Personal profile
Biography
I am a researcher in the field of Epigenetics in diabetes and cardiovascular diseases. My latest work identified the role of exercise induced Epigenetic changes associated with reduced oxidative damage and improved micro vascular phenotype in the elderly. My current interest is to understanding the role of epigenetic mechanisms in diabetes associated atherosclerosis.
Education/Academic qualification
Epigenetics, PhD, Norepinephrine transporter gene silencing by MeCP2 in postural tachycardia syndrome, University of Melbourne
Award Date: 4 Apr 2017
Research area keywords
- Diabetes
- Epigenetics
- cardiovascular complications of diabetes
- Chromatin
- ncRNA
- Atherosclerosis
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
Collaborations and top research areas from the last five years
Projects
- 2 Finished
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Role of EZH2 in atherosusceptible vascular endothelium in diabetes associated atherosclerosis
Khan, W. (Primary Chief Investigator (PCI)), Cooper, M. (Chief Investigator (CI)) & Jandeleit-Dahm, K. (Chief Investigator (CI))
1/04/21 → 31/12/21
Project: Research
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Role of histone methyltransferase EZH2 in diabetes associated atherosclerosis
Khan, W. (Primary Chief Investigator (PCI))
1/04/20 → 31/03/22
Project: Research
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AP-1 Inhibition attenuates foam-cell formation reducing atherosclerosis in Type-1-Diabetes
Aziz, M., Khan, A. W. & Jandeleit-Dahm, K., Dec 2024, In: Atherosclerosis. 399, Supplement 1, 1 p., 118636.Research output: Contribution to journal › Meeting Abstract › peer-review
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Blockade of foam cell formation by an AP-1 inhibitor attenuates atherosclerosis in diabetes
Khan, A. W., Aziz, M., Sourris, K. & Jandeleit-Dahm, K. A. M., Oct 2024, In: European Heart Journal. 45, S1, 1 p., ehae666.3862.Research output: Contribution to journal › Meeting Abstract › peer-review
Open Access -
Interplay between epigenetic mechanisms and transcription factors in atherosclerosis
Aziz, M., Jandeleit-Dahm, K. A. & Khan, A. W., Aug 2024, In: Atherosclerosis. 395, 10 p., 117615.Research output: Contribution to journal › Article › Research › peer-review
Open Access5 Citations (Scopus) -
Repressive H3K27me3 drives hyperglycemia-induced oxidative and inflammatory transcriptional programs in human endothelium
Sánchez-Ceinos, J., Hussain, S., Khan, A. W., Zhang, L., Almahmeed, W., Pernow, J. & Cosentino, F., 5 Apr 2024, In: Cardiovascular Diabetology. 23, 1, 16 p., 122.Research output: Contribution to journal › Article › Research › peer-review
Open Access16 Citations (Scopus) -
Targeting EndMT (endothelial to mesenchymal transition) in atherosclerosis in Type-1-Diabetes
Aziz, M., Khan, A. W. & Jandeleit-Dahm, K. A. M., Dec 2024, In: Atherosclerosis. 399, Supplement 1, 1 p., 118637.Research output: Contribution to journal › Meeting Abstract › peer-review
Prizes
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Diabetes Wellness Junior Grant for “Role of acetyltransferase GCN5 in endothelial oxidative stress in diabetes
Khan, W. (Recipient), 2018
Prize: Other distinction
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Karolinska Institute research Grant “Role of AP-1 transcription factor JunD in diabetes-induced endothelial dysfunction and inflammation
Khan, W. (Recipient), 2018
Prize: Other distinction
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Master’s Scholarship, Faculty development program, University of Balochistan, Pakistan
Khan, W. (Recipient), 2009
Prize: Other distinction
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PhD Scholarship: Melbourne International Fee Remission Scholarship (MIFRS)
Khan, W. (Recipient), 2012
Prize: Other distinction
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PhD stipend Scholarship, Baker IDI heart and diabetes Institute, Melbourne, Australia
Khan, W. (Recipient), 2012
Prize: Other distinction