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Research Output 1990 2018

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2018

Activation of ERBB4 in glioblastoma can contribute to increased tumorigenicity and influence therapeutic response

Donoghue, J. F., Kerr, L. T., Alexander, N. W., Greenall, S. A., Longano, A. B., Gottardo, N. G., Wang, R., Tabar, V., Adams, T. E., Mischel, P. S. & Johns, T. G., 1 Aug 2018, In : Cancers. 10, 8, 16 p., 243.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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A Pre-Clinical Assessment of the Pan-ERBB Inhibitor Dacomitinib in Pediatric and Adult Brain Tumors

Endersby, R., Whitehouse, J., Hii, H., Greenall, S. A., Johns, T. G. & Gottardo, N. G., 1 May 2018, In : Neoplasia. 20, 5, p. 432-442 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Differential Sensitivity of Human Hepatocellular Carcinoma Xenografts to an IGF-II Neutralizing Antibody May Involve Activated STAT3

Greenall, S. A., Donoghue, J., Johns, T. G. & Adams, T. E., 1 Aug 2018, In : Translational Oncology. 11, 4, p. 971-978 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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PI3K activation in neural stem cells drives tumorigenesis which can be ameliorated by targeting the cAMP response element binding protein

Daniel, P. M., Filiz, G., Brown, D. V., Christie, M., Waring, P. M., Zhang, Y., Haynes, J. M., Pouton, C., Flanagan, D., Vincan, E., Johns, T. G., Montgomery, K., Phillips, W. A. & Mantamadiotis, T., 1 Jan 2018, In : Neuro-Oncology. 20, 10, p. 1344-1355 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2017

Combination of palbociclib and radiotherapy for glioblastoma

Whittaker, S., Madani, D., Joshi, S., Chung, S. A., Johns, T., Day, B. W., Khasraw, M. & McDonald, K. L., 3 Jul 2017, In : Cell Death Discovery. 3, 6 p., 17033.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Cyclin-dependent kinase 7 is a therapeutic target in high-grade glioma

Greenall, S. A., Lim, Y. C., Mitchell, C. B., Ensbey, K. S., Stringer, B. W., Wilding, A. L., O'Neill, G. M., McDonald, K. L., Gough, D. J., Day, B. W. & Johns, T. G., 1 Jan 2017, In : Oncogenesis. 6, 5, 13 p., e336.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Development and Biological Evaluation of a Photoactivatable Small Molecule Microtubule-Targeting Agent

Döbber, A., Phoa, A. F., Abbassi, R. H., Stringer, B. W., Day, B. W., Johns, T. G., Abadleh, M., Peifer, C. & Munoz, L., 13 Apr 2017, In : A C S Medicinal Chemistry Letters. 8, 4, p. 395-400 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Dianthin-30 or gelonin versus monomethyl auristatin E, each configured with an anti-calcitonin receptor antibody, are differentially potent in vitro in high-grade glioma cell lines derived from glioblastoma

Gilabert-Oriol, R., Furness, S. G. B., Stringer, B. W., Weng, A., Fuchs, H., Day, B. W., Kourakis, A., Boyd, A. W., Hare, D. L., Thakur, M., Johns, T. G. & Wookey, P. J., 2017, In : Cancer Immunology Immunotherapy. 66, 9, p. 1217–1228 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Structural Optimization and Pharmacological Evaluation of Inhibitors Targeting Dual-Specificity Tyrosine Phosphorylation-Regulated Kinases (DYRK) and CDC-like kinases (CLK) in Glioblastoma

Zhou, Q., Phoa, A. F., Abbassi, R. H., Hoque, M., Reekie, T. A., Font, J. S., Ryan, R. M., Stringer, B. W., Day, B. W., Johns, T. G., Munoz, L. & Kassiou, M., 9 Mar 2017, In : Journal of Medicinal Chemistry. 60, 5, p. 2052-2070 19 p.

Research output: Contribution to journalArticleResearchpeer-review

2016

Axitinib has antiangiogenic and antitumorigenic activity in myxoid liposarcoma

Kerr, L. T., Donoghue, J. F., Wilding, A. L. & Johns, T. G., 2016, In : Sarcoma. 2016, 17 p., 3484673.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Incomplete target neutralization by the anti-cancer antibody rilotumumab

Greenall, S. A., Adams, T. E. & Johns, T. G., 1 Jan 2016, In : mAbs. 8, 2, p. 246-252 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Mitochondrial DNA plasticity is an essential inducer of tumorigenesis

Lee, WTY., Cain, JE., Cuddihy, AR., Dickinson, A., Yeung, K-Y., Kumar, B., Johns, TG., Watkins, DN., Spencer, A., St John, JC. & Johnson, J., 2016, In : Cell Death Discovery. 2, p. 1 - 11 11 p., 16016.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2015

Cytotoxic activity of the MK2 inhibitor CMPD1 in glioblastoma cells is independent of MK2

Gurgis, F. M. S., Akerfeldt, M. C., Heng, B., Wong, C. L., Adams, S., Guillemin, G. J., Johns, T. G., Chircop, M. & Munoz, L., 2015, In : Cell Death Discovery. 1, 11 p., 15028.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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DYRK1A in neurodegeneration and cancer: Molecular basis and clinical implications

Abbassi, R., Johns, T. G., Kassiou, M. & Munoz, L., 2015, In : Pharmacology and Therapeutics. 151, p. 87 - 98 12 p.

Research output: Contribution to journalArticleResearchpeer-review

EGFRvIII-mediated transactivation of receptor tyrosine kinases in glioma: mechanism and therapeutic implications

Greenall, S. A., Donoghue, J. F., Van Sinderen, M. L., Dubljevic, V., Budiman, S. E., Devlin, M., Street, I. P., Adams, T. E. & Johns, T. G., 2015, In : Oncogene. 34, 41, p. 5277 - 5287 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Glioma-specific Domain IV EGFR cysteine mutations promote ligand-induced covalent receptor dimerization and display enhanced sensitivity to dacomitinib in vivo

Greenall, S. A., Donoghue, J. F., Gottardo, N. G., Johns, T. G. & Adams, T. E., 26 Mar 2015, In : Oncogene. 34, 13, p. 1658 - 1666 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Mitochondrial DNA copy number is regulated by DNA methylation and demethylation of POLGA in stem and cancer cells and their differentiated progeny

Lee, W., Johnson, J. L., Gough, D. J., Donoghue, J. F., Cagnone, G., Vaghjiani, V., Brown, K. A., Johns, T. G. & St John, J. C., 2015, In : Cell Death and Disease. 6, 2 (Art. No: e1664), p. 1 - 11 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Neurosphere and adherent culture conditions are equivalent for malignant glioma stem cell lines

Rahman, M., Reyner, K., Deleyrolle, L. P., Millette, S., Azari, H., Day, B. W., Stringer, B. W., Boyd, A. W., Johns, T. G., Blot, V., Duggal, R. & Reynolds, B. A., 2015, In : Anatomy & Cell Biology. 48, 1, p. 25 - 35 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Pharmacology of novel small-molecule tubulin inhibitors in glioblastoma cells with enhanced EGFR signalling

Phoa, A. F., Browne, S., Gurgis, F. M. S., Akerfeldt, M. C., Dobber, A., Renn, C., Peifer, C., Stringer, B. W., Day, B. W., Wong, C., Chircop, M., Johns, T. G., Kassiou, M. & Munoz, L., 2015, In : Biochemical Pharmacology. 98, 4, p. 587 - 601 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Placental-specific sFLT-1 e15a protein is increased in preeclampsia, antagonizes vascular endothelial growth factor signaling, and has antiangiogenic activity

Palmer, K., Kaitu'u-Lino, T. J., Hastie, R., Hannan, N. J., Ye, L., Binder, N. K., Cannon, P. ZF., Tuohey, L., Johns, T. G., Shub, A. & Tong, S., 2015, In : Hypertension. 66, 6, p. 1251 - 1259 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Targeted drug delivery using genetically engineered diatom biosilica

Delalat, B., Sheppard, V. C., Ghaemi, S. R., Rao, S., Prestidge, C. A., McPhee, G., Rogers, M-L., Donoghue, J. F., Pillay, V., Johns, T. G., Kroger, N. & Voelcker, N., 2015, In : Nature Communications. 6, 11 p., 8791.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2014

Combination gefitinib and methotrexate treatment for non-tubal ectopic pregnancies: a case series

Horne, A. W., Skubisz, M. M., Tong, S., Duncan, W. C., Neil, P. R. L., Wallace, E. M. & Johns, T. G., 2014, In : Human Reproduction. 29, 7, p. 1375 - 1379 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Quantitative intratumoural microdistribution and kinetics of {131}-huA33 antibody in patients with colorectal carcinoma

Ciprotti, M., Chong, G., Gan, H. K., Chan, A. TW., Murone, C., MacGregor, D., Lee, F-T., Johns, T. G., Heath, J. K., Ernst, M. R., Burgess, A. & Scott, A. M., 2014, In : EJNMMI Research. 4, p. 2 - 10 9 p., 22.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

The identification of mitochondrial DNA variants in glioblastoma multiforme

Yeung, K. Y. V., Dickinson, A., Donoghue, J. F., Polekhina, G., White, S., Grammatopoulos, D. K., McKenzie, M., Johns, T. G. & St John, J. C., 2014, In : Acta neuropathologica communications. 2, p. 1 - 21 21 p., 1.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

The tumor suppressor microRNA, miR-124a, is regulated by epigenetic silencing and by the transcriptional factor, REST in glioblastoma

Tivnan, A., Zhao, J., Johns, T. G., Day, B., Stringer, B. W., Boyd, A. W., Tiwari, S., Giles, K. M., Teo, C. & McDonald, K., 2014, In : Tumor Biology. 35, 2, p. 1459 - 1465 7 p.

Research output: Contribution to journalArticleResearchpeer-review

2013

Antibody-functionalized porous silicon nanoparticles for vectorization of hydrophobic drugs

Secret, E., Smith, K., Dubljevic, V., Moore, E., Macardle, P., Delalat, B., Rogers, M-L., Johns, T. G., Durand, J-O., Cunin, F. & Voelcker, N., 2013, In : Advanced Healthcare Materials. 2, 5, p. 718 - 727 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Combination gefitinib and methotrexate compared with methotrexate alone to treat ectopic pregnancy

Skubisz, M. M., Horne, A. W., Johns, T. G., Nilsson, U. W., Duncan, W. C., Wallace, E. M., Critchley, H. O. D. & Tong, S., 2013, In : Obstetrics and Gynecology. 122, 4, p. 745 - 751 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Effects of gefitinib, an epidermal growth factor receptor inhibitor, on human placental cell growth

Nilsson, U. W., Johns, T. G., Wilmann, T. M., Kaitu'u-Lino, T. J., Whitehead, C., Dimitriadis, E., Menkhorst, E., Saglam, B., Gao, Y. E., Greenall, S. A., Horne, A. W. & Tong, S., 2013, In : Obstetrics and Gynecology. 122, 4, p. 737 - 744 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Glioma surgical aspirate: A viable source of tumor tissue for experimental research

Day, B., Stringer, B. W., Wilson, J., Jeffree, R. L., Jamieson, P. R., Ensbey, K. S., Bruce, Z. C., Inglis, P. L., Allan, S., Winter, C., Tollesson, G., Campbell, S. F., Lucas, P., Findlay, W., Kadrian, D., Johnson, D., Robertson, T., Johns, T. G., Bartlett, P., Osborne, G. W. & 1 othersBoyd, A. W., 2013, In : Cancers. 5, 2, p. 357 - 371 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Global protein profiling reveals anti-EGFR monoclonal antibody 806-modulated proteins in A431 tumor xenografts

Lee, S. T., Ji, H., Greening, D. W., Speirs, R. W. H., Rigopoulos, A., Pillay, V., Murone, C., Vitali, A., Stuhler, K., Johns, T. G., Corner, G. A., Mariadason, J. M., Simpson, R. J. & Scott, A. M., 2013, In : Growth Factors. 31, 5, p. 154-164 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Phase II single arm open label multicentre clinical trial to evaluate the efficacy and side effects of a combination of gefitinib and methotrexate to treat tubal ectopic pregnancies (GEM II): study protocol

Horne, A. W., Skubisz, M. M., Doust, A., Duncan, W. C., Wallace, E. M., Critchley, H. O. D., Johns, T. G., Norman, J. E., Bhattacharya, S., Mollison, J., Rassmusen, M. & Tong, S., 2013, In : BMJ Open. 3, 7 , p. 1 - 5 5 p.

Research output: Contribution to journalArticleOther

Targeted nanoparticle delivery of doxorubicin into placental tissues to treat ectopic pregnancies

Kaitu'u-Lino, T. J., Pattison, S., Ye, L., Tuohey, L., Sluka, P., MacDiarmid, J., Brahmbhatt, H., Johns, T. G., Horne, A. W., Brown, J. & Tong, S., 2013, In : Endocrinology. 154, 2, p. 911 - 919 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Targeting the ERBB family in cancer: couples therapy

Tebbutt, N., Pedersen, M. W. & Johns, T. G., 2013, In : Nature Reviews Cancer. 13, 9, p. 663 - 673 11 p.

Research output: Contribution to journalArticleResearchpeer-review

The epidermal growth factor receptor variant III (EGFRvIII): where wild things are altered

Gan, H. K., Cvrljevic, A. N. & Johns, T. G., 2013, In : FEBS Journal. 280, 21, p. 5350 - 5370 21 p.

Research output: Contribution to journalArticleResearchpeer-review

The regulation of mitochondrial DNA copy number in glioblastoma cells

Dickinson, A., Yeung, V. K. Y., Donoghue, J. F., Baker, M. J., Kelly, R. D. W., McKenzie, M., Johns, T. G. & St John, J. C., 2013, In : Cell Death and Differentiation. 20, 12, p. 1644 - 1653 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2012

A high-affinity ErbB4Fc fusion protein is a potent antagonist of heregulin-mediated receptor activation

Koziolek, E. J., Donoghue, J. F., Bentley, J. D., Lovrecz, G. O., Dolezal, O., Ward, C. W., Rothacker, J., Nice, E., Burgess, A. W., Hafner, M., Johns, T. G. & Adams, T. E., 2012, In : Growth Factors. 30, 5, p. 310 - 319 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Dual targeting of the epidermal growth factor receptor using the combination of cetuximab and erlotinib: preclinical evaluation and results of the phase II DUX study in chemotherapy-refractory, advanced colorectal cancer

Weickhardt, A. J., Price, T. J., Chong, G., Gebski, V., Pavlakis, N., Johns, T. G., Azad, A., Skrinos, E., Fluck, K., Dobrovic, A., Salemi, R., Scott, A. M., Mariadason, J. M. & Tebbutt, N. C., 2012, In : Journal of Clinical Oncology. 30, 13, p. 1505 - 1512 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Non-agonistic bivalent antibodies that promote c-MET degradation and inhibit tumor growth and others specific for tumor related c-MET

Greenall, S., Gherardi, E., Liu, Z., Donoghue, J. F., Vitali, A. A., Li, Q., Murphy, R., Iamele, L., Scott, A. M. & Johns, T. G., 2012, In : PLoS ONE. 7, 4, 10 p., e34658.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Phosphorylation of dedicator of cytokinesis 1 (Dock180) at tyrosine residue Y722 by Src family kinases mediates EGFRvIII-driven glioblastoma tumorigenesis

Feng, H., Hu, B., Jarzynka, M. J., Li, Y., Keezer, S., Johns, T. G., Tang, C. K., Hamilton, R. L., Vuori, K., Nishikawa, R., Sarkaria, J. N., Fenton, T., Cheng, T., Furnari, F. B., Cavenee, W. K. & Cheng, S-Y., 2012, In : Proceedings of the National Academy of Sciences. 109, 8, p. 3018 - 3023 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
2011

Activation of Src induces mitochondrial localisation of de2-7EGFR (EGFRvIII) in glioma cells: Implications for glucose metabolism

Cvrljevic, A., Akhavan, D., Wu, M., Martinello, P., Furnari, F., Johnston, A., Guo, D., Pike, L., Cavenee, W., Scott, A., Mischel, P., Hoogenraad, N. & Johns, T., 2011, In : Journal of Cell Science. 124, Pt 17, p. 2938 - 2950 13 p.

Research output: Contribution to journalArticleResearchpeer-review

A simple guide screw method for intracranial xenograft studies in mice

Donoghue, J., Bogler, O. & Johns, T., 2011, In : Journal of Visualized Experiments. 55, e3157, 5 p.

Research output: Contribution to journalArticleOther

Glioma specific extracellular missense mutations in the first cysteine rich region of Epidermal Growth Factor Receptor (EGFR) initiate ligand independent activation

Ymer, S., Greenall, S., Cvrljevic, A., Cao, D., Donoghue, J., Epa, V. C., Scott, A., Adams, T. & Johns, T., 2011, In : Cancers. 3, 2, p. 2032 - 2049 18 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
2010

Immuno-PET quantitation of de2-7 epidermal growth factor receptor expression in glioma using 124I-IMP-R4-labeled antibody ch806

Lee, F-T., O'Keefe, G. J., Gan, H. K., Mountain, A. J., Jones, G. R., Saunder, T. H., Sagona, J., Rigopoulos, A., Smyth, F. E., Johns, T. G., Govindan, S. V., Goldenberg, D. M., Old, L. J. & Scott, A. M., 2010, In : Journal of Nuclear Medicine. 51, 6, p. 967 - 972 6 p.

Research output: Contribution to journalArticleResearchpeer-review

MAb 806 enhances the efficacy of ionizing radiation in glioma xenografts expressing the de2-7 epidermal growth factor receptor

Johns, T. G., McKay, M. J., Cvrljevic, A. N., Gan, H. K., Taylor, C., Xu, H., Smyth, F. E. & Scott, A. M., 2010, In : International Journal of Radiation Oncology Biology Physics. 78, 2, p. 572 - 578 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Tumor heterogeneity is an active process maintained by a mutant EGFR-induced cytokine circuit in glioblastoma

Inda, M-M., Bonavia, R., Mukasa, A., Narita, Y., Sah, D. W. Y., Vandenberg, S., Brennan, C., Johns, T. G., Bachoo, R., Hadwiger, P., Tan, P., DePinho, R. A., Cavenee, W. K. & Furnari, F. B., 2010, In : Genes and Development. 24, 16, p. 1731 - 1745 15 p.

Research output: Contribution to journalArticleResearchpeer-review

2009

Antibodies specifically targeting a locally misfolded region of tumor associated EGFR

Garrett, T. PJ., Burgess, A. W., Gan, H. K., Luwor, R. B., Cartwright, G. A., Walker, F., Orchard, S. G., Clayton, A. H. A., Nice, E. C., Rothacker, J., Catimel, B., Cavenee, W. K., Old, L. J., Stockert, E., Ritter, G., Adams, T. E., Hoyne, P. A., Wittrup, D. D., Chao, G., Cochran, J. R. & 8 othersLuo, C. S., Lou, M., Huyton, T., Xu, Y., Fairlie, W. D., Yao, S., Scott, A. M. & Johns, T. G., 2009, In : Proceedings of the National Academy of Sciences. 106, 13, p. 5082 - 5087 6 p.

Research output: Contribution to journalArticleResearchpeer-review

A truncated soluble epidermal growth factor receptor-Fc fusion ligand trap displays anti-tumour activity in vivo

Adams, T. E., Koziolek, E. J., Hoyne, P. H., Bentley, J. D., Lu, L., Lovrecz, G. O., Ward, C. W., Lee, F. T., Scott, A. M., Nash, A., Rothacker, J., Nice, E., Burgess, A. & Johns, T. G., 2009, In : Growth Factors. 27, 3, p. 141 - 154 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Fyn and SRC are effectors of oncogenic epidermal growth factor receptor signaling in glioblastoma patients

Lu, K. V., Zhu, S., Cvrljevic, A. N., Huang, T. T., Sarkaria, S., Ahkavan, D., Dang, J., Dinca, E. B., Plaisier, S. B., Oderberg, I., Lee, Y., Chen, Z., Caldwell, J. S., Xie, Y., Loo, J. A., Seligson, D., Chakravari, A., Lee, F. Y., Weinmann, R., Cloughesy, T. F. & 8 othersNelson, S. F., Bergers, G., Graeber, T., Furnari, F. B., James, C. D., Cavenee, W. K., Johns, T. G. & Mischel, P. S., 2009, In : Cancer Research. 69, 17, p. 6889 - 6898 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Targeting a unique EGFR epitope with monoclonal antibody 806 activates NF-kappaB and initiates tumour vascular normalization

Gan, H. K., Lappas, M., Cao, D. X., Cvrljevic, A. N., Scott, A. M. & Johns, T. G., 2009, In : Journal of Cellular and Molecular Medicine. 13, 9B, p. 3993 - 4001 9 p.

Research output: Contribution to journalArticleResearchpeer-review

The plasticity of oncogene addiction: Implications for targeted therapies directed to receptor tyrosine kinases

Pillay, V., Allaf, L., Wilding, A., Donoghue, J. F., Court, N. W., Greenall, S. A., Scott, A. M. & Johns, T. G., 2009, In : Neoplasia. 11, 5, p. 448 - 458 11 p.

Research output: Contribution to journalArticleResearchpeer-review