Wee Loon Ong graduated from Monash University with BMedSci and MBBS. Following completion of internship at the Alfred Health, he pursued an MPhil in Epidemiology at the University of Cambridge, graduating first with the GSK Prize. He subsequently undertook specialist training in RANZCR Radiation Oncology Clinician-Scientist Training Pathway within the Victorian Network, rotating through the Peter MacCallum Cancer Centre, Ballarat Regional Integrated Cancer Centre, and Austin Health Olivia Newton-John Cancer Centre. He is concurrently pursuing a Doctorate of Medicine higher research degree through the University of Cambridge. He is also an Adjunct Lecturer at the Department of Epidemiology and Preventive Medicine, Monash University, and Adjunct Research Fellow at the University of Mlbourne Centre for Digital Transformation of Health. 

He chairs the RANZCR Radiation Oncology Trainee Committee (ROTC), and sits on the RANZCR Faculty of Radiation Oncology Council, and the Victoria/ Tasmania Training Network (VICTRANET) Network Governance Committee (NGC). He is a member of the European Society of Radiotherapy and Oncology (ESTRO), Australian and New Zealand Urogenital and Prostate Trial Group (ANZUP), Australasian Gastro-Intestinal Trial Group (AGITG), Cooperative Trials Group for Neuro-Oncology (COGNO), and Health Services Research Association of Australia and New Zealand (HSRAANZ). He is also peer reviewer for several journals including British Journal of Cancer, Radiotherapy and Oncology, BJU International.

His current research interest is primarily in health services, patient-centred outcomes research in cancer, and new technology precision radiation therapy. These include research on contemporary pattern of cancer care, and adoption of evidence-based practice in radiation oncology using administrative healthcare databases, and registry database such as the Prostate Cancer Outcomes Registry (PCOR). He was involved in the development of value-based patient-centred standard set of breast cancer outcomes as part of the ICHOM Breast Cancer Working Group. Most recently, he was awarded the Victorian Government Veski Victoria Fellowship for an overseas study mission to bring back knowledge and skill to the Victoria Statewide MRI-Linac facility. He has published widely, relative to opportunity, including first author publication in JAMA Oncology.