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Dr Yonggang (Tyler) Chang is a mid-career researcher (PhD 2008). By training he is a biochemist, Nuclear Magnetic Resonance (NMR) spectroscopist, X-ray crystallographer, and structural biologist who is internationally recognised for his groundbreaking research that demystified the day-to-night transition of biological clocks.

He discovered that protein fold switch or gymnastics is the linchpin of the cyanobacterial clock. It not only underlies the elegant day-to-night transition mechanism of the clock, but also beautifully couples the propagation of the clock rhythm via output pathways to effect ~24 h rhythmic gene expression. This knowledge provides a framework for understanding all biological clocks including those endogenous of humans that have been implicated in metabolism, immunity, aging and cancer. He has authored publications in the general-science journals, including two in Science (2015 first author, 2017 co-author) and four in PNAS (2011 and 2012 first author, 2010 and 2018 co-author).

In 2018, Dr Chang was recruited to Monash University with the goal of establishing his own independent research group. At Monash, Dr Chang has rapidly included the cutting-edge Cryo-EM tool. During the relatively short time at Monash University, Dr Chang has forged collaboration with cell biologist Dr Michelle Halls, enzymologist Professor Christina Michelle, and Cryo-EM developer A/Prof Hans Elmlund. Having assembled a team with expertise in complementary fields, Dr Chang is positioned to leverage the combination of the powerful biophysical techniques, including NMR, X-ray crystallography, and Cryo-EM, to elucidate the interplay of cell signalling pathways including the mTOR signalling pathway that is a central regulator of growth and metabolism.

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Education/Academic qualification

Biochemistry and Molecular Biology, PhD, Structural Basis of Ubiquitin-binding and ubiquitin-like proteins.

1 Sept 20025 Jul 2008

Award Date: 5 Jul 2008

Collaborations and top research areas from the last five years

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