Projects per year
Personal profile
Biography
Dr Josephs leads the Structural DynOmics group at the Monash Institute of Pharmaceutical Sciences (MIPS). Dr Josephs comprehensive interdisciplinary PhD and post-doctoral training has been undertaken at the best national (Monash University) and international laboratories, including Duke University, the University of North Carolina (USA), and Otago University (NZ). She has built extensive biophysical, structural biology and pharmacological technical expertise, and applied these to unravel atomic and molecular insights into proteins that are critical for human health and fundamental to cellular processes. Dr Josephs research projects have spanned programmed cell death, immunology and drug discovery biology; however, her consistent research themes are to elucidate and validate molecular insights into protein structure and dynamics. In the past 2 years Dr Josephs has built an independent research program at MIPS around her core competencies in protein structural dynamics and function applied to understanding GPCR macromolecular interactions critical for cellular signal transduction.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Biochemistry, PhD, University of Otago
Award Date: 8 Dec 2012
Biochemistry, MSc, University of Otago
Award Date: 16 May 2009
Biochemistry, Microbiology and Immunology, BSc, University of Otago
Award Date: 13 May 2006
Research area keywords
- X ray crystallography
- Hydrogen deuterium exchange
- GPCR
- Structural Biology
- molecular modeling
Collaborations and top research areas from the last five years
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Dynamics of calcitonin family receptor activation
Australian Research Council (ARC), Monash University – Internal School Contribution
14/01/25 → 13/01/28
Project: Research
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Structure and dynamics of class B1 G protein coupled receptors
Wootten, D. (Primary Chief Investigator (PCI)), Belousoff, M. (Chief Investigator (CI)) & Josephs, T. (Chief Investigator (CI))
Australian Research Council (ARC), Monash University – Internal School Contribution
2/01/23 → 1/01/26
Project: Research
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A personalised pharmacogenomic approach to inform autosomal dominant hypocalcaemia treatment
1/01/22 → 31/12/26
Project: Research
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Probing the role of dynamics in protein modulation of GPCR phenotype
1/06/21 → 31/12/23
Project: Research
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Lipid-Dependent Activation of the Orphan G Protein-Coupled Receptor, GPR3
Russell, I. C., Zhang, X., Bumbak, F., McNeill, S. M., Josephs, T. M., Leeming, M. G., Christopoulos, G., Venugopal, H., Flocco, M. M., Sexton, P. M., Wootten, D. & Belousoff, M. J., 5 Mar 2024, In: Biochemistry. 63, 5, p. 625-631 7 p.Research output: Contribution to journal › Article › Research › peer-review
6 Citations (Scopus) -
A STAT3 protein complex required for mitochondrial mRNA stability and cancer
Fernando, C. D., Jayasekara, W. S. N., Inampudi, C., Kohonen-Corish, M. R. J., Cooper, W. A., Beilharz, T. H., Josephs, T. M., Garama, D. J. & Gough, D. J., 26 Sept 2023, In: Cell Reports. 42, 9, 14 p., 113033.Research output: Contribution to journal › Article › Research › peer-review
Open Access8 Citations (Scopus) -
The Calcium-Sensing Receptor (CaSR) in Disease
Keller, A. N., Josephs, T. M., Gregory, K. J. & Leach, K., 2023, GPCRs as Therapeutic Targets. Gilchrist, A. (ed.). Hoboken NJ USA: John Wiley & Sons, Vol. 2. p. 580-630 51 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter (Book) › Other › peer-review
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A structural basis for amylin receptor phenotype
Cao, J., Belousoff, M. J., Liang, Y. L., Johnson, R. M., Josephs, T. M., Fletcher, M. M., Christopoulos, A., Hay, D. L., Danev, R., Wootten, D. & Sexton, P. M., 25 Mar 2022, In: Science. 375, 6587, 14 p., eabm9609.Research output: Contribution to journal › Article › Research › peer-review
38 Citations (Scopus) -
Epitope length variants balance protective immune responses and viral escape in HIV-1 infection
Pymm, P., Tenzer, S., Wee, E., Weimershaus, M., Burgevin, A., Kollnberger, S., Gerstoft, J., Josephs, T. M., Ladell, K., McLaren, J. E., Appay, V., Price, D. A., Fugger, L., Bell, J. I., Schild, H., van Endert, P., Harkiolaki, M. & Iversen, A. K. N., 1 Mar 2022, In: Cell Reports. 38, 9, 21 p., 110449.Research output: Contribution to journal › Article › Research › peer-review
Open Access2 Citations (Scopus)
Prizes
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ASBMR Young Investigator Travel Award
Josephs, Tracy (Recipient), 2020
Prize: Prize (including medals and awards)
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Certara New Investigator Award
Josephs, Tracy (Recipient), 2021
Prize: Prize (including medals and awards)