Vijay Dhanasekaran

Assoc Professor

Accepting PhD Students

20012021
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Personal profile

Biography

Our research at the Laboratory of Virus Evolution (LoVE) has been to apply computational and experimental methods at the intersection of medicine, epidemiology and population genetics to identify the determinants of transmission and evolution at various spatio-temporal scales. We have focused on disease surveillance, genome sequencing and the integration of genomic data with clinical, epidemiological and immunological data that are generated through disease surveillance and laboratory experiments using phylogeny based methods. These include, to investigate factors affecting the diversity and evolution 
of pathogens in their natural reservoirs such as birds and bats; in livestock production systems; to elucidate origins of human pandemics; and to infer factors affecting the transmission of human pathogens as driven by host innate and adaptive immune systems, such as influenza, Enterovirus 71 and Dengue.

A unified framework to study infectious disease dynamics. 

A complex interplay of viral, host and ecological factors shape the emergence, evolution and spatio-temporal incidence of rapidly evolving pathogens. The improvement of large scale surveillance and sequencing efforts with the recent unification of epidemiology, ecology and evolutionary genetics has had a profound impact on infectious disease studies and a growing influence on pandemic preparedness and response (for example, the ability to estimate the basic reproductive number (R0) of an epidemic using sequence data), presenting a unique opportunity to develop novel methodologies to incorporate multiple streams of data to understand infectious disease dynamics. 

Research interests

Virus evolution, disease surveillance, interspecies transmission, molecular evolution and epidemiology, vaccine selection, antimicrobial resistance, pandemics, seasonal influenza

Supervision interests

Please see Student Connect for current project listings of Laboratory of Virus Evolution

External positions

Adjunct Associate Professor, WHO Collaborating Centre for Reference and Research on Influenza (Victoria)

Mar 2019Mar 2022

Adjunct, Duke-NUS Medical School Singapore

Research area keywords

  • virus
  • genomics
  • evolution
  • surveillance
  • antimicrobial resistance
  • disease transmission
  • evolutionary epidemiology
  • phenotypic evolution
  • vaccination
  • respiratory viruses
  • enteric viruses
  • one health
  • disease emergence
  • interspecies transmission
  • disease ecology
  • Virology
  • Evolutionary Biology
  • Virus evolution

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Projects 2016 2021

Research Output 2001 2019

5 Citations (Scopus)

Evolution and spatiotemporal dynamics of enterovirus A71 subgenogroups in Vietnam

Thao, N. T. T., Donato, C., Trang, V. T. H., Kien, N. T., Trang, P. M. T., Khanh, T. Q., Nguyet, D. T., Sessions, O. M., Cuong, H. Q., Lan, P. T., Huong, V. T. Q., Rogier Van Doorn, H. & Vijaykrishna, D., 1 Dec 2017, In : Journal of Infectious Diseases. 216, 11, p. 1371-1379 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
33 Citations (Scopus)

Phylodynamics of H1N1/2009 influenza reveals the transition from host adaptation to immune-driven selection

Su, Y. C. F., Bahl, J., Joseph, U., Butt, K. M., Peck, H. A., Koay, E. S. C., Oon, L. L. E., Barr, I. G., Vijaykrishna, D. & Smith, G. J. D., 6 Aug 2015, In : Nature Communications. 6, 13 p., 7952.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
62 Citations (Scopus)

The contrasting phylodynamics of human influenza B viruses

Vijaykrishna, D., Holmes, E. C., Joseph, U., Fourment, M., Su, Y. CF., Halpin, R., Lee, R. TC., Deng, Y-M., Gunalan, V., Lin, X., Stockwell, T. B., Fedorova, N. B., Zhou, B., Spirason, N., Kuhnert, D., Boskova, V., Stadler, T., Costa, A-M., Dwyer, D. E., Huang, Q. S. & 8 others, Jennings, L. C., Rawlinson, W., Sullivan, S. G., Hurt, A. C., Maurer-Stroh, S., Wentworth, D. E., Smith, G. JD. & Barr, I. G., 16 Jan 2015, In : eLife. 4, 23 p., e05055.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
2 Citations (Scopus)

Antarctic penguins as reservoirs of diversity for avian avulaviruses

Wille, M., Aban, M., Wang, J., Moore, N., Shan, S., Marshall, J., González-Acuña, D., Vijaykrishna, D., Butler, J., Wang, J., Hall, R. J., Williams, D. T. & Hurt, A. C., Jun 2019, In : Journal of Virology. 93, 11, 12 p., e0027119.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

A T164S mutation in the dengue virus NS1 protein is associated with greater disease severity in mice

Chan, K. W. K., Watanabe, S., Jin, J. Y., Pompon, J., Teng, D., Alonso, S., Vijaykrishna, D., Halstead, S. B., Marzinek, J. K., Bond, P. J., Burla, B., Torta, F., Wenk, M. R., Ooi, E. E. & Vasudevan, S. G., 26 Jun 2019, In : Science Translational Medicine. 11, 498, 16 p., eaat7726.

Research output: Contribution to journalArticleResearchpeer-review