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Research Output

2019

Central metabolic interactions of immune cells and microbes: prospects for defeating infections

Traven, A. & Naderer, T., 1 Jul 2019, In : EMBO Reports. 20, 7, 17 p., e47995.

Research output: Contribution to journalReview ArticleResearchpeer-review

1 Citation (Scopus)
2018

Glucose Homeostasis Is Important for Immune Cell Viability during Candida Challenge and Host Survival of Systemic Fungal Infection

Tucey, T. M., Verma, J., Harrison, P. F., Snelgrove, S. L., Lo, T. L., Scherer, A. K., Barugahare, A. A., Powell, D. R., Wheeler, R. T., Hickey, M. J., Beilharz, T. H., Naderer, T. & Traven, A., 1 May 2018, In : Cell Metabolism. 27, 5, p. 988-1006.e7 27 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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24 Citations (Scopus)

Leishmania mexicana can utilize amino acids as major carbon sources in macrophages but not in animal models

Saunders, E. C., Naderer, T., Chambers, J., Landfear, S. M. & McConville, M. J., 1 Apr 2018, In : Molecular Microbiology. 108, 2, p. 143-158 16 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Outer membrane vesicles from Neisseria gonorrhoeae target PorB to mitochondria and induce apoptosis

Deo, P., Chow, S. H., Hay, I. D., Kleifeld, O., Costin, A., Elgass, K. D., Jiang, J-H., Ramm, G., Gabriel, K., Dougan, G., Lithgow, T., Heinz, E. & Naderer, T., 30 Mar 2018, In : PLoS Pathogens. 14, 3, 30 p., e1006945.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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14 Citations (Scopus)

Targeting apoptosis pathways in infections

Naderer, T. & Fulcher, M. C., 1 Feb 2018, In : Journal of leukocyte biology. 103, 2, p. 275-285 11 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

5 Citations (Scopus)

Targeting of RNA Polymerase II by a nuclear Legionella pneumophila Dot/Icm effector SnpL

Schuelein, R., Spencer, H., Dagley, L. F., Li, P., Luo, L., Stow, J. L., Abraham, G. C., Naderer, T., Gomez-Valero, L., Buchrieser, C., Sugimoto, C., Yamagishi, J., Webb, A. I., Pasricha, S. & Hartland, E. L., 1 Sep 2018, In : Cellular Microbiology. 20, 9, 44 p., e12852.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

The WD40 Protein BamB Mediates Coupling of BAM Complexes into Assembly Precincts in the Bacterial Outer Membrane

Gunasinghe, S. D., Shiota, T., Stubenrauch, C. J., Schulze, K. E., Webb, C. T., Fulcher, A. J., Dunstan, R. A., Hay, I. D., Naderer, T., Whelan, D. R., Bell, T. D. M., Elgass, K. D., Strugnell, R. A. & Lithgow, T., 29 May 2018, In : Cell Reports. 23, 9, p. 2782-2794 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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10 Citations (Scopus)
2017

Legionella pneumophila strain 130b evades macrophage cell death independent of the effector SidF in the absence of flagellin

Speir, M., Vogrin, A., Seidi, A., Abraham, G., Hunot, S., Han, Q., Dorn 11, G. W., Masters, S. L., Flavell, R. A., Vince, J. E. & Naderer, T., 16 Feb 2017, In : Frontiers in Cellular and Infection Microbiology. 7, 12 p., 35.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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7 Citations (Scopus)

SecretEPDB: A comprehensive web-based resource for secreted effector proteins of the bacterial types III, IV and VI secretion systems

An, Y., Wang, J., Li, C., Revote, J., Zhang, Y., Naderer, T., Hayashida, M., Akutsu, T., Webb, G. I., Lithgow, T. & Song, J., 23 Jan 2017, In : Scientific Reports. 7, 10 p., 41031.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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15 Citations (Scopus)

Towards re-purposing BH3-mimetics in Legionella and viral infections

Naderer, T., 2 Dec 2017, In : Expert Review of Anti-Infective Therapy. 15, 12, p. 1071-1073 3 p.

Research output: Contribution to journalEditorialOtherpeer-review

Open Access
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2016

Eliminating Legionella by inhibiting BCL-XL to induce macrophage apoptosis

Speir, M., Lawlor, K. E., Glaser, S. P., Abraham, G., Chow, S., Vogrin, A., Schulze, K. E., Schuelein, R., O'Reilly, L. A., Mason, K., Hartland, E. L., Lithgow, T., Strasser, A., Lessene, G., Huang, D. C. S., Vince, J. E. & Naderer, T., 24 Feb 2016, In : Nature Microbiology. 1, 3, 9 p., 15034.

Research output: Contribution to journalArticleResearchpeer-review

25 Citations (Scopus)

Legionella pneumophila S1P-lyase targets host sphingolipid metabolism and restrains autophagy

Rolando, M., Escoll, P., Nora, T., Botti, J., Boitez, V., Bedia, C., Daniels, C., Abraham, G., Stogios, P. J., Skarina, T., Christophe, C., Dervins-Ravault, D., Cazalet, C., Hilbi, H., Rupasinghe, T. W. T., Tull, D., McConville, M. J., Ong, S. Y., Hartland, E. L., Codogno, P. & 4 others, Levade, T., Naderer, T., Savchenko, A. & Buchrieser, C., 16 Feb 2016, In : Proceedings of the National Academy of Sciences. 113, 7, p. 1901-1906 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
54 Citations (Scopus)

Macrophage cell death in microbial infections

Chow, S. H., Deo, P. & Naderer, T., Apr 2016, In : Cellular Microbiology. 18, 4, p. 466-474 9 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

17 Citations (Scopus)

The endoplasmic reticulum-mitochondrion tether ERMES orchestrates fungal immune evasion, illuminating inflammasome responses to hyphal signals

Tucey, T. M., Verma-Gaur, J., Nguyen, J., Hewitt, V. L., Lo, T. L., Shingu-Vazquez, M., Robertson, A. A. B., Hill, J. R., Pettolino, F. A., Beddoe, T., Cooper, M. A., Naderer, T. & Traven, A., 1 May 2016, In : mSphere. 1, 3, 18 p., e00074-16.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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14 Citations (Scopus)
2015
11 Citations (Scopus)

Candida and macrophages: A deadly affair

Tucey, T., Naderer, T. & Traven, A., 2 May 2015, In : Microbiology Australia. 36, 2, p. 53-56 4 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

Open Access

Intracellular survival of leishmania major depends on uptake and degradation of extracellular matrix glycosaminoglycans by macrophages

Naderer, T., Heng, J., Saunders, E. C., Kloehn, J., Rupasinghe, T. W. T., Brown, T. J. & McConville, M. J., 2015, In : PLoS Pathogens. 11, 9, 20 p., e1005136.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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18 Citations (Scopus)
2014

Golgi-Located NTPDase1 of Leishmania major Is Required for Lipophosphoglycan Elongation and Normal Lesion Development whereas Secreted NTPDase2 Is Dispensable for Virulence

Sansom, F. M., Ralton, J. E., Sernee, M. F., Cohen, A. M., Hooker, D. J., Hartland, E. L., Naderer, T. & McConville, M. J., 18 Dec 2014, In : PLoS Neglected Tropical Diseases. 8, 12, 12 p., e3402.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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6 Citations (Scopus)

Microbial Egress: A Hitchhiker's Guide to Freedom

Traven, A. & Naderer, T., 2014, In : PLoS Pathogens. 10, 7, 4 p., e1004201.

Research output: Contribution to journalReview ArticleOtherpeer-review

Open Access
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6 Citations (Scopus)

Programmed cell death in Legionella infection

Speir, M., Vince, J. & Naderer, T., 2014, In : Future Microbiology. 9, 1, p. 107 - 118 12 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

The pathogen Candida albicans hijacks pyroptosis for escape from macrophages

Uwamahoro, N., Verma-Gaur, J., Shen, H-H., Qu, Y., Lewis, R., Lu, J., Bambery, K. R., Masters, S. L., Vince, J., Naderer, T. & Traven, A., 2014, In : mBio. 5, 2, p. 1 - 11 11 p., e00003-14.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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74 Citations (Scopus)
2013

Leishmania major Methionine Sulfoxide Reductase A Is Required for Resistance to Oxidative Stress and Efficient Replication in Macrophages

Sansom, F. M., Tang, L., Ralton, J. E., Saunders, E. C., Naderer, T. & McConville, M. J., 20 Feb 2013, In : PLoS ONE. 8, 2, e56064.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
15 Citations (Scopus)

Membrane targeting of the small myristoylated protein 2 (SMP-2) in Leishmania major

Heng, J., Saunders, E. C., Gooley, P. R., McConville, M. J., Naderer, T. & Tull, D., Jul 2013, In : Molecular and Biochemical Parasitology. 190, 1, 5 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)
2012

A bioinformatic strategy for the detection, classification and analysis of bacterial autotransporters

Celik, N., Webb, C. T., Leyton, D. L., Holt, K. E., Heinz, E., Gorrell, R. J., Kwok, T., Naderer, T., Strugnell, R. A., Speed, T. P., Teasdale, R. D., Likic, V. A. & Lithgow, T. J., 2012, In : PLoS ONE. 7, 8, 15 p., e43245.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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43 Citations (Scopus)

Acylation-dependent and-independent membrane targeting and distinct functions of small myristoylated proteins (SMPs) in Leishmania major

Tull, D., Heng, J., Gooley, P. R., Naderer, T. & McConville, M. J., 2012, In : International Journal for Parasitology. 42, 3, p. 239 - 247 9 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Calcineurin signalling in Leishmania parasites

John von Freyend, S., Naderer, T. & McConville, M., 2012.

Research output: Contribution to conferencePoster

Legionella pneumophila secretes a mitochondrial carrier protein during infection

Dolezal, P., Aili, M., Tong, J., Jiang, J-H., Marobbio, C. MT., Lee, S. F., Schuelein, R., Belluzzo, S., Binova, E., Mousnier, A., Frankel, G. M., Giannuzzi, G., Palmieri, F., Gabriel, K., Naderer, T., Hartland, E. L. & Lithgow, T. J., 2012, In : PLoS Pathogens. 8, 1 (Art. ID: e1002459), p. 1 - 13 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
43 Citations (Scopus)

LeishCyc: A Guide to Building a Metabolic Pathway Database and Visualization of Metabolomic Data

Saunders, E. C., MacRae, J. I., Naderer, T., Ng, M., McConville, M. J. & Likic, V. A., 2012, Microbial Systems Biology: Methods and Protocols. Navid, A. (ed.). 1st ed. USA: Humana Press, p. 505 - 529 25 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Other

8 Citations (Scopus)
2011

Calcineurin is required for Leishmania major stress response pathways and for virulence in the mammalian host

Naderer, T., Dandash, O. & McConville, M. J., 2011, In : Molecular Microbiology. 80, 2, p. 471 - 480 10 p.

Research output: Contribution to journalArticleResearchpeer-review

31 Citations (Scopus)

Intracellular growth and pathogenesis of Leishmania parasites

Naderer, T. & McConville, M. J., 2011, In : Essays in Biochemistry. 51, p. 81 - 95 15 p.

Research output: Contribution to journalArticleResearchpeer-review

26 Citations (Scopus)

Isotopomer Profiling of Leishmania mexicana Promastigotes Reveals Important Roles for Succinate Fermentation and Aspartate Uptake in Tricarboxylic Acid Cycle (TCA) Anaplerosis, Glutamate Synthesis, and Growth

Saunders, E., Ng, W., Chambers, J., Ng, M., Naderer, T., Kromer, J., Likic, V. & McConville, M. J., 2011, In : Journal of Biological Chemistry. 286, 31, p. 27706 - 27717 12 p.

Research output: Contribution to journalArticleResearchpeer-review

61 Citations (Scopus)

Metabolic pathways required for the intracellular survival of Leishmania

McConville, M. J. & Naderer, T., 2011, In : Annual Review of Microbiology. 6, p. 543 - 561 19 p.

Research output: Contribution to journalArticleResearchpeer-review

77 Citations (Scopus)
2010

Central carbon metabolism of Leishmania parasites

Saunders, E. C., De Souza, D. P., Naderer, T., Sernee, M. F., Ralton, J. E., Doyle, M. A., MacRae, J. I., Chambers, J. L., Heng, J., Nahid, A., Likic, V. A. & McConville, M. J., 2010, In : Parasitology. 137, 9, p. 1303 - 1313 11 p.

Research output: Contribution to journalArticleOther

42 Citations (Scopus)

Evidence that intracellular stages of Leishmania major utilize amino sugars as a major carbon source

Naderer, T., Heng, J. & McConville, M. J., 2010, In : PLoS Pathogens. 6, 12 (Art. No: e1001245), p. 1 - 10 10 p.

Research output: Contribution to journalArticleResearchpeer-review

39 Citations (Scopus)

Membrane protein SMP-1 is required for normal flagellum function in Leishmania

Tull, D., Naderer, T., Spurck, T., Mertens, H. DT., Heng, J., McFadden, G. I., Gooley, P. R. & McConville, M. J., 2010, In : Journal of Cell Science. 123, 4, p. 544 - 554 11 p.

Research output: Contribution to journalArticleResearchpeer-review

24 Citations (Scopus)
2009

Glycosylated compounds of parasitic protozoa

Heng, J., Naderer, T., Ralph, S. A. & McConville, M. J., 2009, Microbial Glycobiology. Holst, O., Brennan, P. J. & von Itzstein, M. (eds.). 1st ed. UK: Academic Press, p. 203-231 29 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

1 Citation (Scopus)
2008

Role of hexosamine biosynthesis in Leishmania growth and virulence

Naderer, T., Wee, E. & McConville, M. J., 2008, In : Molecular Microbiology. 69, 4, p. 858 - 869 12 p.

Research output: Contribution to journalArticleResearchpeer-review

28 Citations (Scopus)

The Leishmania-macrophage interaction: a metabolic perspective

Naderer, T. & McConville, M. J., 2008, In : Cellular Microbiology. 10, 2, p. 301 - 308 8 p.

Research output: Contribution to journalArticleResearchpeer-review

115 Citations (Scopus)
2007

Analysis of the Leishmania Metabolome

McConville, M. J., De Souza, D. P., Saunders, E. C., Pyke, J. S., Naderer, T., Ellis, M. A., Sernee, F. M., Ralton, J. E. & Likic, V. A., 2007, Leishmania: After the Genome. Myler, P. J. & Fasel, N. (eds.). 1st ed. UK: Ciaster Academic Press, p. 75 - 106 32 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

Conserved motifs reveal details of ancestry and structure in the small TIM chaperones of the mitochondrial intermembrane space

Gentle, I. E., Perry, A. J., Alcock, F. H., Likic, V. A., Dolezal, P., Ng, E. T., Purcell, A. W., McConnville, M., Naderer, T., Chanez, A-L., Charriere, F., Aschinger, C., Schneider, A., Tokatlidis, K. & Lithgow, T. J., 2007, In : Molecular Biology and Evolution. 24, 5, p. 1149 - 1160 12 p.

Research output: Contribution to journalArticleResearchpeer-review

58 Citations (Scopus)

Living in a phagolysosome; metabolism of Leishmania amastigotes

McConville, M. J., De Souza, D. P., Saunders, E. C., Likic, V. A. & Naderer, T., 2007, In : Trends in Parasitology. 23, 8, p. 368 - 375 8 p.

Research output: Contribution to journalArticleResearchpeer-review

130 Citations (Scopus)
2006

Virulence of Leishmania major in macrophages and mice requires the gluconeogenic enzyme fructose-1,6-bisphosphatase

Naderer, T., Ellis, M. A., Sernee, M. F., De Souza, D. P., Curtis, J., Handman, E. & McConville, M. J., 2006, In : Proceedings of the National Academy of Sciences. 103, 14, p. 5502 - 5507 6 p.

Research output: Contribution to journalArticleResearchpeer-review

110 Citations (Scopus)
2004

SMP-1, a member of a new family of small myristoylated proteins in kinetoplastid parasites, is targeted to the flagellum membrane in Leishmania

Tull, D., Vince, J. E., Callaghan, J. M., Naderer, T., Spurck, T., McFadden, G. I., Currie, G., Ferguson, K., Bacic, A. & McConville, M. J., 1 Nov 2004, In : Molecular Biology of the Cell. 15, 11, p. 4775-4786 12 p.

Research output: Contribution to journalArticleResearchpeer-review

86 Citations (Scopus)

Surface determinants of Leishmania parasites and their role in infectivity in the mammalian host

Naderer, T., Vince, J. E. & McConville, M. J., 1 Sep 2004, In : Current Molecular Medicine. 4, 6, p. 649-665 17 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

103 Citations (Scopus)
2003

Evidence that Intracellular β1-2 Mannan Is a Virulence Factor in Leishmania Parasites

Ralton, J. E., Naderer, T., Piraino, H. L., Bashtannyk, T. A., Callaghan, J. M. & McConville, M. J., 17 Oct 2003, In : Journal of Biological Chemistry. 278, 42, p. 40757-40763 7 p.

Research output: Contribution to journalArticleResearchpeer-review

74 Citations (Scopus)
2002

Characterization of a Leishmania mexicana mutant defective in synthesis of free and protein-linked GPI glycolipids

Naderer, T. & McConville, M. J., 1 Jan 2002, In : Molecular and Biochemical Parasitology. 125, 1-2, p. 147-161 15 p.

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)