Projects per year
Personal profile
Biography
Dr Josephs leads G protein coupled receptor (GPCR) structural-dynamics research as an independent investigator in the collaborative Endocrinology and Neuropharmacology Laboratory at the Monash Institute of Pharmaceutical Sciences (MIPS). Dr Josephs comprehensive interdisciplinary PhD and post-doctoral training has been undertaken at the best national (Monash University) and international laboratories, including Duke University, the University of North Carolina (USA), and Otago University (NZ). She has built extensive biophysical, structural biology and pharmacological technical expertise, and applied these to unravel atomic and molecular insights into proteins that are critical for human health and fundamental to cellular processes. Dr Josephs research projects have spanned programmed cell death, immunology and drug discovery biology; however, her consistent research themes are to elucidate and validate molecular insights into protein structure and dynamics. In the past 2 years Dr Josephs has built an independent research program at MIPS around her core competencies in protein structural dynamics and function applied to understanding GPCR macromolecular interactions critical for cellular signal transduction.
Education/Academic qualification
Biochemistry, PhD, University of Otago
Award Date: 8 Dec 2012
Biochemistry, MSc, University of Otago
Award Date: 16 May 2009
Biochemistry, Microbiology and Immunology, BSc, University of Otago
Award Date: 13 May 2006
Research area keywords
- X ray crystallography
- Hydrogen deuterium exchange
- GPCR
- Structural Biology
- molecular modeling
Network
Projects
- 1 Active
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Probing the role of dynamics in protein modulation of GPCR phenotype
25/03/21 → 24/03/24
Project: Research
Research output
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Elucidation of calcium sensing receptor (CaSR) structural conformations using hydrogen-deuterium exchange mass spectroscopy
Josephs, T., Garama, D. & Keller, A., 2020, (Accepted/In press).Research output: Contribution to conference › Other
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International union of basic and clinical pharmacology. CVIII. Calcium-sensing receptor nomenclature, pharmacology, and function
Leach, K., Hannan, F. M., Josephs, T. M., Keller, A. N., Møller, T. C., Ward, D. T., Kallay, E., Mason, R. S., Thakker, R. V., Riccardi, D., Conigrave, A. D. & Bräuner-Osborne, H., Jul 2020, In : Pharmacological Reviews. 72, 3, p. 558-604 47 p.Research output: Contribution to journal › Review Article › Research › peer-review
Open AccessFile6 Citations (Scopus) -
Negative allosteric modulators of the human calcium-sensing receptor bind to overlapping and distinct sites within the 7-transmembrane domain
Josephs, T. M., Keller, A. N., Khajehali, E., DeBono, A., Langmead, C. J., Conigrave, A. D., Capuano, B., Kufareva, I., Gregory, K. J. & Leach, K., Apr 2020, In : British Journal of Pharmacology. 177, 8, p. 1917-1930 14 p.Research output: Contribution to journal › Article › Research › peer-review
5 Citations (Scopus) -
Broad CD8+ T cell cross-recognition of distinct influenza A strains in humans
Grant, E. J., Josephs, T. M., Loh, L., Clemens, E. B., Sant, S., Bharadwaj, M., Chen, W., Rossjohn, J., Gras, S. & Kedzierska, K., 21 Dec 2018, In : Nature Communications. 9, 1, 16 p., 5427.Research output: Contribution to journal › Article › Research › peer-review
Open AccessFile17 Citations (Scopus) -
Identification of global and ligand-specific calcium sensing receptor activation mechanisms S
Keller, A., Kufareva, I., Josephs, T. M., Diao, J., Mai, V. T-V., Conigrave, A. D., Christopoulos, A., Gregory, K. J. & Leach, K., 1 Jun 2018, In : Molecular Pharmacology. 93, 6, p. 619-630 12 p.Research output: Contribution to journal › Article › Research › peer-review
11 Citations (Scopus)