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Personal profile

Biography

Tony is an NHMRC Principal Research Fellow whose international reputation is built around his expertise in the cell communication networks referred to as cellular signalling. He leads a multidisciplinary research program with a focus on metabolism, obesity and type 2 diabetes, but his work also impinges on other health issues including autoimmunity and cancer.



Tony was educated at The University of Melbourne. He completed his PhD with Prof. Bruce E. Kemp, St Vincent's Institute, Melbourne. In 1995 he was awarded a NHMRC C.J. Martin Fellowship and undertook post-doctoral training with Prof. Nicholas K. Tonks, Cold Spring Harbor Laboratory, NY. He established an independent laboratory in the Department of Biochemistry and Molecular Biology, Monash University in 2000 as a NHMRC RD. Wright Fellow and Monash University Logan Fellow. He was awarded a NHMRC Senior Research Fellowship (Level A) in 2005 and a NHMRC Principal Research Fellowship in 2010 that was renewed in 2015.

Keywords

  • Cellular Signalling
  • Obesity
  • Type 2 Diabetes
  • Metabolism
  • Autoimmunity
  • Cancer

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Projects 2000 2021

Research Output 1997 2019

Leptin Signaling in the Arcuate Nucleus Reduces Insulin's Capacity to Suppress Hepatic Glucose Production in Obese Mice

Balland, E., Chen, W., Dodd, G. T., Conductier, G., Coppari, R., Tiganis, T. & Cowley, M. A., 8 Jan 2019, In : Cell Reports. 26, 2, p. 346-355 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Reduced expression of phosphatase PTPN2 promotes pathogenic conversion of Tregs in autoimmunity

Svensson, M. N., Doody, K. M., Schmiedel, B. J., Bhattacharyya, S., Panwar, B., Wiede, F., Yang, S., Santelli, E., Wu, D. J., Sacchetti, C., Gujar, R., Seumois, G., Kiosses, W. B., Aubry, I., Kim, G., Mydel, P., Sakaguchi, S., Kronenberg, M., Tiganis, T., Tremblay, M. L. & 3 othersAy, F., Vijayanand, P. & Bottini, N., 1 Mar 2019, In : The Journal of clinical investigation. 129, 3, p. 1193-1210 18 p.

Research output: Contribution to journalArticleResearchpeer-review

Age-Related Decline in Primary CD8+ T Cell Responses Is Associated with the Development of Senescence in Virtual Memory CD8+ T Cells

Quinn, K. M., Fox, A., Harland, K. L., Russ, B. E., Li, J., Nguyen, T. H. O., Loh, L., Olshanksy, M., Naeem, H., Tsyganov, K., Wiede, F., Webster, R., Blyth, C., Sng, X. Y. X., Tiganis, T., Powell, D., Doherty, P. C., Turner, S. J., Kedzierska, K. & La Gruta, N. L., 19 Jun 2018, In : Cell Reports. 23, 12, p. 3512-3524 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Celastrol-Induced Weight Loss Is Driven by Hypophagia and Independent From UCP1

Pfuhlmann, K., Schriever, S. C., Baumann, P., Kabra, D. G., Harrison, L., Mazibuko-Mbeje, S. E., Contreras, R. E., Kyriakou, E., Simonds, S. E., Tiganis, T., Cowley, M. A., Woods, S. C., Jastroch, M., Clemmensen, C., De Angelis, M., Schramm, K. W., Sattler, M., Messias, A. C., Tschöp, M. H. & Pfluger, P. T., 1 Nov 2018, In : Diabetes. 67, 11, p. 2456-2465 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Celastrol Promotes Weight Loss in Diet-Induced Obesity by Inhibiting the Protein Tyrosine Phosphatases PTP1B and TCPTP in the Hypothalamus

Kyriakou, E., Schmidt, S., Dodd, G. T., Pfuhlmann, K., Simonds, S. E., Lenhart, D., Geerlof, A., Schriever, S. C., De Angelis, M., Schramm, K. W., Plettenburg, O., Cowley, M. A., Tiganis, T., Tschöp, M. H., Pfluger, P. T., Sattler, M. & Messias, A. C., 7 Dec 2018, In : Journal of Medicinal Chemistry. 61, 24, 14 p.

Research output: Contribution to journalArticleResearchpeer-review