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Personal profile


Dr Merson completed his PhD at the Walter & Eliza Hall Institute for Medical Research in 2006, demonstrating the critical role of epigenetics in the regulation of neural stem cell function and adult neurogenesis. He then took up a postdoctoral position within the Multiple Sclerosis Group at the Howard Florey Institute and was awarded a Betty Cuthbert Training Fellowship (2007-2010) jointly funded by the NHMRC and Multiple Sclerosis Research Australia. In 2013, he established his own laboratory within the Multiple Sclerosis Division at the Florey Institute of Neuroscience and Mental Health and in the same year, was awarded a Melbourne Neuroscience Institute Fellowship. In 2016, he was awarded an ARC Future Fellowship and appointed Group Leader in MS Research at the Australian Regenerative Medicine Institute, Monash Univerity. His research examines the life cycle of the oligodendrocyte, the cell type responsible for myelination within the central nervous system focusing on how oligodendrocytes are generated during development, how they are regenerated after injury and their role in supporting the function of axons.


  • Myelination
  • Oligodendrocytes
  • Multiple Sclerosis (MS)
  • Neural stem cell
  • Remyelination
  • Axonal degeneration
  • Demyelination
  • Oligodendrocyte progenitor cells (OPCs)
  • Neural Plasticity

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Projects 2011 2022

Research Output 2001 2019

Amyloid precursor protein and amyloid precursor-like protein 2 have distinct roles in modulating myelination, demyelination, and remyelination of axons

Truong, P. H., Ciccotosto, G. D., Merson, T. D., Spoerri, L., Chuei, M. J., Ayers, M., Xing, Y. L., Emery, B. & Cappai, R., Mar 2019, In : GLIA. 67, 3, p. 525-538 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Pharmacogenetic stimulation of neuronal activity increases myelination in an axon-specific manner

Mitew, S., Gobius, I., Fenlon, L. R., McDougall, S. J., Hawkes, D., Xing, Y. L., Bujalka, H., Gundlach, A. L., Richards, L. J., Kilpatrick, T. J., Merson, T. D. & Emery, B., 1 Dec 2018, In : Nature Communications. 9, 1, 16 p., 306.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Axonal activity-dependent myelination in development: Insights for myelin repair

Mitew, S., Xing, Y. L. & Merson, T. D., 1 Oct 2016, In : Journal of Chemical Neuroanatomy. 76, p. 2-8 7 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Evidence for cooperative selection of axons for myelination by adjacent oligodendrocytes in the optic nerve

Walsh, D. M., Merson, T. D., Landman, K. A. & Hughes, B. D., 1 Nov 2016, In : PLoS ONE. 11, 11, 9 p., e0165673.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

In vivo whole brain, cellular and molecular imaging in nonhuman primate models of neuropathology

Huang, L., Merson, T. D. & Bourne, J. A., 1 Jul 2016, In : Neuroscience and Biobehavioral Reviews. 66, p. 104-118 15 p.

Research output: Contribution to journalArticleResearchpeer-review