Projects per year
Personal profile
Biography
Dr Josephs leads the Structural DynOmics group at the Monash Institute of Pharmaceutical Sciences (MIPS). Dr Josephs comprehensive interdisciplinary PhD and post-doctoral training has been undertaken at the best national (Monash University) and international laboratories, including Duke University, the University of North Carolina (USA), and Otago University (NZ). She has built extensive biophysical, structural biology and pharmacological technical expertise, and applied these to unravel atomic and molecular insights into proteins that are critical for human health and fundamental to cellular processes. Dr Josephs research projects have spanned programmed cell death, immunology and drug discovery biology; however, her consistent research themes are to elucidate and validate molecular insights into protein structure and dynamics. In the past 2 years Dr Josephs has built an independent research program at MIPS around her core competencies in protein structural dynamics and function applied to understanding GPCR macromolecular interactions critical for cellular signal transduction.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Biochemistry, PhD, University of Otago
Award Date: 8 Dec 2012
Biochemistry, MSc, University of Otago
Award Date: 16 May 2009
Biochemistry, Microbiology and Immunology, BSc, University of Otago
Award Date: 13 May 2006
Research area keywords
- X ray crystallography
- Hydrogen deuterium exchange
- GPCR
- Structural Biology
- molecular modeling
Network
Projects
- 3 Active
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A personalised pharmacogenomic approach to inform autosomal dominant hypocalcaemia treatment
1/01/22 → 31/12/26
Project: Research
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Probing the role of dynamics in protein modulation of GPCR phenotype
1/06/21 → 31/12/23
Project: Research
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A structural basis for amylin receptor phenotype
Cao, J., Belousoff, M. J., Liang, Y. L., Johnson, R. M., Josephs, T. M., Fletcher, M. M., Christopoulos, A., Hay, D. L., Danev, R., Wootten, D. & Sexton, P. M., 25 Mar 2022, In: Science. 375, 6587, 14 p., eabm9609.Research output: Contribution to journal › Article › Research › peer-review
16 Citations (Scopus) -
Epitope length variants balance protective immune responses and viral escape in HIV-1 infection
Pymm, P., Tenzer, S., Wee, E., Weimershaus, M., Burgevin, A., Kollnberger, S., Gerstoft, J., Josephs, T. M., Ladell, K., McLaren, J. E., Appay, V., Price, D. A., Fugger, L., Bell, J. I., Schild, H., van Endert, P., Harkiolaki, M. & Iversen, A. K. N., 1 Mar 2022, In: Cell Reports. 38, 9, 21 p., 110449.Research output: Contribution to journal › Article › Research › peer-review
Open Access -
Personalised medicines for familial hypercalcemia and hyperparathyroidism
Josephs, T. M., Zhang, F., Dinh, L. V., Keller, A. N., Conigrave, A. D., Capuano, B., Gregory, K. J. & Leach, K., 9 May 2022, In: Journal of Molecular Endocrinology. 69, 1, p. 243-257 15 p.Research output: Contribution to journal › Article › Research › peer-review
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Development of AC265347-Inspired Calcium-Sensing Receptor Ago-Positive Allosteric Modulators
Dinh, L. V., DeBono, A., Keller, A. N., Josephs, T. M., Gregory, K. J., Leach, K. & Capuano, B., 19 Nov 2021, In: ChemMedChem. 16, 22, p. 3451-3462 12 p.Research output: Contribution to journal › Article › Research › peer-review
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Structure and dynamics of the CGRP receptor in apo and peptide-bound forms
Josephs, T. M., Belousoff, M. J., Liang, Y. L., Piper, S. J., Cao, J., Garama, D. J., Leach, K., Gregory, K. J., Christopoulos, A., Hay, D. L., Danev, R., Wootten, D. & Sexton, P. M., 9 Apr 2021, In: Science. 372, 6538, 11 p., eabf7258.Research output: Contribution to journal › Article › Research › peer-review
37 Citations (Scopus)
Prizes
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ASBMR Young Investigator Travel Award
Josephs, Tracy (Recipient), 2020
Prize: Prize (including medals and awards)
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Certara New Investigator Award
Josephs, Tracy (Recipient), 2021
Prize: Prize (including medals and awards)