Tracey Gaspari

Dr

20002021
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Personal profile

Biography

Dr Tracey Gaspari is a Research Fellow in the Department of Pharmacology at Monash University. Tracey originally completed her PhD in pharmacology at Monash University in the area of interaction of xanthines and beta2-adrenoceptor agonists, two classes of drugs used to treat asthma and premature labour. Following this Tracey then moved to working in the cardiovascular field, initially with Prof John Ludbrook at the Royal Melbourne Hospital where her research included investigating mechanisms involved in haemorrhagic shock. From there she moved to the Howard Florey institute and worked with Prof Greg Dusting where her interest in the renin angiotensin system and cardiovascular disease began. There was a short stint working for the biotechnology company, Thrombogenix, before Tracey returned to Monash University and the Pharmacology Department in 2001.

With cardiovascular disease still the biggest cause of morbidity and mortality in the modernized world, Tracey's work has focussed on the cardio-protective effects of shorter angiotensin peptides and non-AT1 receptors, particularly in the area of atherosclerosis. More recently, in collaboration with Dr Siew Yeen Chai in the Physiology Department, Tracey has highlighted the protective role associated with inhibition of the enzyme, insulin regulated aminopeptidase (IRAP), also known as the angiotensin subtype 4 receptor, in both atherosclerosis and cardiac remodelling. There is still much to be done to understand the role of IRAP in the development of cardiovascular disease. However the development of exciting, novel synthetic inhibitors of this enzyme has helped to bring the possibility of a new therapeutic strategy to treat cardiovascular disease that little bit closer.

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Projects 2018 2021

Research Output 2000 2019

3 Citations (Scopus)

Effects of high- and low-dose aspirin on adaptive immunity and hypertension in the stroke-prone spontaneously hypertensive rat

Khan, S. I., Shihata, W. A., Andrews, K. L., Lee, M. K. S., Moore, X-L., Jefferis, A-M., Vinh, A., Gaspari, T., Dragoljevic, D., Jennings, G. L., Murphy, A. J. & Chin-Dusting, J. P. F., 1 Jan 2019, In : FASEB Journal. 33, 1, p. 1510-1521 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Serelaxin inhibits the profibrotic TGF-β1/IL-1β axis by targeting TLR-4 and the NLRP3 inflammasome in cardiac myofibroblasts

Tapia Caceres, F., Gaspari, T. A., Samuel, C. S. & Pinar, A. A., Dec 2019, In : FASEB Journal. 33, 12, p. 14717-14733 17 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Dapagliflozin attenuates human vascular endothelial cell activation and induces vasorelaxation: A potential mechanism for inhibition of atherogenesis

Gaspari, T., Spizzo, I., Liu, H., Hu, Y., Simpson, R. W., Widdop, R. E. & Dear, A. E., 1 Jan 2018, In : Diabetes and Vascular Disease Research. 15, 1, p. 64-73 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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16 Citations (Scopus)

Anti-fibrotic potential of AT2 receptor agonists

Wang, Y., Del Borgo, M., Lee, H. W., Baraldi, D., Hirmiz, B., Gaspari, T. A., Denton, K. M., Aguilar, M-I., Samuel, C. S. & Widdop, R. E., 31 Aug 2017, In : Frontiers in Pharmacology. 8, 7 p., 564.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
File
7 Citations (Scopus)

The effect of tocopheryl phosphates (TPM) on the development of atherosclerosis in apolipoprotein-E deficient mice

Libinaki, R., Vinh, A., Tesanovic-Klajic, S., Widdop, R. & Gaspari, T., 1 Dec 2017, In : Clinical and Experimental Pharmacology and Physiology. 44, S1, p. 107-116 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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