19942018

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Article
2018

Evaluation of Serum Glycoprotein Biomarker Candidates for Detection of Esophageal Adenocarcinoma and Surveillance of Barrett's Esophagus

Shah, A. K., Hartel, G. F., Brown, I., Winterford, C., Na, R., Cao, K. A. L., Spicer, B. A., Dunstone, M. A., Phillips, W. A., Lord, R. V., Barbour, A., Watson, D. I., Joshi, V., Whiteman, D. C. & Hill, M. M., 1 Dec 2018, In : Molecular & Cellular Proteomics. 17, 12, p. 2324-2334 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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7 Citations (Scopus)

Identification of Pik3ca mutation as a genetic driver of prostate cancer that cooperates with Pten loss to accelerate progression and castration-resistant growth

Pearson, H. B., Li, J., Meniel, V. S., Fennell, C. M., Waring, P., Montgomery, K. G., Rebello, R. J., Macpherson, A. A., Koushyar, S., Furic, L., Cullinane, C., Clarkson, R. W., Smalley, M. J., Simpson, K. J., Phesse, T. J., Shepherd, P. R., Humbert, P. O., Sansom, O. J. & Phillips, W. A., 1 Jun 2018, In : Cancer Discovery. 8, 6, p. 764-779 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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21 Citations (Scopus)

PI3K activation in neural stem cells drives tumorigenesis which can be ameliorated by targeting the cAMP response element binding protein

Daniel, P. M., Filiz, G., Brown, D. V., Christie, M., Waring, P. M., Zhang, Y., Haynes, J. M., Pouton, C., Flanagan, D., Vincan, E., Johns, T. G., Montgomery, K., Phillips, W. A. & Mantamadiotis, T., 1 Jan 2018, In : Neuro-Oncology. 20, 10, p. 1344-1355 12 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)
2016

Intramuscular transplantation improves engraftment rates for esophageal patient-derived tumor xenografts

Read, M., Liu, D. S. H., Duong, C. P., Cullinane, C. M., Murray, W. K., Fennell, C. M., Shortt, J., Westerman, D. A., Burton, P. R., Clemons, N. J. & Phillips, W. A., 2016, In : Annals of Surgical Oncology. 23, 1, p. 305 - 311 7 p.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)
2015

Heterozygous expression of the oncogenic Pik3ca (H1047R) mutation during murine development results in fatal embryonic and extraembryonic defects

Hare, L. M., Schwarz, Q. P., Wiszniak, S., Gurung, R., Montgomery, K. G., Mitchell, C. A. & Phillips, W. A., 1 Aug 2015, In : Developmental Biology. 404, 1, p. 14-26 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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16 Citations (Scopus)

The polarity protein Scrib mediates epidermal development and exerts a tumor suppressive function during skin carcinogenesis

Pearson, H. B., McGlinn, E., Phesse, T. J., Schluter, H., Srikumar, A., Godde, N. J., Woelwer, C. B., Ryan, A. J., Phillips, W. A., Ernst, M. R., Kaur, P. & Humbert, P. O., 2015, In : Molecular Cancer. 14, 1, 16 p., 169.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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18 Citations (Scopus)

Ubiquitous expression of the Pik3caH1047R mutation promotes hypoglycemia, hypoinsulinemia, and organomegaly

Kinross, K. M., Montgomery, K. G., Mangiafico, S. P., Hare, L. M., Kleinschmidt, M., Bywater, M. J., Poulton, I. J., Vrahnas, C., Henneicke, H., Malaterre, J., Waring, P. M., Cullinane, C., Sims, N. A., McArthur, G. A., Andrikopoulos, S. & Phillips, W. A., Apr 2015, In : The FASEB Journal. 29, 4, p. 1426-1434 9 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)
2014

Assessing the subcellular distribution of oncogenic phosphoinositide 3-kinase using microinjection into live cells

Layton, M. J., Rynkiewicz, N. K., Ivetac, I., Horan, K. A., Mitchell, C. A. & Phillips, W. A., 2014, In : Bioscience Reports. 34, 2 (Art. ID: e00104), p. 165 - 180 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Esophageal stem cells and genetics/epigenetics in esophageal cancer

Croagh, D., Frede, J., Jones, P. H., Kaur, P., Partensky, C. & Phillips, W. A., 29 Sep 2014, In : Annals of the New York Academy of Sciences. 1325, 1, p. 8-14 7 p.

Research output: Contribution to journalArticleOtherpeer-review

4 Citations (Scopus)

Physiological expression of the PI3K-activating mutation Pik3ca(H1047R) combines with Apc loss to promote development of invasive intestinal adenocarcinomas in mice

Hare, L. M., Phesse, T. J., Waring, P. M., Montgomery, K. G., Kinross, K. M., Mills, K. D., Roh, V., Heath, J. K., Ramsay, R. G., Ernst, M. R. & Phillips, W. A., 2014, In : Biochemical Journal. 458, 2, p. 251 - 258 8 p.

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)
2013

Barrett's esophagus: Cancer and molecular biology

Gibson, M. K., Dhaliwal, A. S., Clemons, N. J., Phillips, W. A., Dvorak, K., Tong, D., Law, S., Pirchi, E. D., Räsänen, J., Krasna, M. J., Parikh, K., Krishnadath, K. K., Chen, Y., Griffiths, L., Colleypriest, B. J., Farrant, J. M., Tosh, D., Das, K. M. & Bajpai, M., Oct 2013, In : Annals of the New York Academy of Sciences. 1300, 1, p. 296-314 19 p.

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)

Differential AKT dependency displayed by mouse models of BRAF V600E-Initiated melanoma

Durban, V. M., Deuker, M. M., Bosenberg, M. W., Phillips, W. & McMahon, M., 2 Dec 2013, In : Journal of Clinical Investigation. 123, 12, p. 5104-5118 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
43 Citations (Scopus)

Human perforin mutations and susceptibility to multiple primary cancers

Trapani, J. A., Thia, K. Y. T., Andrews, M. C., Davis, I. D., Gedye, C., Parente, P., Svobodova, S., Chia, J., Browne, K. A., Campbell, I. G., Phillips, W. A., Voskoboinik, I. & Cebon, J. S., Apr 2013, In : OncoImmunology. 2, 4, 5 p., e24185.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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43 Citations (Scopus)

Molecular changes in the phosphatidylinositide 3-kinase (PI3K) pathway are common in gastric cancer

Tran, T. N., Brettingham-Moore, K. H., Duong, C. P., Mitchell, C., Clemons, N. J. & Phillips, W. A., Aug 2013, In : World Journal of Surgical Oncology. 108, 2, p. 113-120 8 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Mutationally activated PIK3CAH1047R cooperates with BRAF V600E to promote lung cancer progression

Trejo, C. L., Green, S., Marsh, V., Collisson, E. A., Iezza, G., Phillips, W. A. & McMahon, M., 1 Nov 2013, In : Cancer Research. 73, 21, p. 6448-6461 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
23 Citations (Scopus)

Synergistic inhibition of ovarian cancer cell growth by combining selective PI3K/mTOR and RAS/ERK pathway inhibitors

Sheppard, K. E., Cullinane, C. M., Hannan, K. M., Wall, M., Chan, J. C., Barber, F., Foo, J., Cameron, D., Neilsen, A., Ng, P., Ellul, J., Kleinschmidt, M., Kinross, K. M., Bowtell, D. D. L., Christensen, J. G., Hicks, R., Johnstone, R. W., McArthur, G. A., Hannan, R. D., Phillips, W. A. & 1 others, Pearson, R. B., 2013, In : European Journal of Cancer. 49, 18, p. 3936 - 3944 9 p.

Research output: Contribution to journalArticleResearchpeer-review

52 Citations (Scopus)
2012

A Central role for RAF→MEK→ERK signaling in the genesis of pancreatic ductal adenocarcinoma

Collisson, E. A., Trejo, C. L., Silva, J. M., Gu, S., Korkola, J. E., Heiser, L. M., Charles, R. P., Rabinovich, B. A., Hann, B., Dankort, D., Spellman, P. T., Phillips, W. A., Gray, J. W. & McMahon, M., Aug 2012, In : Cancer Discovery. 2, 8, p. 685-693 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
153 Citations (Scopus)

An activating {Pik3ca} mutation coupled with {Pten} loss is sufficient to initiate ovarian tumorigenesis in mice

Kinross, K. M., Montgomery, K. G., Kleinschmidt, M., Waring, P., Ivetac, I., Tikoo, A., Saad, M., Hare, L. M., Roh, V., Mantamadiotis, T., Sheppard, K. E., Ryland, G. L., Campbell, I. G., Gorringe, K. L., Christensen, J. G., Cullinane, C. M., Hicks, R. J., Pearson, R. B., Johnstone, R. W., McArthur, G. A. & 1 others, Phillips, W., 2012, In : Journal of Clinical Investigation. 122, 2, p. 553 - 557 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
129 Citations (Scopus)
Open Access
7 Citations (Scopus)

Comparison of growth factor signalling pathway utilisation in cultured normal melanocytes and melanoma cell lines

Kim, J. E., Stones, C., Joseph, W. R., Leung, E., Finlay, G. J., Shelling, A. N., Phillips, W. A., Shepherd, P. R. & Baguley, B. C., 4 Apr 2012, In : BMC Cancer. 12, 141.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
16 Citations (Scopus)

Correlations between histopathological diagnosis of chemotherapy-induced hepatic injury, clinical features, and perioperative morbidity

Pilgrim, C. H. C., Satgunaseelan, L., Pham, A., Murray, W. K., Link, E. K., Smith, M., Usatoff, V., Evans, P. M., Banting, S., Thomson, B. N. J., Phillips, W. A. & Michael, M., May 2012, In : HPB. 14, 5, p. 333-340 8 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

Developing a quantitative in vivo tissue reconstitution assay to assess the relative potency of candidate populations of mouse oesophageal epithelial cells

Croagh, D., Redvers, R., Phillips, W. A. & Kaur, P., 2012, In : Methods in Molecular Biology. 879, p. 73-88 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Physiological levels of Pik3ca(H1047R) mutation in the mouse mammary gland results in ductal hyperplasia and formation of ER alpha-positive tumors

Tikoo, A., Roh, V., Montgomery, K. G., Ivetac, I., Waring, P., Pelzer, R., Hare, L. M., Shackleton, M., Humbert, P. O. & Phillips, W. A., 2012, In : PLoS ONE. 7, 5, 13 p., e36924.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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41 Citations (Scopus)

Sox9 drives columnar differentiation of esophageal squamous epithelium: A possible role in the pathogenesis of Barrett's esophagus

Clemons, N. J., Wang, D. H., Croagh, D., Tikoo, A., Fennell, C. M., Murone, C., Scott, A. M., Watkins, D. N. & Phillips, W. A., 2012, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 303, 12, p. G1335 - G1346 12 p.

Research output: Contribution to journalArticleResearchpeer-review

37 Citations (Scopus)

Targeting cancer with PI3K pathway inhibitors: Who to aim at?

Kinross, K. M., Sheppard, K. E., Pearson, R. B. & Phillips, W. A., 1 Aug 2012, In : Translational Cancer Research. 1, 2, p. 119-121 3 p.

Research output: Contribution to journalArticleOtherpeer-review

2 Citations (Scopus)

Targeting PI3 kinase/AKT/mTOR signaling in cancer

Sheppard, K. E., Kinross, K. M., Solomon, B., Pearson, R. B. & Phillips, W. A., 2012, In : Critical Reviews in Oncogenesis. 17, 1, p. 69 - 95 27 p.

Research output: Contribution to journalArticleResearchpeer-review

173 Citations (Scopus)
2011

Deregulation of MYCN, LIN28B and LET7 in a molecular subtype of aggressive high-grade serous ovarian cancers

Helland, Å., Anglesio, M. S., George, J., Cowin, P. A., Johnstone, C. N., House, C. M., Sheppard, K. E., Etemadmoghadam, D., Melnyk, N., Rustgi, A. K., Phillips, W. A., Johnsen, H., Holm, R., Kristensen, G. B., Birrer, M. J., Pearson, R. B., Børresen-Dale, A. L., Huntsman, D. G., DeFazio, A., Creighton, C. J. & 2 others, Smyth, G. K. & Bowtell, D. D. L., 2011, In : PLoS ONE. 6, 4, e18064.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
125 Citations (Scopus)

MRNA gene expression correlates with histologically diagnosed chemotherapy-induced hepatic injury

Pilgrim, C. H. C., Brettingham-Moore, K. H., Pham, A., Murray, W. K., Link, E. K., Smith, M., Usatoff, V., Evans, P. M., Banting, S., Thomson, B. N. J., Michael, M. & Phillips, W. A., Nov 2011, In : HPB. 13, 11, p. 811-816 6 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Pretreatment transcriptional profiling for predicting response to neoadjuvant chemoradiotherapy in rectal adenocarcinoma

Brettingham-Moore, K. H., Duong, C. P., Greenawalt, D. M., Heriot, A. G., Ellul, J., Dow, C. A., Murray, W. K., Hicks, R. J., Tjandra, J., Chao, M., Bui, A., Joon, D. L., Thomas, R. J. S. & Phillips, W. A., 1 May 2011, In : Clinical Cancer Research. 17, 9, p. 3039-3047 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
34 Citations (Scopus)

Using gene expression profiling to predict response and prognosis in gastrointestinal cancers-the promise and the perils

Brettingham-Moore, K. H., Duong, C. P., Heriot, A. G., Thomas, R. J. S. & Phillips, W. A., May 2011, In : Annals of Surgical Oncology. 18, 5, p. 1484-1491 8 p.

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)
2010

Aberrant epithelial-mesenchymal Hedgehog signaling characterizes Barrett's metaplasia

Wang, D. H., Clemons, N. J., Miyashita, T., Dupuy, A. J., Zhang, W., Szczepny, A., Corcoran-Schwartz, I. M., Wilburn, D. L., Montgomery, E. A., Wang, J. S., Jenkins, N. A., Copeland, N. A., Harmon, J. W., Phillips, W. A. & Watkins, D. N., 2010, In : Gastroenterology. 138, 5, p. 1810 - 1822.e2 15 p.

Research output: Contribution to journalArticleResearchpeer-review

121 Citations (Scopus)
2008

Reconstitution of stratified murine and human oesophageal epithelia in an in vivo transplant culture system

Croagh, D., Cheng, S., Tikoo, A., Nandurkar, S., Thomas, R. J. S., Kaur, P. & Phillips, W. A., 25 Sep 2008, In : Scandinavian Journal of Gastroenterology. 43, 10, p. 1158-1168 11 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)
2006

A specific role for AKT3 in the genesis of ovarian cancer through modulation of G2-M phase transition

Cristiano, B. E., Chan, J. C. C., Hannan, K. M., Lundie, N. A., Marmy-Conus, N. J., Campbell, I. G., Phillips, W. A., Robbie, M., Hannan, R. D. & Pearson, R. B., 2006, In : Cancer Research. 66, 24, p. 11718 - 11725 8 p.

Research output: Contribution to journalArticleResearchpeer-review

73 Citations (Scopus)

Identification of candidate murine esophageal stem cells using a combination of cell kinetic studies and cell surface markers

Croagh, D., Phillips, W. A., Redvers, R. P., Thomas, R. JS. & Kaur, P., 2006, In : Stem Cells. 25, 2, p. 313 - 318 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Mutation analysis of PIK3CA and PIK3CB in esophageal cancer and Barrett's esophagus

Phillips, W. A., Russell, S. E., Ciavarella, M. L., Choong, D. Y. H., Montgomery, K. G., Smith, K., Pearson, R. B., Thomas, R. J. S. & Campbell, I. G., 2006, In : International Journal of Cancer. 118, 10, p. 2644 - 2646 3 p.

Research output: Contribution to journalArticleResearchpeer-review

61 Citations (Scopus)

Mutations in the MYB Intron I Regulatory Sequence Increase Transcription in Colon Cancers

Mantamadiotis, T., Hugo, H., Suraweera, N., Drabsch, Y., Purcell, D., Phillips, W. A., Dobrovic, A., Zupi, G., Gonda, T. J., Iacopetta, B. & Ramsay, R. G., 2006, In : Genes Chromosomes & Cancer. 45, p. 1143 - 1154 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2004

Mutation of the PIK3CA gene in ovarian and breast cancer

Campbell, I. G., Russell, S. E., Choong, D. Y. H., Montgomery, K. G., Ciavarella, M. L., Hooi, C. S. F., Cristiano, B. E., Pearson, R. B. & Phillips, W. A., 1 Nov 2004, In : Cancer Research. 64, 21, p. 7678-7681 4 p.

Research output: Contribution to journalArticleResearchpeer-review

730 Citations (Scopus)
1998

Increased levels of phosphatidylinositol 3-kinase activity in colorectal tumors

Phillips, W. A., St. Clair, F., Munday, A. D., Thomas, R. J. S. & Mitchell, C. A., 1 Jul 1998, In : Cancer. 83, 1, p. 41-47 7 p.

Research output: Contribution to journalArticleResearchpeer-review

87 Citations (Scopus)

Increased levels of phosphatidylinositol 3-Kinase activity in human colorectal tumours cancer

Mitchell, C. A., Munday, A. D., St Clair, F., Phillips, W. & Thomas, R. J. S., 1998, In : Cancer. p. 41 - 47 7 p.

Research output: Contribution to journalArticleResearchpeer-review

1995

Role of YopD in the virulence of Yersinia enterocolitica.

Hartland, E. L., Green, S. P., Phillips, W. A. & Robins-Browne, R. M., 1 Dec 1995, In : Contributions to Microbiology and Immunology. 13, p. 235-238 4 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Role of YopH in the suppression of tyrosine phosphorylation and respiratory burst activity in murine macrophages infected with Yersinia enterocolitica

Green, S. P., Hartland, E. L., Robins-Browne, R. M. & Phillips, W. A., 1 Jan 1995, In : Journal of leukocyte biology. 57, 6, p. 972-977 6 p.

Research output: Contribution to journalArticleResearchpeer-review

37 Citations (Scopus)
1994

Essential role of YopD in inhibition of the respiratory burst of macrophages by Yersinia enterocolitica

Hartland, E. L., Green, S. P., Phillips, W. A. & Robins-Browne, R. M., 1 Jan 1994, In : Infection and Immunity. 62, 10, p. 4445-4453 9 p.

Research output: Contribution to journalArticleResearchpeer-review

64 Citations (Scopus)