Trevor Lithgow

Professor

  • 19 Innovation walk, 76

    3800 Monash University

    Australia

  • Room 252, 19 Innovation Walk, 76

    3800 Melbourne

1988 …2020
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Personal profile

Biography

Uncovering clues to new disease control strategies Discoveries on ways to visualize the molecular machines that bacteria use to build their surface structure lays the foundation for helping scientists to develop new ways to fight disease.

New imaging technologies at Monash University mean that these machines can be seen in unprecedented detail, with this level of scrutiny highlighting their weak-points too.

Having defined the general principles of how the bacterial surface structures tease and then invade human cells, the Lithgow lab is now working towards an understanding of the weaknesses in this process.

"This matters if we are to become creative enough to design new ways to prevent the increasing numbers of bacterial infections that are resistant to off-the-shelf antibiotics."

Keywords

  • bacteria
  • bacterial evolution
  • membrane biochemistry
  • mitochondrial biology
  • protein transport

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2009 2020

Research Output 1988 2018

An investigation into the Omp85 protein BamK in hypervirulent Klebsiella pneumoniae, and its role in outer membrane biogenesis

Torres, V. V. L., Heinz, E., Stubenrauch, C. J., Wilksch, J. J., Cao, H., Yang, J., Clements, A., Dunstan, R. A., Alcock, F., Webb, C. T., Dougan, G., Strugnell, R. A., Hay, I. D. & Lithgow, T., Sep 2018, In : Molecular Microbiology. 109, 5, p. 584-599 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Bastion3: A two-layer ensemble predictor of type III secreted effectors

Wang, J., Li, J., Yang, B., Xie, R., Marquez-Lago, T. T., Leier, A., Hayashida, M., Akutsu, T., Zhang, Y., Chou, K-C., Selkrig, J., Zhou, T., Song, J. & Lithgow, T., 2 Nov 2018, (Accepted/In press) In : Bioinformatics. 9 p., bty914.

Research output: Contribution to journalArticleResearchpeer-review

Bastion6: A bioinformatics approach for accurate prediction of type VI secreted effectors

Wang, J., Yang, B., Leier, A., Marquez-Lago, T., Hayashida, M., Rocker, A., Zhang, Y., Akutsu, T., Chou, K-C., Strugnell, R. A., Song, J. & Lithgow, T., 1 Jan 2018, In : Bioinformatics. 34, 15, p. 2546-2555 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Comprehensive assessment and performance improvement of effector protein predictors for bacterial secretion systems III, IV and VI

An, Y., Wang, J., Li, C., Leier, A., Marquez-Lago, T., Wilksch, J., Zhang, Y., Webb, G. I., Song, J. & Lithgow, T., 1 Jan 2018, In : Briefings in Bioinformatics. 19, 1, p. 148-161 14 p., bbw100.

Research output: Contribution to journalArticleResearchpeer-review

FusC, a member of the M16 protease family acquired by bacteria for iron piracy against plants

Grinter, R., Hay, I. D., Song, J., Wang, J., Teng, D., Dhanesakaran, V., Wilksch, J. J., Davies, M. R., Littler, D., Beckham, S. A., Henderson, I. R., Strugnell, R. A., Dougan, G. & Lithgow, T., 2 Aug 2018, In : PLoS Biology. 16, 8, 21 p., e2006026.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Prizes

1000 Talents Program Foreign Expert Prize

Trevor James Lithgow (Recipient), 2017

Prize: National/international honour

Beckman-Coutler Discovery Science Award

Trevor James Lithgow (Recipient), 2008

Prize: Prize (including medals and awards)

Distinguished Alumni Award

Trevor James Lithgow (Recipient), 2010

Prize: National/international honour

Fellow of the Australian Academy of Sciences

Trevor James Lithgow (Recipient), 2010

Prize: Election to learned society

Fellow of the Australian Society of Microbiology

Trevor James Lithgow (Recipient), 2017

Prize: National/international honour

Activities 2017 2018

  • 3 Contribution to conference
  • 1 External research organisation, centre or institute
  • 1 Membership of an advisory panel/policy group/ board
  • 1 Membership of industry collaboration/ network

Melbourne Museum-BDI Microbe Exhibition

Trevor Lithgow (Contributor)
Mar 2018Jul 2019

Activity: Community Talks, Presentations, Exhibitions and EventsPublic event

Bacterial Protein export

Trevor Lithgow (Invited speaker)
2018 → …

Activity: Participating in or organising an event typesContribution to conference

Protein Transport Across Cell Membranes (Gordon Research Conference) 2018

Trevor Lithgow (Session chair)
2018

Activity: Participating in or organising an event typesContribution to conference

EMBL Symposia

Trevor Lithgow (Speaker)
2017

Activity: Participating in or organising an event typesContribution to conference

Scientific Director

Trevor Lithgow (Fellow)
2017

Activity: External Academic EngagementExternal research organisation, centre or institute

Press / Media

Mysterious mechanism of plant-rotting bacterium exposed

Trevor James Lithgow & Rhys William Grinter

2/08/183/08/18

1 item of media coverage, 2 media contributions

Press/Media: Research

It takes a village: how Monash researchers built their own microscope to decipher superbugs

Trevor James Lithgow, Sachith Dilshan Gunasinghe & Toby Desmond Maynard Bell

29/05/186/06/18

4 items of media coverage, 3 media contributions

Press/Media: Research

Key to ‘superbug’ antibiotic resistance discovered

Matthew James Belousoff & Trevor James Lithgow

10/05/1719/05/18

12 items of media coverage, 6 media contributions

Press/Media: Research

Genome scale model of a superbug

Trevor James Lithgow, Jian Li & Jiangning Song

16/03/1830/03/18

2 media contributions

Press/Media: Research