Tracey Gaspari

Dr

1994 …2021

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Personal profile

Biography

Dr Tracey Gaspari is a Research Fellow in the Department of Pharmacology at Monash University. Tracey originally completed her PhD in pharmacology at Monash University in the area of interaction of xanthines and beta2-adrenoceptor agonists, two classes of drugs used to treat asthma and premature labour. Following this Tracey then moved to working in the cardiovascular field, initially with Prof John Ludbrook at the Royal Melbourne Hospital where her research included investigating mechanisms involved in haemorrhagic shock. From there she moved to the Howard Florey institute and worked with Prof Greg Dusting where her interest in the renin angiotensin system and cardiovascular disease began. There was a short stint working for the biotechnology company, Thrombogenix, before Tracey returned to Monash University and the Pharmacology Department in 2001.

With cardiovascular disease still the biggest cause of morbidity and mortality in the modernized world, Tracey's work has focussed on the cardio-protective effects of shorter angiotensin peptides and non-AT1 receptors, particularly in the area of atherosclerosis. More recently, in collaboration with Dr Siew Yeen Chai in the Physiology Department, Tracey has highlighted the protective role associated with inhibition of the enzyme, insulin regulated aminopeptidase (IRAP), also known as the angiotensin subtype 4 receptor, in both atherosclerosis and cardiac remodelling. There is still much to be done to understand the role of IRAP in the development of cardiovascular disease. However the development of exciting, novel synthetic inhibitors of this enzyme has helped to bring the possibility of a new therapeutic strategy to treat cardiovascular disease that little bit closer.

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