Vinod Ganju

Dr

20072019

Research output per year

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2019

Deep multi-region whole-genome sequencing reveals heterogeneity and gene-by-environment interactions in treatment-naive, metastatic lung cancer

Leong, T. L., Gayevskiy, V., Steinfort, D. P., De Massy, M. R., Gonzalez-Rajal, A., Marini, K. D., Stone, E., Chin, V., Havryk, A., Plit, M., Irving, L. B., Jennings, B. R., McCloy, R. A., Jayasekara, W. S. N., Alamgeer, M., Boolell, V., Field, A., Russell, P. A., Kumar, B., Gough, D. J. & 8 others, Szczepny, A., Ganju, V., Rossello, F. J., Cain, J. E., Papenfuss, A. T., Asselin-Labat, M. L., Cowley, M. J. & Watkins, D. N., 7 Mar 2019, In : Oncogene. 38, 10, p. 1661-1675 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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3 Citations (Scopus)

Tumor inherent interferon regulators as biomarkers of long-term chemotherapeutic response in TNBC

Brockwell, N. K., Rautela, J., Owen, K. L., Gearing, L. J., Deb, S., Harvey, K., Spurling, A., Zanker, D., Chan, C. L., Cumming, H. E., Deng, N., Zakhour, J. M., Duivenvoorden, H. M., Robinson, T., Harris, M., White, M., Fox, J., Ooi, C., Kumar, B., Thomson, J. & 7 others, Potasz, N., Swarbrick, A., Hertzog, P., Molloy, T. J., O’Toole, S., Ganju, V. & Parker, B. S., 29 Aug 2019, In : npj Precision Oncology. 3, 13 p., 21.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2018

A phase IIa study of HA-irinotecan, formulation of hyaluronic acid and irinotecan targeting CD44 in extensive-stage small cell lung cancer

Alamgeer, M., Neil Watkins, D., Banakh, I., Kumar, B., Gough, D. J., Markman, B. & Ganju, V., 1 Apr 2018, In : Investigational New Drugs. 36, 2, p. 288-298 11 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

Inhibition of activin signaling in lung adenocarcinoma increases the therapeutic index of platinum chemotherapy

Marini, K., Croucher, D. R., McCloy, R. A., Vaghjiani, V., Gonzalez-Rajal, A., Hastings, J. F., Chin, V. T., Szczepny, A., Kostyrko, K., Marquez, C., Jayasekara, W. S. N., Alamgeer, M., Boolell, V., Han, J. Z. R., Waugh, T., Lee, H. C., Oakes, S. R., Kumar, B., Harrison, C. A., Hedger, M. P. & 13 others, Lorensuhewa, N., Kita, B., arrow, R. B., Robinson, B. W. S., de Kretser, D. M., Wu, J., Ganju, V., Sweet-Cordero, E. A., Burgess, A., Martelotto, L. G., Rossello, F. J., Cain, J. & Watkins, D. N., 25 Jul 2018, In : Science Translational Medicine. 10, 451, 13 p., eaat3504.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

Methylation of all BRCA1 copies predicts response to the PARP inhibitor rucaparib in ovarian carcinoma

Kondrashova, O., Topp, M., Nesic, K., Lieschke, E., Ho, G. Y., Harrell, M. I., Zapparoli, G. V., Hadley, A., Holian, R., Boehm, E., Heong, V., Sanij, E., Pearson, R. B., Krais, J. J., Johnson, N., McNally, O., Ananda, S., Alsop, K., Hutt, K. J., Kaufmann, S. H. & 11 others, Lin, K. K., Harding, T. C., Traficante, N., Australian Ovarian Cancer Study (AOCS), deFazio, A., McNeish, I. A., Bowtell, D. D., Swisher, E. M., Dobrovic, A., Wakefield, M. J. & Scott, C. L., 1 Dec 2018, In : Nature Communications. 9, 1, 16 p., 3970.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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45 Citations (Scopus)
2017

First-line selective internal radiotherapy plus chemotherapy versus chemotherapy alone in patients with liver metastases from colorectal cancer (FOXFIRE, SIRFLOX, and FOXFIRE-Global): a combined analysis of three multicentre, randomised, phase 3 trials

Wasan, H. S., Gibbs, P., Sharma, N. K., Taieb, J., Heinemann, V., Ricke, J., Peeters, M., Findlay, M., Weaver, A., Mills, J., Wilson, C., Adams, R., Francis, A., Moschandreas, J., Virdee, P. S., Dutton, P., Love, S., Gebski, V., Gray, A., FOXFIRE trial investigators & 4 others, SIRFLOX trial investigators, FOXFIRE-Global trial investigators, van Hazel, G. & Sharma, R. A., 1 Sep 2017, In : The Lancet Oncology. 18, 9, p. 1159-1171 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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90 Citations (Scopus)

Randomized, double-blind, phase III trial of ipilimumab versus placebo in asymptomatic or minimally symptomatic patients with metastatic chemotherapy-naive castration-resistant prostate cancer

Beer, T. M., Kwon, E. D., Drake, C. G., Fizazi, K., Logothetis, C., Gravis, G., Ganju, V., Polikoff, J., Saad, F., Humanski, P., Piulats, J. M., Mella, P. G., Ng, S. S., Jaeger, D., Parnis, F. X., Franke, F. A., Puente, J., Carvajal, R., Sengeløv, L., McHenry, M. B. & 3 others, Varma, A., Van Den Eertwegh, A. J. & Gerritsen, W., 1 Jan 2017, In : Journal of Clinical Oncology. 35, 1, p. 40-47 8 p.

Research output: Contribution to journalArticleResearchpeer-review

229 Citations (Scopus)

The role of canonical and non-canonical Hedgehog signaling in tumor progression in a mouse model of small cell lung cancer

Szczepny, A., Rogers, S., Jayasekara, W. S. N., Park, K., McCloy, R. A., Cochrane, C. R., Ganju, V., Cooper, W. A., Sage, J., Peacock, C. D., Cain, J. E., Burgess, A. & Watkins, D. N., 28 Sep 2017, In : Oncogene. 36, 39, p. 5544-5550 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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29 Citations (Scopus)
2016

A randomized controlled trial of a nurse-led supportive care package (Survivorcare) for survivors of colorectal cancer

Jefford, M., Gough, K., Dowsky, A., Russell, L., Aranda, S., Butow, P., Phipps-Nelson, J., Young, J., Krishnasamy, M., Ugalde, A., King, D., Strickland, A., Franco, M., Blum, R., Johnson, C., Ganju, V., Shapiro, J., Chong, G., Charlton, J., Haydon, A. & 1 others, Schofield, P., 1 Aug 2016, In : Oncologist. 21, 8, p. 1014-1023 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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27 Citations (Scopus)

RAD51B in familial breast cancer

Pelttari, L. M., Khan, S., Vuorela, M., Kiiski, J. I., Vilske, S., Nevanlinna, V., Ranta, S., Schleutker, J., Winqvist, R., Kallioniemi, A., Dörk, T., Bogdanova, N. V., Figueroa, J., Pharoah, P. D. P., Schmidt, M. K., Dunning, A. M., García-Closas, M., Bolla, M. K., Dennis, J., Michailidou, K. & 78 others, Wang, Q., Hopper, J. L., Southey, M. C., Rosenberg, E. H., Fasching, P. A., Beckmann, M. W., Peto, J., Dos-Santos-silva, I., Sawyer, E. J., Tomlinson, I., Burwinkel, B., Surowy, H., Guénel, P., Truong, T., Bojesen, S. E., Nordestgaard, B. G., Benitez, J., González-Neira, A., Neuhausen, S. L., Anton-Culver, H., Brenner, H., Arndt, V., Meindl, A., Schmutzler, R. K., Brauch, H., Brüning, T., Lindblom, A., Margolin, S., Mannermaa, A., Hartikainen, J. M., Chenevix-Trench, G., kConFab/AOCS Investigators, Van Dyck, L., Janssen, H., Chang-Claude, J., Rudolph, A., Radice, P., Peterlongo, P., Hallberg, E., Olson, J. E., Giles, G., Milne, R. L., Haiman, C. A., Schumacher, F., Simard, J., Dumont, M., Kristensen, V., Borresen-Dale, A. L., Zheng, W., Beeghly-Fadiel, A., Grip, M., Andrulis, I. L., Glendon, G., Devilee, P., Seynaeve, C., Hooning, M. J., Collée, M., Cox, A., Cross, S. S., Shah, M., Luben, R. N., Hamann, U., Torres, D., Jakubowska, A., Lubinski, J., Couch, F. J., Yannoukakos, D., Orr, N., Swerdlow, A., Darabi, H., Li, J., Czene, K., Hall, P., Easton, D. F., Mattson, J., Blomqvist, C., Aittomäki, K. & Nevanlinna, H., 1 Jan 2016, In : PLoS ONE. 11, 5, 18 p., e0153788.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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13 Citations (Scopus)
2015

High-throughput amplicon-based copy number detection of 11 genes in formalin-fixed paraffin-embedded ovarian tumour samples by MLPA-seq

Kondrashova, O., Love, C. J., Lunke, S., Hsu, A. L., Australian Ovarian Cancer Study (AOCS) Group, Waring, P. M. & Taylor, G. R., 16 Nov 2015, In : PLoS ONE. 10, 11, 14 p., e0143006.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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5 Citations (Scopus)

Prognostic factorsofsurvival inarandomizedphaseIIItrial (MPACT)of weekly nab-paclitaxel plus gemcitabine versus gemcitabine alone in patients with metastatic pancreatic cancer

Tabernero, J., Gabrielachiorean, E., Infante, J. R., Hingorani, S. R., Ganju, V., Weekes, C., Scheithauer, W., Ramanathan, R. K., Goldstein, D., Penenberg, D. N., Romano, A., Ferrara, S. & Von Hoff, D. D., 12 Jan 2015, In : Oncologist. 20, 2, p. 143-150 8 p.

Research output: Contribution to journalArticleResearchpeer-review

72 Citations (Scopus)

The evolution of therapies in non-small cell lung cancer

Boolell, V., Alamgeer, M., Watkins, D. N. & Ganju, V., 2015, In : Cancers. 7, 3, p. 1815 - 1846 32 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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71 Citations (Scopus)
2014

Changes in aldehyde dehydrogenase-1 expression during neoadjuvant chemotherapy predict outcome in locally advanced breast cancer

Alamgeer, M., Ganju, V., Kumar, B., Fox, J., Hart, S. A., White, M., Harris, M. T., Stuckey, J., Prodanovic, Z., Schneider, M. E. & Watkins, D. N., 2014, In : Breast Cancer Research. 16, 2 (Art. No: R44), p. 1 - 13 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
32 Citations (Scopus)

Genomic characterisation of small cell lung cancer patient-derived xenografts generated from endobronchial ultrasound-guided transbronchial needle aspiration specimens

Leong, T., Marini, K. D., Rossello, F. J., Jayasekara, W. S. N., Russell, P. A., Prodanovic, Z., Kumar, B., Ganju, V., Alamgeer, M., Irving, L. B., Steinfort, D. P., Peacock, C. D., Cain, J., Szczepny, A. & Watkins, D. N., 2014, In : PLoS ONE. 9, 9 , 11 p., e106862.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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29 Citations (Scopus)

Selective Internal Radiation Therapy (SIRT) with yttrium-90 resin microspheres plus standard systemic chemotherapy regimen of FOLFOX versus FOLFOX alone as first-line treatment of non-resectable liver metastases from colorectal cancer: The SIRFLOX study

Gibbs, P., Gebski, V., Van Buskirk, M., Thurston, K., Cade, D. N., Van Hazel, G. A. & the SIRFLOX Study Group, 1 Dec 2014, In : BMC Cancer. 14, 1, 897.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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35 Citations (Scopus)
2013

Cancer stem cells in lung cancer: evidence and controversies

Alamgeer, M., Peacock, C. D., Matsui, W. H., Ganju, V. & Watkins, D. N., 2013, In : Respirology. 18, 5, p. 757 - 764 8 p.

Research output: Contribution to journalArticleResearchpeer-review

90 Citations (Scopus)

Novel therapeutic targets in non-small cell lung cancer

Alamgeer, M., Ganju, V. & Watkins, D. N., 2013, In : Current Opinion in Pharmacology. 13, 3, p. 394 - 401 8 p.

Research output: Contribution to journalArticleResearchpeer-review

52 Citations (Scopus)

The prognostic significance of aldehyde dehydrogenase 1A1 (ALDH1A1) and CD133 expression in early stage non-small cell lung cancer

Alamgeer, M., Ganju, V., Szczepny, A., Russell, P. A., Prodanovic, Z., Kumar, B., Wainer, Z., Brown, T. J., Schneider-Kolsky, M., Conron, M., Wright, G. & Watkins, D. N., 2013, In : Thorax. 68, 12, p. 1095 - 1104 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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50 Citations (Scopus)
2011

Hyaluronan-Irinotecan improves progression-free survival in 5-fluorouracil refractory patients with metastatic colorectal cancer: a randomized phase II trial

Gibbs, P., Clingan, P., Ganju, V., Strickland, A. H., Wong, S. S., Tebbutt, N. C., Underhill, C. R., Fox, R. M., Clavant, S. P., Leung, J. Y., Pho, M. H. & Brown, T. J., 2011, In : Cancer Chemotherapy and Pharmacology. 67, p. 153 - 163 10 p.

Research output: Contribution to journalArticleResearchpeer-review

29 Citations (Scopus)
2010

The role of chemotherapeutic drugs in the evaluation of breast tumour response to chemotherapy using serial FDG-PET

Schneider-Kolsky, M. E., Hart, S. A., Fox, J., Midolo, P., Stuckey, J., Hofman, M. & Ganju, V., 2010, In : Breast Cancer Research. 12, 3 (R37), p. 1 - 30 30 p.

Research output: Contribution to journalArticleResearchpeer-review

24 Citations (Scopus)
2009

A phase I trial of Capecitabine+Gemcitabine with radical radiation for locally advanced pancreatic cancer

Michael, M., Price, T. V., Ngan, H. Y. S., Ganju, V., Strickland, A. H., Muller, A. A., Khamly, K., Milner, A. D., Dilulio, J., Matera, A., Zalcberg, J. R. & Leong, T., 13 Jan 2009, In : British Journal of Cancer. 100, 1, p. 37-43 7 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)
2007

Tolerability of accelerated chest irradiation and impact on survival of prophylactic cranial irradiation in patients with limited-stage small cell lung cancer: Review of a single institution's experience

Ng, M., Chong, J., Milner, A., MacManus, M., Wheeler, G., Wirth, A., Michael, M., Ganju, V., McKendrick, J. & Ball, D. L., 2007, In : Journal of Thoracic Oncology. 2, 6, p. 506 - 513 8 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)