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2020

CDK13 cooperates with CDK12 to control global RNA polymerase II processivity

Fan, Z., Devlin, J. R., Hogg, S. J., Doyle, M. A., Harrison, P. F., Todorovski, I., Cluse, L. A., Knight, D. A., Sandow, J. J., Gregory, G., Fox, A., Beilharz, T. H., Kwiatkowski, N., Scott, N. E., Vidakovic, A. T., Kelly, G. P., Svejstrup, J. Q., Geyer, M., Gray, N. S., Vervoort, S. J. & 1 others, Johnstone, R. W., 29 Apr 2020, In : Science Advances. 6, 18, 18 p., eaaz5041.

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Dissecting the Roles of Mitochondrial Complex I Intermediate Assembly Complex Factors in the Biogenesis of Complex I

Formosa, L. E., Muellner-Wong, L., Reljic, B., Sharpe, A. J., Jackson, T. D., Beilharz, T. H., Stojanovski, D., Lazarou, M., Stroud, D. A. & Ryan, M. T., 21 Apr 2020, In : Cell Reports. 31, 3, 14 p., 107541.

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1 Citation (Scopus)

FGF13 promotes metastasis of triple-negative breast cancer

Johnstone, C. N., Pattison, A. D., Harrison, P. F., Powell, D. R., Lock, P., Ernst, M., Anderson, R. L. & Beilharz, T. H., 1 Jul 2020, In : International Journal of Cancer. 147, 1, p. 230-243 14 p.

Research output: Contribution to journalArticleResearchpeer-review

The YEATS Domain Histone Crotonylation Readers Control Virulence-Related Biology of a Major Human Pathogen

Wang, Q., Verma, J., Vidan, N., Wang, Y., Tucey, T. M., Lo, T. L., Harrison, P. F., See, M., Swaminathan, A., Kuchler, K., Tscherner, M., Song, J., Powell, D. R., Sopta, M., Beilharz, T. H. & Traven, A., 21 Apr 2020, In : Cell Reports. 31, 3, 16 p., 107528.

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2019

Topconfects: A package for confident effect sizes in differential expression analysis provides a more biologically useful ranked gene list

Harrison, P. F., Pattison, A. D., Powell, D. R. & Beilharz, T. H., 28 Mar 2019, In : Genome Biology. 20, 1, 12 p., 67.

Research output: Contribution to journalArticleOtherpeer-review

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1 Citation (Scopus)
2018

Alternative polyadenylation in the regulation and dysregulation of gene expression

Turner, R. E., Pattison, A. D. & Beilharz, T. H., Mar 2018, In : Seminars in Cell and Developmental Biology. 75, p. 61-69 9 p.

Research output: Contribution to journalArticleOtherpeer-review

12 Citations (Scopus)

A Metabolic Checkpoint for the Yeast-to-Hyphae Developmental Switch Regulated by Endogenous Nitric Oxide Signaling

Koch, B., Barugahare, A. A., Lo, T. L., Huang, C., Schittenhelm, R. B., Powell, D. R., Beilharz, T. H. & Traven, A., 20 Nov 2018, In : Cell Reports. 25, 8, p. 2244-2258 15 p.

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12 Citations (Scopus)

Functional and genomic characterisation of a xenograft model system for the study of metastasis in triple-negative breast cancer

Johnstone, C. N., Pattison, A. D., Gorringe, K. L., Harrison, P. F., Powell, D. R., Lock, P., Baloyan, D., Ernst, M., Stewart, A. G., Beilharz, T. H. & Anderson, R. L., 29 May 2018, In : Disease Models and Mechanisms. 11, 5, 14 p., 032250.

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4 Citations (Scopus)

Glucose Homeostasis Is Important for Immune Cell Viability during Candida Challenge and Host Survival of Systemic Fungal Infection

Tucey, T. M., Verma, J., Harrison, P. F., Snelgrove, S. L., Lo, T. L., Scherer, A. K., Barugahare, A. A., Powell, D. R., Wheeler, R. T., Hickey, M. J., Beilharz, T. H., Naderer, T. & Traven, A., 1 May 2018, In : Cell Metabolism. 27, 5, p. 988-1006.e7 27 p.

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36 Citations (Scopus)

miR-222 isoforms are differentially regulated by type-I interferon

Nejad, C., Pillman, K. A., Siddle, K. J., Pépin, G., Anko, M. L., McCoy, C. E., Beilharz, T. H., Quintana-Murci, L., Goodall, G. J., Bracken, C. P. & Gantier, M. P., 1 Mar 2018, In : RNA. 24, 3, p. 332-341 10 p.

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11 Citations (Scopus)

SRSF3 promotes pluripotency through nanog mRNA export and coordination of the pluripotency gene expression program

Ratnadiwakara, M., Archer, S. K., Dent, C. I., Ruiz De Los Mozos, I., Beilharz, T. H., Knaupp, A. S., Nefzger, C. M., Polo, J. M. & Anko, M-L., 9 May 2018, In : eLife. 7, 28 p., e37419.

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9 Citations (Scopus)
2017

Coordination of cell cycle progression and mitotic spindle assembly involves histone H3 lysine 4 methylation by set1/COMPASS

Beilharz, T. H., Harrison, P. F., Miles, D. M., See, M. M., Le, U. M. M., Kalanon, M., Curtis, M. J., Hasan, Q., Saksouk, J., Margaritis, T., Holstege, F., Geli, V. & Dichtl, B., 1 Jan 2017, In : Genetics. 205, 1, p. 185-199 15 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Lin-41 and oma ribonucleoprotein complexes mediate a translational repression-to-activation switch controlling oocyte meiotic maturation and the oocyte-to-embryo transition in caenorhabditis elegans

Tsukamoto, T., Gearhart, M. D., Spike, C. A., Huelgas-Morales, G., Mews, M., Boag, P. R., Beilharz, T. H. & Greenstein, D., 2017, In : Genetics. 206, 4, p. 2007-2039 33 p.

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14 Citations (Scopus)

PiRNAs and Aubergine cooperate with Wispy poly(A) polymerase to stabilize mRNAs in the germ plasm

Dufourt, J., Bontonou, G., Chartier, A., Jahan, C., Meunier, A. C., Pierson, S., Harrison, P. F., Papin, C., Beilharz, T. H. & Simonelig, M., 1 Dec 2017, In : Nature Communications. 8, 1, 12 p., 1305.

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12 Citations (Scopus)

Translation complex profile sequencing to study the in vivo dynamics of mRNA-ribosome interactions during translation initiation, elongation and termination

Shirokikh, N. E., Archer, S. K., Beilharz, T. H., Powell, D. & Preiss, T., 1 Apr 2017, In : Nature Protocols. 12, 4, p. 697-731 35 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)
2016

Accessory subunits are integral for assembly and function of human mitochondrial complex I

Stroud, D. A., Surgenor, E. E., Formosa, L. E., Reljic, B., Frazier, A. E., Dibley, M. G., Osellame, L. D., Stait, T., Beilharz, T. H., Thorburn, D. R., Salim, A. & Ryan, M. T., 6 Oct 2016, In : Nature. 538, 7623, p. 123-126 4 p.

Research output: Contribution to journalArticleResearchpeer-review

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111 Citations (Scopus)

Epitope-tagged yeast strains reveal promoter driven changes to 3'-end formation and convergent antisense-transcription from common 3' UTRs

Swaminathan, A. & Beilharz, T. H., 8 Jan 2016, In : Nucleic Acids Research. 44, 1, p. 377-386 10 p.

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5 Citations (Scopus)

Role of miRNAs and alternative mRNA 3'-end cleavage and polyadenylation of their mRNA targets in cardiomyocyte hypertrophy

Soetanto, R., Hynes, C. J., Patel, H. R., Humphreys, D. T., Evers, M., Duan, G., Parker, B. J., Archer, S. K., Clancy, J. L., Graham, R. M., Beilharz, T. H., Smith, N. J. & Preiss, T., May 2016, In : Biochimica et Biophysica Acta - Gene Regulatory Mechanisms. 1859, 5, p. 744-756 13 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)
2015

Integration of posttranscriptional gene networks into metabolic adaptation and biofilm maturation in candida albicans

Verma-Gaur, J., Qu, Y., Harrison, P. F., Lo, T. L., Quenault, T. L., Dagley, M. J., Belousoff, M. J., Powell, D. R., Beilharz, T. H. & Traven, A., 2015, In : PLoS Genetics. 11, 10, 28 p., e1005590.

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22 Citations (Scopus)

PAT-seq: a method to study the integration of 3'-UTR dynamics with gene expression in the eukaryotic transcriptome

Harrison, P. F., Powell, D. R., Clancy, J. L., Preiss, T., Boag, P. R., Traven, A., Seemann, T. & Beilharz, T. H., 2015, In : Rna-A Publication of the Rna Society. 21, 8, p. 1502 - 1510 9 p.

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33 Citations (Scopus)

POS-1 promotes endo-mesoderm development by inhibiting the cytoplasmic polyadenylation of neg-1 mRNA

Elewa, A., Shirayama, M., Kaymak, E., Harrison, P. F., Powell, D. R., Du, Z., Chute, C. D., Woolf, H., Yi, D., Ishidate, T., Srinivasan, J., Bao, Z., Beilharz, T. H., Ryder, S. P. & Mello, C. C., 2015, In : Developmental Cell. 34, 1, p. 108 - 118 11 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Probing the closed-loop model of mRNA translation in living cells

Archer, S. K., Shirokikh, N. E., Hallwirth, C. V., Beilharz, T. H. & Priess, T., 2015, In : RNA Biology. 12, 3, p. 248 - 254 7 p.

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28 Citations (Scopus)
2014

Using Klenow-mediated extension to measure poly(A)-tail length and position in the transcriptome

Lee, M. C., Jaenicke, A. & Beilharz, T. H., 2014, In : Methods in Molecular Biology. 1125, p. 25 - 42 18 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)
2013

ifet-1 is a broad-scale translational repressor required for normal P granule formation in C. elegans

Sengupta, M. S., Low, W. Y. L., Patterson, J. R., Kim, H-M., Traven, A., Beilharz, T. H., Colaiacovo, M. P., Schisa, J. A. & Boag, P. R., 2013, In : Journal of Cell Science. 126, 3, p. 850 - 859 10 p.

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17 Citations (Scopus)

Introns regulate gene expression in Cryptococcus neoformans in a Pab2p dependent pathway

Goebels, C., Thonn, A., Gonzalez-Hilarion, S., Rolland, O., Moyrand, F., Beilharz, T. H. & Janbon, G., 2013, In : PLoS Genetics. 9, 8, 15 p., e1003686.

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24 Citations (Scopus)

In vivo mutation of pre-mRNA processing factor 8 (Prpf8) affects transcript splicing, cell survival and myeloid differentiation

Keightley, M-C., Crowhurst, M., Layton, J. E., Beilharz, T. H., Markmiller, S. J., Varma, S., Hogan, B. M., de Jong-Curtain, T. A., Heath, J. K. & Lieschke, G., 2013, In : FEBS Letters. 587, 14, p. 2150 - 2157 8 p.

Research output: Contribution to journalArticleResearchpeer-review

33 Citations (Scopus)

Yeast hEST1A/B (SMG5/6)-like proteins contribute to environment-sensing adaptive gene expression responses

Lai, X., Beilharz, T. H., Au, W-C., Hammet, A., Preiss, T., Basrai, M. A. & Heierhorst, J., 2013, In : G3: Genes, Genomes, Genetics. 3, 10, p. 1649 - 1659 11 p.

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2 Citations (Scopus)
2012

A model system for mitochondrial biogenesis reveals evolutionary rewiring of protein import and membrane assembly pathways

Hewitt, V. L., Heinz, E., Shingu-Vazquez, M. A., Qu, Y., Jelicic, B., Lo, T. L., Beilharz, T. H., Dumsday, G., Gabriel, K., Traven, A. & Lithgow, T. J., 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 49, p. E3358 - E3366 9 p.

Research output: Contribution to journalArticleResearchpeer-review

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17 Citations (Scopus)

ePAT: a simple method to tag adenylated RNA to measure poly(A)-tail length and other 3' RACE applications

Jaenicke, A., Vancuylenberg, J., Boag, P., Traven, A. & Beilharz, T. H., 2012, In : Rna-A Publication of the Rna Society. 18, 6, p. 1289 - 1295 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
49 Citations (Scopus)

Mitochondrial sorting and assembly machinery subunit Sam37 in Candida albicans: insight into the roles of mitochondria in fitness, cell wall integrity, and virulence

Qu, Y., Jelicic, B., Pettolino, F. A., Perry, A. J., Lo, T., Hewitt, V. L., Bantun, F., Beilharz, T. H., Peleg, A. Y., Lithgow, T. J., Djordjevic, J. & Traven, A., 2012, In : Eukaryotic Cell. 11, 4, p. 532 - 544 13 p.

Research output: Contribution to journalArticleResearchpeer-review

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31 Citations (Scopus)

The functions of mediator in Candida albicans support a role in shaping species-specific gene expression

Uwamahoro, N., Qu, Y., Jelicic, B., Lo, T., Beaurepaire, C., Bantun, F., Quenault, T., Boag, P., Ramm, G., Callaghan, J. M., Beilharz, T. H., Nantel, A., Peleg, A. Y. & Traven, A., 2012, In : PLoS Genetics. 8, 4 (Art. ID: e1002613), p. 1 - 18 18 p.

Research output: Contribution to journalArticleResearchpeer-review

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31 Citations (Scopus)

The mRNA decay pathway regulates expressionof the Flo11 adhesin and biofilm formation in Saccharomyces cerevisiae

Lo, T. L., Qu, Y., Uwamahoro, N., Quenault, T. L., Beilharz, T. H. & Traven, A., 2012, In : Genetics. 191, 4, p. 1387 - 1391 5 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Transcriptional profiling of a yeast colony provides new insight into the heterogeneity of multicellular fungal communities

Traven, A., Jaenicke, A., Harrison, P., Swaminathan, A., Seemann, T. & Beilharz, T. H., 2012, In : PLoS ONE. 7, 9, 11 p., e46243.

Research output: Contribution to journalArticleResearchpeer-review

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23 Citations (Scopus)
2011

Cell wall integrity is linked to mitochondria and phospholipid homeostasis in Candida albicans through the activity of the post-transcriptional regulator Ccr4-Pop2

Dagley, M. J., Gentle, I. E., Beilharz, T. H., Pettolino, F. A., Djordjevic, J., Lo, T., Uwamahoro, N., Rupasinghe, T. W. T., Tull, D., McConville, M. J., Beaurepaire, C., Nantel, A., Lithgow, T. J., Mitchell, A. P. & Traven, A., 2011, In : Molecular Microbiology. 79, 4, p. 968 - 989 22 p.

Research output: Contribution to journalArticleResearchpeer-review

74 Citations (Scopus)

mRNA isoform diversity can obscure detection of miRNA-mediated control of translation

Clancy, J. L., Wei, G. H., Echner, N., Humphreys, D. T., Beilharz, T. H. & Preiss, T., 2011, In : Rna-A Publication of the Rna Society. 17, 6, p. 1025 - 1031 7 p.

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)

Probing connectivity between transcriptional and post-transcriptional gene networks

Boyd, S., Keith, J. M., Traven, A. & Beilharz, T. H., 1 Nov 2011, In : Microbiology Australia. 32, 4, p. 166-168 3 p.

Research output: Contribution to journalArticleOtherpeer-review

Open Access
2009

microRNA-mediated messenger RNA deadenylation contributes to translational repression in mammalian cells

Beilharz, T. H., Humphreys, D. T., Clancy, J. L., Thermann, R., Martin, D. IK., Hentze, M. W. & Preiss, T., 2009, In : PLoS ONE. 4, 8, p. e6783-1 - e6783-12 12 p.

Research output: Contribution to journalArticleResearchpeer-review

68 Citations (Scopus)

The Ccr4-Pop2-NOT mRNA deadenylase contributes to septin organization in Saccharomyces cerevisiae

Traven, A., Beilharz, T. H., Lo, T. L., Lueder, F. B., Preiss, T. & Heierhorst, J., 2009, In : Genetics. 182, 4, p. 955 - 966 12 p.

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)

Transcriptome-wide measurement of mRNA polyadenylation state

Beilharz, T. H. & Preiss, T., 2009, In : Methods. 48, 3, p. 294 - 300 7 p.

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)
2007

A network of multiple regulatory layers shapes gene expression in fission yeast

Lackner, D. H., Beilharz, T. H., Marguerat, S., Mata, J., Watt, S., Schubert, F., Preiss, T. & Bahler, J., 2007, In : Molecular Cell. 26, 1, p. 145 - 155 11 p.

Research output: Contribution to journalArticleResearchpeer-review

148 Citations (Scopus)

Widespread use of poly(A) tail length control to accentuate expression of the yeast transcriptome

Beilharz, T. H. & Preiss, T., 2007, In : Rna-A Publication of the Rna Society. 13, 7, p. 982 - 997 16 p.

Research output: Contribution to journalArticleResearchpeer-review

95 Citations (Scopus)
2006

Ccr4 contributes to tolerance of replication stress through control of CRT1 mRNA poly(A) tail length

Woolstencroft, R. N., Beilharz, T. H., Crook, M. A., Preiss, T., Durocher, D. & Tyers, M., 2006, In : Journal of Cell Science. 119, Pt 24, p. 5178 - 5192 15 p.

Research output: Contribution to journalArticleResearchpeer-review

45 Citations (Scopus)

Integral membrane proteins in the mitochondrial outer membrane of Saccharomyces cerevisiae

Burri, L., Vascotto, K., Gentle, I. E., Chan, N. C., Beilharz, T., Stapleton, D. I., Ramage, L. & Lithgow, T. J., 2006, In : FEBS Journal. 273, 7, p. 1507 - 1515 9 p.

Research output: Contribution to journalArticleResearchpeer-review

36 Citations (Scopus)
2004

Distinct roles for the Hsp40 and Hsp90 molecular chaperones during cystic fibrosis transmembrane conductance regulator degradation in yeast

Youker, R. T., Walsh, P., Beilharz, T., Lithgow, T. J. & Brodsky, J. L., 2004, In : Molecular Biology of the Cell. 15, 11, p. 4787 - 4797 11 p.

Research output: Contribution to journalArticleResearchpeer-review

116 Citations (Scopus)

Translational profiling: The genome-wide measure of the nascent proteome

Beilharz, T. H. & Preiss, T., Aug 2004, In : Briefings in Functional Genomics and Proteomics. 3, 2, p. 103-111 9 p.

Research output: Contribution to journalArticleResearchpeer-review

45 Citations (Scopus)
2003

A SNARE required for retrograde transport to the endoplasmic reticulum

Burri, L., Varlamov, O., Doege, C. A., Hofmann, K., Beilharz, T., Rothman, J. E., Sollner, T. H. & Lithgow, T. J., 2003, In : Proceedings of the National Academy of Sciences of the United States of America. 100, 17, p. 9873 - 9877 5 p.

Research output: Contribution to journalArticleResearchpeer-review

71 Citations (Scopus)

Bipartite signals mediate subcellular targeting of tail-anchored membrane proteins in Saccharomyces cerevisiae

Beilharz, T., Egan, B., Silver, P. A., Hofmann, K. & Lithgow, T. J., 2003, In : The Journal of Biological Chemistry. 278, 10, p. 8219 - 8223 5 p.

Research output: Contribution to journalArticleResearchpeer-review

124 Citations (Scopus)

Multiple cargo binding sites on the COPII subunit Sec24p ensure capture of diverse membrane proteins into transport vesicles

Miller, E. A., Beilharz, T. H., Malkus, P. N., Lee, M. CS., Hamamoto, S., Orci, L. & Schekman, R., 2003, In : Cell. 114, 4, p. 497 - 509 13 p.

Research output: Contribution to journalArticleResearchpeer-review

363 Citations (Scopus)
2002

A conserved proline residue is present in the transmembrane-spanning domain of Tom7 and other tail-anchored protein subunits of the TOM translocase

Allen, R., Egan, B., Gabriel, K., Beilharz, T. & Lithgow, T. J., 2002, In : FEBS Letters. 514, 2-3, p. 347 - 350 4 p.

Research output: Contribution to journalArticleResearchpeer-review

41 Citations (Scopus)
2000

A protein complex containing Tho2, Hpr1, Mft1 and a novel protein, Thp2, connects transcription elongation with mitotic recombination in Saccharomyces cerevisiae

Chavez, S., Beilharz, T., Rondon, A. G., Erdjument-Bromage, H., Tempst, P., Svejstrup, J. Q., Lithgow, T. J. & Aguilera, A., 2000, In : The EMBO Journal. 19, 21, p. 5824 - 5834 11 p.

Research output: Contribution to journalArticleResearchpeer-review

227 Citations (Scopus)