Projects per year
Personal profile
Biography
After completing his undergraduate studies at the University Vienna, Austria, and a Masters at the University of Nottingham, UK, Thomas Naderer obtained his PhD from the University of Melbourne, Australia in 2004. He worked as a post-doctoral scientist in the laboratory of Prof Malcolm McConville (University of Melbourne) before joining the NHMRC Program on Cellular Microbiology headed by Prof Trevor Lithgow, Monash University. In 2012 he established the macrophage-pathogen interaction group with funding from the NHMRC.
Thomas was awarded an ARC Future Fellowship in 2017, to address how host cell death, as part of the immune defense system, controls invading microbes. In 2020, Thomas joined the Monash Centre to Impact AMR and currently leads the working group on Community Action and Empowerment.
Research interests
Macrophages are the first line immune cells that destroy invading microbes and thus prevent infectious diseases. Several microbes, however, can hide within macrophages to cause disease. Our recent research, published in Nature Microbiology, has shown that drugs that kill infected macrophages prevent infectious diseases.
Several superbugs secret weapons to kill macrophages and to promote their own survival. In these cases, our research is focused in preventing macrophage death by targeting host factors with existing drugs to restore protective immunity.
We currently work on microbes that cause life-threatening pneumonia, systemic fungal infections and sexually transmitted diseases. We believe that understanding the macrophage-microbe interaction is key for the development of new treatment options.
1. Programmed cell death signalling in infections
2. Bacterial vesicles and toxins that target macrophages
3. Pathogen evasion of macrophage attack
4. Metabolic interactions between macrophages and microbes
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Collaborations and top research areas from the last five years
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Mitochondrial apoptosis signals more than death in innate immune cells
Lawlor, K. (Primary Chief Investigator (PCI)) & Naderer, T. (Chief Investigator (CI))
Australian Research Council (ARC), Monash University – Internal Department Contribution
1/01/25 → 31/12/27
Project: Research
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The mesenchymal stromal cell paradox – living cell therapy or dying therapeutic cell?
Heng, T. (Primary Chief Investigator (PCI)), Mueller, S. N. (Associate Investigator (AI)), Poon, I. (Associate Investigator (AI)), Naderer, T. (Associate Investigator (AI)), Creek, D. (Associate Investigator (AI)) & Nagy, A. (Associate Investigator (AI))
1/01/22 → 31/12/25
Project: Research
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CSIRO AMR & Nutrition Pilot Clinical Study
Lithgow, T. (Primary Chief Investigator (PCI)), Naderer, T. (Chief Investigator (CI)) & Dunse, K. (Project Manager)
8/06/22 → 8/06/23
Project: Research
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CSIRO AMR & Nutrition Pilot Clinical Study
Lithgow, T. (Primary Chief Investigator (PCI)), Naderer, T. (Chief Investigator (CI)), Dunse, K. (Project Manager), Greening, C. (Chief Investigator (CI)), Tran, C. (Chief Investigator (CI)) & Barlow, C. (Chief Investigator (CI))
8/06/22 → 8/06/23
Project: Research
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Neisseria gonorrhoeae secreted vesicles kill immune cells by disabling mitochondria
Naderer, T. (Primary Chief Investigator (PCI))
National Health and Medical Research Council (NHMRC) (Australia)
1/01/20 → 31/12/23
Project: Research
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Characterization of outer membrane vesicles released by clinical isolates of Neisseria gonorrhoeae
Dhital, S., Deo, P., Stuart, I., Huang, C., Zavan, L., Han, M.-L., Kaparakis-Liaskos, M., Ramm, G., Schittenhelm, R. B., Howden, B. & Naderer, T., Jun 2024, In: Proteomics. 24, 11, 13 p., 2300087.Research output: Contribution to journal › Article › Research › peer-review
Open Access4 Citations (Scopus) -
A1 is induced by pathogen ligands to limit myeloid cell death and NLRP3 inflammasome activation
Speir, M., Tye, H., Gottschalk, T. A., Simpson, D. S., Djajawi, T. M., Deo, P., Ambrose, R. L., Conos, S. A., Emery, J., Abraham, G., Pascoe, A., Hughes, S. A., Weir, A., Hawkins, E. D., Kong, I., Herold, M. J., Pearson, J. S., Lalaoui, N., Naderer, T. & Vince, J. E. & 1 others, , 2023, In: EMBO Reports. 24, 11, 19 p., e56865.Research output: Contribution to journal › Article › Research › peer-review
Open Access4 Citations (Scopus) -
Editorial: Understanding the effects of metabolites and trace minerals on microbes during infection
Naderer, T., Mu, A., Monteith, A. J. & Wong Fok Lung, T., 30 Aug 2023, In: Frontiers in Cellular and Infection Microbiology. 13, 4 p., 1276271.Research output: Contribution to journal › Editorial › Other › peer-review
Open Access -
FBXO11 governs macrophage cell death and inflammation in response to bacterial toxins
Jeon, Y., Chow, S. H., Stuart, I., Weir, A., Yeung, A. T., Hale, C., Sridhar, S., Dougan, G., Vince, J. E. & Naderer, T., 1 Jun 2023, In: Life Science Alliance. 6, 6, 16 p., e202201735.Research output: Contribution to journal › Article › Research › peer-review
Open Access3 Citations (Scopus) -
Correlative proteomics identify the key roles of stress tolerance strategies in Acinetobacter baumannii in response to polymyxin and human macrophages
Kho, Z. Y., Azad, M. A. K., Han, M.-L., Zhu, Y., Huang, C., Schittenhelm, R. B., Naderer, T., Velkov, T., Selkrig, J., Zhou, Q. T. & Li, J., 1 Mar 2022, In: PLoS Pathogens. 18, 3, p. e1010308 25 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access10 Citations (Scopus)
Activities
- 1 Membership of industry collaboration/ network
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Monash Antimicrobial Resistance Group (Event)
Lithgow, T. (Chair/Co-Chair), Cryle, M. (Member), Tuck, K. (Member), Traven, A. (Member), Naderer, T. (Member), Rood, J. (Member), Lyras, D. (Member), Peleg, A. (Member), Aguilar, M. (Member), Coulibaly, F. (Member), McGowan, S. (Member), Okeeffe, M. A. (Member), Belousoff, M. (Member) & Heraud, P. (Member)
1 Mar 2017 → 1 Jan 2019Activity: Industry, Government and Philanthropy Engagement and Partnerships › Membership of industry collaboration/ network
Press/Media
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Superbugs: The health threat that has failed to capture public attention, Monash Lens, 18 November 2020, https://www.monash.edu/discovery-institute/news-and-events/news/2020-articles/superbugs-the-health-threat-that-has-failed-to-capture-public-attention
Davis, M., Naderer, T. & Traven, A.
20/11/20
1 Media contribution
Press/Media: Article/Feature
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Monash study exposes key tactic used by deadly fungus
1/05/18 → 7/05/18
2 Media contributions
Press/Media: Research
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Study exposes key tactic used by deadly fungus
1/05/18
1 item of Media coverage, 1 Media contribution
Press/Media: Research