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Research Output 2004 2017

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2017
4 Citations (Scopus)

Systems approach to the pharmacological actions of HDAC inhibitors reveals EP300 activities and convergent mechanisms of regulation in diabetes

Rafehi, H., Kaspi, A., Ziemann, M., Okabe, J., Karagiannis, T. C. & El-Osta, A., 2 Nov 2017, In : Epigenetics. 12, 11, p. 991-1003 13 p.

Research output: Contribution to journalArticleResearchpeer-review

2016
3 Citations (Scopus)

Strand breakage by decay of DNA-bound 124I provides a basis for combined PET imaging and Auger endoradiotherapy

Lobachevsky, P., Clark, G. R., Pytel, P. D., Leung, B., Skene, C., Andrau, L., White, J. M., Karagiannis, T., Cullinane, C., Lee, B. Q., Stuchbery, A., Kibedi, T., Hicks, R. J. & Martin, R. F., Nov 2016, In : International Journal of Radiation Biology. 92, 11, p. 686-697 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2015
74 Citations (Scopus)

Dietary sulforaphane in cancer chemoprevention: the role of epigenetic regulation and HDAC inhibition

Tortorella, S., Royce, S. G., Licciardi, P. V. & Karagiannis, T. C., 2015, In : Antioxidants and Redox Signaling. 22, 16, p. 1382 - 1424 43 p.

Research output: Contribution to journalArticleResearchpeer-review

Exploration of mechanisms in nutriepigenomics: Identification of chromatin-modifying compounds from Olea Europaea

Bonvino, N. P., Ray, N. B., Luu, V. T., Liang, J., Hung, A. & Karagiannis, T., Sep 2015, In : Hellenic Journal of Nuclear Medicine. 18, Suppl 1, p. 51-62 12 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

RNA sequencing supports distinct reactive oxygen species-mediated pathways of apoptosis by high and low size mass fractions of Bay leaf (Lauris nobilis) in HT-29 cells

Rodd, A. L., Ververis, K., Sayakkarage, D., Khan, A. W., Rafehi, H., Ziemann, M., Loveridge, S. J., Lazarus, R., Kerr, C. A., Lockett, T., El-Osta, A., Karagiannis, T. C. & Bennett, L. E., 2015, In : Food & Function. 6, 8, p. 2507-2524 18 p.

Research output: Contribution to journalArticleResearchpeer-review

2014

Biological effects of the olive polyphenol, hydroxytyrosol: An extra view from genome-wide transcriptome analysis

Ververis, K., Bollu, S., Rodd, A. L., Swarup, O., Karagiannis, T. & Nan, J. N., 2014, In : Journal of Nuclear Medicine. 17, Suppl 1, p. 62-69 8 p.

Research output: Contribution to journalArticleResearchpeer-review

58 Citations (Scopus)

Derivative of bardoxolone methyl, dh404, in an inverse dose-dependent manner lessens diabetes-Associated atherosclerosis and improves diabetic kidney disease

Tan, S. M., Sharma, A., Stefanovic, N., Yuen, D. Y. C., Karagiannis, T. C., Meyer, C., Ward, K. W., Cooper, M. E. & De Haan, J. B., Sep 2014, In : Diabetes. 63, 9, p. 3091-3103 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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9 Citations (Scopus)

Histone deacetylase inhibitors potentiate photochemotherapy in cutaneous T-cell lymphoma MyLa cells

Sung, J. J., Ververis, K. & Karagiannis, T. C., 5 Feb 2014, In : Journal of Photochemistry and Photobiology B: Biology. 131, p. 104-112 9 p.

Research output: Contribution to journalArticleResearchpeer-review

37 Citations (Scopus)

Oropharyngeal dysphagia, free water protocol and quality of life: An update from a prospective clinical trial

Karagiannis, M. & Karagiannis, T. C., Jan 2014, In : Journal of Nuclear Medicine. 17, Suppl 1, p. 26-29 4 p.

Research output: Contribution to journalArticleResearchpeer-review

45 Citations (Scopus)

Vascular histone deacetylation by pharmacological HDAC inhibition

Rafehi, H., Balcerczyk, A., Lunke, S., Kaspi, A., Ziemann, M., Harikrishnan, K. N., Okabe, J., Khurana, I., Ooi, J., Khan, A. W., Du, X-J., Chang, L. H. C., Haviv, I., Keating, S. T., Karagiannis, T. & El-Osta, A., 2014, In : Genome Research. 24, 8, p. 1271-1284 14 p.

Research output: Contribution to journalArticleResearchpeer-review

2013
27 Citations (Scopus)

Immunomodulatory effects of histone deacetylase inhibitors

Licciardi, P. V., Ververis, K., Tang, M. L., El-Osta, A. & Karagiannis, T. C., 2013, In : Current Molecular Medicine. 13, 4, p. 640-647 8 p.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

Trefoil factor-2 reverses airway remodeling changes in allergic airways disease

Royce, S. G., Lim, C., Muljadi, R. C. M., Samuel, C. S., Ververis, K., Karagiannis, T. C., Giraud, A. S. & Tang, M. LK., 2013, In : American Journal of Respiratory Cell and Molecular Biology. 48, 1, p. 135 - 144 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2012
14 Citations (Scopus)

Combination phototherapy with a histone deacetylase inhibitor and a potent DNA-binding bibenzimidazole: Effects in haematological cell lines

Rodd, A. L., Ververis, K. & Karagiannis, T., 2012, In : Lymphoma. 2012, 13 p., 405327.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Controversies surrounding the potential use of histone deacetylase Inhibitors for the treatment of asthma

Royce, S. G., Ververis, K. & Karagiannis, T. C., 2012, In : ISRN Pulmonology. 2012, 10 p., 452307.

Research output: Contribution to journalArticleOtherpeer-review

Open Access
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Current and emerging therapeutics for cutaneous T-Cell lymphoma: Histone deacetylase inhibitors

Rodd, A. L., Ververis, K. & Karagiannis, T. C., 2012, In : Lymphoma. 2012, 10 p., 290685.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
15 Citations (Scopus)

Effects of the histone deacetylase inhibitor, trichostatin A, in a chronic allergic airways disease model in mice

Royce, S. G., Dang, W., Yuan, G. Y., Tran, J., El-Osta, A., Karagiannis, T. & Tang, M. L. K., Aug 2012, In : Archivum Immunologiae et Therapiae Experimentalis. 60, 4, p. 295-306 12 p.

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)

Epigenetic mechanisms in the pathogenesis of diabetic foot ulcers

Rafehi, H., El-Osta, A. & Karagiannis, T. C., 2012, In : Journal of Diabetes and its Complications. 26, 6, p. 554-561 8 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)
15 Citations (Scopus)

Histone deacetylases and their role in asthma

Royce, S. G. & Karagiannis, T. C., 2012, In : Journal of Asthma. 49, 2, p. 121 - 128 8 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Influence of natural and synthetic histone deacetylase inhibitors on chromatin

Licciardi, P. V., Kwa, F., Ververis, K., Di Costanzo, N., Balcerczyk, A., Tang, M. L., El-Osta, A. & Karagiannis, T. C., 2012, In : Antioxidants and Redox Signaling. 17, 2, p. 340-354 15 p.

Research output: Contribution to journalArticleResearchpeer-review

29 Citations (Scopus)

Investigation into the biological properties of the olive polyphenol, hydroxytyrosol: mechanistic insights by genome-wide mRNA-Seq analysis

Rafehi, H., Smith, A. J., Balcerczyk, A., Ziemann, M., Ooi, J., Loveridge, S. J., Baker, E. K., El-Osta, A. & Karagiannis, T. C., 2012, In : Genes and Nutrition. 7, 2, p. 343-355 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Investigation of the biological properties of Cinnulin PF in the context of diabetes: mechanistic insights by genome-wide mRNA-Seq analysis

Rafehi, H., Ververis, K., Balcerczyk, A., Ziemann, M., Ooi, J., Hu, S., Kwa, F., Loveridge, S. J., Georgiadis, G. T., El-Osta, A. & Karagiannis, T., 2012, In : Pathobiology of Aging & Age-related Diseases. 2, 1, 14 p., 11905.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
8 Citations (Scopus)

Molecular model of naphthalene-induced DNA damage in the murine lung

Karagiannis, T. C., Li, X., Tang, M. M., Orlowski, C., El-Osta, A., Tang, M. L. K. & Royce, S. G., 2012, In : Human and Experimental Toxicology. 31, 1, p. 42-50 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Overview of the classical histone deacetylase enzymes and histone deacetylase inhibitors

Ververis, K. & Karagiannis, T. C., 2012, In : ISRN Cell Biology. 2012, 12 p., 130360.

Research output: Contribution to journalArticleOtherpeer-review

Open Access
File

Potential of chromatin modifying compounds for the treatment of Alzheimer's disease

Karagiannis, T. & Ververis, K., 20 Feb 2012, In : Pathobiology of Aging & Age-related Diseases. 2012, 2, p. 1-8 8 p., PMC3417541.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Regulation of immune responses by histone deacetylase inhibitors

Licciardi, P. V. & Karagiannis, T. C., 2012, In : ISRN Hematology. 2012, 10 p., 690901.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2011
80 Citations (Scopus)

Clonogenic assay: Adherent cells

Rafehi, H., Orlowski, C., Georgiadis, G. T., Ververis, K., El-Osta, A. & Karagiannis, T. C., Mar 2011, In : Journal of Visualized Experiments. 49, 4 p., e2573.

Research output: Contribution to journalArticleOtherpeer-review

22 Citations (Scopus)

Effects of oral intake of water in patients with oropharyngeal dysphagia

Karagiannis, M. JP., Chivers, L. & Karagiannis, T. C., Mar 2011, In : BMC Geriatrics. 11, 9.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
36 Citations (Scopus)

Genetic and epigenetic events in diabetic wound healing

Rafehi, H., El-Osta, A. & Karagiannis, T. C., 2011, In : International Wound Journal. 8, 1, p. 12 - 21 10 p.

Research output: Contribution to journalArticleResearchpeer-review

126 Citations (Scopus)

Genome-wide analysis distinguishes hyperglycemia regulated epigenetic signatures of primary vascular cells

Pirola, L., Balcerczyk, A., Tothill, R. W., Haviv, I., Kaspi, A., Lunke, S., Ziemann, M., Karagiannis, T., Tonna, S., Kowalczyk, A., Beresford-Smith, B., Macintyre, G., Kelong, M., Hongyu, Z., Zhu, J. & El-Osta, A., Oct 2011, In : Genome Research. 21, 10, p. 1601-1615 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Histone deacetylase inhibition and dietary short-chain fatty acids

Licciardi, P. V., Ververis, K. & Karagiannis, T. C., 2011, In : ISRN Allergy. 2011, 8 p., 869647.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
13 Citations (Scopus)

Histone deacetylase inhibitors augment doxorubicin-induced DNA damage in cardiomyocytes

Ververis, K., Rodd, A. L., Tang, M. M., El-Osta, A. & Karagiannis, T. C., Dec 2011, In : Cellular and Molecular Life Sciences. 68, 24, p. 4101-4114 14 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Photosensitization by iodinated DNA minor groove binding ligands: Evaluation of DNA double-strand break induction and repair

Briggs, B., Ververis, K., Rodd, A. L., Foong, L. J. L., Da Silva, F. M. & Karagiannis, T. C., 3 May 2011, In : Journal of Photochemistry and Photobiology B: Biology. 103, 2, p. 145-152 8 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Protection by methylproamine of irradiated human keratinocytes correlates with reduction of DNA damage

Lobachevsky, P., Vasireddy, R., Broadhurst, S., Sprung, C., Karagiannis, T., Smith, A., Radford, I., McKay, M. & Martin, R., 2011, In : International Journal of Radiation Biology. 87, 3, p. 274 - 283 10 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

Protective effects of valproic acid against airway hyperresponsiveness and airway remodeling in a mouse model of allergic airways disease

Royce, S. G., Dang, W., Ververis, K., De Sampayo, N., El-Osta, A., Tang, M. L. K. & Karagiannis, T. C., Dec 2011, In : Epigenetics. 6, 12, p. 1463 - 1470 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Resveratrol has protective effects against airway remodeling and airway hyperreactivity in a murine model of allergic airways disease

Royce, S. G., Dang, W., Yuan, G. Y., Tran, J., El-Osta, A., Karagiannis, T. & Tang, M. LK., 2011, In : Pathobiology of Aging & Age-related Diseases. 1, 10 p., 7134.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2010
45 Citations (Scopus)

Epigenome targeting by probiotic metabolites

Licciardi, P. V., Wong, S-S., Tang, M. L. K. & Karagiannis, T. C., 2010, In : Gut Pathogens. 2, 1, 24.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Evaluation of the spatial distribution of γH2AX following ionizing radiation

Vasireddy, R. S., Tang, M. M., Mah, L-J., Georgiadis, G. T., El-Osta, A. & Karagiannis, T. C., Aug 2010, In : Journal of Visualized Experiments. 42, e2203.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Methylproamine protects against ionizing radiation by preventing DNA double-strand breaks

Sprung, C., Vasireddy, R., Karagiannis, T., Loveridge, S., Martin, R. & McKay, M., 2010, In : Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 692, 1-2, p. 49 - 52 4 p.

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)

Quantification of γH2AX foci in response to Ionising radiation

Mah, L. J., Vasireddy, R. S., Tang, M. M., Georgiadis, G. T., El-Osta, A. & Karagiannis, T. C., Apr 2010, In : Journal of Visualized Experiments. 38, e1957.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Quantitation of gammaH2AX Foci in Tissue Samples

Tang, M. M., Mah, L-J., Vasireddy, R. S., Georgiadis, G. T., El-Osta, A., Royce, S. G. & Karagiannis, T., 2010, In : Journal of Visualized Experiments. 2010, 40, p. 1 - 3 3 p.

Research output: Contribution to journalArticleResearchpeer-review

29 Citations (Scopus)

Trichostatin A accentuates doxorubicin-induced hypertrophy in cardiac myocytes

Karagiannis, T. C., Lin, A. J. E., Ververis, K., Chang, L., Tang, M. M., Okabe, J. & El-Osta, A., Oct 2010, In : Aging. 2, 10, p. 659-668 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
19 Citations (Scopus)

γ-radiation-induced γh2AX formation occurs preferentially in actively transcribing euchromatic loci

Vasireddy, R. S., Karagiannis, T. C. & El-Osta, A., Jan 2010, In : Cellular and Molecular Life Sciences. 67, 2, p. 291-294 4 p.

Research output: Contribution to journalArticleResearchpeer-review

2008
41 Citations (Scopus)

Effect of valproic acid on radiation-induced DNA damage in euchromatic and heterochromatic compartments

Harikrishnan, K. N., Karagiannis, T. C., Chow, M. Z. & El-Osta, A., 15 Feb 2008, In : Cell Cycle. 7, 4, p. 468-476 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2007
50 Citations (Scopus)

Disparity of histone deacetylase inhibition on repair of radiation-induced DNA damage on euchromatin and constitutive heterochromatin compartments

Karagiannis, T. C., Kn, H. & El-Osta, A., 7 Jun 2007, In : Oncogene. 26, 27, p. 3963-3971 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2006
12 Citations (Scopus)

Receptor-mediated DNA-targeted photoimmunotherapy

Karagiannis, T. C., Lobachevsky, P. N., Leung, B. K. Y., White, J. M. & Martin, R. F., 2006, In : Cancer Research. 66, 21, p. 10548 - 10552 5 p.

Research output: Contribution to journalArticleResearchpeer-review

35 Citations (Scopus)

The epigenetic modifier, valproic acid, enhances radiation sensitivity

Karagiannis, T. C., Kn, H. & El-Osta, A., 1 Jan 2006, In : Epigenetics. 1, 3, p. 131-137 7 p.

Research output: Contribution to journalArticleResearchpeer-review