20082020

Research output per year

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Personal profile

Biography

Born in France, I obtained my PhD from the "Université des Alpes" in Grenoble. 

I then moved for a first postdoc at the MRC-LMB in Cambridge to learn Cryo-electron Microscopy.

Research interests

My research interests focus on understanding how large multi-modular enzymes called Non-Ribosomal Peptide Synthetases operate to assemble antibiotics. I use several structural biology techniques namely X-ray Crystallography and electron microscopy.

Education/Academic qualification

Structural Biology, Doctorate, Joseph Fourier University

Award Date: 10 Oct 2011

Research area keywords

  • Non-Ribosomal Peptide Synthetases
  • Biochemistry
  • Structural Biology

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Projects

Research Output

Cellular and structural basis of synthesis of the unique intermediate dehydro-F420-0 in mycobacteria

Grinter, R., Ney, B., Brammananth, R., Barlow, C. K., Cordero, P. R. F., Gillett, D. L., Izoré, T., Cryle, M. J., Harold, L. K., Cook, G. M., Taiaroa, G., Williamson, D. A., Warden, A. C., Oakeshott, J. G., Taylor, M. C., Crellin, P. K., Jackson, C. J., Schittenhelm, R. B., Coppel, R. L. & Greening, C., Jun 2020, In : mSystems. 5, 3, 14 p., e00389-20.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

The structure of human thyroglobulin

Coscia, F., Taler-Verčič, A., Chang, V. T., Sinn, L., O’Reilly, F. J., Izoré, T., Renko, M., Berger, I., Rappsilber, J., Turk, D. & Löwe, J., 5 Feb 2020, In : Nature. 578, p. 627-630 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Drosophila melanogaster nonribosomal peptide synthetase Ebony encodes an atypical condensation domain

Izoré, T., Tailhades, J., Hansen, M. H., Kaczmarski, J. A., Jackson, C. J. & Cryle, M. J., 19 Feb 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 8, p. 2913-2918 6 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Kistamicin biosynthesis reveals the biosynthetic requirements for production of highly crosslinked glycopeptide antibiotics

Greule, A., Izoré, T., Iftime, D., Tailhades, J., Schoppet, M., Zhao, Y., Peschke, M., Ahmed, I., Kulik, A., Adamek, M., Goode, R. J. A., Schittenhelm, R. B., Kaczmarski, J. A., Jackson, C. J., Ziemert, N., Krenske, E. H., De Voss, J. J., Stegmann, E. & Cryle, M. J., 13 Jun 2019, In : Nature Communications. 10, 1, 15 p., 2613.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
10 Citations (Scopus)

MreB filaments align along greatest principal membrane curvature to orient cell wall synthesis

Hussain, S., Wivagg, C. N., Szwedziak, P., Wong, F., Schaefer, K., Izoré, T., Renner, L. D., Holmes, M. J., Sun, Y., Bisson-Filho, A. W., Walker, S., Amir, A., Löwe, J. & Garner, E. C., 22 Feb 2018, In : eLife. 7, 36 p., e32471.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
45 Citations (Scopus)