Thomas Caradoc-Davies

Dr

20102019
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Research Output 2010 2019

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2019
4 Citations (Scopus)

Highly Potent and Selective Plasmin Inhibitors Based on the Sunflower Trypsin Inhibitor-1 Scaffold Attenuate Fibrinolysis in Plasma

Swedberg, J. E., Wu, G., Mahatmanto, T., Durek, T., Caradoc-Davies, T. T., Whisstock, J. C., Law, R. H. P. & Craik, D. J., 2019, In : Journal of Medicinal Chemistry. 62, 2, p. 552-560 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Structure and Function Characterization of the a1a2 Motifs of Streptococcus pyogenes M Protein in Human Plasminogen Binding

Quek, A. J. H., Mazzitelli, B. A., Wu, G., Leung, E. W. W., Caradoc-Davies, T. T., Lloyd, G. J., Jeevarajah, D., Conroy, P. J., Sanderson-Smith, M., Yuan, Y., Ayinuola, Y. A., Castellino, F. J., Whisstock, J. C. & Law, R. H. P., 6 Sep 2019, In : Journal of Molecular Biology. 431, 19, p. 3804-3813 10 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Tranexamic acid is an active site inhibitor of urokinase plasminogen activator

Wu, G., Mazzitelli, B. A., Quek, A. J., Veldman, M. J., Conroy, P. J., Caradoc-Davies, T. T., Ooms, L. M., Tuck, K. L., Schoenecker, J. G., Whisstock, J. C. & Law, R. H. P., 12 Mar 2019, In : Blood Advances. 3, 5, p. 729-733 5 p.

Research output: Contribution to journalArticleResearchpeer-review

2018
3 Citations (Scopus)

A Cyclic Peptide Inhibitor of the iNOS-SPSB Protein-Protein Interaction as a Potential Anti-Infective Agent

Sadek, M. M., Barlow, N., Leung, E. W. W., Williams-Noonan, B. J., Yap, B. K., Shariff, F. M., Caradoc-Davies, T. T., Nicholson, S. E., Chalmers, D. K., Thompson, P. E., Law, R. H. P. & Norton, R. S., 19 Oct 2018, In : ACS Chemical Biology. 13, 10, p. 2930-2938 9 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

The first transmembrane region of complement component-9 acts as a brake on its self-assembly

Spicer, B. A., Law, R. H. P., Caradoc-Davies, T. T., Ekkel, S. M., Bayly-Jones, C., Pang, S-S., Conroy, P. J., Ramm, G., Radjainia, M., Venugopal, H., Whisstock, J. C. & Dunstone, M. A., 15 Aug 2018, In : Nature Communications. 9, 1, 7 p., 3266.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2017
2 Citations (Scopus)

Antibodies: From novel repertoires to defining and refining the structure of biologically important targets

Conroy, P. J., Law, R. H. P., Caradoc-Davies, T. T. & Whisstock, J. C., 1 Mar 2017, In : Methods. 116, p. 12-22 11 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

Parallel and antiparallel cyclic d/l peptide nanotubes

Silk, M. R., Newman, J., Ratcliffe, J. C., White, J. F., Caradoc-Davies, T., Price, J. R., Perrier, S., Thompson, P. E. & Chalmers, D. K., 2017, In : Chemical Communications. 53, 49, p. 6613-6616 4 p.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

Structural basis of autoregulatory scaffolding by apoptosis signal-regulating kinase 1

Weijman, J. F., Kumar, A., Jamieson, S. A., King, C. M., Caradoc-Davies, T. T., Ledgerwood, E. C., Murphy, J. M. & Mace, P. D., 14 Mar 2017, In : Proceedings of the National Academy of Sciences. 114, 11, p. E2096-E2105 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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5 Citations (Scopus)

X-ray crystal structure of plasmin with tranexamic acid–derived active site inhibitors

Law, R. H. P., Wu, G., Leung, E. W. W., Hidaka, K., Quek, A. J., Caradoc-Davies, T. T., Jeevarajah, D., Conroy, P. J., Kirby, N. M., Norton, R. S., Tsuda, Y. & Whisstock, J. C., 9 May 2017, In : Blood Advances. 1, 12, p. 766-771 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2016
15 Citations (Scopus)

A pipeline for structure determination of in vivo-grown crystals using in cellulo diffraction

Boudes, M., Garriga, D., Fryga, A., Caradoc-Davies, T. & Coulibaly, F., 2016, In : Acta Crystallographica Section D: Structural Biology. 72, 4, p. 576-585 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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32 Citations (Scopus)

High-density grids for efficient data collection from multiple crystals

Baxter, E. L., Aguila, L., Alonso-Mori, R., Barnes, C. O., Bonagura, C. A., Brehmer, W., Brunger, A. T., Calero, G., Caradoc-Davies, T. T., Chatterjee, R., Degrado, W. F., Fraser, J. S., Ibrahim, M., Kern, J., Kobilka, B. K., Kruse, A. C., Larsson, K. M., Lemke, H. T., Lyubimov, A. Y., Manglik, A. & 13 others, McPhillips, S. E., Norgren, E., Pang, S. S., Soltis, S. M., Song, J., Thomaston, J., Tsai, Y., Weis, W. I., Woldeyes, R. A., Yachandra, V., Yano, J., Zouni, A. & Cohen, A. E., 2016, In : Acta Crystallographica Section D: Structural Biology. D72, p. 2-11 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2015
54 Citations (Scopus)

Conformational changes during pore formation by the perforin-related protein pleurotolysin

Lukoyanova, N., Kondos, S. C., Farabella, I., Law, R. H. P., Reboul, C. F., Caradoc-Davies, T. T., Spicer, B., Kleifeld, O., Traore, D. A. K., Ekkel, S. M., Voskoboinik, I., Trapani, J. A., Hatfaludi, T. Z., Oliver, K., Hotze, E. M., Tweten, R. K., Whisstock, J. C., Topf, M., Saibil, H. R. & Dunstone, M. A., 2015, In : PLoS Biology. 13, 2, 15 p., e1002049.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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106 Citations (Scopus)

MX1: A bending-magnet crystallography beamline serving both chemical and macromolecular crystallography communities at the Australian Synchrotron

Cowieson, N. P., Aragao, D., Clift, M., Ericsson, D. J., Gee, C. L., Harrop, S. J., Mudie, N., Panjikar, S., Price, J. R., Riboldi-Tunnicliffe, A., Williamson, R. & Caradoc-Davies, T., 2015, In : Journal of Synchrotron Radiation. 22, 1, p. 187-190 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2014
19 Citations (Scopus)

Operation of the Australian Store.Synchrotron for macromolecular crystallography

Meyer, G. R., Aragao, D., Mudie, N. J., Caradoc-Davies, T. T., McGowan, S., Bertling, P. J., Groenewegen, D., Quenette, S. M., Bond, C. S., Buckle, A. M. & Androulakis, S. G., 2014, In : Acta Crystallographica Section D: Biological Crystallography. 70, 10, p. 2510 - 2519 10 p.

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)

Reconciling the structural attributes of avian antibodies

Conroy, P., Law, R. H. P., Gilgunn, S., Hearty, S., Caradoc-Davies, T. T., Lloyd, G., O'Kennedy, R. & Whisstock, J., 2014, In : Journal of Biological Chemistry. 289, 22, p. 15384 - 15392 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2013
7 Citations (Scopus)

Chiral edge-shared octahedral chains in liskeardite, [(Al,Fe) 32(AsO4)18(OH)42(H 2O)22]52H2O, an open framework mineral with a pharmacoalumite-related structure

Grey, I. E., Mumme, W. G., Macrae, C. M., Caradoc-Davies, T., Price, J. R., Rumsey, M. S. & Mills, S. J., Dec 2013, In : Mineralogical Magazine. 77, 8, p. 3125-3135 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Combined synchrotron X-ray tomography and X-ray powder diffraction using a fluorescing metal foil

Kappen, P., Arhatari, B. D., Luu, M. B., Balaur, E. & Caradoc-Davies, T., Jun 2013, In : Review of Scientific Instruments. 84, 6, 7 p., 063703.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Fragment screening for the modelling community: SPR, ITC, and crystallography

Dolezal, O., Doughty, L., Hattarki, M. K., Fazio, V. J., Caradoc-Davies, T. T., Newman, J. & Peat, T. S., 1 Aug 2013, In : Australian Journal of Chemistry. 66, 12, p. 1507-1517 11 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Hylbrownite, Na3MgP3O10 center dot 12H(2)O, a new triphosphate mineral from the Dome Rock Mine, South Australia: Description and crystal structure

Elliott, P., Brugger, J., Caradoc-Davies, T. T. & Pring, A., 2013, In : Mineralogical Magazine. 77, 3, p. 385 - 398 14 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

The structure of the caspase recruitment domain of BinCARD reveals that all three cysteines can be oxidized

Chen, K-E., Richards, A. A., Caradoc-Davies, T. T., Vajjhala, P. R., Robin, G., Lua, L. H. L., Hill, J. M., Schroder, K., Sweet, M. J., Kellie, S., Kobe, B. & Martin, J., May 2013, In : Acta Crystallographica Section D: Biological Crystallography. 69, 5, p. 774-784 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2012
17 Citations (Scopus)

The DINGO dataset: A comprehensive set of data for the SAMPL challenge

Newman, J., Dolezal, O., Fazio, V., Caradoc-Davies, T. & Peat, T. S., May 2012, In : Journal of Computer-Aided Molecular Design. 26, 5, p. 497-503 7 p.

Research output: Contribution to journalArticleResearchpeer-review

101 Citations (Scopus)

The x-ray crystal structure of full-length human plasminogen

Law, R. HP., Caradoc-Davies, T. T., Cowieson, N. P., Horvath, A. J., Quek, A. J., Amarante Da Encarnacao, J., Steer, D. L., Cowan, A. D., Zhang, Q., Lu, B. GC., Pike, R. N., Smith, A. I., Coughlin, P. B. & Whisstock, J. C., 2012, In : Cell Reports. 1, 3, p. 185 - 190 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
3 Citations (Scopus)

Use of a repetitive seeding protocol to obtain diffraction-quality crystals of a putative human D-xylulokinase

Bunker, R. D., Dickson, J. MJ., Caradoc-Davies, T. T., Loomes, K. M. & Baker, E. N., Oct 2012, In : Acta Crystallographica. Section F: Structural Biology Communications. 68, 10, p. 1259-1262 4 p.

Research output: Contribution to journalArticleResearchpeer-review

2011
40 Citations (Scopus)

Structural basis for hemoglobin capture by Staphylococcus aureus cell-surface protein, IsdH

Kumar, K. K., Jacques, D. A., Pishchany, G., Caradoc-Davies, T., Spirig, T., Malmirchegini, G. R., Langley, D. B., Dickson, C. F., Mackay, J. P., Clubb, R. T., Skaar, E. P., Guss, J. M. & Gell, D. A., 4 Nov 2011, In : Journal of Biological Chemistry. 286, 44, p. 38439-38447 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2010
8 Citations (Scopus)

A new mechanistic pathway under Sonogashira reaction protocol involving multiple acetylene insertions

Jones, R. C., Canty, A. J., Caradoc-Davies, T., Davies, N. W., Gardiner, M. G., Marriott, P., Ruhle, C. P. G. & Tolhurst, V. -A., 2010, In : Dalton Transactions. 39, 16, p. 3799 - 3801 3 p.

Research output: Contribution to journalArticleResearchpeer-review

27 Citations (Scopus)

Characterization of tetra-aryl benzene isomers by using preparative gas chromatography with mass spectrometry, nuclear magnetic resonance spectroscopy, and x-ray crystallographic methods

Ruhle, C., Niere, J., Morrison, P., Jones, R., Caradoc-Davies, T., Canty, A., Gardiner, M., Tolhurst, V-A. & Marriott, P., 2010, In : Analytical Chemistry. 82, 11, p. 4501 - 4509 9 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)
56 Citations (Scopus)

Structure of the Plasmodium falciparum M17 aminopeptidase and significance for the design of drugs targeting the neutral exopeptidases

McGowan, S., Oellig, C., Birru, W. A., Caradoc-Davies, T. T., Stack, C. M., Lowther, J., Skinner-Adams, T. S., Mucha, A., Kafarski, P., Grembecka, J., Trenholme, K. R., Buckle, A. M., Gardiner, D. L., Dalton, J. P. & Whisstock, J., 2010, In : Proceedings of the National Academy of Sciences. 107, 6, p. 2449 - 2454 6 p.

Research output: Contribution to journalArticleResearchpeer-review

225 Citations (Scopus)

The structural basis for membrane binding and pore formation by lymphocyte perforin

Law, R. H. P., Lukoyanova, N., Voskoboinik, I., Caradoc-Davies, T. T., Baran, K., Dunstone, M. A., D'Angelo, M., Orlova, E. V., Coulibaly, F. J., Verschoor, S., Browne, K. A., Ciccone, A., Kuiper, M. J., Bird, P. I., Trapani, J. A., Saibil, H. R. & Whisstock, J. C., 2010, In : Nature. 468, 7322, p. 447 - 451 5 p.

Research output: Contribution to journalArticleResearchpeer-review

22 Citations (Scopus)

The X-ray crystal structure of Escherichia coli succinic semialdehyde dehydrogenase; structural insights into NADP+/enzyme interactions

Langendorf, C., Key, T., Fenalti, G., Kan, W-T., Buckle, A. M., Caradoc-Davies, T. T., Tuck, K. L., Law, R. H. P. & Whisstock, J., 2010, In : PLoS ONE. 5, 2, p. 1 - 12 12 p.

Research output: Contribution to journalArticleResearchpeer-review