Projects per year
Personal profile
Biography
Dr Merson completed his PhD at the Walter & Eliza Hall Institute for Medical Research in 2006, demonstrating the critical role of epigenetics in the regulation of neural stem cell function and adult neurogenesis. He then took up a postdoctoral position within the Multiple Sclerosis Group at the Howard Florey Institute and was awarded a Betty Cuthbert Training Fellowship (2007-2010) jointly funded by the NHMRC and Multiple Sclerosis Research Australia. In 2013, he established his own laboratory within the Multiple Sclerosis Division at the Florey Institute of Neuroscience and Mental Health and in the same year, was awarded a Melbourne Neuroscience Institute Fellowship. In 2016, he was awarded an ARC Future Fellowship and appointed Group Leader in MS Research at the Australian Regenerative Medicine Institute, Monash Univerity. His research examines the life cycle of the oligodendrocyte, the cell type responsible for myelination within the central nervous system focusing on how oligodendrocytes are generated during development, how they are regenerated after injury and their role in supporting the function of axons.
Research area keywords
- Myelination
- Oligodendrocytes
- Multiple Sclerosis (MS)
- Neural stem cell
- Remyelination
- Axonal degeneration
- Demyelination
- Oligodendrocyte progenitor cells (OPCs)
- Neural Plasticity
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Projects
A novel discovery pipeline for regenerative therapies targeting multiple sclerosis
National Health & Medical Research Council (NHMRC)
1/01/20 → 31/12/23
Project: Research
The role of neuronal activity in promoting remyelination of the brain
1/01/17 → 31/12/18
Project: Research
Fluorescent Fish: Installation of fluorescence microscopes for screening of fluorescent transgenic animals Fish/Aqua Core
Kaslin, J., Currie, P., Lieschke, G., Ramialison, M., Bryson-Richardson, R., Keightley, C., Peleg, A., Abud, H., McGlinn, E., Merson, T., Hobbs, R., Anko, M. & Bird, P.
1/12/16 → 31/12/17
Project: Research
Ultramicroscope II: 3D Fluorescence Light-Sheet Microscopy from Macro Structure to Cellular Resolution.
Smyth, I., Merson, T., Bertram, J., Cole, T., O'Bryan, M., Oldfield, B., Medcalf, R., Rosa, M., McGlinn, E., Mitchell, C., Daly, R., Karagiannis, T. C., Kaslin, J., Warr, C., Bowman, J. & Harper, I.
1/11/16 → 31/12/17
Project: Research
Research Output
Amyloid precursor protein and amyloid precursor-like protein 2 have distinct roles in modulating myelination, demyelination, and remyelination of axons
Truong, P. H., Ciccotosto, G. D., Merson, T. D., Spoerri, L., Chuei, M. J., Ayers, M., Xing, Y. L., Emery, B. & Cappai, R., Mar 2019, In : GLIA. 67, 3, p. 525-538 14 p.Research output: Contribution to journal › Article › Research › peer-review
2
Citations
(Scopus)
Migration and Differentiation of Neural Stem Cells Diverted From the Subventricular Zone by an Injectable Self-Assembling β-Peptide Hydrogel
Motamed, S., Del Borgo, M. P., Zhou, K., Kulkarni, K., Crack, P. J., Merson, T. D., Aguilar, M-I., Finkelstein, D. I. & Forsythe, J. S., 8 Nov 2019, In : Frontiers in Bioengineering and Biotechnology. 7, 12 p., 315.Research output: Contribution to journal › Article › Research › peer-review
Open Access
File
Pharmacogenetic stimulation of neuronal activity increases myelination in an axon-specific manner
Mitew, S., Gobius, I., Fenlon, L. R., McDougall, S. J., Hawkes, D., Xing, Y. L., Bujalka, H., Gundlach, A. L., Richards, L. J., Kilpatrick, T. J., Merson, T. D. & Emery, B., 1 Dec 2018, In : Nature Communications. 9, 1, 16 p., 306.Research output: Contribution to journal › Article › Research › peer-review
Open Access
File
60
Citations
(Scopus)
Axonal activity-dependent myelination in development: Insights for myelin repair
Mitew, S., Xing, Y. L. & Merson, T. D., 1 Oct 2016, In : Journal of Chemical Neuroanatomy. 76, p. 2-8 7 p.Research output: Contribution to journal › Review Article › Research › peer-review
6
Citations
(Scopus)
Evidence for cooperative selection of axons for myelination by adjacent oligodendrocytes in the optic nerve
Walsh, D. M., Merson, T. D., Landman, K. A. & Hughes, B. D., 1 Nov 2016, In : PLoS ONE. 11, 11, 9 p., e0165673.Research output: Contribution to journal › Article › Research › peer-review
Open Access
File
3
Citations
(Scopus)