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Research Group Head, Oncogenic Signalling Lab

Centre for Cancer Research

Hudson Institute of Medical Research

NHMRC Principal Research Fellow


After completing a PhD in 1993 at Monash University in the Department of Biochemistry, Professor Terrance Johns joined La Trobe University’s Neuroimmunology Laboratory as a Postdoctoral Fellow. During his time there, he helped develop a new model of multiple sclerosis that remains in use around the world today.

In 1998, Professor Johns commenced as a Research Fellow at the Ludwig Institute for Cancer Research and went on to establish the Oncogenic Signalling Laboratory. The main focus of this laboratory is the development of antibodies that target receptors important to the survival and growth of cancer. In particular, at the Ludwig Institute, Professor Johns was a key leader in the development of mAb 806, a novel antibody that is directed to the epidermal growth factor receptor (EGFR) and is currently in clinical trials.

Professor Johns brought his oncogenic signalling research to Monash University and the then Monash Institute of Medical Research (now Hudson Institute of Medical Research) in March 2008. He continues to develop novel antibodies designed to treat cancer, with a focus on glioma (brain cancer). In particular, his laboratory analyses the key signalling pathways associated with the growth of glioma, to guide the development of new therapeutic antibodies.

With an established track record in translational research, Professor Johns has had key roles in many clinical trials, including the CABARET trial for patients with recurrent high-grade glioma. In recent years, he has received funding from some of the world’s biggest pharmaceutical and biotech companies, including Pfizer, Roche and Amgen, for preclinical and clinical testing of drug candidates.

In 2012, he founded the Brain Cancer Discovery Collaborative, an Australia-wide consortium of researchers and clinicians dedicated to ensuring that promising therapeutic discoveries are translated into the clinic for the treatment of patients with brain cancer.

Recently, he extended his expertise in cancer therapy to developing new treatments for ectopic pregnancy, a life-threatening condition in which the fetus is implanted outside the uterus.

His recent achievements and current research interests include the following:

  • developing cancer-specific antibodies that recognise key receptor tyrosine kinases that drive cancer, such as EGFR and c-Met
  • understanding the biology and intracellular signalling properties of EGFR variants and other receptor tyrosine kinases in high-grade glioma
  • identifying mechanisms of resistance to EGFR-targeted therapies
  • designing strategies for overcoming resistance, such as dual targeting of EGFR
  • developing new treatments for diffuse intrinsic pontine glioma (DIPG), an incurable childhood cancer
  • developing new treatments for ectopic pregnancy.


Research area keywords

  • Brain Cancer
  • Glioma
  • Antibody Therapy
  • Receptor tyrosine kinases

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Research Output

Most clinical anti-EGFR antibodies do not neutralize both wtEGFR and EGFRvIII activation in glioma

Greenall, S. A., McKenzie, M., Seminova, E., Dolezal, O., Pearce, L. A., Bentley, J. D., Kuchibhotla, M., Chen, S. C., McDonald, K. L., Kornblum, H. I., Endersby, R., Adams, T. E. & Johns, T., Aug 2019, In : Neuro-Oncology. 21, 8, p. 1016-1027 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Activation of ERBB4 in glioblastoma can contribute to increased tumorigenicity and influence therapeutic response

Donoghue, J. F., Kerr, L. T., Alexander, N. W., Greenall, S. A., Longano, A. B., Gottardo, N. G., Wang, R., Tabar, V., Adams, T. E., Mischel, P. S. & Johns, T. G., 1 Aug 2018, In : Cancers. 10, 8, 16 p., 243.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
9 Citations (Scopus)

A Pre-Clinical Assessment of the Pan-ERBB Inhibitor Dacomitinib in Pediatric and Adult Brain Tumors

Endersby, R., Whitehouse, J., Hii, H., Greenall, S. A., Johns, T. G. & Gottardo, N. G., 1 May 2018, In : Neoplasia. 20, 5, p. 432-442 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
4 Citations (Scopus)

Differential Sensitivity of Human Hepatocellular Carcinoma Xenografts to an IGF-II Neutralizing Antibody May Involve Activated STAT3

Greenall, S. A., Donoghue, J., Johns, T. G. & Adams, T. E., 1 Aug 2018, In : Translational Oncology. 11, 4, p. 971-978 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
2 Citations (Scopus)

Gefitinib and Methotrexate to Treat Ectopic Pregnancies with a Pre-Treatment Serum hCG 1000–10,000 IU/L: Phase II Open Label, Single Arm Multi-Centre Trial

Skubisz, M. M., Tong, S., Doust, A., Mollison, J., Johns, T. G., Neil, P., Robinson, M., Bhattacharya, S., Wallace, E., Krzys, N., Colin Duncan, W. & Horne, A. W., Jul 2018, In : EBioMedicine. 33, p. 276-281 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
2 Citations (Scopus)