Personal profile
Biography
Dr Josephs leads the Structural DynOmics group at the Monash Institute of Pharmaceutical Sciences (MIPS). Dr Josephs comprehensive interdisciplinary PhD and post-doctoral training has been undertaken at the best national (Monash University) and international laboratories, including Duke University, the University of North Carolina (USA), and Otago University (NZ). She has built extensive biophysical, structural biology and pharmacological technical expertise, and applied these to unravel atomic and molecular insights into proteins that are critical for human health and fundamental to cellular processes. Dr Josephs research projects have spanned programmed cell death, immunology and drug discovery biology; however, her consistent research themes are to elucidate and validate molecular insights into protein structure and dynamics. In the past 2 years Dr Josephs has built an independent research program at MIPS around her core competencies in protein structural dynamics and function applied to understanding GPCR macromolecular interactions critical for cellular signal transduction.
Education/Academic qualification
Biochemistry, PhD, University of Otago
Award Date: 8 Dec 2012
Biochemistry, MSc, University of Otago
Award Date: 16 May 2009
Biochemistry, Microbiology and Immunology, BSc, University of Otago
Award Date: 13 May 2006
Research area keywords
- X ray crystallography
- Hydrogen deuterium exchange
- GPCR
- Structural Biology
- molecular modeling
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
Collaborations and top research areas from the last five years
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Dynamics of calcitonin family receptor activation
Josephs, T. (Primary Chief Investigator (PCI)) & Sexton, P. (Chief Investigator (CI))
ARC - Australian Research Council, Monash University – Internal School Contribution
2/06/25 → 1/06/28
Project: Research
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A personalised pharmacogenomic approach to inform autosomal dominant hypocalcaemia treatment
Josephs, T. (Primary Chief Investigator (PCI))
1/01/22 → 31/12/26
Project: Research
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Structure and dynamics of class B1 G protein coupled receptors
Wootten, D. (Primary Chief Investigator (PCI)), Belousoff, M. (Chief Investigator (CI)) & Josephs, T. (Chief Investigator (CI))
ARC - Australian Research Council, Monash University – Internal School Contribution
2/01/23 → 31/12/25
Project: Research
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Probing the role of dynamics in protein modulation of GPCR phenotype
Sexton, P. (Primary Chief Investigator (PCI)) & Josephs, T. (Chief Investigator (CI))
1/06/21 → 31/12/23
Project: Research
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A calcium-sensing receptor allelic series and underdiagnosis of genetically driven hypocalcemia
Chang, J. B., Barnhill, C. P., Apostolov, A. M., Soliai, M. M., Hecker, J., Nierenberg, J. L., Stapleton Smith, L. M., Mathew, A. S., Zeng, X., Diao, J., Fernando, C. D., Chen, Q., Dulken, B. W., Petukhov, A., Altman, R., Josephs, T. M., Lasky-Su, J. A., Gorvin, C. M., Roberts, M. S. & Adler, S. H. & 3 others, , 7 Aug 2025, In: American Journal of Human Genetics. 112, 8, p. 1818-1832 15 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access -
A novel chemoreactive calcilytic for the potential treatment of autosomal dominant hypocalcemia
Dangerfield, J., DeBono, A., Keller, A. N., Josephs, T. M., Shackleford, D. M., Gregory, K. J., Leach, K. & Capuano, B., Oct 2025, In: Acta Pharmaceutica Sinica B. 15, 10, p. 5387-5399 13 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access -
Next-Generation Analogues of AC265347 as Positive Allosteric Modulators of the Calcium-Sensing Receptor: Pharmacological Investigation of Structural Modifications at the Stereogenic Centre
Dinh, L. V., Dangerfield, J., DeBono, A., Keller, A. N., Josephs, T. M., Gregory, K. J., Leach, K. & Capuano, B., 13 Mar 2025, In: International Journal of Molecular Sciences. 26, 6, 17 p., 2580.Research output: Contribution to journal › Article › Research › peer-review
Open Access -
Unique Biased Agonism Profile of βCGRP on CGRP Family Receptors
Mennen, G., Ying, Z., Fletcher, M. M., Abdur Razzak, M., Humphrys, L., Josephs, T. M., Sexton, P. M., Wootten, D. & Zhao, P., 17 Jun 2025, In: Biochemistry. 64, 12, p. 2556–2576 21 p.Research output: Contribution to journal › Article › Research › peer-review
2 Link opens in a new tab Citations (Scopus) -
Lipid-Dependent Activation of the Orphan G Protein-Coupled Receptor, GPR3
Russell, I. C., Zhang, X., Bumbak, F., McNeill, S. M., Josephs, T. M., Leeming, M. G., Christopoulos, G., Venugopal, H., Flocco, M. M., Sexton, P. M., Wootten, D. & Belousoff, M. J., 5 Mar 2024, In: Biochemistry. 63, 5, p. 625-631 7 p.Research output: Contribution to journal › Article › Research › peer-review
14 Link opens in a new tab Citations (Scopus)
Prizes
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ASBMR Young Investigator Travel Award
Josephs, T. (Recipient), 2020
Prize: Prize (including medals and awards)
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Certara New Investigator Award
Josephs, T. (Recipient), 2021
Prize: Prize (including medals and awards)