Projects per year
Personal profile
Biography
Prof Vaughan Macefield leads the Human Neurophysiology Lab in the Department of Neuroscience, having been at the Baker Heart and Diabetes Institute from 2018-2022. In 1986 he completed his PhD in respiratory neurophysiology at The University of New South Wales, using animal models, before undertaking postdoctoral studies in human neurophysiology in Sydney, Sweden and the US.
He was based at Neuroscience Research Australia in Sydney from 1994, before being appointed Foundation Chair of Integrative Physiology at the School of Medicine, Western Sydney University, from 2006-2016, and Foundation Chair of Physiology at Mohammed Bin Rashid University in Dubai from 2016-2017.
Vaughan specializes in recording from single nerve fibres via microelectrodes inserted into the peripheral nerves of awake human participants (microneurography) and is best known for developing the methodology for recording the firing properties of single, type-identified, sympathetic neurones supplying muscle and skin – as well as his work on the properties of mechanoreceptors in muscle and skin. Most recently, he made the first microelectrode recordings from the human vagus nerve, via ultrasound-guided microneurography.
For the last 20 years he has also been using functional magnetic resonance imaging (fMRI) of the brain to identifycortical and subcortical structures involved in the control of blood pressure and the processing of pain, and developed the methodology for recording muscle sympathetic nerve activity (MSNA) at the same time as performing fMRI of the brain (MSNA-coupled fMRI) in health and disease.
Education/Academic qualification
Neurophysiology, DSc, Invasive studies of the human sympathetic nervous system in health and disease, University of New South Wales (UNSW)
1 Jan 2016 → 31 Dec 2016
Award Date: 19 Jun 2017
Neurophysiology, PhD, University of New South Wales (UNSW)
1 Jan 1983 → 30 Nov 1986
Award Date: 1 Feb 1987
Anatomy & Physiology, BSc(Hons I), Double Major in Anatomy and Physiology, University of New South Wales (UNSW)
1 Mar 1979 → 31 Dec 1982
Award Date: 1 May 1983
External positions
Baker Heart and Diabetes Institute
Research area keywords
- Microneurography
- Muscle sympathetic nerve activity (MSNA)
- Functional magnetic resonance imaging (fMRI)
- High blood pressure
- Hypertension
- Cortical and subcortical areas
- Pain
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
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SDG 5 Gender Equality
Collaborations and top research areas from the last five years
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IMPACT: Centre for Investigating Mechanisms, Peripheral And Central Traits (IMPACT) in Chronic Cough
Mazzone, S. (Primary Chief Investigator (PCI)), Khor, Y. (Chief Investigator (CI)), Macefield, V. (Chief Investigator (CI)), Donald , A. (Chief Investigator (CI)), Vertigan, A. (Chief Investigator (CI)), Szmulewicz, D. (Chief Investigator (CI)), Vogel, A. P. (Chief Investigator (CI)), Richards, A. (Chief Investigator (CI)), Moe, A. A. K. (Chief Investigator (CI)), Slovarp, L. (Chief Investigator (CI)), Harding, I. (Associate Investigator (AI)), Birring, S. S. I. (Associate Investigator (AI)), Farrell, M. (Associate Investigator (AI)), Turner, R. (Associate Investigator (AI)), Guilleminault, L. (Associate Investigator (AI)), Donald, A. (Associate Investigator (AI)), Wijsenbeek, M. (Associate Investigator (AI)) & Parker, B. (Associate Investigator (AI))
1/11/25 → 31/10/30
Project: Research
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Neural Basis of Disturbed Cardiovascular Control in Post-Acute Sequelae of COVID-19
Howden, E. (Primary Chief Investigator (PCI)), Macefield, V. (Chief Investigator (CI)), Moneghetti, K. J. (Chief Investigator (CI)), Corcoran, S. J. (Chief Investigator (CI)), Holland, A. (Chief Investigator (CI)), Burton, A. R. (Chief Investigator (CI)) & Taylor, C. E. (Chief Investigator (CI))
1/02/25 → 31/01/27
Project: Research
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Microelectrode recordings from the vagus nerve in awake humans
Macefield, V. (Primary Chief Investigator (PCI)), Wright, L. (Chief Investigator (CI)), Esler, M. (Chief Investigator (CI)) & Moneghetti, K. J. (Associate Investigator (AI))
1/01/23 → 31/12/27
Project: Research
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REVEAL – Research Evaluating Vagal Excitation and Anatomical Linkages
Osborn, J. (Primary Chief Investigator (PCI)), Eberly, L. (Chief Investigator (CI)), Ikramuddin, S. (Chief Investigator (CI)), Lim, H. H. (Chief Investigator (CI)), Macefield, V. (Chief Investigator (CI)), Nahas, Z. H. (Chief Investigator (CI)), Aaronson, S. T. (Chief Investigator (CI)), Baker, S. E. (Chief Investigator (CI)), Camilleri, M. (Chief Investigator (CI)), Conway, C. (Chief Investigator (CI)), Crawford, P. (Chief Investigator (CI)), Darrow, D. P. (Chief Investigator (CI)), Drawz, P. E. (Chief Investigator (CI)), Dudley, S. C. (Chief Investigator (CI)), Fonkoue, I. T. (Chief Investigator (CI)), George, M. S. (Chief Investigator (CI)), Henry, T. R. (Chief Investigator (CI)), Hering, B. J. (Chief Investigator (CI)), Ingram, M. (Chief Investigator (CI)), Johnson, M. D. (Chief Investigator (CI)), Keller-Ross, M. L. (Chief Investigator (CI)), Lim, K. O. (Chief Investigator (CI)), Loavenbruck, A. (Chief Investigator (CI)), McCarty, C. A. (Chief Investigator (CI)), Meyer, M. (Chief Investigator (CI)), Micera, S. (Chief Investigator (CI)), Mueller, B. (Chief Investigator (CI)), Murray, T. (Chief Investigator (CI)), Netoff, T. (Chief Investigator (CI)), O'Brien, T. (Chief Investigator (CI)), Panoskaltsis-Mortari, A. (Chief Investigator (CI)), Park, M. C. (Chief Investigator (CI)), Puchalska, P. (Chief Investigator (CI)), Ramachandran, S. (Chief Investigator (CI)), Singh, A. (Chief Investigator (CI)), Talkachova, A. (Chief Investigator (CI)), Tignanelli, C. (Chief Investigator (CI)), Walczak, T. (Chief Investigator (CI)), Williams, N. (Chief Investigator (CI)), Willie, J. T. (Chief Investigator (CI)) & Worrell, G. (Chief Investigator (CI))
NIH - National Institutes of Health (United States of America)
1/09/23 → 31/08/25
Project: Research
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REVEAL – Research Evaluating Vagal Excitation and Anatomical Linkages (Clinical Core)
Osborn, J. W. (Primary Chief Investigator (PCI)), Macefield, V. (Chief Investigator (CI)) & O'Brien, T. (Chief Investigator (CI))
1/09/23 → 31/08/25
Project: Research
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Automatic/nomic nervous systems: Response to ‘The autonomic nervous system concept at the heart of the matter’
Macefield, V. G. & Barboi, A. C., 1 Mar 2026, In: Journal of Physiology. 604, 5, p. 2363-2364 2 p.Research output: Contribution to journal › Letter › Other › peer-review
Open Access -
Clinical autonomic research: welcome to 2026
Macefield, V. G., Kaufmann, H. & Jordan, J., Feb 2026, In: Clinical Autonomic Research. 36, 1, p. 1-2 2 p.Research output: Contribution to journal › Editorial › Other › peer-review
Open Access -
Listen to your feet
Macefield, V. G., 1 Jan 2026, In: Journal of Physiology. 604, 1, p. 23-25 3 p.Research output: Contribution to journal › Comment / Debate › Other › peer-review
Open Access -
Microelectrode recordings from the human cervical vagus nerve during maximal breath-holds
Macefield, V. G., Bain, A. R., Badour, M. I., Kumric, M., Drvis, I., Barak, O. F., Bozic, J. & Dujic, Z., Feb 2026, In: Experimental Physiology. 111, 2, p. 501-516 16 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access3 Link opens in a new tab Citations (Scopus) -
Response to the letter by Dr Karemaker
Barboi, A. C. & Macefield, V. G., 15 Apr 2026, In: Journal of Physiology. 604, 8, p. 3495-3496 2 p.Research output: Contribution to journal › Letter › Other › peer-review