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Personal profile

Biography

A/Professor Tracy Heng is a Laboratory Head in the Department of Anatomy and Developmental Biology, Faculty of Medicine, Nursing and Health Sciences at Monash University. Tracy obtained her PhD at Monash University in 2006, developing strategies to improve immune function in ageing and disease. She undertook postdoctoral training with Profs Harald von Boehmer, Christophe Benoist and Diane Mathis at Harvard Medical School in Boston to establish the Immunological Genome Project (immgen.org), a widely utilised resource for immunological gene expression profiling. She returned to Australia in 2009 and was awarded an ARC Postdoctoral (Industry) Fellowship to develop her research in alliance with industry. Tracy is a recipient of the 2015 Young Tall Poppy Science Award (Australian Institute of Policy and Science) and the 2016 Metcalf Prize for Stem Cell Research (National Stem Cell Foundation of Australia). She is currently an NHMRC R.D. Wright Biomedical Career Development Fellow and leads a research program at the Biomedicine Discovery Institute focussed on overcoming immunological barriers to stem cell therapies.

Research interests

Our research aims to understand the immune response to stem cell transplantation and cell therapy, with a view to overcome immunological barriers and other challenges for effective translation of such treatments.

Supervision interests

PhD Supervision:

Di Zheng (Phd Candidate); Mechanisms of mesenchymal stem cell therapy

Joshua D'Rozario (PhD awarded 2018); The regulation of the innate immune system by fibroblastic reticular cells.

Jessica Morison (PhD awarded 2014); Low-intensity conditioning for the induction of allogeneic tolerance in aged recipients.

Honours/Master Supervision:

Assifa Hisana (Master Candidate); The role of apoptosis and efferocytosis in mesenchymal stromal cell therapy.

Georgia Wallis (First Class Honours awarded 2018); Role of apoptosis in mesenchymal stromal cell therapy.

Darshana Cherian (First Class Honours awarded 2018); Comparison of microcarriers for scale-up manufacture of mesenchymal stem cells.

Cara Anticevic (First Class Honours awarded 2015); Improving donor stem cell engraftment in aged recipients with minimal conditioning.

Senora Mendonca (First Class Honours awarded 2015); Investigating the role of mesenchymal stromal cells in allergic asthma.

Research area keywords

  • mesenchymal stem cells
  • stromal cells
  • T cells
  • thymus
  • immune ageing
  • cell therapy
  • immunomodulation
  • haematopoietic stem cell transplantation
  • bone marrow transplantation
  • immune tolerance

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2009 2022

Research Output 2005 2017

Thymospheres are formed by mesenchymal cells with the potential to generate adipocytes, but not epithelial cells

Sheridan, J. M., Keown, A., Policheni, A., Roesley, S. N. A., Rivlin, N., Ritchie, M. E., Jain, R., Abramson, J., Heng, T. S. P. & Gray, D. H. D., 24 Oct 2017, In : Cell Reports. 21, 4, p. 934-942 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Lymph node stroma join the cancer support network

Fletcher, A. L. & Heng, T. SP., Dec 2016, In : Cell Death and Differentiation. 23, 12, p. 1899-1901 3 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

Open Access

Establishment of transplantation tolerance via minimal conditioning in aged recipients

Morison, J. K., Homann, J., Hammett, M. V., Seach, N. L., Layton, D. S., Malin, M. A., Thorburn, A. N., Chidgey, A. P., Boyd, R. L. & Heng, T. S. P., 2014, In : American Journal of Transplantation. 14, 11, p. 2478 - 2490 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Gene expression during the generation and activation of mouse neutrophils: implication of novel functional and regulatory pathways

Ericson, J. A., Duffau, P., Yasuda, K., Ortiz-Lopez, A., Rothamel, K., Rifkin, I. R., Monach, P. & ImmGen Consortium, Oct 2014, In : PLoS ONE. 9, 10, 16 p., e108553.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Lymph node fibroblastic reticular cell transplants show robust therapeutic efficacy in high-mortality murine sepsis

Fletcher, A. L., Elman, J. S., Astarita, J., Murray, R. M., Saeidi, N., D'Rozario, J., Knoblich, K., Brown, F. D., Schildberg, F. A., Nieves, J. M., Heng, T. SP., Boyd, R. L., Turley, S. J. & Parekkadan, B., 2014, In : Science Translational Medicine. 6, 249 (Art. No: 249ra109), p. 1 - 14 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Prizes

Australian Postdoctoral (Industry) Fellowship

Tracy Heng (Recipient), 2011

Prize: Competitive Fellowships

Faculty Early Career Research Fellows Publication Prize

Tracy Heng (Recipient), 2015

Prize: Prize (including medals and awards)

Metcalf Prize for Stem Cell Research

Tracy Heng (Recipient), 2016

Prize: Prize (including medals and awards)

R.D. Wright Biomedical Career Development Fellowship

Tracy Heng (Recipient), 2016

Prize: Competitive Fellowships

Young Tall Poppy Science Award

Tracy Heng (Recipient), 2015

Prize: Prize (including medals and awards)

Activities 2012 2018

  • 2 Membership of industry collaboration/ network
  • 1 Membership of an advisory panel/policy group/ board

Regeneus Ltd. (External organisation)

Tracy Heng (Member)
20182022

Activity: Industry, Government and Philanthropy Engagement and PartnershipsMembership of industry collaboration/ network

Australian Academy of Science Theo Murphy High Flyers Think Tank (Event)

Tracy Heng (Member)
2015

Activity: Industry, Government and Philanthropy Engagement and PartnershipsMembership of an advisory panel/policy group/ board

Mesoblast Limited (External organisation)

Tracy Heng (Member)
20122018

Activity: Industry, Government and Philanthropy Engagement and PartnershipsMembership of industry collaboration/ network

Press / Media

Metcalf Prize for Stem Cell Research

Tracy Heng

24/07/163/08/16

3 Media contributions

Press/Media: Profile/Interview

Establishment of transplantation tolerance via minimal conditioning in aged recipients

Tracy Heng

20/09/1411/11/14

3 items of Media coverage, 1 Media contribution

Press/Media: Article/Feature