Projects per year
Personal profile
Biography
I am a molecular geneticist interested in the genetic mechanisms of sex determination, sex differentiation, and sex bias in disease.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Department of Genetics, Bachelor of Science (Hons)
Department of Medicine, Doctor of Philosophy
Research area keywords
- Genomics
- Disease model development
- Sex Determination
- Sex Differences
- Transcription factors
- Parkinson's Disease
- molecular basis of disease
- Genetic risk
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Improving the diagnosis of Differences of Sex Development (DSD)
Harley, V. (Primary Chief Investigator (PCI)), Vilain, E. (Chief Investigator (CI)), Le, T. (Associate Investigator (AI)), Bagheri-Fam, S. (Associate Investigator (AI)), Rosenbluh, S. (Associate Investigator (AI)), Vu, D. C. (Associate Investigator (AI)), Délot, E. C. (Associate Investigator (AI)), Landen, S. (Associate Investigator (AI)) & Reyes, A. (Associate Investigator (AI))
1/01/24 → 31/12/26
Project: Research
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Transformative rat models to study sex differences in disease
Arnold, A. (Primary Chief Investigator (PCI)), Eghbali, M. (Chief Investigator (CI)), Dwinell, M. R. (Chief Investigator (CI)), Geurts, A. (Chief Investigator (CI)), Harley, V. (Chief Investigator (CI)), Sandberg, K. (Chief Investigator (CI)), O'Donnell, L. (Chief Investigator (CI)) & Browne, J. (Chief Investigator (CI))
NIH - National Institutes of Health (United States of America)
15/06/21 → 31/08/26
Project: Research
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SRY antisense oligonucleotide as a gene therapy for males with Parkinson disease
Harley, V. (Primary Chief Investigator (PCI)), Wilton, S. (Chief Investigator (CI)) & Thyagarajan, D. (Chief Investigator (CI))
1/01/22 → 31/12/22
Project: Research
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Improving the diagnosis of Disorders Sex Development (DSD)
Harley, V. (Primary Chief Investigator (PCI)) & Vilain, E. (Chief Investigator (CI))
1/01/21 → 31/12/23
Project: Research
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Genetic regulation of avian sex determination
Smith, C. (Primary Chief Investigator (PCI)), Harley, V. (Chief Investigator (CI)) & Serralbo, O. (Chief Investigator (CI))
1/01/20 → 30/06/24
Project: Research
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A role for TRPC3 in mammalian testis development
Ming, Z., Bagheri-Fam, S., Frost, E. R., Ryan, J. M. & Harley, V. R., 2024, In: Frontiers in Cell and Developmental Biology. 12, 11 p., 1337714.Research output: Contribution to journal › Article › Research › peer-review
Open Access1 Citation (Scopus) -
Reprograming skin fibroblasts into Sertoli cells: a patient-specific tool to understand effects of genetic variants on gonadal development
Parivesh, A., Délot, E., Reyes, A., Ryan, J., Bhattacharya, S., Harley, V. & Vilain, E., Dec 2024, In: Biology of Sex Differences. 15, 1, 17 p., 24.Research output: Contribution to journal › Article › Research › peer-review
Open Access2 Citations (Scopus) -
Y chromosome damage underlies testicular abnormalities in ATR-X syndrome
León, N. Y., Le, T. N. U., Garvie, A., Wong, L. H., Bagheri-Fam, S. & Harley, V. R., 17 May 2024, In: iScience. 27, 5, 16 p., 109629.Research output: Contribution to journal › Article › Research › peer-review
Open Access -
FGF9 variant in 46,XY DSD patient suggests a role for dimerization in sex determination
Croft, B., Bird, A. D., Ono, M., Eggers, S., Bagheri-Fam, S., Ryan, J. M., Reyes, A. P., van den Bergen, J., Baxendale, A., Thompson, E. M., Kueh, A. J., Stanton, P., Thomas, T., Sinclair, A. H. & Harley, V. R., Mar 2023, In: Clinical Genetics. 103, 3, p. 277-287 11 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access5 Citations (Scopus) -
Genetic Association Studies in Transgender Cohorts: A Systematic Review and Meta-Analysis
Ashley, B. & Harley, V. R., 7 Mar 2023, bioRxiv preprints, 2023 48 p.Research output: Contribution to specialist publication › Article › Research