Projects per year
Personal profile
Biography
An internationally recognised researcher in experimental medicine, Dr Tapmeier joined the Ritchie Centre in August 2020 to investigate endometriosis and uterine fibroids, conditions affecting millions of women. Symptoms include severe pain, abnormal uterine bleeding, infertility and miscarriages, and new avenues of diagnosis and treatment are urgently needed.
Dr Tapmeier completed his PhD in Transplantation Immunology on the “Role of CD4+ T cells in renal fibrosis” at King’s College London in 2009 and went to the University of Oxford for post-doctoral studies in cancer immunology funded by the Medical Research Council (MRC) and Cancer Research UK (CRUK). Having improved upon the existing unilateral ureteric obstruction (UUO) model of kidney disease in mice while at King’s College London, he established an intravital imaging system at Oxford to observe vascular developments in murine tumours. He also researched novel pH-based diagnostic probes (pHLIP) in mouse models of breast cancer.
In 2015, Dr Tapmeier joined the Oxford – Bayer Alliance for Women’s Health to research new avenues of treatment in endometriosis and uterine fibroids at the Endometriosis CaRe Centre within the Nuffield Department of Women’s & Reproductive Health. There, he wrote the protocol for a study into the biology of uterine fibroids and endometriosis, the “Fibroids and Endometriosis Oxford” (FENOX) study (2018 – 2028, ISRCTN 13560263). His research into exosomes within peritoneal fluid was presented at the 13th World Congress on Endometriosis (WCE) 2017 in Vancouver and is the subject of his DPhil student’s thesis at Oxford, Dr Hannah Nazri.
In 2019, Dr Tapmeier relocated to the ANU at Canberra as an Honorary Lecturer in Cancer Biology and joined the ANU’s COVID-19 response as a volunteer from March 2020 onwards.
Dr Tapmeier won the Sarah Agboolah Studentship for his PhD studies in London, travel bursaries from Amgen to attend the Renal Week meetings, and funding for lab exchanges with TcLand in Nantes, France (KCL, UK) and with Bayer AG in Berlin, Germany (MRC, UK). He won a grant for his research into exosomes from the Medical Sciences Division of the University of Oxford, and an industry collaborative grant from the Oxford – Bayer Alliance to lead the investigation into angiogenesis mechanisms in uterine fibroids. He is named as contributor to IP and patents within the Alliance.
He is a member of the European Society of Human Reproduction and Embryology (ESHRE) and a reviewer for Fertility & Sterility, the Journal of Extracellular Vesicles, for Experimental and Molecular Pathology, and for the Journal of Translational Medicine.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Immunology, PhD, The Role of T Cells in Renal Fibrosis, King's College London
16 Oct 2005 → 2 Feb 2009
Award Date: 2 Feb 2009
Humanbiologie, Diplom, Analyse von Chromatinveränderungen am IL-12p40-Promotor nach Aktivierung durch Toll-like-Rezeptor-abhängige mikrobielle Stimuli, Philipps-Universitat Marburg (Philipps University of Marburg)
16 Oct 1997 → 3 Feb 2003
Award Date: 3 Feb 2003
External positions
Visiting Fellow, University of Oxford
11 Apr 2019 → …
Research area keywords
- Endometriosis, Immunology, Cancer, Uterine Fibroids
Collaborations and top research areas from the last five years
Projects
- 1 Finished
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TIA voucher for MedChem on NPSR1 Antagonist in Endometriosis
Therapeutic Innovation Australia Limited
29/08/22 → 28/08/23
Project: Research
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The over-activated peritoneal immune environment in endometriosis is characterised by a lack of PD-1 inhibition
Tresso, A., Thota, N., James, C., Borash, N., Brennan, E., Bayat, S., Vollenhoven, B. & Tapmeier, T., 2 Sept 2024, 17 p. bioRxiv.Research output: Other contribution › Research
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A macrophage is a macrophage is a macrophage-in metastasis
Tapmeier, T. T., 6 Jun 2023, In: Oncotarget. 14, p. 561-562 2 p.Research output: Contribution to journal › Editorial › Other › peer-review
Open Access -
The role of small extracellular vesicle-miRNAs in endometriosis
Nazri, H. M., Greaves, E., Quenby, S., Dragovic, R., Tapmeier, T. T. & Becker, C. M., 4 Dec 2023, In: Human Reproduction. 38, 12, p. 2296-2311 16 p.Research output: Contribution to journal › Review Article › Research › peer-review
Open Access8 Citations (Scopus) -
Evolving polarisation of infiltrating and alveolar macrophages in the lung during metastatic progression of melanoma suggests CCR1 as a therapeutic target
Tapmeier, T. T., Howell, J. H., Zhao, L., Papiez, B. W., Schnabel, J. A., Muschel, R. J. & Gal, A., 14 Oct 2022, In: Oncogene. 41, 46, p. 5032-5045 14 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access11 Citations (Scopus) -
Small extracellular vesicles (sEV) in peritoneal fluid and peripheral blood as biomarkers of endometriosis
Farley, J., Steele, J., Shah, A., Schittenhelm, R. & Tapmeier, T., Jul 2022, In: Human Reproduction. 37, S1, p. i15-i16 2 p., O-028.Research output: Contribution to journal › Meeting Abstract
Open Access
Press/Media
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Endometriosis: gene identified which could be potential treatment target – new study
6/09/21
1 Media contribution
Press/Media: Article/Feature
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New insights into endometriosis, predicting RNA folding, and the surprising career of the spirometer
26/08/21
1 Media contribution
Press/Media: Blogs, Podcasts and Social Media › Podcasts
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Inflammation gene may be possible drug target for endometriosis
25/08/21
1 item of Media coverage
Press/Media: Profile/Interview
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Peritoneal fluid exosomes as potential biomarkers for endometriosis: mind and bridge the gap between innovation and validation/development into benefit for patients
1/02/20
1 item of Media coverage
Press/Media: Expert Comment