Wayne Lin

Dr

20152019
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Research Output 2015 2019

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2019

Comparative metabolomics and transcriptomics reveal multiple pathways associated with polymyxin killing in pseudomonas aeruginosa

Han, M-L., Zhu, Y., Creek, D. J., Lin, Y-W., Gutu, A. D., Hertzog, P., Purcell, T., Shen, H-H., Moskowitz, S. M., Velkov, T. & Li, J., 1 Jan 2019, In : mSystems. 4, 1, 18 p., e00149-18.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Understanding the Impacts of Surface Compositions on the In-Vitro Dissolution and Aerosolization of Co-Spray-Dried Composite Powder Formulations for Inhalation

Mangal, S., Xu, R., Park, H., Zemlyanov, D., Shetty, N., Lin, Y-W., Morton, D., Chan, H-K., Li, J. & Zhou, T. Q., 1 Jan 2019, In : Pharmaceutical Research. 36, 15 p.

Research output: Contribution to journalArticleResearchpeer-review

2018

Alterations of Metabolic and Lipid Profiles in Polymyxin-Resistant Pseudomonas aeruginosa

Han, M-L., Zhu, Y., Creek, D. J., Lin, Y-W., Anderson, D., Shen, H-H., Tsuji, B., Gutu, A. D., Moskowitz, S. M., Velkov, T. & Li, J., 1 Jun 2018, In : Antimicrobial Agents and Chemotherapy. 62, 6, 14 p., e02656-17.

Research output: Contribution to journalArticleResearchpeer-review

Co-Delivery of Ciprofloxacin and Colistin in Liposomal Formulations with Enhanced In Vitro Antimicrobial Activities against Multidrug Resistant Pseudomonas aeruginosa

Wang, S., Yu, S., Lin, Y., Zou, P., Chai, G., Yu, H. H., Wickremasinghe, H., Shetty, N., Ling, J., Li, J. & Zhou, Q. T., 1 Oct 2018, In : Pharmaceutical Research. 35, 10, 13 p., 187.

Research output: Contribution to journalArticleResearchpeer-review

Composite particle formulations of colistin and meropenem with improved in-vitro bacterial killing and aerosolization for inhalation

Mangal, S., Park, H., Zeng, L., Yu, H. H., Lin, Y., Velkov, T., Denman, J. A., Zemlyanov, D., Li, J. & Zhou, Q. T., 5 Sep 2018, In : International Journal of Pharmaceutics. 548, 1, p. 443-453 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Efficacy of systemically administered polymyxins in mouse burn wound infection caused by multidrug-resistant Gram-negative pathogens: A proof-of-concept study

Lin, Y-W., Chen, K., Wang, J., Velkov, T., Zhou, Q. & Li, J., May 2018, In : Antimicrobial Agents and Chemotherapy. 62, 5, 5 p., e02527-17.

Research output: Contribution to journalArticleResearchpeer-review

Elucidating the pharmacokinetics/pharmacodynamics of aerosolized colistin against multidrug-resistant acinetobacter baumannii and klebsiella pneumoniae in a mouse lung infection model

Lin, Y-W., Zhou, Q. T., Han, M-L., Chen, K., Onufrak, N. J., Wang, J., Turnidge, J. D., Howden, B. P., Forrest, A., Chan, H. K. & Li, J., 1 Feb 2018, In : Antimicrobial Agents and Chemotherapy. 62, 2, 9 p., e01790.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Lipidomic analysis of the outer membrane vesicles from paired polymyxin-susceptible and -resistant Klebsiella pneumoniae clinical isolates

Jasim, R., Han, M-L., Zhu, Y., Hu, X., Hussein, M. H., Lin, Y-W., Zhou, T. Q., Dong, C. Y. D., Li, J. & Velkov, T., 10 Aug 2018, In : International Journal of Molecular Sciences. 19, 8, 13 p., 2356.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Mechanism-based pharmacokinetic/pharmacodynamic modeling of aerosolized colistin in a mouse lung infection model

Lin, Y-W., Zhou, Q. T., Han, M-L., Onufrak, N. J., Chen, K., Wang, J., Forrest, A., Chan, H-K. & Li, J., 1 Mar 2018, In : Antimicrobial Agents and Chemotherapy. 62, 3, 14 p., e01965-17.

Research output: Contribution to journalArticleResearchpeer-review

Mechanistic Insights From Global Metabolomics Studies into Synergistic Bactericidal Effect of a Polymyxin B Combination With Tamoxifen Against Cystic Fibrosis MDR Pseudomonas aeruginosa

Hussein, M., Han, M-L., Zhu, Y., Schneider-Futschik, E. K., Hu, X., Zhou, Q. T., Lin, Y-W., Anderson, D., Creek, D. J., Hoyer, D., Li, J. & Velkov, T., 1 Jan 2018, In : Computational and Structural Biotechnology Journal. 16, p. 587-599 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Metabolic Analyses Revealed Time-Dependent Synergistic Killing by Colistin and Aztreonam Combination Against Multidrug-Resistant Acinetobacter baumannii

Han, M-L., Liu, X., Velkov, T., Lin, Y-W., Zhu, Y., Li, M., Yu, H. H., Zhou, Z., Creek, D. J., Zhang, J. & Li, J., 16 Nov 2018, In : Frontiers in Microbiology. 9, 12 p., 2776.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Polymyxin b in combination with enrofloxacin exerts synergistic killing against extensively drug-resistant pseudomonas aeruginosa

Lin, Y-W., Yu, H. H., Zhao, J., Han, M-L., Zhu, Y., Akter, J., Wickremasinghe, H., Walpola, H., Wirth, V., Rao, G. G., Forrest, A., Velkov, T. & Li, J., 1 Jun 2018, In : Antimicrobial Agents and Chemotherapy. 62, 6, 13 p., e00028-18.

Research output: Contribution to journalArticleResearchpeer-review

2017

Aerosolized polymyxin B for treatment of respiratory tract infections: Determination of pharmacokinetic-pharmacodynamic indices for aerosolized polymyxin B against Pseudomonas aeruginosa in a mouse lung infection model

Lin, Y. W., Zhou, Q., Onufrak, N. J., Wirth, V., Chen, K., Wang, J., Forrest, A., Chan, H-K. & Li, J., 1 Aug 2017, In : Antimicrobial Agents and Chemotherapy. 61, 8, 15 p., e00211-17.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Pharmacokinetics/pharmacodynamics of pulmonary delivery of colistin against Pseudomonas aeruginosa in a mouse lung infection model

Lin, Y. W., Zhou, Q. T., Cheah, S-E., Zhao, J., Chen, K., Wang, J., Chan, H-K. & Li, J., 1 Mar 2017, In : Antimicrobial Agents and Chemotherapy. 61, 3, 11 p., e02025-16.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Potential toxicity of polymyxins in human lung epithelial cells

Ahmed, M. U., Velkov, T., Lin, Y-W., Yun, B., Nowell, C. J., Zhou, F., Zhou, Q. T., Chan, K., Azad, M. A. K. & Li, J., 1 Jun 2017, In : Antimicrobial Agents and Chemotherapy. 61, 6, 12 p., e02690-16.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Pulmonary Pharmacokinetics of colistin following administration of dry powder aerosols in rats

Lin, Y. W., Zhou, Q. T., Hu, Y., Onufrak, N. J., Sun, S., Wang, J., Forrest, A., Chan, H. K. & Li, J., 1 Nov 2017, In : Antimicrobial Agents and Chemotherapy. 61, 11, 12 p., e00973.

Research output: Contribution to journalArticleResearchpeer-review

2015

Measuring Bipolar Charge and Mass Distributions of Powder Aerosols by a Novel Tool (BOLAR)

Wong, J., Lin, Y. W., Kwok, P. C. L., Niemelä, V., Crapper, J. & Chan, H. K., 8 Sep 2015, In : Molecular Pharmaceutics. 12, 9, p. 3433-3440 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Powder production and particle engineering for dry powder inhaler formulations

Lin, Y-W., Wong, J., Qu, L., Chan, H-K. & Zhou, Q. T., 2015, In : Current Pharmaceutical Design. 21, 27, p. 3902-3916 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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