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Research Output 2009 2017

2017

Endosomal NOX2 oxidase exacerbates virus pathogenicity and is a target for antiviral therapy

To, E. E., Vlahos, R., Luong, R., Halls, M. L., Reading, P. C., King, P. T., Chan, C., Drummond, G. R., Sobey, C. G., Broughton, B. R. S., Starkey, M. R., van der Sluis, R., Lewin, S. R., Bozinovski, S., O'Neill, L. A. J., Quach, T., Porter, C. J. H., Brooks, D. A., O'Leary, J. & Selemidis, S., 1 Dec 2017, In : Nature Communications. 8, 1, 17 p., 69.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Neurokinin 1 receptor signaling in endosomes mediates sustained nociception and is a viable therapeutic target for prolonged pain relief

Jensen, D. D., Lieu, T., Halls, M. L., Veldhuis, N. A., Imlach, W. L., Mai, Q. N., Poole, D. P., Quach, T., Aurelio, L., Conner, J., Klein Herenbrink, C., Barlow, N., Simpson, J. S., Scanlon, M. J., Graham, B., McCluskey, A., Robinson, P. J., Escriou, V., Nassini, R., Materazzi, S. & 6 othersGeppetti, P., Hicks, G. A., Christie, M. J., Porter, C. J. H., Canals, M. & Bunnett, N. W., 31 May 2017, In : Science Translational Medicine. 9, 392, 15 p., aal3447.

Research output: Contribution to journalArticleResearchpeer-review

Glyceride-mimetic prodrugs incorporating self-immolative spacers promote lymphatic transport, avoid first-pass metabolism, and enhance oral bioavailability

Hu, L., Quach, T., Han, S., Lim, S. F., Yadav, P., Senyschyn, D., Trevaskis, N. L., Simpson, J. S. & Porter, C. J. H., 2016, In : Angewandte Chemie - International Edition. 55, 44, p. 13700 –13705 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Lymphatic transport and lymphocyte targeting of a triglyceride mimetic prodrug is enhanced in a large animal model: studies in greyhound dogs

Han, S., Hu, L., Gracia, G., Quach, T., Simpson, J. S., Edwards, G. A., Trevaskis, N. L. & Porter, C. J. H., 3 Oct 2016, In : Molecular Pharmaceutics. 13, 10, p. 3351-3361 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2015

Profiling the role of deacylation-reacylation in the lymphatic transport of a triglyceride-mimetic prodrug

Han, S., Hu, L., Quach, T., Simpson, J. S., Trevaskis, N. & Porter, C. J., 2015, In : Pharmaceutical Research. 32, 5, p. 1830-1844 15 p.

Research output: Contribution to journalArticleResearchpeer-review

2014

Galanin-3 receptor antagonism by SNAP 37889 reduces motivation to self-administer alcohol and attenuates cue-induced reinstatement of alcohol-seeking in iP rats

Ash, B. L., Quach, T., Williams, S. J., Lawrence, A. J. & Djouma, E., 2014, In : Journal of Pharmacological Sciences. 125, 2, p. 211-216 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Targeted delivery of a model immunomodulator to the lymphatic system: Comparison of alkyl ester versus triglyceride mimetic lipid prodrug strategies

Han, S., Quach, T., Hu, L., Wahab, A., Charman, W. N., Stella, V. J., Trevaskis, N., Simpson, J. S. & Porter, C. J., 2014, In : Journal of Controlled Release. 177, 1, p. 1 - 10 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2013

Intestinal bile secretion promotes drug absorption from lipid colloidal phases via induction of supersaturation

Yeap, Y. Y., Trevaskis, N., Quach, T., Tso, P., Charman, W. N. & Porter, C. J., 2013, In : Molecular Pharmaceutics. 10, 5, p. 1874 - 1889 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Total synthesis of the proposed structure of 8-deshydroxyajudazol a: A modified approach to 2,4-disubstituted oxazoles

Birkett, S., Ganame, D., Hawkins, B. C., Meiries, S., Quach, T. & Rizzacasa, M. A., 4 Jan 2013, In : Journal of Organic Chemistry. 78, 1, p. 116-123 8 p.

Research output: Contribution to journalArticleResearchpeer-review

2012

Fleetamine (3-O-α-d-glucopyranosyl-swainsonine): The synthesis of a hypothetical inhibitor of endo-α-mannosidase

Quach, T., Tsegay, S., Thompson, A. J., Kukushkin, N. V., Alonzi, D. S., Butters, T. D., Davies, G. J. & Williams, S. J., 15 Jul 2012, In : Tetrahedron Asymmetry. 23, 13, p. 992-997 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Localization of oleuropeyl glucose esters and a flavanone to secretory cavities of myrtaceae

Heskes, A. M., Goodger, J. Q. D., Tsegay, S., Quach, T., Williams, S. J. & Woodrow, I. E., 20 Jul 2012, In : PLoS ONE. 7, 7, e40856.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
2011

Copper(i)-catalyzed cycloaddition of silver acetylides and azides: Incorporation of volatile acetylenes into the triazole core

Proietti Silvestri, I., Andemarian, F., Khairallah, G. N., Wan Yap, S., Quach, T., Tsegay, S., Williams, C. M., O'Hair, R. A. J., Donnelly, P. S. & Williams, S. J., 7 Sep 2011, In : Organic and Biomolecular Chemistry. 9, 17, p. 6082-6088 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Liposomal circular Dichroism. Assignment of remote stereocenters in plakinic acids K and L from a plakortis - Xestospongia sponge association (Organic Letters (2010) 12 (1525))

Dalisay, D. S., Quach, T. & Molinski, T. F., 5 Aug 2011, In : Organic Letters. 13, 15, p. 4152 1 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

Total synthesis of 8-deshydroxyajudazol B

Birkett, S., Ganame, D., Hawkins, B. C., Meiries, S., Quach, T. & Rizzacasa, M. A., 15 Apr 2011, In : Organic Letters. 13, 8, p. 1964-1967 4 p.

Research output: Contribution to journalLetterResearchpeer-review

2010

Liposomal circular dichroism. assignment of remote stereocenters in plakinic acids K and L from a plakortis-xestospongia sponge association

Dalisay, D. S., Quach, T. & Molinski, T. F., 2 Apr 2010, In : Organic Letters. 12, 7, p. 1524-1527 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Total synthesis of enigmazole a from cinachyrella enigmatica. Bidirectional bond constructions with an ambident 2,4-disubstituted oxazole synthon

Skepper, C. K., Quach, T. & Molinski, T. F., 4 Aug 2010, In : Journal of the American Chemical Society. 132, 30, p. 10286-10292 7 p.

Research output: Contribution to journalArticleResearchpeer-review

2009

Amplification of the cotton effect of a single chromophore through liposomal ordering-stereochemical assignment of plakinic acids I and J

Dalisay, D. S., Quach, T., Nicholas, G. N. & Molinski, T. F., 2 Jun 2009, In : Angewandte Chemie - International Edition. 48, 24, p. 4367-4371 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Oxazoline-oxazinone oxidative rearrangement. Divergent syntheses of (2S,3S)-4,4,4-trifluorovaline and (2S,4S)-5,5,5-trifluoroleucine

Pigza, J. A., Quach, T. & Molinski, T. F., 7 Aug 2009, In : Journal of Organic Chemistry. 74, 15, p. 5510-5515 6 p.

Research output: Contribution to journalArticleResearchpeer-review