

Drug-receptor kinetics and sigma-1 receptor affinity differentiate clinically evaluated histamine H3 receptor antagonists

Riddy, D. M., Cook, A. E., Shackleford, D. M., Pierce, T. L., Mocaer, E., Mannoury la Cour, C., Sors, A., Charman, W. N., Summers, R. J., Sexton, P. M., Christopoulos, A. & Langmead, C. J., 1 Jan 2019, In : Neuropharmacology. 144, p. 244-255 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
2018

Divergent effects of strontium and calcium-sensing receptor positive allosteric modulators (calcimimetics) on human osteoclast activity

Diepenhorst, N. A., Leach, K., Keller, A. N., Rueda, P., Cook, A. E., Pierce, T. L., Nowell, C., Pastoureau, P., Sabatini, M., Summers, R. J., Charman, W. N., Sexton, P. M., Christopoulos, A. & Langmead, C. J., 1 Nov 2018, In : British Journal of Pharmacology. 175, 21, p. 4095-4108 14 p.

Research output: Contribution to journalArticleResearchpeer-review

2017

High throughput, quantitative analysis of human osteoclast differentiation and activity

Diepenhorst, N., Nowell, C., Rueda, P., Henriksen, K., Pierce, T., Cook, A., Pastoureau, P., Sabatini, M., Charman, W., Christopoulos, A., Summers, R., Sexton, P. & Langmead, C., 15 Feb 2017, In : Analytical Biochemistry. 519, p. 51-56 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Isoform-specific biased agonism of histamine H3 receptor agonists

Riddy, D. M., Cook, A. E., Diepenhorst, N. A., Bosnyak, S., Brady, R., La Cour, C. M., Mocaer, E., Summers, R. J., Charman, W. N., Sexton, P. M., Christopoulos, A. & Langmead, C. J., 1 Feb 2017, In : Molecular Pharmacology. 91, 2, p. 87-99 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Structure-Activity Relationship of the Antimalarial Ozonide Artefenomel (OZ439)

Dong, Y., Wang, X., Kamaraj, S., Bulbule, V. J., Chiu, F. C. K., Chollet, J., Dhanasekaran, M., Hein, C. D., Papastogiannidis, P., Morizzi, J., Shackleford, D. M., Barker, H., Ryan, E., Scheurer, C., Tang, Y., Zhao, Q., Zhou, L., White, K. L., Urwyler, H., Charman, W. N. & 4 others, Matile, H., Wittlin, S., Charman, S. A. & Vennerstrom, J. L., 13 Apr 2017, In : Journal of Medicinal Chemistry. 60, 7, p. 2654-2668 15 p.

Research output: Contribution to journalArticleResearchpeer-review

The role of lecithin degradation on the pH dependent stability of halofantrine encapsulated fat nano-emulsions

Haidar, I., Harding, I. H., Bowater, I. C., Eldridge, D. S. & Charman, W. N., 7 Aug 2017, In : International Journal of Pharmaceutics. 528, 1-2, p. 524-535 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2016

50 years of oral lipid-based formulations: provenance, progress and future perspectives

Feeney, O. M., Crum, M. F., McEvoy, C., Trevaskis, N., Williams, H., Pouton, C., Charman, W. N., Bergstrom, C. & Porter, C. J. H., 1 Jun 2016, In : Advanced Drug Delivery Reviews. 101, p. 167-194 27 p.

Research output: Contribution to journalArticleResearchpeer-review

Computational prediction of formulation strategies for beyond-rule-of-5 compounds

Bergstrom, C., Charman, W. N. & Porter, C. J. H., 1 Jun 2016, In : Advanced Drug Delivery Reviews. 101, p. 6-21 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Murine GPRC6A mediates cellular responses to L-amino acids, but not osteocalcin variants

Rueda, P., Harley, E., Lu, Y., Stewart, G. D., Fabb, S., Diepenhorst, N., Cremers, B., Rouillon, M-H., Wehrle, I., Geant, A., Lamarche, G., Leach, K., Charman, W. N., Christopoulos, A., Summers, R. J., Sexton, P. M. & Langmead, C. J., 1 Jan 2016, In : PLoS ONE. 11, 1, p. 1-19 19 p., e0146846.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
2014

Synthesis, structure-activity relationships and brain uptake of a novel series of benzopyran inhibitors of insulin-regulated aminopeptidase

Mountford, S. J., Albiston, A. L., Charman, W. N., Ng, L., Holien, J. K., Parker, M. W., Nicolazzo, J., Thompson, P. & Chai, S. Y., 2014, In : Journal of Medicinal Chemistry. 57, 4, p. 1368 - 1377 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Targeted delivery of a model immunomodulator to the lymphatic system: Comparison of alkyl ester versus triglyceride mimetic lipid prodrug strategies

Han, S., Quach, T., Hu, L., Wahab, A., Charman, W. N., Stella, V. J., Trevaskis, N., Simpson, J. S. & Porter, C. J., 2014, In : Journal of Controlled Release. 177, 1, p. 1 - 10 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2013

A mouse model to evaluate the impact of species, sex, and lipid load on lymphatic drug transport

Trevaskis, N., Caliph, S. M., Nguyen, G., Tso, P., Charman, W. N. & Porter, C. J., 2013, In : Pharmaceutical Research. 30, 12, p. 3254 - 3270 17 p.

Research output: Contribution to journalArticleResearchpeer-review

Computational prediction of drug solubility in lipid based formulation excipients

Persson, L. C., Porter, C. J., Charman, W. N. & Bergstrom, C. A. S., 2013, In : Pharmaceutical Research. 30, 12, p. 3225 - 3237 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Intestinal bile secretion promotes drug absorption from lipid colloidal phases via induction of supersaturation

Yeap, Y. Y., Trevaskis, N., Quach, T., Tso, P., Charman, W. N. & Porter, C. J., 2013, In : Molecular Pharmaceutics. 10, 5, p. 1874 - 1889 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Strategies to address low drug solubility in discovery and development

Williams, H. D., Trevaskis, N., Charman, S. A., Shanker, R., Charman, W. N., Pouton, C. W. & Porter, C. J., 2013, In : Pharmacological Reviews. 65, 1, p. 315 - 499 185 p.

Research output: Contribution to journalArticleResearchpeer-review

2012

Antimalarial activity of pyrroloiminoquinones from the Australian marine sponge Zyzzya sp.

Davis, R. A., Buchanan, M. S., Duffy, S., Avery, V. M., Charman, S. A., Charman, W. N., White, K. L., Shackleford, D., Edstein, M. D., Andrews, K., Camp, D. G. & Quinn, R. J., 2012, In : Journal of Medicinal Chemistry. 55, 12, p. 5851 - 5858 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Malarial dihydrofolate reductase as a paradigm for drug development against a resistance-compromised target

Yuthavong, Y., Tarnchompoo, B., Vilaivan, T., Chitnumsub, P., Kamchonwongpaisan, S., Charman, S. A., McLennan, D. N., White, K. L., Vivas, L., Bongard, E., Thongphanchang, C., Taweechai, S., Vanichtanankul, J., Rattanajak, R., Arwon, U., Fantauzzi, P., Yuvaniyama, J., Charman, W. N. & Matthews, D., 2012, In : Proceedings of the National Academy of Sciences. 109, 42, p. 16823 - 16828 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Correction to "targeted drug delivery to lymphocytes: a route to site-specific immunomodulation?"

Trevaskis, N. L., Charman, W. N. & Porter, C. J. H., 5 Dec 2011, In : Molecular Pharmaceutics. 8, 6, p. 2484 1 p.

Research output: Contribution to journalArticleOtherpeer-review

Lead optimization of aryl and aralkyl amine-based triazolopyrimidine inhibitors of plasmodium falciparum dihydroorotate dehydrogenase with antimalarial activity in mice

Gujjar, R., El Mazouni, F., White, K., White, J., Creason, S., Shackleford, D., Deng, X., Charman, W., Bathurst, I., Burrows, J., Floyd, D., Matthews, D., Buckner, F., Charman, S., Phillips, M. & Rathod, P., 2011, In : Journal of Medicinal Chemistry. 54, p. 3935 - 3949 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Structure-guided lead optimization of triazolopyrimidine-ring substituents identifies potent Plasmodium falciparum dihydroorotate dehydrogenase inhibitors with clinical candidate potential

Coteron, J., Marco, M., Esquivias, J., Deng, X., White, K., White, J., Koltun, M., El Mazouni, F., Kokkonda, S., Katneni, K., Bhamidipati, R., Shackleford, D., Angulo-Barturen, I., Ferrer, S., Jimenez-Diaz, M. B., Gamo, F-J., Goldsmith, E., Charman, W., Bathurst, I., Floyd, D. & 5 others, Matthews, D., Burrows, J., Rathod, P., Charman, S. & Phillips, M., 2011, In : Journal of Medicinal Chemistry. 54, 15, p. 5540 - 5561 22 p.

Research output: Contribution to journalArticleResearchpeer-review

Synthetic ozonide drug candidate OZ439 offers new hope for a single-dose cure of uncomplicated malaria

Charman, S., Arbe-Barnes, S., Bathurst, I., Brun, R., Campbell, M., Charman, W., Chiu, F., Chollet, J., Craft, C., Creek, D., Dong, Y., Matile, H., Maurer, M., Morizzi, J., Nguyen, T., Papastogiannidis, P., Scheurer, C., Shackleford, D., Sriraghavan, K., Stingelin, L. & 7 others, Tang, Y., Urwyler, H., Wang, X., White, K., Wittlin, S., Zhou, L. & Vennerstrom, J., 2011, In : Proceedings of the National Academy of Sciences. 108, 11, p. 4400 - 4405 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
2010

Synthesis and Biological Evaluation of Polysulfated Oligosaccharide Glycosides as Inhibitors of Angiogenesis and Tumor Growth

Johnstone, K. D., Karoli, T., Liu, L., Dredge, K., Copeman, E., Li, C. P., Davis, K., Hammond, E., Bytheway, I., Kostewicz, E. S., Chiu, F. C. K., Shackleford, D., Charman, S. A., Charman, W. N., Harenberg, J., Gonda, T. & Ferro, V., 2010, In : Journal of Medicinal Chemistry. 53, 4, p. 1686 - 1699 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Targeted drug delivery to lymphocytes: a route to site-specific immunomodulation?

Trevaskis, N., Charman, W. & Porter, C., 2010, In : Molecular Pharmaceutics. 7, 6, p. 2297 - 2309 13 p.

Research output: Contribution to journalArticleResearchpeer-review

The comparative antimalarial properties of weak base and neutral synthetic ozonides

Tang, Y., Wittlin, S., Charman, S. A., Chollet, J., Chiu, F. C. K., Morizzi, J., Johnson, L., Santo Tomas, J., Scheurer, C., Snyder, C., Zhou, L., Dong, Y., Charman, W. N., Matile, H., Urwyler, H., Dorn, A. & Vennerstrom, J., 2010, In : Bioorganic and Medicinal Chemistry Letters. 20, 2, p. 563 - 566 4 p.

Research output: Contribution to journalArticleResearchpeer-review

The role of the intestinal lymphatics in the absorption of two highly lipophilic cholesterol ester transfer protein inhibitors (CP524,515 and CP532,623)

Trevaskis, N., McEvoy, C. L., McIntosh, M. P., Edwards, G. A., Shanker, R., Charman, W. N. & Porter, C. J., 2010, In : Pharmaceutical Research. 27, p. 878 - 893 16 p.

Research output: Contribution to journalArticleResearchpeer-review

The structure - activity relationship of the antimalarial ozonide arterolane (OZ277)

Dong, Y., Wittlin, S., Sriraghavan, K., Chollet, J., Charman, S. A., Charman, W. N., Scheurer, C., Urwyler, H., Santo Tomas, J., Snyder, C., Creek, D. J., Morizzi, J., Koltun, M., Matile, H., Wang, X., Padmanilayam, M., Tang, Y., Dorn, A., Brun, R. & Vennerstrom, J., 2010, In : Journal of Medicinal Chemistry. 53, p. 481 - 491 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2009

Identification of a metabolically stable triazolopyrimidine-based dihydroorotate dehydrogenase inhibitor with antimalarial activity in mice

Gujjar, R., Marwaha, A., El Mazouni, F., White, J., White, K. L., Creason, S., Shackleford, D., Baldwin, J., Charman, W. N., Buckner, F. S., Charman, S. A., Rathod, P. & Phillips, M., 2009, In : Journal of Medicinal Chemistry. 52, 7, p. 1864 - 1872 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Intestinal lymphatic transport enhances the post-prandial oral bioavailability of a novel cannabinoid receptor agonist via avoidance of first-pass metabolism

Trevaskis, N., Shackleford, D., Charman, W. N., Edwards, G. A., Gardin, A., Appel-Dingemanse, S., Kretz, O., Galli, B. & Porter, C. J., 2009, In : Pharmaceutical Research. 26, 6, p. 1486 - 1495 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Stability of peroxide antimalarials in the presence of human hemoglobin

Creek, D. J., Ryan, E., Charman, W. N., Chiu, F. C. K., Prankerd, R., Vennerstrom, J. & Charman, S. A., 2009, In : Antimicrobial Agents and Chemotherapy. 53, 8, p. 3496 - 3500 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Trypanothione reductase high-throughput screening campaign identifies novel classes of inhibitors with antiparasitic activity

Holloway, G. A., Charman, W. N., Fairlamb, A. H., Brun, R., Kaiser, M., Kostewicz, E. S., Novello, P. M., Parisot, J. P., Richardson, J., Street, I. P., Watson, K. G. & Baell, J. B., 2009, In : Antimicrobial Agents and Chemotherapy. 53, 7, p. 2824 - 2833 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2008

Characterization of the two major CYP450 metabolites of ozonide (1,2,4-trioxolane) OZ277

Zhou, L., Alker, A., Ruf, A., Wang, X., Chiu, F. C. K., Morizzi, J., Charman, S. A., Charman, W. N., Scheurer, C., Wittlin, S., Dong, Y., Hunziker, D. & Vennerstrom, J., 2008, In : Bioorganic and Medicinal Chemistry Letters. 18, 5, p. 1555 - 1558 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Enhancing intestinal drug solubilisation using lipid-based delivery systems

Porter, C. J., Pouton, C. W., Cuine, J. & Charman, W. N., 2008, In : Advanced Drug Delivery Reviews. 60, 6, p. 673 - 691 19 p.

Research output: Contribution to journalArticleResearchpeer-review

Evaluation of the impact of surfactant digestion on the bioavailability of Danazol after oral administration of lipidic self-emulsifying formulations to dogs

Cuine, J., McEvoy, C. L., Charman, W. N., Pouton, C. W., Edwards, G. A., Benameur, H. & Porter, C. J., 2008, In : Journal of Pharmaceutical Sciences. 97, 2, p. 995 - 1012 18 p.

Research output: Contribution to journalArticleResearchpeer-review

Lipid-based delivery systems and intestinal lymphatic drug transport: a mechanistic update

Trevaskis, N., Charman, W. N. & Porter, C. J., 2008, In : Advanced Drug Delivery Reviews. 60, 6, p. 702 - 716 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Pharmacy Education in the Context of Australian Practice

Marriott, J. L., Nation, R. L., Roller, L., Costelloe, M. T., Galbraith, K. J., Stewart, P. J. & Charman, W. N., 2008, In : American Journal of Pharmaceutical Education. 72, 6, p. 1 - 12 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Relationship between antimalarial activity and heme alkylation for spiro- and dispiro-1,2,4-trioxolane antimalarials

Creek, D. J., Charman, W. N., Chiu, F. C. K., Prankerd, R. J., Dong, Y., Vennerstrom, J. & Charman, S. A., 2008, In : Antimicrobial Agents and Chemotherapy. 52, 4, p. 1291 - 1296 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Iron-mediated degradation kinetics of substituted dispiro-1,2,4-trioxolane antimalarials

Creek, D. J., Charman, W. N., Chiu, F. C. K., Prankerd, R. J., McCullough, K. J., Dong, Y., Vennerstrom, J. & Charman, S. A., 2007, In : Journal of Pharmaceutical Sciences. 96, 11, p. 2945 - 2956 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Lipids and lipid-based formulations: optimizing the oral delivery of lipophilic drugs

Porter, C. J., Trevaskis, N. & Charman, W. N., 2007, In : Nature Reviews Drug Discovery. 6, 14, p. 231 - 248 18 p.

Research output: Contribution to journalArticleResearchpeer-review

Low dose lipid formulations: effects on gastric emptying and biliary secretion

Kossena, G. A., Charman, W. N., Wilson, C., O'Mahony, B., Lindsay, B., Hempenstall, J., Davidson, C., Crowley, P. & Porter, C. J., 2007, In : Pharmaceutical Research. 24, 11, p. 2084 - 2096 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Probing the Flexibility of the DsbA Oxidoreductase from Vibrio cholerae-a 15N - 1H Heteronuclear NMR Relaxation Analysis of Oxidized and Reduced Forms of DsbA

Horne, H. J., d'Auvergne, E. J., Coles, M., Velkov, T., Chin, Y., Charman, W. N., Prankerd, R. J., Gooley, P. & Scanlon, M., 2007, In : Journal of Molecular Biology. 371, 3, p. 703 - 716 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Weak base dispiro-1,2,4-trioxolanes: potent antimalarial ozonides

Tang, Y., Dong, Y., Wittlin, S., Charman, S. A., Chollet, J., Chiu, F. C. K., Charman, W. N., Matile, H., Urwyler, H., Dorn, A., Bajpai, S., Wang, X., Padmanilayam, M., Karle, J. M., Brun, R. & Vennerstrom, J., 2007, In : Bioorganic and Medicinal Chemistry Letters. 17, 5, p. 1260 - 1265 6 p.

Research output: Contribution to journalArticleResearchpeer-review

2006

Alteration of the intravenous pharmacokinetics of a synthetic ozonide antimalarial in the presence of a modified cyclodextrin

Charman, S. A., Perry, C. S., Chiu, F. C. K., McIntosh, K. A., Prankerd, R. J. & Charman, W. N., 2006, In : Journal of Pharmaceutical Sciences. 95, 2, p. 256 - 267 12 p.

Research output: Contribution to journalArticleResearchpeer-review

An acute and coincident increase in FABP expression and lymphatic lipid and drug transport occurs during intestinal infusion of lipid-based drug formulations to rats

Trevaskis, N. L., Lo, C. M., Ma, L. Y., Tso, P., Irving, H. R., Porter, C. J. H. & Charman, W. N., 2006, In : Pharmaceutical Research. 23, 8, p. 1786 - 1796 11 p.

Research output: Contribution to journalArticleResearchpeer-review