19962020

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Article
2020

A Review of Design Considerations for Hemocompatibility within Microfluidic Systems

Szydzik, C., Brazilek, R. J. & Nesbitt, W. S., 1 Jul 2020, In : Seminars in Thrombosis and Hemostasis. 46, 5, p. 622-636 15 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

In vitro flow based systems to study platelet function and thrombus formation: Recommendations for standardization: Communication from the SSC on Biorheology of the ISTH

Mangin, P. H., Gardiner, E. E., Nesbitt, W. S., Kerrigan, S. W., Korin, N., Lam, W. A., Panteleev, M. A. & for the Subcommittee on Biorheology, 1 Mar 2020, In : Journal of Thrombosis and Haemostasis. 18, 3, p. 748-752 5 p.

Research output: Contribution to journalArticleOtherpeer-review

1 Citation (Scopus)
2019

Active Micropump-Mixer for Rapid Antiplatelet Drug Screening in Whole Blood

Szydzik, C., Brazilek, R. J., Akbaridoust, F., De Silva, C., Moon, M., Marusic, I., Ooi, A. S. H., Nandurkar, H. H., Hamilton, J. R., Mitchell, A. & Nesbitt, W. S., 20 Aug 2019, In : Analytical Chemistry. 91, 16, p. 10830-10839 10 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

The mode of anesthesia influences outcome in mouse models of arterial thrombosis

Sashindranath, M., Sturgeon, S., French, S. L., Craenmehr, D. D. D., Selan, C., Freddi, S., Johnson, C., Cody, S., Nesbitt, W., Hamilton, J., Cody, S. H., Nesbitt, W., Hamilton, J. & Nandurkar, H., Apr 2019, In : Thrombosis and Haemostasis. 3, 2, p. 197-206 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

The PI 3-kinase PI3KC2α regulates mouse platelet membrane structure and function independently of membrane lipid composition

Selvadurai, M. V., Brazilek, R. J., Moon, M. J., Rinckel, J. Y., Eckly, A., Gachet, C., Meikle, P. J., Nandurkar, H. H., Nesbitt, W. S. & Hamilton, J. R., 1 Jan 2019, In : FEBS Letters. 593, 1, p. 88-96 9 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)
2018

Elastomeric microvalve geometry affects haemocompatibility

Szydzik, C., Brazilek, R. J., Khoshmanesh, K., Akbaridoust, F., Knoerzer, M., Thurgood, P., Muir, I., Marusic, I., Nandurkar, H., Mitchell, A. & Nesbitt, W. S., 1 Jan 2018, In : Lab on a Chip. 18, 12, p. 1778-1792 15 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)
2017

Application of a strain rate gradient microfluidic device to von Willebrand's disease screening

Brazilek, R. J., Tovar-Lopez, F. J., Wong, A. K. T., Tran, H., Davis, A. S., McFadyen, J. D., Kaplan, Z., Chunilal, S., Jackson, S. P., Nandurkar, H., Mitchell, A. & Nesbitt, W. S., 2017, In : Lab on a Chip. 17, 15, p. 2595-2608 14 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)
2016

Fabrication of complex PDMS microfluidic structures and embedded functional substrates by one-step injection moulding

Szydzik, C., Niego, B., Dalzell, G., Knoerzer, M., Ball, F., Nesbitt, W. S., Medcalf, R. L., Khoshmanesh, K. & Mitchell, A., 2016, In : RSC Advances. 6, 91, p. 87988-87994 7 p.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

Inhibition of protease-activated receptor 4 impairs platelet procoagulant activity during thrombus formation in human blood

French, S. L., Arthur, J. F., Lee, H., Nesbitt, W., Andrews, R. K., Gardiner, E. & Hamilton, J. R., 1 Aug 2016, In : Journal of Thrombosis and Haemostasis. 14, 8, p. 1642-1654 13 p.

Research output: Contribution to journalArticleResearchpeer-review

24 Citations (Scopus)
2015

Nonlinear Dynamic Modelling of Platelet Aggregation via Microfluidic Devices

Combariza, M. E., Yu, X., Nesbitt, W. S., Mitchell, A. & Tovar-Lopez, F. J., 1 Jul 2015, In : IEEE Transactions on Biomedical Engineering. 62, 7, p. 1718-1727 10 p., 7044579.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)
2014

Dok-2 adaptor protein regulates the shear-dependent adhesive function of platelet integrin aIIb{beta}3 in mice

Hughan, S. C., Spring, C. M., Schoenwaelder, S. M., Sturgeon, S. A., Alwis, I., Yuan, Y-P., McFadyen, J. D., Westein, E., Goddard, D. M., Ono, A., Yamanashi, Y., Nesbitt, W. S. & Jackson, S., 2014, In : The Journal of Biological Chemistry. 289, 8, p. 5051 - 5060 10 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)
2013

An investigation on platelet transport during thrombus formation at micro-scale stenosis

Tovar-Lopez, F. J., Rosengarten, G., Nasabi, M., Sivan, V., Khoshmanesh, K., Jackson, S., Mitchell, A. & Nesbitt, W. S., 2013, In : PLoS ONE. 8, 10 (Art. ID: e74123), p. 1 - 11 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
24 Citations (Scopus)
2012

A live cell micro-imaging technique to examine platelet calcium signaling dynamics under blood flow

Nesbitt, W. S., Harper, I. S., Schoenwaelder, S. M., Yuan, Y. & Jackson, S. P., 2012, In : Methods in Molecular Biology. 788, p. 73 - 89 17 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)
2011

Structural and hydrodynamic simulation of an acute stenosis-dependent thrombosis model in mice

Tovar-Lopez, F. J., Rosengarten, G., Khoshmanesh, K., Westein, E., Jackson, S., Nesbitt, W. S. & Mitchell, A., 2011, In : Journal of Biomechanics. 44, 6, p. 1031 - 1039 9 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)
2010

A microfluidics device to monitor platelet aggregation dynamics in response to strain rate micro-gradients in flowing blood

Tovar-Lopez, F. J., Rosengarten, G., Westein, E., Khoshmanesh, K., Jackson, S., Mitchell, A. & Nesbitt, W. S., 2010, In : Lab on a Chip. 10, 3, p. 291 - 302 12 p.

Research output: Contribution to journalArticleResearchpeer-review

89 Citations (Scopus)

Phosphoinositide 3-kinase p110beta regulates integrin alphaIIbbeta3 avidity and the cellular transmission of contractile forces

Schoenwaelder, S. M., Ono, A., Nesbitt, W. S., Lim, J. M. C., Jarman, K. E. & Jackson, S., 2010, In : The Journal of Biological Chemistry. 285, 4, p. 2886 - 2896 11 p.

Research output: Contribution to journalArticleResearchpeer-review

56 Citations (Scopus)
2009

A shear gradient-dependent platelet aggregation mechanism drives thrombus formation

Nesbitt, W. S., Westein, E., Tovar-Lopez, F. J., Tolouei, E., Mitchell, A., Jia, F., Carberry, J. J., Fouras, A. & Jackson, S., 2009, In : Nature Medicine. 15, 6, p. 665 - 673 9 p.

Research output: Contribution to journalArticleResearchpeer-review

518 Citations (Scopus)

Dynamics of platelet thrombus formation

Jackson, S., Nesbitt, W. S. & Westein, E., 2009, In : Journal of Thrombosis and Haemostasis. 7, S1, p. 17 - 20 4 p.

Research output: Contribution to journalArticleResearchpeer-review

144 Citations (Scopus)
2008

Identification of a fibrin-independent platelet contractile mechanism regulating primary hemostasis and thrombus growth

Ono, A., Westein, E., Hsiao, S. T-F., Nesbitt, W. S., Hamilton, J. R., Schoenwaelder, S. M. & Jackson, S., 2008, In : Blood. 112, 1, p. 90 - 99 10 p.

Research output: Contribution to journalArticleResearchpeer-review

79 Citations (Scopus)
2007

Identification of a 2-stage platelet aggregation process mediating shear-dependent thrombus formation

Maxwell, M. J., Westein, E., Nesbitt, W. S., Giuliano, S., Dopheide, S. M. & Jackson, S., 2007, In : Blood. 109, 2, p. 566 - 576 11 p.

Research output: Contribution to journalArticleResearchpeer-review

149 Citations (Scopus)
2006

Imaging signaling processes in platelets

Nesbitt, W. S. & Jackson, S., 2006, In : Blood Cells, Molecules, and Diseases. 36, 2, p. 139 - 144 6 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

The impact of blood rheology on the molecular and cellular events underlying arterial thrombosis.

Nesbitt, W. S., Mangin, P., Salem, H. H. & Jackson, S., 2006, In : Journal of Molecular Medicine. 84, 12, p. 989 - 995 7 p.

Research output: Contribution to journalArticleResearchpeer-review

45 Citations (Scopus)
2005

Importance of temporal flow gradients and integrin alphaIIbbeta3 mechanotransduction for shear activation of platelets

Goncalves, I., Nesbitt, W. S., Yuan, Y. & Jackson, S. P., 2005, In : The Journal of Biological Chemistry. 280, 15, p. 15430 - 15437 8 p.

Research output: Contribution to journalArticleResearchpeer-review

43 Citations (Scopus)

PI 3-kinase p110beta: A new target for antithrombotic therapy

Jackson, S. P., Schoenwaelder, S. M., Goncalves, I., Nesbitt, W. S., Yap, C. L-S., Wright, C. E., Kenche, V. B., Anderson, K. E., Dopheide, S. M., Yuan, Y., Sturgeon, S. A., Prabaharan, H., Thompson, P. E., Smith, G. D., Shepherd, P. R., Daniele, N., Kulkarni, S., Abbott, B., Saylik, D., Jones, C. & 6 others, Lu, L., Giuliano, S., Hughan, S. C., Angus, J. A., Robertson, A. D. & Salem, H. H., 2005, In : Nature Medicine. 11, 5, p. 507 - 514 8 p.

Research output: Contribution to journalArticleResearchpeer-review

468 Citations (Scopus)
2003

Bidirectional integrin signalling regulating platelet adhesion under flow: contribution of protein kinase C

Giuliano, S., Nesbitt, W. S., Rooney, M. M. & Jackson, S. P., 2003, In : Biochemical Journal. 372, p. 163 - 172 10 p.

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)

Intercellular calcium communication regulates platelet aggregation and thrombus growth

Nesbitt, W. S., Giuliano, S., Kulkarni, S., Dopheide, S. M., Harper, I. S. & Jackson, S. P., 2003, In : Journal of Cell Biology. 160, 7, p. 1151 - 1161 11 p.

Research output: Contribution to journalArticleResearchpeer-review

123 Citations (Scopus)

Signaling events underlying thrombus formation

Jackson, S. P., Nesbitt, W. S. & Kulkarni, S., 2003, In : Journal of Thrombosis and Haemostasis. 1, 7, p. 1602 - 1612 11 p.

Research output: Contribution to journalArticleResearchpeer-review

308 Citations (Scopus)
2002

Distinct Glycoprotein Ib/V/IX and Integrin IIb3-dependent Calcium Signals Cooperatively Regulate Platelet Adhesion under Flow

Nesbitt, W. S., Kulkarni, S., Giuliano, S., Goncalves, I., Dopheide, S. M., Yap, C. L., Harper, I. S., Salem, H. H. & Jackson, S. P., 2002, In : The Journal of Biological Chemistry. 277, 4, p. 2965 - 2972 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Distinct glycoprotein Ib/V/IX and integrin αIIbβ3-dependent calcium signals cooperatively regulate platelet adhesion under flow

Nesbitt, W. S., Kulkarni, S., Giuliano, S., Goncalves, I., Dopheide, S. M., Yap, C. L., Harper, I. S., Salem, H. H. & Jackson, S. P., 25 Jan 2002, In : The Journal of Biological Chemistry. 277, 4, p. 2965-2972 8 p.

Research output: Contribution to journalArticleResearchpeer-review

138 Citations (Scopus)
2000

Synergistic adhesive interactions and signaling mechanisms operating between platelet glycoprotein Ib/IX and integrin αIIbβ3: Studies in human platelets and transfected Chinese hamster ovary cells

Yap, C. L., Hughan, S. C., Cranmer, S. L., Nesbitt, W. S., Rooney, M. M., Giuliano, S., Kulkarni, S., Dopheide, S. M., Yuan, Y., Salem, H. H. & Jackson, S. P., 29 Dec 2000, In : The Journal of Biological Chemistry. 275, 52, p. 41377-41388 12 p.

Research output: Contribution to journalArticleResearchpeer-review

96 Citations (Scopus)

Synergistic adhesive interactions and signaling mechanisms operating between platelet glycoprotein Ib.IX and intergrin alphaIIbBeta3

Yap, C. L., Hughan, S. C., Cranmer, S. L., Nesbitt, W. S., Rooney, M. M., Giuliano, S., Kulkarni, S., Dopheide, S. M., Yuan, Y., Salem, H. H. H. & Jackson, S. P., 2000, In : The Journal of Biological Chemistry. p. 41377 - 41388 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Synergistic adhesive interactions and signaling mechanisms operating between platelet gp ib/ix and integrin αiibβ3: studies in human platelets and transfected K562 and CHO cells

Jackson, S. P., Domagala, T., Hughan, S. C., Cranmer, S. L., Nesbitt, W. S., Kulkarni, S., Dopheide, S. M., Yuan, Y., Lanza, F. & Yap, C. L., 1 Dec 2000, In : Blood. 96, 11 PART I

Research output: Contribution to journalArticleResearchpeer-review

1999

The von Willebrand factor-glycoprotein Ib/V/IX interaction induces actin polymerisation and cytoskeletal reorganisation in rolling platelets and glycoprotein Ib/V/IX-transfected cells

Yuan, Y., Kulkarni, S., Ulsemer, P., Cranmer, S. L., Yap, C. L., Nesbitt, W. S., Harper, I. S., Mistry, N., Dopheide, S. M., Hughan, S. C., Williamson, D., De La Salle, C., Salem, H. H., Lanza, F. & Jackson, S. P., 1999, In : The Journal of Biological Chemistry. p. 36241 - 36251 11 p.

Research output: Contribution to journalArticleResearchpeer-review

The von Willebrand factor-glycoprotein Ib/V/IX interaction induces actin polymerization and cytoskeletal reorganization in rolling platelets and glycoprotein Ib/V/IX-transfected cells

Yuan, Y., Kulkarni, S., Ulsemer, P., Cranmer, S. L., Yap, C. L., Nesbitt, W. S., Harper, I., Mistry, N., Dopheide, S. M., Hughan, S. C., Williamson, D., De La Salle, C., Salem, H. H., Lanza, F. & Jackson, S. P., 17 Dec 1999, In : The Journal of Biological Chemistry. 274, 51, p. 36241-36251 11 p.

Research output: Contribution to journalArticleResearchpeer-review

98 Citations (Scopus)
1996

Molecular genetic analysis of the central hydrophobic domain of subunit 8 of yeast mitochondrial ATP synthase

Papakonstantinou, T., Law, R. H. P., Nesbitt, W. S., Nagley, P. & Devenish, R. J., 20 Aug 1996, In : Current Genetics. 30, 1, p. 12-18 7 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)