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Tom Karagiannis

Dr

20042020
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Research Output 2004 2017

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Review Article
2017
2 Citations (Scopus)

Pharmacological histone deacetylation distinguishes transcriptional regulators

Rafehi, H., Karagiannis, T. C. & El-Osta, A., 1 May 2017, In : Current Topics in Medicinal Chemistry. 17, 14, p. 1611 - 1622 12 p.

Research output: Contribution to journal › Review Article › Research › peer-review

2015
121 Citations (Scopus)

Cancer metabolism and the Warburg effect: the role of HIF-1 and PI3K

Courtnay, R., Ngo, D. C., Malik, N., Ververis, K., Tortorella, S. M. & Karagiannis, T. C., 1 Apr 2015, In : Molecular Biology Reports. 42, 4, p. 841-851 11 p.

Research output: Contribution to journal › Review Article › Research › peer-review

29 Citations (Scopus)

Introduction to the molecular basis of cancer metabolism and the Warburg effect

Ngo, D. C., Ververis, K., Tortorella, S. M. & Karagiannis, T. C., 1 Apr 2015, In : Molecular Biology Reports. 42, 4, p. 819-823 5 p.

Research output: Contribution to journal › Review Article › Research › peer-review

8 Citations (Scopus)

Lactate as an insidious metabolite due to the Warburg effect

Luc, R., Tortorella, S. M., Ververis, K. & Karagiannis, T. C., 1 Apr 2015, In : Molecular Biology Reports. 42, 4, p. 835-840 6 p.

Research output: Contribution to journal › Review Article › Research › peer-review

15 Citations (Scopus)

The early life origin theory in the development of cardiovascular disease and type 2 diabetes

Lindblom, R., Ververis, K., Tortorella, S. M. & Karagiannis, T. C., 1 Apr 2015, In : Molecular Biology Reports. 42, 4, p. 791-797 7 p.

Research output: Contribution to journal › Review Article › Research › peer-review

4 Citations (Scopus)

The Implication of Cancer Progenitor Cells and the Role of Epigenetics in the Development of Novel Therapeutic Strategies for Chronic Myeloid Leukemia

Tortorella, S. M., Hung, A. & Karagiannis, T. C., 1 Jun 2015, In : Antioxidants and Redox Signaling. 22, 16, p. 1425-1462 38 p.

Research output: Contribution to journal › Review Article › Research › peer-review

42 Citations (Scopus)

The Warburg effect: molecular aspects and therapeutic possibilities

Ngo, H., Tortorella, S. M., Ververis, K. & Karagiannis, T. C., 1 Apr 2015, In : Molecular Biology Reports. 42, 4, p. 825-834 10 p.

Research output: Contribution to journal › Review Article › Research › peer-review

2014
30 Citations (Scopus)

The significance of transferrin receptors in oncology: The development of functional nano-based drug delivery systems

Tortorella, S. & Karagiannis, T. C., 2014, In : Current Drug Delivery. 11, 4, p. 427-443 17 p.

Research output: Contribution to journal › Review Article › Research › peer-review

7 Citations (Scopus)

The timeless influence of Hippocratic ideas on diet, salicylates and personalized medicine

Karagiannis, T. C., 2014, In : Hellenic Journal of Nuclear Medicine. 17, 1, p. 2-6 5 p.

Research output: Contribution to journal › Review Article › Other › peer-review

131 Citations (Scopus)

Transferrin receptor-mediated endocytosis: A useful target for cancer therapy

Tortorella, S. & Karagiannis, T. C., 2014, In : Journal of Membrane Biology. 247, 4, p. 291-307 17 p.

Research output: Contribution to journal › Review Article › Research › peer-review

2013
196 Citations (Scopus)

Histone deacetylase inhibitors (HDACIS): Multitargeted anticancer agents

Ververis, K., Hiong, A., Karagiannis, T. C. & Licciardi, P. V., 23 Feb 2013, In : Biologics: Targets and Therapy. 7, 1, p. 47-60 14 p.

Research output: Contribution to journal › Review Article › Research › peer-review

Open Access
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The potential role of HDAC inhibitors in de-silencing latent HIV virus

Ververis, K. & Karagiannis, T. C., 2013, In : Drugs of the Future. 38, 8, p. 575-583 9 p.

Research output: Contribution to journal › Review Article › Research › peer-review

2012
40 Citations (Scopus)

Controversies surrounding the clinical potential of cinnamon for the management of diabetes

Rafehi, H., Ververis, K. & Karagiannis, T. C., Jun 2012, In : Diabetes, Obesity and Metabolism. 14, 6, p. 493-499 7 p.

Research output: Contribution to journal › Review Article › Research › peer-review

7 Citations (Scopus)

Factors influencing epigenetic mechanisms and related diseases

Karagiannis, T. C. & Maulik, N., 15 Jul 2012, In : Antioxidants and Redox Signaling. 17, 2, p. 192-194 3 p.

Research output: Contribution to journal › Review Article › Other › peer-review

28 Citations (Scopus)

Mechanisms of action of phenolic compounds in olive

Rafehi, H., Ververis, K. & Karagiannis, T. C., Jun 2012, In : Journal of Dietary Supplements. 9, 2, p. 96-109 14 p.

Research output: Contribution to journal › Review Article › Research › peer-review

5 Citations (Scopus)

Safety and efficacy of Pralatrexate in the management of relapsed or refractory peripheral T-cell lymphoma

Rodd, A. L., Ververis, K. & Karagiannis, T. C., 2012, In : Clinical Medicine Insights: Oncology. 6, p. 305-314 10 p.

Research output: Contribution to journal › Review Article › Research › peer-review

Open Access
File
2011
26 Citations (Scopus)

Chromatin modifying agents - The cutting edge of anticancer therapy

Kwa, F. A. A., Balcerczyk, A., Licciardi, P., El-Osta, A. & Karagiannis, T. C., Jul 2011, In : Drug Discovery Today. 16, 13-14, p. 543-547 5 p.

Research output: Contribution to journal › Review Article › Research › peer-review

13 Citations (Scopus)

Double-strand breaks and the concept of short- and long-term epigenetic memory

Orlowski, C., Mah, L-J., Vasireddy, R. S., El-Osta, A. & Karagiannis, T. C., Apr 2011, In : Chromosoma. 120, 2, p. 129-149 21 p.

Research output: Contribution to journal › Review Article › Research › peer-review

19 Citations (Scopus)

Evaluation of the efficacy of radiation-modifying compounds using γH2AX as a molecular marker of DNA double-strand breaks

Mah, L-J., Orlowski, C., Ververis, K., Vasireddy, R. S., El-Osta, A. & Karagiannis, T. C., 25 Jan 2011, In : Genome Integrity. 2, 11 p., 3.

Research output: Contribution to journal › Review Article › Research › peer-review

Open Access
File
21 Citations (Scopus)

Potential non-oncological applications of histone deacetylase inhibitors

Ververis, K. & Karagiannis, T. C., 2011, In : American Journal of Translational Research. 3, 5, p. 454-467 14 p.

Research output: Contribution to journal › Review Article › Research › peer-review

Open Access
File
11 Citations (Scopus)

Utility of γH2AX as a molecular marker of DNA double-strand breaks in nuclear medicine: Applications to radionuclide therapy employing auger electron-emitting isotopes

Mah, L-J., Orlowski, C., Ververis, K., El-Osta, A. & Karagiannis, T. C., Jun 2011, In : Current Radiopharmaceuticals. 4, 1, p. 59-67 9 p.

Research output: Contribution to journal › Review Article › Research › peer-review

2010
423 Citations (Scopus)

γh2AX: A sensitive molecular marker of DNA damage and repair

Mah, L. J., El-Osta, A. & Karagiannis, T. C., Apr 2010, In : Leukemia. 24, 4, p. 679-686 8 p.

Research output: Contribution to journal › Review Article › Research › peer-review

63 Citations (Scopus)

γH2AX as a molecular marker of aging and disease

Mah, L. J., El-Osta, A. & Karagiannis, T. C., 2010, In : Epigenetics. 5, 2, p. 129-136 8 p.

Research output: Contribution to journal › Review Article › Research › peer-review

2007
32 Citations (Scopus)

Chromatin modifications and DNA double-strand breaks: The current state of play

Karagiannis, T. C. & El-Osta, A., 1 Jan 2007, In : Leukemia. 21, 2, p. 195-200 6 p.

Research output: Contribution to journal › Review Article › Research › peer-review

87 Citations (Scopus)

Will broad-spectrum histone deacetylase inhibitors be superseded by more specific compounds?

Karagiannis, T. C. & El-Osta, A., 1 Jan 2007, In : Leukemia. 21, 1, p. 61-65 5 p.

Research output: Contribution to journal › Review Article › Research › peer-review

2006
31 Citations (Scopus)

Clinical potential of histone deacetylase inhibitors as stand alone therapeutics and in combination with other chemotherapeutics or radiotherapy for cancer

Karagiannis, T. C. & El-Osta, A., 1 Jan 2006, In : Epigenetics. 1, 3, p. 121-126 6 p.

Research output: Contribution to journal › Review Article › Research › peer-review

70 Citations (Scopus)

Modulation of cellular radiation responses by histone deacetylase inhibitors

Karagiannis, T. C. & El-Osta, A., 29 Jun 2006, In : Oncogene. 25, 28, p. 3885-3893 9 p.

Research output: Contribution to journal › Review Article › Research › peer-review

31 Citations (Scopus)

The paradox of histone deacetylase inhibitor-mediated modulation of cellular responses to radiation

Karagiannis, T. C. & El-Osta, A., 1 Feb 2006, In : Cell Cycle. 5, 3, p. 288-295 8 p.

Research output: Contribution to journal › Review Article › Research › peer-review

2005
107 Citations (Scopus)

RNA interference and potential therapeutic applications of short interfering RNAs

Karagiannis, T. C. & El-Osta, A., 1 Oct 2005, In : Cancer Gene Therapy. 12, 10, p. 787-795 9 p.

Research output: Contribution to journal › Review Article › Research › peer-review

2004
62 Citations (Scopus)

Double-strand breaks: Signaling pathways and repair mechanisms

Karagiannis, T. C. & El-Osta, A., 1 Sep 2004, In : Cellular and Molecular Life Sciences. 61, 17, p. 2137-2147 11 p.

Research output: Contribution to journal › Review Article › Research › peer-review

7 Citations (Scopus)

Epigenetic changes activate widespread signals in response to double-strand breaks

Karagiannis, T. C. & El-Osta, A., 1 Jan 2004, In : Cancer Biology and Therapy. 3, 7, p. 617-623 7 p.

Research output: Contribution to journal › Review Article › Research › peer-review

24 Citations (Scopus)

siRNAs: Mechanism of RNA interference, in vivo and potential clinical applications

Karagiannis, T. C. & El-Osta, A., 1 Jan 2004, In : Cancer Biology and Therapy. 3, 11

Research output: Contribution to journal › Review Article › Research › peer-review