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Personal profile


Tony is an NHMRC Principal Research Fellow whose international reputation is built around his expertise in the cell communication networks referred to as cellular signalling. He leads a multidisciplinary research program with a focus on metabolism, obesity and type 2 diabetes, but his work also impinges on other health issues including autoimmunity and cancer.

Tony was educated at The University of Melbourne. He completed his PhD with Prof. Bruce E. Kemp, St Vincent's Institute, Melbourne. In 1995 he was awarded a NHMRC C.J. Martin Fellowship and undertook post-doctoral training with Prof. Nicholas K. Tonks, Cold Spring Harbor Laboratory, NY. He established an independent laboratory in the Department of Biochemistry and Molecular Biology, Monash University in 2000 as a NHMRC RD. Wright Fellow and Monash University Logan Fellow. He was awarded a NHMRC Senior Research Fellowship (Level A) in 2005 and a NHMRC Principal Research Fellowship in 2010 that was renewed in 2015.


  • Cellular Signalling
  • Obesity
  • Type 2 Diabetes
  • Metabolism
  • Autoimmunity
  • Cancer

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Projects 2000 2021

Research Output 1997 2019

Activation of naïve CD4 + T cells re-tunes STAT1 signaling to deliver unique cytokine responses in memory CD4 + T cells

Twohig, J. P., Cardus Figueras, A., Andrews, R., Wiede, F., Cossins, B. C., Derrac Soria, A., Lewis, M. J., Townsend, M. J., Millrine, D., Li, J., Hill, D. G., Uceda Fernandez, J., Liu, X., Szomolay, B., Pepper, C. J., Taylor, P. R., Pitzalis, C., Tiganis, T., Williams, N. M., Jones, G. W. & 1 othersJones, S. A., 1 Apr 2019, In : Nature Immunology. 20, 4, p. 458-470 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Erratum. Celastrol-Induced Weight Loss Is Driven by Hypophagia and Independent From UCP1. Diabetes 2018;67:2456-2465

Pfuhlmann, K., Schriever, S. C., Baumann, P., Kabra, D. G., Harrison, L., Mazibuko-Mbeje, S. E., Contreras, R. E., Kyriakou, E., Simonds, S. E., Tiganis, T., Cowley, M. A., Woods, S. C., Jastroch, M., Clemmensen, C., De Angelis, M., Schramm, K. W., Sattler, M., Messias, A. C., Tschöp, M. H. & Pfluger, P. T., 1 Mar 2019, In : Diabetes. 68, 3, 1 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

Open Access

Leptin Signaling in the Arcuate Nucleus Reduces Insulin's Capacity to Suppress Hepatic Glucose Production in Obese Mice

Balland, E., Chen, W., Dodd, G. T., Conductier, G., Coppari, R., Tiganis, T. & Cowley, M. A., 8 Jan 2019, In : Cell Reports. 26, 2, p. 346-355 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Persistent leptin signalling in the arcuate nucleus impairs hypothalamic insulin signalling and glucose homeostasis in obese mice

Balland, E., Chen, W., Tiganis, T. & Cowley, M. A., 16 Apr 2019, (Accepted/In press) In : Neuroendocrinology.

Research output: Contribution to journalArticleResearchpeer-review

Reduced expression of phosphatase PTPN2 promotes pathogenic conversion of Tregs in autoimmunity

Svensson, M. N., Doody, K. M., Schmiedel, B. J., Bhattacharyya, S., Panwar, B., Wiede, F., Yang, S., Santelli, E., Wu, D. J., Sacchetti, C., Gujar, R., Seumois, G., Kiosses, W. B., Aubry, I., Kim, G., Mydel, P., Sakaguchi, S., Kronenberg, M., Tiganis, T., Tremblay, M. L. & 3 othersAy, F., Vijayanand, P. & Bottini, N., 1 Mar 2019, In : The Journal of clinical investigation. 129, 3, p. 1193-1210 18 p.

Research output: Contribution to journalArticleResearchpeer-review