Warwick Nesbitt

Dr

19962019
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Research Output 1996 2019

2019

Active Micropump-Mixer for Rapid Antiplatelet Drug Screening in Whole Blood

Szydzik, C., Brazilek, R. J., Akbaridoust, F., De Silva, C., Moon, M., Marusic, I., Ooi, A. S. H., Nandurkar, H. H., Hamilton, J. R., Mitchell, A. & Nesbitt, W. S., 20 Aug 2019, In : Analytical Chemistry. 91, 16, p. 10830-10839 10 p.

Research output: Contribution to journalArticleResearchpeer-review

The mode of anesthesia influences outcome in mouse models of arterial thrombosis

Sashindranath, M., Sturgeon, S., French, S. L., Craenmehr, D. D. D., Selan, C., Freddi, S., Johnson, C., Cody, S., Nesbitt, W., Hamilton, J., Cody, S. H., Nesbitt, W., Hamilton, J. & Nandurkar, H., Apr 2019, In : Thrombosis and Haemostasis. 3, 2, p. 197-206 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
1 Citation (Scopus)

The PI 3-kinase PI3KC2α regulates mouse platelet membrane structure and function independently of membrane lipid composition

Selvadurai, M. V., Brazilek, R. J., Moon, M. J., Rinckel, J. Y., Eckly, A., Gachet, C., Meikle, P. J., Nandurkar, H. H., Nesbitt, W. S. & Hamilton, J. R., 1 Jan 2019, In : FEBS Letters. 593, 1, p. 88-96 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2018
1 Citation (Scopus)

Elastomeric microvalve geometry affects haemocompatibility

Szydzik, C., Brazilek, R. J., Khoshmanesh, K., Akbaridoust, F., Knoerzer, M., Thurgood, P., Muir, I., Marusic, I., Nandurkar, H., Mitchell, A. & Nesbitt, W. S., 1 Jan 2018, In : Lab on a Chip. 18, 12, p. 1778-1792 15 p.

Research output: Contribution to journalArticleResearchpeer-review

2017
5 Citations (Scopus)

Application of a strain rate gradient microfluidic device to von Willebrand's disease screening

Brazilek, R. J., Tovar-Lopez, F. J., Wong, A. K. T., Tran, H., Davis, A. S., McFadyen, J. D., Kaplan, Z., Chunilal, S., Jackson, S. P., Nandurkar, H., Mitchell, A. & Nesbitt, W. S., 2017, In : Lab on a Chip. 17, 15, p. 2595-2608 14 p.

Research output: Contribution to journalArticleResearchpeer-review

2016

A Shear Micro-Gradient Microfluidic to Monitor Platelet Aggregation Dynamics in the Context of Von Willebrand Disease

Nandurkar, H., Nesbitt, W., Brazilek, R., Tovar-Lopez, F., Wong, A., Tran, H., Davis, A. & Mitchell, A., 2016, In : Blood. 128, 22, p. 3753-3753 1 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

10 Citations (Scopus)

Fabrication of complex PDMS microfluidic structures and embedded functional substrates by one-step injection moulding

Szydzik, C., Niego, B., Dalzell, G., Knoerzer, M., Ball, F., Nesbitt, W. S., Medcalf, R. L., Khoshmanesh, K. & Mitchell, A., 2016, In : RSC Advances. 6, 91, p. 87988-87994 7 p.

Research output: Contribution to journalArticleResearchpeer-review

20 Citations (Scopus)

Inhibition of protease-activated receptor 4 impairs platelet procoagulant activity during thrombus formation in human blood

French, S. L., Arthur, J. F., Lee, H., Nesbitt, W., Andrews, R. K., Gardiner, E. & Hamilton, J. R., 1 Aug 2016, In : Journal of Thrombosis and Haemostasis. 14, 8, p. 1642-1654 13 p.

Research output: Contribution to journalArticleResearchpeer-review

2015

Dynamic evaluation and control of blood clotting using a microfluidic platform for high-throughput diagnostics

Combariza, M. E., Yu, X., Nesbitt, W., Tovar-Lopez, F., Rabus, D. G. & Mitchell, A., 1 Jan 2015, Micro+Nano Materials, Devices, and Systems. Palomba, S. & Eggleton, B. J. (eds.). Bellingham WA USA: SPIE, 10 p. 96681U. (Proceedings of SPIE; vol. 9668).

Research output: Chapter in Book/Report/Conference proceedingConference PaperResearchpeer-review

10 Citations (Scopus)

Nonlinear Dynamic Modelling of Platelet Aggregation via Microfluidic Devices

Combariza, M. E., Yu, X., Nesbitt, W. S., Mitchell, A. & Tovar-Lopez, F. J., 1 Jul 2015, In : IEEE Transactions on Biomedical Engineering. 62, 7, p. 1718-1727 10 p., 7044579.

Research output: Contribution to journalArticleResearchpeer-review

2014
7 Citations (Scopus)

Dok-2 adaptor protein regulates the shear-dependent adhesive function of platelet integrin aIIb{beta}3 in mice

Hughan, S. C., Spring, C. M., Schoenwaelder, S. M., Sturgeon, S. A., Alwis, I., Yuan, Y-P., McFadyen, J. D., Westein, E., Goddard, D. M., Ono, A., Yamanashi, Y., Nesbitt, W. S. & Jackson, S., 2014, In : Journal of Biological Chemistry. 289, 8, p. 5051 - 5060 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Microfluidics devices to investigate blood cell dynamics during thrombus formation driven by shear-gradients on microstenosis

Tovar-Lopez, F. J., Nguyen, T., Nasabi, M., Sivan, V., Mitchell, A. & Nesbitt, W. S., 1 Jan 2014, 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014. San Diego CA USA: Chemical and Biological Microsystems Society, p. 357-359 3 p.

Research output: Chapter in Book/Report/Conference proceedingConference PaperOther

2013
5 Citations (Scopus)

A multimode-TIRFM and microfluidic technique to examine platelet adhesion dynamics

Nesbitt, W. S., Tovar-Lopez, F. J., Westein, E., Harper, I. S. & Jackson, S., 2013, Adhesion Protein Protocols. Coutts, A. S. (ed.). USA: Humana Press, Vol. 1046. p. 39 - 58 20 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

24 Citations (Scopus)

An investigation on platelet transport during thrombus formation at micro-scale stenosis

Tovar-Lopez, F. J., Rosengarten, G., Nasabi, M., Sivan, V., Khoshmanesh, K., Jackson, S., Mitchell, A. & Nesbitt, W. S., 2013, In : PLoS ONE. 8, 10 (Art. ID: e74123), p. 1 - 11 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
1 Citation (Scopus)

Modeling of dynamic platelet aggregation in response to shear rate micro-gradients in a microfluidics device

Combariza, M. E., Yu, X., Tovar-Lopezy, F., Nesbitt, W. S. & Mitchell, A., 2013, Proceedings of the Biosignals and Biorobotics Conference (BRC), 2013 ISSNIP. Zappulla, F., Grenier, G., Moore, K. & Hassler, S. (eds.). USA: IEEE, Institute of Electrical and Electronics Engineers, Vol. 2013. p. 286 - 290 5 p.

Research output: Chapter in Book/Report/Conference proceedingConference PaperResearchpeer-review

Regulation of dynamic platelet aggregation in response to shear rate micro-gradients in a microfluidics device applying switching control

Combariza, M. E., Yu, X., Nesbitt, W. S., Mitchell, A. & Tovar-Lopez, F. J., 1 Jan 2013, p. 644-649. 6 p.

Research output: Contribution to conferencePaperOtherpeer-review

2012
6 Citations (Scopus)

A live cell micro-imaging technique to examine platelet calcium signaling dynamics under blood flow

Nesbitt, W. S., Harper, I. S., Schoenwaelder, S. M., Yuan, Y. & Jackson, S. P., 2012, In : Methods in Molecular Biology. 788, p. 73 - 89 17 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Four-stage mechanistic model of dynamic platelet aggregation in a microfluidic chip

Combariza, M. E., Tovar-Lopez, F. J., Nesbitt, W. S., Yu, X. & Mitchell, A., 1 Jan 2012, Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012. Chemical and Biological Microsystems Society, p. 1564-1566 3 p.

Research output: Chapter in Book/Report/Conference proceedingConference PaperResearchpeer-review

Vacuum flow focusing microfluidics to study blood cell dynamics under shear gradient aggregation mechanism

Tovar-Lopez, F. J., Nasabi, M., Sivan, V., Khoshmanesh, K., Jackson, S., Rosengarten, G., Mitchell, A. & Nesbitt, W. S., 1 Jan 2012, Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012. Chemical and Biological Microsystems Society, p. 740-742 3 p.

Research output: Chapter in Book/Report/Conference proceedingConference PaperResearchpeer-review

2011
1 Citation (Scopus)

Blood cell diffusion visualization using multiple hydrodynamic flow focusing

Tovar-Lopez, F. J., Rosengarten, G., Nasabi, M., Sivan, V., Jackson, S. P., Nesbitt, W. S. & Mitchell, A., 1 Dec 2011, 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011. Vol. 1. p. 45-47 3 p.

Research output: Chapter in Book/Report/Conference proceedingConference PaperResearchpeer-review

10 Citations (Scopus)

Structural and hydrodynamic simulation of an acute stenosis-dependent thrombosis model in mice

Tovar-Lopez, F. J., Rosengarten, G., Khoshmanesh, K., Westein, E., Jackson, S., Nesbitt, W. S. & Mitchell, A., 2011, In : Journal of Biomechanics. 44, 6, p. 1031 - 1039 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2010
83 Citations (Scopus)

A microfluidics device to monitor platelet aggregation dynamics in response to strain rate micro-gradients in flowing blood

Tovar-Lopez, F. J., Rosengarten, G., Westein, E., Khoshmanesh, K., Jackson, S., Mitchell, A. & Nesbitt, W. S., 2010, In : Lab on a Chip. 10, 3, p. 291 - 302 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Erratum: A microfluidics device to monitor platelet aggregation dynamics in response to strain rate micro-gradients in flowing blood (Lab on a Chip (2010) 10 (291-302) DOI: 10.1039/b916757a)

Tovar-Lopez, F. J., Rosengarten, G., Westein, E., Khoshmanesh, K., Jackson, S. P., Mitchell, A. & Nesbitt, W. S., 21 Dec 2010, In : Lab on a Chip. 10, 24, 1 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

53 Citations (Scopus)

Phosphoinositide 3-kinase p110beta regulates integrin alphaIIbbeta3 avidity and the cellular transmission of contractile forces

Schoenwaelder, S. M., Ono, A., Nesbitt, W. S., Lim, J. M. C., Jarman, K. E. & Jackson, S., 2010, In : Journal of Biological Chemistry. 285, 4, p. 2886 - 2896 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2009

A novel platform to study platelet aggregation and thrombus growth based on micro strain-rate changes

Tovar-Lopez, F. J., Rosengarten, G., Khoshmanesh, K., Jackson, S. P., Mitchell, A. & Nesbitt, W. S., 1 Jan 2009, Proceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences. Chemical and Biological Microsystems Society, p. 1112-1114 3 p.

Research output: Chapter in Book/Report/Conference proceedingConference PaperResearchpeer-review

A novel scanning method to measure shear rate around a thrombus using micro particle image velocimetry

Tolouel, E., Nesbitt, W., Fouras, A., Carberry, J. & Jackson, S., 2009, Proceedings of the ASME Summer Bioengineering Conference, SBC2008. PART B ed. p. 881-882 2 p.

Research output: Chapter in Book/Report/Conference proceedingConference PaperResearchpeer-review

485 Citations (Scopus)

A shear gradient-dependent platelet aggregation mechanism drives thrombus formation

Nesbitt, W. S., Westein, E., Tovar-Lopez, F. J., Tolouei, E., Mitchell, A., Jia, F., Carberry, J. J., Fouras, A. & Jackson, S., 2009, In : Nature Medicine. 15, 6, p. 665 - 673 9 p.

Research output: Contribution to journalArticleResearchpeer-review

141 Citations (Scopus)

Dynamics of platelet thrombus formation

Jackson, S., Nesbitt, W. S. & Westein, E., 2009, In : Journal of Thrombosis and Haemostasis. 7, S1, p. 17 - 20 4 p.

Research output: Contribution to journalArticleResearchpeer-review

2008

A High Spatial Method to Determine Trhee Dimensional Velocity Gradient Tensor using Micro Particle Image Velocimetry

Adrian, R. J. (ed.), Tolouei, E., Nesbitt, W. S., Fouras, A. & Carberry, J. J., 2008, p. 1.3.2 - 1.3.2. 1 p.

Research output: Contribution to conferenceAbstractOther

79 Citations (Scopus)

Identification of a fibrin-independent platelet contractile mechanism regulating primary hemostasis and thrombus growth

Ono, A., Westein, E., Hsiao, S. T-F., Nesbitt, W. S., Hamilton, J. R., Schoenwaelder, S. M. & Jackson, S., 2008, In : Blood. 112, 1, p. 90 - 99 10 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Microstamp patterning of protein arrays

Nasabi, M., Mitchell, A., Kalantar-Zadeh, K. & Nesbitt, W. S., 24 Nov 2008, Proceedings of the 2008 International Conference on Nanoscience and Nanotechnology, ICONN 2008. p. 117-120 4 p. 4639260

Research output: Chapter in Book/Report/Conference proceedingConference PaperResearchpeer-review

2007
145 Citations (Scopus)

Identification of a 2-stage platelet aggregation process mediating shear-dependent thrombus formation

Maxwell, M. J., Westein, E., Nesbitt, W. S., Giuliano, S., Dopheide, S. M. & Jackson, S., 2007, In : Blood. 109, 2, p. 566 - 576 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2006
2 Citations (Scopus)

Imaging signaling processes in platelets

Nesbitt, W. S. & Jackson, S., 2006, In : Blood Cells, Molecules, and Diseases. 36, 2, p. 139 - 144 6 p.

Research output: Contribution to journalArticleResearchpeer-review

45 Citations (Scopus)

The impact of blood rheology on the molecular and cellular events underlying arterial thrombosis.

Nesbitt, W. S., Mangin, P., Salem, H. H. & Jackson, S., 2006, In : Journal of Molecular Medicine. 84, 12, p. 989 - 995 7 p.

Research output: Contribution to journalArticleResearchpeer-review

2005
41 Citations (Scopus)

Importance of temporal flow gradients and integrin alphaIIbbeta3 mechanotransduction for shear activation of platelets

Goncalves, I., Nesbitt, W. S., Yuan, Y. & Jackson, S. P., 2005, In : Journal of Biological Chemistry. 280, 15, p. 15430 - 15437 8 p.

Research output: Contribution to journalArticleResearchpeer-review

455 Citations (Scopus)

PI 3-kinase p110beta: A new target for antithrombotic therapy

Jackson, S. P., Schoenwaelder, S. M., Goncalves, I., Nesbitt, W. S., Yap, C. L-S., Wright, C. E., Kenche, V. B., Anderson, K. E., Dopheide, S. M., Yuan, Y., Sturgeon, S. A., Prabaharan, H., Thompson, P. E., Smith, G. D., Shepherd, P. R., Daniele, N., Kulkarni, S., Abbott, B., Saylik, D., Jones, C. & 6 others, Lu, L., Giuliano, S., Hughan, S. C., Angus, J. A., Robertson, A. D. & Salem, H. H., 2005, In : Nature Medicine. 11, 5, p. 507 - 514 8 p.

Research output: Contribution to journalArticleResearchpeer-review

2004
28 Citations (Scopus)

Techniques to examine platelet adhesive interactions under flow

Kulkarni, S., Nesbitt, W. S., Dopheide, S. M., Hughan, S. C., Harper, I. S. & Jackson, S. P., 2004, Methods in Molecular Biology: Platelets and Megakaryocytes. Gibbins, J. M. & Mahaut-Smith, M. P. (eds.). 1st ed. USA: Humana Press, p. 165 - 186 22 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

2003
14 Citations (Scopus)

Bidirectional integrin signalling regulating platelet adhesion under flow: contribution of protein kinase C

Giuliano, S., Nesbitt, W. S., Rooney, M. M. & Jackson, S. P., 2003, In : Biochemical Journal. 372, p. 163 - 172 10 p.

Research output: Contribution to journalArticleResearchpeer-review

117 Citations (Scopus)

Intercellular calcium communication regulates platelet aggregation and thrombus growth

Nesbitt, W. S., Giuliano, S., Kulkarni, S., Dopheide, S. M., Harper, I. S. & Jackson, S. P., 2003, In : Journal of Cell Biology. 160, 7, p. 1151 - 1161 11 p.

Research output: Contribution to journalArticleResearchpeer-review

301 Citations (Scopus)

Signaling events underlying thrombus formation

Jackson, S. P., Nesbitt, W. S. & Kulkarni, S., 2003, In : Journal of Thrombosis and Haemostasis. 1, 7, p. 1602 - 1612 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2002

Distinct Glycoprotein Ib/V/IX and Integrin IIb3-dependent Calcium Signals Cooperatively Regulate Platelet Adhesion under Flow

Nesbitt, W. S., Kulkarni, S., Giuliano, S., Goncalves, I., Dopheide, S. M., Yap, C. L., Harper, I. S., Salem, H. H. & Jackson, S. P., 2002, In : Journal of Biological Chemistry. 277, 4, p. 2965 - 2972 8 p.

Research output: Contribution to journalArticleResearchpeer-review

134 Citations (Scopus)

Distinct glycoprotein Ib/V/IX and integrin αIIbβ3-dependent calcium signals cooperatively regulate platelet adhesion under flow

Nesbitt, W. S., Kulkarni, S., Giuliano, S., Goncalves, I., Dopheide, S. M., Yap, C. L., Harper, I. S., Salem, H. H. & Jackson, S. P., 25 Jan 2002, In : Journal of Biological Chemistry. 277, 4, p. 2965-2972 8 p.

Research output: Contribution to journalArticleResearchpeer-review

2000
94 Citations (Scopus)

Synergistic adhesive interactions and signaling mechanisms operating between platelet glycoprotein Ib/IX and integrin αIIbβ3: Studies in human platelets and transfected Chinese hamster ovary cells

Yap, C. L., Hughan, S. C., Cranmer, S. L., Nesbitt, W. S., Rooney, M. M., Giuliano, S., Kulkarni, S., Dopheide, S. M., Yuan, Y., Salem, H. H. & Jackson, S. P., 29 Dec 2000, In : Journal of Biological Chemistry. 275, 52, p. 41377-41388 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Synergistic adhesive interactions and signaling mechanisms operating between platelet glycoprotein Ib.IX and intergrin alphaIIbBeta3

Yap, C. L., Hughan, S. C., Cranmer, S. L., Nesbitt, W. S., Rooney, M. M., Giuliano, S., Kulkarni, S., Dopheide, S. M., Yuan, Y., Salem, H. H. H. & Jackson, S. P., 2000, In : Journal of Biological Chemistry. p. 41377 - 41388 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Synergistic adhesive interactions and signaling mechanisms operating between platelet gp ib/ix and integrin αiibβ3: studies in human platelets and transfected K562 and CHO cells

Jackson, S. P., Domagala, T., Hughan, S. C., Cranmer, S. L., Nesbitt, W. S., Kulkarni, S., Dopheide, S. M., Yuan, Y., Lanza, F. & Yap, C. L., 1 Dec 2000, In : Blood. 96, 11 PART I

Research output: Contribution to journalArticleResearchpeer-review

1999

The von Willebrand factor-glycoprotein Ib/V/IX interaction induces actin polymerisation and cytoskeletal reorganisation in rolling platelets and glycoprotein Ib/V/IX-transfected cells

Yuan, Y., Kulkarni, S., Ulsemer, P., Cranmer, S. L., Yap, C. L., Nesbitt, W. S., Harper, I. S., Mistry, N., Dopheide, S. M., Hughan, S. C., Williamson, D., De La Salle, C., Salem, H. H., Lanza, F. & Jackson, S. P., 1999, In : Journal of Biological Chemistry. p. 36241 - 36251 11 p.

Research output: Contribution to journalArticleResearchpeer-review

95 Citations (Scopus)

The von Willebrand factor-glycoprotein Ib/V/IX interaction induces actin polymerization and cytoskeletal reorganization in rolling platelets and glycoprotein Ib/V/IX-transfected cells

Yuan, Y., Kulkarni, S., Ulsemer, P., Cranmer, S. L., Yap, C. L., Nesbitt, W. S., Harper, I., Mistry, N., Dopheide, S. M., Hughan, S. C., Williamson, D., De La Salle, C., Salem, H. H., Lanza, F. & Jackson, S. P., 17 Dec 1999, In : Journal of Biological Chemistry. 274, 51, p. 36241-36251 11 p.

Research output: Contribution to journalArticleResearchpeer-review

1998

Structure and function of membrane sector-associated proteins of yeast mitochondrial ATP synthase

Devenish, R. J., Artika, I. M., Boyle, G. M., Lourbakos, A., Nesbitt, W. S., Prescott, M., Roucou, X. & Nagley, P., 1998, p. C-53 - C-53. 1 p.

Research output: Contribution to conferenceAbstractOther

1996
12 Citations (Scopus)

Molecular genetic analysis of the central hydrophobic domain of subunit 8 of yeast mitochondrial ATP synthase

Papakonstantinou, T., Law, R. H. P., Nesbitt, W. S., Nagley, P. & Devenish, R. J., 20 Aug 1996, In : Current Genetics. 30, 1, p. 12-18 7 p.

Research output: Contribution to journalArticleResearchpeer-review