1985 …2021
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Personal profile

Biography

The endocrine system controls cell-cell communication and coordinates almost all our daily activities. Abnormalities in hormones, receptors and cell signalling pathways underpin many common diseases such as diabetes, high blood pressure and obesity. We are studying the actions of two important steroid hormones, cortisol (a glucocorticoid) and aldosterone (a mineralocorticoid) that are secreted by the adrenal gland and regulate important aspects of systemic physiology and homeostasis, in humans and other mammals. Cortisol has many homeostatic roles in a wide range of tissues both during embryogenesis, particularly the developing lung. Premature babies have underdeveloped lungs and require treatment with synthetic glucocorticoids. Glucocorticoids exert their effects by binding to the intracellular glucocorticoid and mineralocorticoid receptors, GR and MR respectively. Both are members of the nuclear receptor super-family of ligand dependent nuclear transcriptional regulators. We utilize a range of molecular, biochemical and genetic techniques in both cell-based and animal systems to investigate these cell signalling pathways and their specific roles.

Research area keywords

  • steroid receptors
  • steroids
  • lung development
  • nuclear receptors
  • SDR enzymes
  • hydroxysteroid dehydrogenases

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Projects 2002 2021

Research Output 1985 2019

1 Citation (Scopus)

Identification of Betamethasone-Regulated Target Genes and Cell Pathways in Fetal Rat Lung Mesenchymal Fibroblasts

Seow, B. K. L., McDougall, A. R. A., Short, K. L., Wallace, M. J., Hooper, S. B. & Cole, T. J., 1 Aug 2019, In : Endocrinology. 160, 8, p. 1868-1884 17 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

The science of steroids

Cole, T. J., Short, K. L. & Hooper, S. B., 1 Jun 2019, In : Seminars in Fetal and Neonatal Medicine. 24, 3, p. 170-175 6 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Glucocorticoids influence versican and chondroitin sulphate proteoglycan levels in the fetal sheep lung

McDougall, A. R. A., Fosang, A. J., Faggian, J., Wallace, M. J., Crossley, K. J., Cole, T. J. & Hooper, S. B., 20 Aug 2018, In : Respiratory Research. 19, 1, 12 p., 155.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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9 Citations (Scopus)

30 YEARS OF THE MINERALOCORTICOID RECEPTOR: Mineralocorticoid receptor null mice: Informing cell-type-specific roles

Cole, T. J. & Young, M. J., 1 Jul 2017, In : Journal of Endocrinology. 234, 1, p. T83-T92 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Essential Hormones

Cole, T. J., 2017, Tietz - Essential Textbook of Clinical Chemistry and Molecular Diagnostics. Nader, R. & Horvath, A. (eds.). 6th ed. USA: Elsevier, p. 600-608 8 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review