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Research Output 1991 2019

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2014
60 Citations (Scopus)

Fluorine modulates species selectivity in the triazolopyrimidine class of Plasmodium falciparum dihydroorotate dehydrogenase inhibitors

Deng, X., Kokkonda, S., El Mazouni, F., White, J., Burrows, J., Kaminsky, W., Charman, S. A., Matthews, D., Rathod, P. K. & Phillips, M. A., 2014, In : Journal of Medicinal Chemistry. 57, 12, p. 5381 - 5394 14 p.

Research output: Contribution to journalArticleResearchpeer-review

24 Citations (Scopus)

Medicinal chemistry optimization of antiplasmodial imidazopyridazine hits from high throughput screening of a SoftFocus kinase library: Part 1

Le Manach, C., Cabrera, D. G., Douelle, F., Nchinda, A. T., Younis, Y., Taylor, D., Wiesner, L., White, K. L., Ryan, E., March, C., Duffy, S., Avery, V. M., Waterson, D., Witty, M. J., Wittlin, S., Charman, S. A., Street, L. J. & Chibale, K., 2014, In : Journal of Medicinal Chemistry. 57, 6, p. 2789 - 2798 10 p.

Research output: Contribution to journalArticleResearchpeer-review

27 Citations (Scopus)

Orally bioavailable 6-chloro-7-methoxy-4(1H)-quinolones efficacious against multiple stages of Plasmodium

Cross, M., Flanigan, D. L., Monastyrskyi, A., LaCrue, A. N., Saenz, F. E., Maignan, J. R., Mutka, T. S., White, K. L., Shackleford, D., Bathurst, I. C., Fronczek, F. R., Wojtas, L., Guida, W. C., Charman, S. A., Burrows, J., Kyle, D. E. & Manetsch, R., 2014, In : Journal of Medicinal Chemistry. 57, 21, p. 8860 - 8879 20 p.

Research output: Contribution to journalArticleResearchpeer-review

65 Citations (Scopus)

Pyrazoleamide compounds are potent antimalarials that target Na+ homeostasis in intraerythrocytic Plasmodium falciparum

Vaidya, A. B., Morrisey, J. M., Zhang, Z., Das, S., Daly, T. M., Otto, T. D., Spillman, N. J., Wyvratt, M., Siegl, P., Marfurt, J., Wirjanata, G., Sebayang, B. F., Price, R. N., Chatterjee, A., Nagle, A. S., Stasiak, M., Charman, S. A., Angulo-Barturen, I., Ferrer, S. B., Jimenez-Diaz, M. B. & 11 others, Martinez, M. S., Gamo-Benito, F. J., Avery, V. M., Ruecker, A., Delves, M. J., Kirk, K., Berriman, M., Kortagere, S., Burrows, J., Fan, E. & Bergman, L. W., 2014, In : Nature Communications. 5, 5521, p. 1 - 10 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
38 Citations (Scopus)

Pyridyl benzamides as a novel class of potent inhibitors for the kinetoplastid Trypanosoma brucei

Ferrins, L., Gazdik, M., Rahmani, R. S., Varghese, S., Sykes, M. L., Jones, A. J., Avery, V. M., White, K. L., Ryan, E., Charman, S. A., Kaiser, M., Bergstrom, C. A. S. & Baell, J. B., 2014, In : Journal of Medicinal Chemistry. 57, 15, p. 6393 - 6402 10 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

Total synthesis of thiaplakortone A: Derivatives as metabolically stable leads for the treatment of malaria

Pouwer, R. H., Deydier, S. M., Le, P. V., Schwartz, B. D., Franken, N. C., Davis, R. A., Coster, M., Charman, S. A., Edstein, M. D., Skinner-Adams, T. S., Andrews, K. T., Jenkins, I. D. & Quinn, R. J., 2014, In : ACS Medicinal Chemistry Letters. 5, 2, p. 178 - 182 5 p.

Research output: Contribution to journalArticleResearchpeer-review

2013
20 Citations (Scopus)

3-(Oxazolo[4,5-b]pyridin-2-yl)anilides as a novel class of potent inhibitors for the kinetoplastid Trypanosoma brucei, the causative agent for human African trypanosomiasis

Ferrins, L., Rahmani, R. S., Sykes, M. L., Jones, A. J., Avery, V. M., Teston, E., Almohaywi, B., Yin, J., Smith, J., Chris, H., White, K. L., Ryan, E., Campbell, M., Charman, S. A., Kaiser, M. & Baell, J. B., 2013, In : European Journal of Medicinal Chemistry. 66, p. 450 - 465 16 p.

Research output: Contribution to journalArticleResearchpeer-review

37 Citations (Scopus)

A prodrug approach toward cancer-related carbonic anhydrase inhibition

Carroux, C. J., Rankin, G. M., Moeker, J., Bornaghi, L. F., Katneni, K., Morizzi, J., Charman, S. A., Vullo, D., Supuran, C. T. & Poulsen, S-A., 2013, In : Journal of Medicinal Chemistry. 56, 23, p. 9623 - 9634 12 p.

Research output: Contribution to journalArticleResearchpeer-review

49 Citations (Scopus)

Comparative antimalarial activities and ADME profiles of ozonides (1,2,4-trioxolanes) OZ277, OZ439, and their 1,2-dioxolane, 1,2,4-trioxane, and 1,2,4,5-tetraoxane isosteres

Wang, X., Dong, Y., Wittlin, S., Charman, S. A., Chiu, F. C. K., Chollet, J., Katneni, K., Mannila, J. M., Morizzi, J., Ryan, E., Scheurer, C., Steuten, J. A., Santo Tomas, J., Snyder, C. & Vennerstrom, J., 2013, In : Journal of Medicinal Chemistry. 56, 6, p. 2547 - 2555 9 p.

Research output: Contribution to journalArticleResearchpeer-review

53 Citations (Scopus)

Complexes of Trypanosoma cruzi sterol 14a-demethylase (CYP51) with two pyridine-based drug candidates for Chagas disease: Structural basis for pathogen selectivity

Hargrove, T. Y., Wawrzak, Z., Alexander, P. W., Chaplin, J. H., Keenan, M., Charman, S. A., Perez, C., Waterman, M., Chatelain, E. & Lepesheva, G. I., 2013, In : Journal of Biological Chemistry. 288, 44, p. 31602 - 31615 14 p.

Research output: Contribution to journalArticleResearchpeer-review

20 Citations (Scopus)

Design, structure-activity relationship and in vivo efficacy of piperazine analogues of fenarimol as inhibitors of Trypanosoma cruzi

Keenan, M., Alexander, P. W., Diao, H., Best, W. M., Khong, A., Kerfoot, M., Thompson, R. C. A., White, K. L., Shackleford, D., Ryan, E., Gregg, A. D., Charman, S. A., von Geldern, T. W., Scandale, I. & Chatelain, E., 2013, In : Bioorganic & Medicinal Chemistry. 21, 7, p. 1756 - 1763 8 p.

Research output: Contribution to journalArticleResearchpeer-review

33 Citations (Scopus)

Discovery and structure-activity relationships of pyrrolone antimalarials

Murugesan, D., Mital, A., Kaiser, M., Shackleford, D., Morizzi, J., Katneni, K., Campbell, M., Hudson, A., Charman, S. A., Yeates, C. & Gilbert, I. H., 2013, In : Journal of Medicinal Chemistry. 56, 7, p. 2975 - 2990 16 p.

Research output: Contribution to journalArticleResearchpeer-review

55 Citations (Scopus)

First-in-man safety and pharmacokinetics of synthetic ozonide OZ439 demonstrates an improved exposure profile relative to other peroxide antimalarials

Moehrle, J., Duparc, S., Siethoff, C., van Giersbergen, P. L. M., Craft, C. J., Arbe-Barnes, S., Charman, S. A., Gutierrez, M., Wittlin, S. & Vennerstrom, J., Feb 2013, In : British Journal of Clinical Pharmacology. 75, 2, p. 524-537 14 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

In vitro and in vivo characterization of the antimalarial lead compound SSJ-183 in Plasmodium models

Schleiferbock, S., Scheurer, C., Ihara, M., Itoh, I., Bathurst, I. C., Burrows, J., Fantauzzi, P., Lotharius, J., Charman, S. A., Morizzi, J., Shackleford, D., White, K. L., Brun, R. & Wittlin, S., 2013, In : Drug Design, Development and Therapy. 7, p. 1377 - 1384 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
120 Citations (Scopus)

Quinolone-3-diarylethers: A new class of antimalarial drug

Nilsen, A., LaCrue, A. N., White, K. L., Forquer, I., Cross, M., Marfurt, J., Mather, M. W., Delves, M. J., Shackleford, D., Saenz, F. E., Morrisey, J. M., Steuten, J. A., Mutka, T., Li, Y., Wirjanata, G., Ryan, E., Duffy, S., Kelly, J. X., Sebayang, B. F., Zeeman, A-M. & 21 others, Noviyanti, R., Sinden, R. E., Kocken, C. H. M., Price, R. N., Avery, V. M., Angulo-Barturen, I., Jimenez-Diaz, M. B., Ferrer, S. B., Herreros, E., Sanz, L. M., Gamo, F-J., Bathurst, I. C., Burrows, J., Siegl, P., Guy, R. K., Winter, R. W., Vaidya, A. B., Charman, S. A., Kyle, D. E., Manetsch, R. & Risco, M. K., 2013, In : Science Translational Medicine. 5, 177, p. 1 - 13 13 p.

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)

Selection and optimization of hits from a high-throughput phenotypic screen against Trypanosoma cruzi

Keenan, M., Alexander, P. W., Chaplin, J. H., Abbott, M. J., Diao, H., Wang, S. Z., Best, W. M., Perez, C., Cornwall, S. MJ., Keatley, S. K., Thompson, R. C. A., Charman, S. A., White, K. L., Ryan, E., Chen, G., Ioset, J. R., von Geldern, T. W. & Chatelain, E., 2013, In : Future Medicinal Chemistry. 5, 15, p. 1733 - 1752 20 p.

Research output: Contribution to journalArticleResearchpeer-review

662 Citations (Scopus)

Strategies to address low drug solubility in discovery and development

Williams, H. D., Trevaskis, N., Charman, S. A., Shanker, R., Charman, W. N., Pouton, C. W. & Porter, C. J., 2013, In : Pharmacological Reviews. 65, 1, p. 315 - 499 185 p.

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)

Structure-activity-relationship studies around the 2-amino group and pyridine core of antimalarial 3,5-diarylaminopyridines lead to a novel series of pyrazine analogues with oral in vivo activity

Younis, Y., Douelle, F., Cabrera, D. G., Le Manach, C., Nchinda, A. T., Paquet, T., Street, L. J., White, K. L., Zabiulla, M. K., Joseph, J. T., Bashyam, S., Waterson, D., Witty, M. J., Wittlin, S., Charman, S. A. & Chibale, K., 2013, In : Journal of Medicinal Chemistry. 56, 21, p. 8860 - 8871 12 p.

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)

Structure-activity relationship studies of pyrrolone antimalarial agents

Murugesan, D., Kaiser, M., White, K. L., Norval, S., Riley, J., Wyatt, P. G., Charman, S. A., Read, K. D., Yeates, C. & Gilbert, I. H., 2013, In : ChemMedChem. 8, 9, p. 1537 - 1544 8 p.

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)

Synthesis of acylated glycoconjugates as templates to investigate in vitro biopharmaceutical properties

Carroux, C. J., Moeker, J., Motte, J., Lopez, M., Bornaghi, L. F., Katneni, K., Ryan, E., Morizzi, J., Shackleford, D., Charman, S. A. & Poulsen, S-A., 2013, In : Bioorganic and Medicinal Chemistry Letters. 23, 2, p. 455 - 459 5 p.

Research output: Contribution to journalArticleResearchpeer-review

29 Citations (Scopus)

Two analogues of fenarimol show curative activity in an experimental model of chagas disease

Keenan, M., Chaplin, J. H., Alexander, P. W., Abbott, M. J., Best, W. M., Khong, A., Botero, A., Perez, C., Cornwall, S., Thompson, R. C. A., White, K. L., Shackleford, D., Koltun, M., Chiu, F. C. K., Morizzi, J., Ryan, E., Campbell, M., von Geldern, T. W., Scandale, I., Chatelain, E. & 1 others, Charman, S. A., 2013, In : Journal of Medicinal Chemistry. 56, 24, p. 10158 - 10170 13 p.

Research output: Contribution to journalArticleResearchpeer-review

2012
77 Citations (Scopus)

3,5-Diaryl-2-aminopyridines as a novel class of orally active antimalarials demonstrating single dose cure in mice and clinical candidate potential

Younis, Y., Douelle, F., Feng, T-S., Cabrera, D. G., Le Manach, C., Nchinda, A. T., Duffy, S., White, K. L., Shackleford, D., Morizzi, J., Mannila, J. M., Katneni, K., Bhamidipati, R., Zabiulla, M. K., Joseph, J. T., Bashyam, S., Waterson, D., Witty, M. J., Hardick, D., Wittlin, S. & 3 others, Avery, V. M., Charman, S. A. & Chibale, K., 2012, In : Journal of Medicinal Chemistry. 55, 7, p. 3479 - 3487 9 p.

Research output: Contribution to journalArticleResearchpeer-review

45 Citations (Scopus)

Analogues of fenarimol are potent inhibitors of Trypanosoma cruzi and are efficacious in a murine model of chagas disease

Keenan, M., Abbott, M. J., Alexander, P. W., Armstrong, T., Best, W. M., Berven, B., Botero, A., Chaplin, J. H., Charman, S. A., Chatelain, E., von Geldern, T. W., Kerfoot, M., Khong, A., Nguyen, T. T., McManus, J. D., Morizzi, J., Ryan, E., Scandale, I., Thompson, R. C. A., Wang, S. Z. & 1 others, White, K. L., 2012, In : Journal of Medicinal Chemistry. 55, 9, p. 4189 - 4204 16 p.

Research output: Contribution to journalArticleResearchpeer-review

38 Citations (Scopus)

Antimalarial activity of pyrroloiminoquinones from the Australian marine sponge Zyzzya sp.

Davis, R. A., Buchanan, M. S., Duffy, S., Avery, V. M., Charman, S. A., Charman, W. N., White, K. L., Shackleford, D., Edstein, M. D., Andrews, K., Camp, D. G. & Quinn, R. J., 2012, In : Journal of Medicinal Chemistry. 55, 12, p. 5851 - 5858 8 p.

Research output: Contribution to journalArticleResearchpeer-review

25 Citations (Scopus)

Assessing the utility of an anti-malarial pharmacokinetic-pharmacodynamic model for aiding drug clinical development

Zaloumis, S., Humberstone, A. J., Charman, S. A., Price, R. N., Moehrle, J., Gamo-Benito, J., McCaw, J., Jamsen, K., Smith, K. & Simpson, J. A., 2012, In : Malaria Journal. 11, 303, p. 1 - 14 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
41 Citations (Scopus)

Bioisosteric transformations and permutations in the triazolopyrimidine scaffold to identify the minimum pharmacophore required for inhibitory activity against Plasmodium falciparum dihydroorotate dehydrogenase

Marwaha, A., White, J., El Mazouni, F., Creason, S., Kokkonda, S., Buckner, F. S., Charman, S. A., Phillips, M. & Rathod, P., 2012, In : Journal of Medicinal Chemistry. 55, 17, p. 7425 - 7436 12 p.

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)

Computational prediction of CNS drug exposure based on a novel in vivo dataset

Bergstrom, C. A. S., Charman, S. A. & Nicolazzo, J., 2012, In : Pharmaceutical Research. 29, 11, p. 3131 - 3142 12 p.

Research output: Contribution to journalArticleResearchpeer-review

75 Citations (Scopus)

Endochin-like quinolones are highly efficacious against acute and latent experimental toxoplasmosis

Doggett, J. S., Nilsen, A., Forquer, I., Wegmann, K. W., Jones-Brando, L., Yolken, R. H., Bordon, C., Charman, S. A., Katneni, K., Schultz, T., Burrows, J., Hinrichs, D. J., Meunier, B., Carruthers, V. B. & Risco, M. K., 2012, In : Proceedings of the National Academy of Sciences. 109, 39, p. 15936 - 15941 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
112 Citations (Scopus)

Malarial dihydrofolate reductase as a paradigm for drug development against a resistance-compromised target

Yuthavong, Y., Tarnchompoo, B., Vilaivan, T., Chitnumsub, P., Kamchonwongpaisan, S., Charman, S. A., McLennan, D. N., White, K. L., Vivas, L., Bongard, E., Thongphanchang, C., Taweechai, S., Vanichtanankul, J., Rattanajak, R., Arwon, U., Fantauzzi, P., Yuvaniyama, J., Charman, W. N. & Matthews, D., 2012, In : Proceedings of the National Academy of Sciences. 109, 42, p. 16823 - 16828 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
59 Citations (Scopus)

Metallocene-based inhibitors of cancer-associated carbonic anhydrase enzymes IX and XII

Salmon, A. J., Williams, M. L., Wu, Q. K., Morizzi, J., Gregg, D. J., Charman, S. A., Vullo, D., Supuran, C. T. & Poulsen, S-A., 2012, In : Journal of Medicinal Chemistry. 55, 11, p. 5506 - 5517 12 p.

Research output: Contribution to journalArticleResearchpeer-review

42 Citations (Scopus)

Pharmacological characterization, structural studies, and in vivo activities of anti-chagas disease lead compounds derived from tipifarnib

Buckner, F. S., Bahia, M. T., Suryadevara, P. K., White, K. L., Shackleford, D., Chennamaneni, N. K., Hulverson, M. A., Laydbak, J. U., Chatelain, E., Scandale, I., Verlinde, C. L. M. J., Charman, S. A., Lepesheva, G. I. & Gelb, M. H., 2012, In : Antimicrobial Agents and Chemotherapy. 56, 9, p. 4914 - 4921 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
1 Citation (Scopus)

Probing a potential in vivo drug-excipient interaction: Temporal effects of a modified beta-cyclodextrin on the intravenous pharmacokinetics of a model high-affinity drug ligand

Mannila, A. H., Morizzi, J., Nguyen, T. T., Charman, S. A., McIntosh, M. P. & Shackleford, D., 2012, In : Journal of Pharmaceutical Sciences. 101, 9, p. 3381 - 3389 9 p.

Research output: Contribution to journalArticleResearchpeer-review

25 Citations (Scopus)

Structure-activity relationship studies of orally active antimalarial 3,5-substituted 2-aminopyridines

Cabrera, D. G., Douelle, F., Younis, Y., Feng, T-S., Le Manach, C., Nchinda, A. T., Street, L. J., Scheurer, C., Kamber, J., White, K. L., Montagnat, O. D., Ryan, E., Katneni, K., Zabiulla, M. K., Joseph, J. T., Bashyam, S., Waterson, D., Witty, M. J., Charman, S. A., Wittlin, S. & 1 others, Chibale, K., 2012, In : Journal of Medicinal Chemistry. 55, 24, p. 11022 - 11030 9 p.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

The involvement of a Na+ - and Cl- -dependent transporter in the brain uptake of amantadine and rimantadine

Kooijmans, S. A. A., Senyschyn, D., Mezhiselvam, M. M., Morizzi, J., Charman, S. A., Weksler, B., Romero, I-A., Couraud, P. & Nicolazzo, J., 2012, In : Molecular Pharmaceutics. 9, p. 883 - 893 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2011
55 Citations (Scopus)

Antimalarial Pyrido[1,2-a]benzimidazoles

Ndakala, A., Gessner, R., Gitari, P., October, N., White, K., Hudson, A., Fakorede, F., Shackleford, D., Kaiser, M., Yates, C., Charman, S. & Chibale, K., 2011, In : Journal of Medicinal Chemistry. 54, p. 4581 - 4589 9 p.

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)

Central nervous system exposure of next generation quinoline methanols is reduced relative to mefloquine after intravenous dosing in mice

Dow, G., Milner, E., Bathurst, I., Bhonsle, J., Caridha, D., Gardner, S., Gerena, L., Kozar, M., Lanteri, C., Mannila, A., McCalmont, W., Moon, J., Read, K., Norval, S., Roncal, N., Shackleford, D., Sousa, J., Steuten, J., White, K., Zeng, Q. & 1 others, Charman, S., 2011, In : Malaria Journal. 10, 150, p. e1 - e11 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
103 Citations (Scopus)

Discovery of 7-hydroxy-6-methoxy-2-methyl-3-(3,4,5-trimethoxybenzoyl)benzo[b]furan (BNC105), a tubulin polymerization inhibitor with potent antiproliferative and tumor vascular disrupting properties

Flynn, B., Gurmit, G., Grobelny, D., Chaplin, J., Paul, D., Leske, A., Lavranos, T., Chalmers, D., Charman, S., Kostewicz, E., Shackleford, D., Morizzi, J., Hamel, E., Jung, K. & Kremmidiotis, G., 2011, In : Journal of Medicinal Chemistry. 54, 17, p. 6014 - 6027 14 p.

Research output: Contribution to journalArticleResearchpeer-review

103 Citations (Scopus)

Lead optimization of aryl and aralkyl amine-based triazolopyrimidine inhibitors of plasmodium falciparum dihydroorotate dehydrogenase with antimalarial activity in mice

Gujjar, R., El Mazouni, F., White, K., White, J., Creason, S., Shackleford, D., Deng, X., Charman, W., Bathurst, I., Burrows, J., Floyd, D., Matthews, D., Buckner, F., Charman, S., Phillips, M. & Rathod, P., 2011, In : Journal of Medicinal Chemistry. 54, p. 3935 - 3949 15 p.

Research output: Contribution to journalArticleResearchpeer-review

49 Citations (Scopus)

Novel orally active antimalarial thiazoles

Cabera, D., Douelle, F., Feng, T-S., Nchinda, A., Younis, Y., White, K., Wu, Q., Ryan, E., Burrows, J., Waterson, D., Witty, M., Wittlin, S., Charman, S. & Chibale, K., 2011, In : Journal of Medicinal Chemistry. 54, p. 7713 - 7719 7 p.

Research output: Contribution to journalArticleResearchpeer-review

182 Citations (Scopus)

Structure-guided lead optimization of triazolopyrimidine-ring substituents identifies potent Plasmodium falciparum dihydroorotate dehydrogenase inhibitors with clinical candidate potential

Coteron, J., Marco, M., Esquivias, J., Deng, X., White, K., White, J., Koltun, M., El Mazouni, F., Kokkonda, S., Katneni, K., Bhamidipati, R., Shackleford, D., Angulo-Barturen, I., Ferrer, S., Jimenez-Diaz, M. B., Gamo, F-J., Goldsmith, E., Charman, W., Bathurst, I., Floyd, D. & 5 others, Matthews, D., Burrows, J., Rathod, P., Charman, S. & Phillips, M., 2011, In : Journal of Medicinal Chemistry. 54, 15, p. 5540 - 5561 22 p.

Research output: Contribution to journalArticleResearchpeer-review

250 Citations (Scopus)

Synthetic ozonide drug candidate OZ439 offers new hope for a single-dose cure of uncomplicated malaria

Charman, S., Arbe-Barnes, S., Bathurst, I., Brun, R., Campbell, M., Charman, W., Chiu, F., Chollet, J., Craft, C., Creek, D., Dong, Y., Matile, H., Maurer, M., Morizzi, J., Nguyen, T., Papastogiannidis, P., Scheurer, C., Shackleford, D., Sriraghavan, K., Stingelin, L. & 7 others, Tang, Y., Urwyler, H., Wang, X., White, K., Wittlin, S., Zhou, L. & Vennerstrom, J., 2011, In : Proceedings of the National Academy of Sciences. 108, 11, p. 4400 - 4405 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
2010
4 Citations (Scopus)

Brain uptake of diazepam and phenytoin in a genetic animal model of absence epilepsy

Nicolazzo, J., Steuten, J. A., Charman, S. A., Taylor, N., Davies, P. & Petrou, S., 2010, In : Clinical and Experimental Pharmacology and Physiology. 37, p. 647 - 649 3 p.

Research output: Contribution to journalArticleResearchpeer-review

36 Citations (Scopus)

Discovery of novel benzo[ a ]phenoxazine SSJ-183 as a drug candidate for malaria

Ge, J-F., Arai, C., Yang, M., Bakar, A., Lu, J., Ismail, N. S. M., Wittlin, S., Kaiser, M., Brun, R., Charman, S. A., Nguyen, T., Morizzi, J., Itoh, I. & Ihara, M., 2010, In : ACS Medicinal Chemistry Letters. 1, 7, p. 360 - 364 5 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

Preclinical comparison of intravenous melphalan pharmacokinetics administered in formulations containing either (SBE)7m-beta-cyclodextrin or a co-solvent system

Koltun, M., Morizzi, J., Katneni, K., Charman, S. A., Shackleford, D. & McIntosh, M. P., 2010, In : Biopharmaceutics and Drug Disposition. 31, 8-9, p. 450 - 454 5 p.

Research output: Contribution to journalArticleResearchpeer-review

49 Citations (Scopus)

Sulfonamide linked neoglycoconjugates-A new class of inhibitors for cancer-associated carbonic anhydrases

Lopez, M., Bornaghi, L. F., Innocenti, A., Vullo, D., Charman, S. A., Supuran, C. T. & Poulsen, S-A., 2010, In : Journal of Medicinal Chemistry. 53, p. 2913 - 2926 14 p.

Research output: Contribution to journalArticleResearchpeer-review

54 Citations (Scopus)

Synthesis and Biological Evaluation of Polysulfated Oligosaccharide Glycosides as Inhibitors of Angiogenesis and Tumor Growth

Johnstone, K. D., Karoli, T., Liu, L., Dredge, K., Copeman, E., Li, C. P., Davis, K., Hammond, E., Bytheway, I., Kostewicz, E. S., Chiu, F. C. K., Shackleford, D., Charman, S. A., Charman, W. N., Harenberg, J., Gonda, T. & Ferro, V., 2010, In : Journal of Medicinal Chemistry. 53, 4, p. 1686 - 1699 14 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

The comparative antimalarial properties of weak base and neutral synthetic ozonides

Tang, Y., Wittlin, S., Charman, S. A., Chollet, J., Chiu, F. C. K., Morizzi, J., Johnson, L., Santo Tomas, J., Scheurer, C., Snyder, C., Zhou, L., Dong, Y., Charman, W. N., Matile, H., Urwyler, H., Dorn, A. & Vennerstrom, J., 2010, In : Bioorganic and Medicinal Chemistry Letters. 20, 2, p. 563 - 566 4 p.

Research output: Contribution to journalArticleResearchpeer-review

76 Citations (Scopus)

The structure - activity relationship of the antimalarial ozonide arterolane (OZ277)

Dong, Y., Wittlin, S., Sriraghavan, K., Chollet, J., Charman, S. A., Charman, W. N., Scheurer, C., Urwyler, H., Santo Tomas, J., Snyder, C., Creek, D. J., Morizzi, J., Koltun, M., Matile, H., Wang, X., Padmanilayam, M., Tang, Y., Dorn, A., Brun, R. & Vennerstrom, J., 2010, In : Journal of Medicinal Chemistry. 53, p. 481 - 491 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2009
2 Citations (Scopus)

2,5-Dimethyl-2,4-hexadiene induced photodechlorination of 9,10-dichloroanthracene

Saltiel, J., Smothers, W. K., Schanze, K. S., Charman, S. A. & Bonneau, R., 2009, In : Photochemical & Photobiological Sciences. 8, 6, p. 856 - 867 12 p.

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)

CYT997: a novel orally active tubulin polymerization inhibitor with potent cytotoxic and vascular disrupting activity in vitro and in vivo

Burns, C., Fantino, E., Phillips, I. D., Su, S., Harte, M., Bukczynska, P. E., Frazzetto, M., Joffe, M., Kruszelnicki, I., Wang, B., Wang, Y., Wilson, N., Dilley, R. J., Wan, S. S., Charman, S. A., Shackleford, D., Fida, R., Malcontenti-Wilson, C. & Wilks, A. F., 2009, In : Molecular Cancer Therapeutics. 8, 11, p. 3036 - 3045 10 p.

Research output: Contribution to journalArticleResearchpeer-review