• 19 Innovation walk, 76

    3800 Monash University

    Australia

  • Room 252, 19 Innovation Walk, 76

    3800 Melbourne

Accepting PhD Students

1988 …2020
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Personal profile

Biography

Uncovering clues to new disease control strategies Discoveries on ways to visualize the molecular machines that bacteria use to build their surface structure lays the foundation for helping scientists to develop new ways to fight disease.

Nanoscale imaging technologies at Monash University mean that these machines can be seen in unprecedented detail, with this level of scrutiny highlighting their weak-points too, with new antimicrobial drugs now in the pipeline.

These same approaches to understanding bacterial cell biology are now being applied to investigate the interaction of bacteriophages (phages) with bacterial cell surfaces. Phage therapies are on the horizon as a major means to treat antimicrobial-resistant (AMR) infections.

"This matters if we are to become creative enough to design new ways to prevent the increasing numbers of bacterial infections that are resistant to off-the-shelf antibiotics."

Research area keywords

  • antimicrobial resistance
  • bacterial evolution
  • membrane biochemistry
  • bacterial cell biology
  • protein transport

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2009 2020

Research Output 1988 2019

An Outbreak of Carbapenem-Resistant and Hypervirulent Klebsiella pneumoniae in an Intensive Care Unit of a Major Teaching Hospital in Wenzhou, China

Zhao, Y., Zhang, X., Torres, V. V. L., Liu, H., Rocker, A., Zhang, Y., Wang, J., Chen, L., Bi, W., Lin, J., Strugnell, R. A., Zhang, S., Lithgow, T., Zhou, T. & Cao, J., 19 Aug 2019, In : Frontiers in Public Health. 7, 11 p., 229.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
4 Citations (Scopus)

Atlas of group A streptococcal vaccine candidates compiled using large-scale comparative genomics

Davies, M. R., McIntyre, L., Mutreja, A., Lacey, J. A., Lees, J. A., Towers, R. J., Duchêne, S., Smeesters, P. R., Frost, H. R., Price, D. J., Holden, M. T. G., David, S., Giffard, P. M., Worthing, K. A., Seale, A. C., Berkley, J. A., Harris, S. R., Rivera-Hernandez, T., Berking, O., Cork, A. J. & 18 others, Torres, R. S. L. A., Lithgow, T., Strugnell, R. A., Bergmann, R., Nitsche-Schmitz, P., Chhatwal, G. S., Bentley, S. D., Fraser, J. D., Moreland, N. J., Carapetis, J. R., Steer, A. C., Parkhill, J., Saul, A., Williamson, D. A., Currie, B. J., Tong, S. Y. C., Dougan, G. & Walker, M. J., 1 Jun 2019, In : Nature Genetics. 51, 6, p. 1035-1043 9 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Bastion3: A two-layer ensemble predictor of type III secreted effectors

Wang, J., Li, J., Yang, B., Xie, R., Marquez-Lago, T. T., Leier, A., Hayashida, M., Akutsu, T., Zhang, Y., Chou, K-C., Selkrig, J., Zhou, T., Song, J. & Lithgow, T., 1 Jun 2019, In : Bioinformatics. 35, 12, p. 2017-2028 12 p., bty914.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

cryoEM-Guided Development of Antibiotics for Drug-Resistant Bacteria

Belousoff, M. J., Venugopal, H., Wright, A., Seoner, S., Stuart, I., Stubenrauch, C., Bamert, R. S., Lupton, D. W. & Lithgow, T., 5 Mar 2019, In : ChemMedChem. 14, 5, p. 527-231 5 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Determination of the molecular basis for coprogen import by Gram-negative bacteria

Grinter, R. & Lithgow, T., May 2019, In : IUCrJ. 6, 3, p. 401-411 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Prizes

1000 Talents Program Foreign Expert Prize

Trevor Lithgow (Recipient), 2017

Prize: National/international honour

Beckman-Coutler Discovery Science Award

Trevor Lithgow (Recipient), 2008

Prize: Prize (including medals and awards)

Distinguished Alumni Award

Trevor Lithgow (Recipient), 2010

Prize: National/international honour

Fellow of the Australian Academy of Sciences

Trevor Lithgow (Recipient), 2010

Prize: Election to learned society

Fellow of the Australian Society of Microbiology

Trevor Lithgow (Recipient), 2017

Prize: National/international honour

Activities 2017 2018

  • 3 Contribution to conference
  • 1 External research organisation, centre or institute
  • 1 Membership of an advisory panel/policy group/ board
  • 1 Membership of industry collaboration/ network

Bacterial Protein export

Trevor Lithgow (Invited speaker)
2018 → …

Activity: Participating in or organising an event typesContribution to conference

Protein Transport Across Cell Membranes (Gordon Research Conference) 2018

Trevor Lithgow (Session chair)
2018

Activity: Participating in or organising an event typesContribution to conference

Melbourne Museum-Gut Feeling exhibition

Trevor Lithgow (Contributor)
Mar 2018Jul 2019

Activity: Community Talks, Presentations, Exhibitions and EventsPublic event

EMBO|EMBL Symposium 2017

Trevor Lithgow (Speaker)
2017

Activity: Participating in or organising an event typesContribution to conference

Scientific Director

Trevor Lithgow (Fellow)
2017

Activity: External Academic EngagementExternal research organisation, centre or institute

Press / Media

Mysterious mechanism of plant-rotting bacterium exposed

Trevor Lithgow & Rhys William Grinter

2/08/183/08/18

1 item of Media coverage, 3 Media contributions

Press/Media: Research

It takes a village: how Monash researchers built their own microscope to decipher superbugs

Trevor Lithgow, Sachith Dilshan Gunasinghe & Toby Desmond Maynard Bell

29/05/186/06/18

4 items of Media coverage, 3 Media contributions

Press/Media: Research

Key to ‘superbug’ antibiotic resistance discovered

Matthew James Belousoff & Trevor Lithgow

10/05/1719/05/18

12 items of Media coverage, 6 Media contributions

Press/Media: Research

Genome scale model of a superbug

Trevor Lithgow, Jian Li & Jiangning Song

16/03/1830/03/18

2 Media contributions

Press/Media: Research