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Personal profile

Biography

Tony is an NHMRC Principal Research Fellow whose international reputation is built around his expertise in the cell communication networks referred to as cellular signalling. He leads a multidisciplinary research program with a focus on metabolism, obesity and type 2 diabetes, but his work also impinges on other health issues including autoimmunity and cancer.



Tony was educated at The University of Melbourne. He completed his PhD with Prof. Bruce E. Kemp, St Vincent's Institute, Melbourne. In 1995 he was awarded a NHMRC C.J. Martin Fellowship and undertook post-doctoral training with Prof. Nicholas K. Tonks, Cold Spring Harbor Laboratory, NY. He established an independent laboratory in the Department of Biochemistry and Molecular Biology, Monash University in 2000 as a NHMRC RD. Wright Fellow and Monash University Logan Fellow. He was awarded a NHMRC Senior Research Fellowship (Level A) in 2005 and a NHMRC Principal Research Fellowship in 2010 that was renewed in 2015.

Research area keywords

  • Cellular Signalling
  • Obesity
  • Type 2 Diabetes
  • Metabolism
  • Autoimmunity
  • Cancer

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Projects

Research Output

PTPN2 phosphatase deletion in T cells promotes anti-tumour immunity and CAR T-cell efficacy in solid tumours

Wiede, F., Lu, K-H., Du, X., Liang, S., Hochheiser, K., Dodd, G. T., Goh, P. K., Kearney, C., Meyran, D., Beavis, P. A., Henderson, M. A., Park, S. L., Waithman, J., Zhang, S., Zhang, Z. Y., Oliaro, J., Gebhardt, T., Darcy, P. K. & Tiganis, T., 15 Jan 2020, In : The EMBO Journal. 39, 2, 26 p., e103637.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
3 Citations (Scopus)

A class of γδ T cell receptors recognize the underside of the antigen-presenting molecule MR1

Le Nours, J., Gherardin, N. A., Ramarathinam, S. H., Awad, W., Wiede, F., Gully, B. S., Khandokar, Y., Praveena, T., Wubben, J. M., Sandow, J. J., Webb, A. I., von Borstel, A., Rice, M. T., Redmond, S. J., Seneviratna, R., Sandoval-Romero, M. L., Li, S., Souter, M. N. T., Eckle, S. B. G., Corbett, A. J. & 15 others, Reid, H. H., Liu, L., Fairlie, D. P., Giles, E. M., Westall, G. P., Tothill, R. W., Davey, M. S., Berry, R., Tiganis, T., McCluskey, J., Pellicci, D. G., Purcell, A. W., Uldrich, A. P., Godfrey, D. I. & Rossjohn, J., 20 Dec 2019, In : Science. 366, 6472, p. 1522-1527 6 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Activation of naïve CD4 + T cells re-tunes STAT1 signaling to deliver unique cytokine responses in memory CD4 + T cells

Twohig, J. P., Cardus Figueras, A., Andrews, R., Wiede, F., Cossins, B. C., Derrac Soria, A., Lewis, M. J., Townsend, M. J., Millrine, D., Li, J., Hill, D. G., Uceda Fernandez, J., Liu, X., Szomolay, B., Pepper, C. J., Taylor, P. R., Pitzalis, C., Tiganis, T., Williams, N. M., Jones, G. W. & 1 others, Jones, S. A., 1 Apr 2019, In : Nature Immunology. 20, 4, p. 458-470 13 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Erratum. Celastrol-Induced Weight Loss Is Driven by Hypophagia and Independent From UCP1. Diabetes 2018;67:2456-2465

Pfuhlmann, K., Schriever, S. C., Baumann, P., Kabra, D. G., Harrison, L., Mazibuko-Mbeje, S. E., Contreras, R. E., Kyriakou, E., Simonds, S. E., Tiganis, T., Cowley, M. A., Woods, S. C., Jastroch, M., Clemmensen, C., De Angelis, M., Schramm, K. W., Sattler, M., Messias, A. C., Tschöp, M. H. & Pfluger, P. T., 1 Mar 2019, In : Diabetes. 68, 3, 1 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

Open Access
Open Access
File
2 Citations (Scopus)