Thomas Davis

Professor

1984 …2021
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Research Output 1984 2019

2019

Amyloid Self-Assembly of hIAPP8-20 via the Accumulation of Helical Oligomers, α-Helix to β-Sheet Transition, and Formation of β-Barrel Intermediates

Sun, Y., Kakinen, A., Xing, Y., Faridi, P., Nandakumar, A., Purcell, A. W., Davis, T. P., Ke, P. C. & Ding, F., 2019, (Accepted/In press) In : Small. 10 p., 1805166.

Research output: Contribution to journalArticleResearchpeer-review

Functional Brush Poly(2-ethyl-2-oxazine)s: Synthesis by CROP and RAFT, Thermoresponsiveness and Grafting onto Iron Oxide Nanoparticles

Klein, T., Parkin, J., de Jongh, P. A. J. M., Esser, L., Sepehrizadeh, T., Zheng, G., De Veer, M., Alt, K., Hagemeyer, C. E., Haddleton, D. M., Davis, T. P., Thelakkat, M. & Kempe, K., 12 Feb 2019, (Accepted/In press) In : Macromolecular Rapid Communications. 6 p., 1800911.

Research output: Contribution to journalArticleResearchpeer-review

Nucleation of β-rich oligomers and β-barrels in the early aggregation of human islet amyloid polypeptide

Sun, Y., Kakinen, A., Xing, Y., Pilkington, E. H., Davis, T. P., Ke, P. C. & Ding, F., 1 Feb 2019, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1865, 2, p. 434-444 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Physical and toxicological profiles of human IAPP amyloids and plaques

Kakinen, A., Sun, Y., Javed, I., Faridi, A., Pilkington, E. H., Faridi, P., Purcell, A. W., Zhou, R., Ding, F., Lin, S., Ke, P. C. & Davis, T. P., 15 Jan 2019, In : Science Bulletin. 64, 1, p. 26-35 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Synthesis and identification of novel pryidazinylpyrazolone based diazo compounds as inhibitors of human islet amyloid polypeptide aggregation

Bin Farrukh, S. U., Javed, I., Ather, A. Q., Emwas, A-H., Alazmi, M., Gao, X., Chotana, G. A., Davis, T. P., Ke, P. C. & Saleem, R. S. Z., Mar 2019, In : Bioorganic Chemistry. 84, p. 339-346 8 p.

Research output: Contribution to journalArticleResearchpeer-review

2018

A tunable one-pot three-component synthesis of an 125I and Gd-labelled star polymer nanoparticle for hybrid imaging with MRI and nuclear medicine

Esser, L., Lengkeek, N. A., Moffat, B. A., Vu, M. N., Greguric, I., Quinn, J. F., Davis, T. P. & Whittaker, M. R., 7 Jul 2018, In : Polymer Chemistry. 9, 25, p. 3528-3535 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Controlling Nanomaterial Size and Shape for Biomedical Applications via Polymerization-Induced Self-Assembly

Khor, S. Y., Quinn, J. F., Whittaker, M. R., Truong, N. P. & Davis, T. P., 1 Jan 2018, (Accepted/In press) In : Macromolecular Rapid Communications. 22 p.

Research output: Contribution to journalArticleResearchpeer-review

Elucidating the Influences of Size, Surface Chemistry, and Dynamic Flow on Cellular Association of Nanoparticles Made by Polymerization-Induced Self-Assembly

Khor, S. Y., Vu, M. N., Pilkington, E. H., Johnston, A. P. R., Whittaker, M. R., Quinn, J. F., Truong, N. P. & Davis, T. P., 23 Aug 2018, In : Small. 14, 34, 13 p., 1801702.

Research output: Contribution to journalArticleResearchpeer-review

Exploiting macromolecular design to optimize the antibacterial activity of alkylated cationic oligomers

Grace, J. L., Schneider-Futschik, E. K., Elliott, A. G., Amado, M., Truong, N. P., Cooper, M. A., Li, J., Davis, T. P., Quinn, J. F., Velkov, T. & Whittaker, M. R., 25 Oct 2018, (Accepted/In press) In : Biomacromolecules. 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Graphene quantum dots against human IAPP aggregation and toxicity in vivo

Wang, M., Sun, Y., Cao, X., Peng, G., Javed, I., Kakinen, A., Davis, T. P., Lin, S., Liu, J., Ding, F. & Ke, P. C., 14 Nov 2018, In : Nanoscale. 10, 42, p. 19995-20006 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Human plasma proteome association and cytotoxicity of nano-graphene oxide grafted with stealth polyethylene glycol and poly(2-ethyl-2-oxazoline)

Wang, M., Gustafsson, O. J. R., Siddiqui, G., Javed, I., Kelly, H. G., Blin, T., Yin, H., Kent, S. J., Creek, D. J., Kempe, K., Ke, P. C. & Davis, T. P., 21 Jun 2018, In : Nanoscale. 10, 23, p. 10863-10875 13 p.

Research output: Contribution to journalArticleResearchpeer-review

In Vivo Mitigation of Amyloidogenesis through Functional-Pathogenic Double-Protein Coronae

Javed, I., Yu, T., Peng, G., Sánchez-Ferrer, A., Faridi, A., Kakinen, A., Zhao, M., Mezzenga, R., Davis, T. P., Lin, S. & Ke, P. C., 12 Sep 2018, In : Nano Letters. 18, 9, p. 5797-5804 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Minimum information reporting in bio–nano experimental literature

Faria, M., Björnmalm, M., Thurecht, K. J., Kent, S. J., Parton, R. G., Kavallaris, M., Johnston, A. P. R., Gooding, J. J., Corrie, S. R., Boyd, B. J., Thordarson, P., Whittaker, A. K., Stevens, M. M., Prestidge, C. A., Porter, C. J. H., Parak, W. J., Davis, T. P., Crampin, E. J. & Caruso, F., 1 Sep 2018, In : Nature Nanotechnology. 13, 9, p. 777-785 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Mitigating Human IAPP Amyloidogenesis In Vivo with Chiral Silica Nanoribbons

Faridi, A., Sun, Y., Okazaki, Y., Peng, G., Gao, J., Kakinen, A., Faridi, P., Zhao, M., Javed, I., Purcell, A. W., Davis, T. P., Lin, S., Oda, R., Ding, F. & Ke, P. C., 22 Nov 2018, In : Small. 14, 47, 13 p., 1802825.

Research output: Contribution to journalArticleResearchpeer-review

Nano-assemblies of cationic mPEG brush block copolymers with gadolinium polyoxotungstate [Gd(W5O18)2]9- form stable, high relaxivity MRI contrast agents

Ly, J., Li, Y., Vu, M. N., Moffat, B. A., Jack, K. S., Quinn, J. F., Whittaker, M. R. & Davis, T. P., 21 Apr 2018, In : Nanoscale. 10, 15, p. 7270-7280 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Nanoparticle-Proteome In Vitro and In Vivo

Wang, M., Gustafsson, O. J. R., Pilkington, E. H., Kakinen, A., Javed, I., Faridi, A., Davis, T. P. & Ke, P. C., 1 Jan 2018, In : Journal of Materials Chemistry B. 6, 38, p. 6026-6041 16 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Nanoscale inhibition of polymorphic and ambidextrous IAPP amyloid aggregation with small molecules

Kakinen, A., Adamcik, J., Wang, B., Ge, X., Mezzenga, R., Davis, T. P., Ding, F. & Ke, P. C., Jul 2018, In : Nano Research. 11, 7, p. 3636-3647 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Overcoming Surfactant-Induced Morphology Instability of Noncrosslinked Diblock Copolymer Nano-Objects Obtained by RAFT Emulsion Polymerization

Truong, N. P., Zhang, C., Nguyen, T. A. H., Anastasaki, A., Schulze, M. W., Quinn, J. F., Whittaker, A. K., Hawker, C. J., Whittaker, M. R. & Davis, T. P., 20 Feb 2018, In : ACS Macro Letters. 7, 2, p. 159-165 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Profiling the Serum Protein Corona of Fibrillar Human Islet Amyloid Polypeptide

Pilkington, E. H., Gustafsson, O. J. R., Xing, Y., Hernandez-Fernaud, J., Zampronio, C., Kakinen, A., Faridi, A., Ding, F., Wilson, P., Ke, P. C. & Davis, T. P., 26 Jun 2018, In : ACS Nano. 12, 6, p. 6066-6078 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Recent advances in magnetic nanoparticle-based molecular probes for hepatocellular carcinoma diagnosis and therapy

Zhang, Q., Wang, S., Qiao, R., Whittaker, M. R., Quinn, J. F., Davis, T. P. & Li, H., 1 Jan 2018, In : Current Pharmaceutical Design. 24, 21, p. 2432-2437 6 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Recent advances in the delivery of hydrogen sulfide: via a macromolecular approach

Urquhart, M. C., Ercole, F., Whittaker, M. R., Boyd, B. J., Davis, T. P. & Quinn, J. F., 21 Sep 2018, In : Polymer Chemistry. 9, 35, p. 4431-4439 9 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Serum albumin impedes the amyloid aggregation and hemolysis of human islet amyloid polypeptide and alpha synuclein

Kakinen, A., Javed, I., Faridi, A., Davis, T. P. & Ke, P. C., Sep 2018, In : Biochimica et Biophysica Acta - Biomembranes. 1860, 9, p. 1803-1809 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Understanding Effects of PAMAM Dendrimer Size and Surface Chemistry on Serum Protein Binding with Discrete Molecular Dynamics Simulations

Wang, B., Sun, Y., Davis, T. P., Ke, P. C., Wu, Y. & Ding, F., 4 Sep 2018, In : ACS Sustainable Chemistry & Engineering. 6, 9, p. 11704-11715 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Uptake and transcytosis of functionalized superparamagnetic iron oxide nanoparticles in an: In vitro blood brain barrier model

Ivask, A., Pilkington, E. H., Blin, T., Käkinen, A., Vija, H., Visnapuu, M., Quinn, J. F., Whittaker, M. R., Qiao, R., Davis, T. P., Ke, P. C. & Voelcker, N. H., 1 Feb 2018, In : Biomaterials Science. 6, 2, p. 314-323 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2017

A Decade of the Protein Corona

Ke, P. C., Lin, S., Parak, W. J., Davis, T. P. & Caruso, F., 26 Dec 2017, In : ACS Nano. 11, 12, p. 11773-11776 4 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

A hydrogel-based localized release of colistin for antimicrobial treatment of burn wound infection

Zhu, C., Zhao, J., Kempe, K., Wilson, P., Wang, J., Velkov, T., Li, J., Davis, T. P., Whittaker, M. R. & Haddleton, D. M., 2017, In : Macromolecular Bioscience. 17, 2, 7 p., 1600320.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

A traceless reversible polymeric colistin prodrug to combat multidrug-resistant (MDR) gram-negative bacteria

Zhu, C., Schneider, E. K., Wang, J., Kempe, K., Wilson, P., Velkov, T., Li, J., Davis, T., Whittaker, M. R. & Haddleton, D. M., 2017, In : Journal of Controlled Release. 259, 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Brushed Polyethylene Glycol and Phosphorylcholine as Promising Grafting Agents against Protein Binding

Wang, B., Blin, T., Kakinen, A., Ge, X., Pilkington, E. H., Quinn, J., Whittaker, M. R., Davis, T. P., Ke, P. C. & Ding, F., 3 Feb 2017, In : Biophysical Journal. 112, 3

Research output: Contribution to journalLetterOtherpeer-review

Cationic acrylate oligomers comprising amino acid mimic moieties demonstrate improved antibacterial killing efficiency

Grace, J., Elliott, A. G., Huang, J. X., Schneider, E. K., Truong Phuoc, N., Cooper, M. A., Li, J., Davis, T., Quinn, J., Velkov, T. & Whittaker, M. R., 2017, In : Journal of Materials Chemistry B. 5, 3, p. 531-536 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Cofibrillization of Pathogenic and Functional Amyloid Proteins with Gold Nanoparticles against Amyloidogenesis

Javed, I., Sun, Y., Adamcik, J., Wang, B., Kakinen, A., Pilkington, E. H., Ding, F., Mezzenga, R., Davis, T. P. & Ke, P. C., 11 Dec 2017, In : Biomacromolecules. 18, 12, p. 4316-4322 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Comb poly(oligo(2-ethyl-2-oxazoline)methacrylate)-peptide conjugates prepared by aqueous Cu(0)-mediated polymerization and reductive amination

Collins, J., Wallis, S. J., Simula, A., Whittaker, M. R., McIntosh, M. P., Wilson, P., Davis, T. P., Haddleton, D. M. & Kempe, K., 1 Jan 2017, In : Macromolecular Rapid Communications. 38, 2, 7 p., 1600534.

Research output: Contribution to journalArticleResearchpeer-review

Copolyampholytes Produced from RAFT Polymerization of Protic Ionic Liquids

Fouillet, C. C. J., Greaves, T. L., Quinn, J. F., Davis, T. P., Adamcik, J., Sani, M. A., Separovic, F., Drummond, C. J. & Mezzenga, R., 28 Nov 2017, In : Macromolecules. 50, 22, p. 8965-8978 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Differential effects of silver and iron oxide nanoparticles on IAPP amyloid aggregation

Wang, M., Kakinen, A., Pilkington, E. H., Davis, T. P. & Ke, P-C., 1 Mar 2017, In : Biomaterials Science. 5, 3, p. 485-493 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Effects of protein corona on IAPP amyloid aggregation, fibril remodelling, and cytotoxicity

Pilkington, E. H., Xing, Y., Wang, B., Kakinen, A., Wang, M., Davis, T. P., Ding, F. & Ke, P-C., 1 Dec 2017, In : Scientific Reports. 7, 1, 13 p., 2455.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Engineered hydrogen-bonded glycopolymer capsules and their interactions with antigen presenting cells

Kempe, K., Xiang, S. D., Wilson, P., Rahim, M. A., Ju, Y., Whittaker, M. R., Haddleton, D. M., Plebanski, M., Caruso, F. & Davis, T. P., 22 Feb 2017, In : ACS Applied Materials and Interfaces. 9, 7, p. 6444-6452 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Garlic-inspired trisulfide linkers for thiol-stimulated H2S release

Ercole, F., Whittaker, M. R., Halls, M. L., Boyd, B. J., Davis, T. P. & Quinn, J. F., 2017, In : Chemical Communications. 53, 57, p. 8030-8033 4 p.

Research output: Contribution to journalArticleResearchpeer-review

File

Glutathione responsive polymers and their application in drug delivery systems

Quinn, J., Whittaker, M. & Davis, T., 7 Jan 2017, In : Polymer Chemistry. 8, 1, p. 97-126 30 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Hydrolyzable Poly[Poly(Ethylene Glycol) Methyl Ether Acrylate]-Colistin Prodrugs through Copper-Mediated Photoinduced Living Radical Polymerization

Zhu, C., Schneider, E. K., Nikolaou, V., Klein, T., Li, J., Davis, T. P., Whittaker, M. R., Wilson, P., Kempe, K., Velkov, T. & Haddleton, D. M., 19 Jul 2017, In : Bioconjugate Chemistry. 28, 7, p. 1916-1924 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Implications of peptide assemblies in amyloid diseases

Ke, P. C., Sani, M. A., Ding, F., Kakinen, A., Javed, I., Separovic, F., Davis, T. P. & Mezzenga, R., 7 Nov 2017, In : Chemical Society Reviews. 46, 21, p. 6492-6531 40 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Influence of Size and Shape on the Biodistribution of Nanoparticles Prepared by Polymerization-Induced Self-Assembly

Kaga, S., Truong, N. P., Esser, L., Senyschyn, D., Sanyal, A., Sanyal, R., Quinn, J. F., Davis, T. P., Kaminskas, L. M. & Whittaker, M. R., 11 Dec 2017, In : Biomacromolecules. 18, 12, p. 3963-3970 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Light-Mediated Atom Transfer Radical Polymerization of Semi-Fluorinated (Meth)acrylates: Facile Access to Functional Materials

Discekici, E. H., Anastasaki, A., Kaminker, R., Willenbacher, J., Truong, N. P., Fleischmann, C., Oschmann, B., Lunn, D. J., Read De Alaniz, J., Davis, T. P., Bates, C. M. & Hawker, C. J., 26 Apr 2017, In : Journal of the American Chemical Society. 139, 16, p. 5939-5945 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Lipidated polymers for the stabilization of cubosomes: Nanostructured drug delivery vehicles

Grace, J. L., Alcaraz, N., Truong, N. P., Davis, T. P., Boyd, B. J., Quinn, J. F. & Whittaker, M. R., 2017, In : Chemical Communications. 53, 76, p. 10552-10555 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Lysophosphatidylcholine modulates the aggregation of human islet amyloid polypeptide

Xing, Y., Pilkington, E. H., Wang, M., Nowell, C. J., Kakinen, A., Sun, Y., Wang, B., Davis, T. P., Ding, F. & Ke, P. C., 7 Dec 2017, In : Physical Chemistry Chemical Physics. 19, 45, p. 30627-30635 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Modular photo-induced RAFT polymerised hydrogels: Via thiol-ene click chemistry for 3D cell culturing

Tan, V. T. G., Nguyen, D. H. T., Utama, R. H., Kahram, M., Ercole, F., Quinn, J. F., Whittaker, M. R., Davis, T. P. & Justin Gooding, J., 21 Oct 2017, In : Polymer Chemistry. 8, 39, p. 6123-6133 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Modulating protein amyloid aggregation with nanomaterials

Wang, B., Pilkington, E. H., Sun, Y., Davis, T. P. T., Ke, P. C. & Ding, F., 1 Sep 2017, In : Environmental Science: Nano. 4, 9, p. 1772-1783 12 p.

Research output: Contribution to journalArticleResearchpeer-review

NanoEHS beyond toxicity-focusing on biocorona

Lin, S., Mortimer, M., Chen, R., Kakinen, A., Riviere, J. E., Davis, T. P., Ding, F. & Ke, P-C., 2017, In : Environmental Science: Nano. 4, 7, p. 1433-1454 22 p.

Research output: Contribution to journalArticleResearchpeer-review

Nanotechnology in Medical Research

Mansfeld, F. M., Davis, T. P. & Kavallaris, M., 2017, Micro- and Nanotechnology in Vaccine Development: A volume in Micro and Nano Technologies. Skwarczynski, M. & Toth, I. (eds.). Oxford UK: Elsevier, p. 21-45 25 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

Nitric oxide-sensing actuators for modulating structure in lipid-based liquid crystalline drug delivery systems

Liu, Q., Hu, J., Whittaker, M. R., Davis, T. P. & Boyd, B. J., 15 Dec 2017, In : Journal of Colloid and Interface Science. 508, p. 517-524 8 p.

Research output: Contribution to journalArticleResearchpeer-review

One-Pot Synthesis of ABCDE Multiblock Copolymers with Hydrophobic, Hydrophilic, and Semi-Fluorinated Segments

Anastasaki, A., Oschmann, B., Willenbacher, J., Melker, A., Van Son, M. H. C., Truong, N. P., Schulze, M. W., Discekici, E. H., McGrath, A. J., Davis, T. P., Bates, C. M. & Hawker, C. J., 13 Nov 2017, In : Angewandte Chemie - International Edition. 56, 46, p. 14483-14487 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Plasma Proteome Association and Catalytic Activity of Stealth Polymer-Grafted Iron Oxide Nanoparticles

Wang, M., Siddiqui, G., Gustafsson, O. J. R., Käkinen, A., Javed, I., Voelcker, N. H., Creek, D. J., Ke, P. C. & Davis, T. P., 27 Sep 2017, In : Small. 13, 36, 1701528.

Research output: Contribution to journalArticleResearchpeer-review