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Research Output 1991 2019

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2014

Medicinal chemistry optimization of antiplasmodial imidazopyridazine hits from high throughput screening of a SoftFocus kinase library: Part 1

Le Manach, C., Cabrera, D. G., Douelle, F., Nchinda, A. T., Younis, Y., Taylor, D., Wiesner, L., White, K. L., Ryan, E., March, C., Duffy, S., Avery, V. M., Waterson, D., Witty, M. J., Wittlin, S., Charman, S. A., Street, L. J. & Chibale, K., 2014, In : Journal of Medicinal Chemistry. 57, 6, p. 2789 - 2798 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Orally bioavailable 6-chloro-7-methoxy-4(1H)-quinolones efficacious against multiple stages of Plasmodium

Cross, M., Flanigan, D. L., Monastyrskyi, A., LaCrue, A. N., Saenz, F. E., Maignan, J. R., Mutka, T. S., White, K. L., Shackleford, D., Bathurst, I. C., Fronczek, F. R., Wojtas, L., Guida, W. C., Charman, S. A., Burrows, J., Kyle, D. E. & Manetsch, R., 2014, In : Journal of Medicinal Chemistry. 57, 21, p. 8860 - 8879 20 p.

Research output: Contribution to journalArticleResearchpeer-review

Pyrazoleamide compounds are potent antimalarials that target Na+ homeostasis in intraerythrocytic Plasmodium falciparum

Vaidya, A. B., Morrisey, J. M., Zhang, Z., Das, S., Daly, T. M., Otto, T. D., Spillman, N. J., Wyvratt, M., Siegl, P., Marfurt, J., Wirjanata, G., Sebayang, B. F., Price, R. N., Chatterjee, A., Nagle, A. S., Stasiak, M., Charman, S. A., Angulo-Barturen, I., Ferrer, S. B., Jimenez-Diaz, M. B. & 11 others, Martinez, M. S., Gamo-Benito, F. J., Avery, V. M., Ruecker, A., Delves, M. J., Kirk, K., Berriman, M., Kortagere, S., Burrows, J., Fan, E. & Bergman, L. W., 2014, In : Nature Communications. 5, 5521, p. 1 - 10 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Pyridyl benzamides as a novel class of potent inhibitors for the kinetoplastid Trypanosoma brucei

Ferrins, L., Gazdik, M., Rahmani, R. S., Varghese, S., Sykes, M. L., Jones, A. J., Avery, V. M., White, K. L., Ryan, E., Charman, S. A., Kaiser, M., Bergstrom, C. A. S. & Baell, J. B., 2014, In : Journal of Medicinal Chemistry. 57, 15, p. 6393 - 6402 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Total synthesis of thiaplakortone A: Derivatives as metabolically stable leads for the treatment of malaria

Pouwer, R. H., Deydier, S. M., Le, P. V., Schwartz, B. D., Franken, N. C., Davis, R. A., Coster, M., Charman, S. A., Edstein, M. D., Skinner-Adams, T. S., Andrews, K. T., Jenkins, I. D. & Quinn, R. J., 2014, In : A C S Medicinal Chemistry Letters. 5, 2, p. 178 - 182 5 p.

Research output: Contribution to journalArticleResearchpeer-review

2013

3-(Oxazolo[4,5-b]pyridin-2-yl)anilides as a novel class of potent inhibitors for the kinetoplastid Trypanosoma brucei, the causative agent for human African trypanosomiasis

Ferrins, L., Rahmani, R. S., Sykes, M. L., Jones, A. J., Avery, V. M., Teston, E., Almohaywi, B., Yin, J., Smith, J., Chris, H., White, K. L., Ryan, E., Campbell, M., Charman, S. A., Kaiser, M. & Baell, J. B., 2013, In : European Journal of Medicinal Chemistry. 66, p. 450 - 465 16 p.

Research output: Contribution to journalArticleResearchpeer-review

A prodrug approach toward cancer-related carbonic anhydrase inhibition

Carroux, C. J., Rankin, G. M., Moeker, J., Bornaghi, L. F., Katneni, K., Morizzi, J., Charman, S. A., Vullo, D., Supuran, C. T. & Poulsen, S-A., 2013, In : Journal of Medicinal Chemistry. 56, 23, p. 9623 - 9634 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Comparative antimalarial activities and ADME profiles of ozonides (1,2,4-trioxolanes) OZ277, OZ439, and their 1,2-dioxolane, 1,2,4-trioxane, and 1,2,4,5-tetraoxane isosteres

Wang, X., Dong, Y., Wittlin, S., Charman, S. A., Chiu, F. C. K., Chollet, J., Katneni, K., Mannila, J. M., Morizzi, J., Ryan, E., Scheurer, C., Steuten, J. A., Santo Tomas, J., Snyder, C. & Vennerstrom, J., 2013, In : Journal of Medicinal Chemistry. 56, 6, p. 2547 - 2555 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Complexes of Trypanosoma cruzi sterol 14a-demethylase (CYP51) with two pyridine-based drug candidates for Chagas disease: Structural basis for pathogen selectivity

Hargrove, T. Y., Wawrzak, Z., Alexander, P. W., Chaplin, J. H., Keenan, M., Charman, S. A., Perez, C., Waterman, M., Chatelain, E. & Lepesheva, G. I., 2013, In : Journal of Biological Chemistry. 288, 44, p. 31602 - 31615 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Design, structure-activity relationship and in vivo efficacy of piperazine analogues of fenarimol as inhibitors of Trypanosoma cruzi

Keenan, M., Alexander, P. W., Diao, H., Best, W. M., Khong, A., Kerfoot, M., Thompson, R. C. A., White, K. L., Shackleford, D., Ryan, E., Gregg, A. D., Charman, S. A., von Geldern, T. W., Scandale, I. & Chatelain, E., 2013, In : Bioorganic & Medicinal Chemistry. 21, 7, p. 1756 - 1763 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Discovery and structure-activity relationships of pyrrolone antimalarials

Murugesan, D., Mital, A., Kaiser, M., Shackleford, D., Morizzi, J., Katneni, K., Campbell, M., Hudson, A., Charman, S. A., Yeates, C. & Gilbert, I. H., 2013, In : Journal of Medicinal Chemistry. 56, 7, p. 2975 - 2990 16 p.

Research output: Contribution to journalArticleResearchpeer-review

First-in-man safety and pharmacokinetics of synthetic ozonide OZ439 demonstrates an improved exposure profile relative to other peroxide antimalarials

Moehrle, J., Duparc, S., Siethoff, C., van Giersbergen, P. L. M., Craft, C. J., Arbe-Barnes, S., Charman, S. A., Gutierrez, M., Wittlin, S. & Vennerstrom, J., Feb 2013, In : British Journal of Clinical Pharmacology. 75, 2, p. 524-537 14 p.

Research output: Contribution to journalArticleResearchpeer-review

In vitro and in vivo characterization of the antimalarial lead compound SSJ-183 in Plasmodium models

Schleiferbock, S., Scheurer, C., Ihara, M., Itoh, I., Bathurst, I. C., Burrows, J., Fantauzzi, P., Lotharius, J., Charman, S. A., Morizzi, J., Shackleford, D., White, K. L., Brun, R. & Wittlin, S., 2013, In : Drug Design, Development and Therapy. 7, p. 1377 - 1384 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Quinolone-3-diarylethers: A new class of antimalarial drug

Nilsen, A., LaCrue, A. N., White, K. L., Forquer, I., Cross, M., Marfurt, J., Mather, M. W., Delves, M. J., Shackleford, D., Saenz, F. E., Morrisey, J. M., Steuten, J. A., Mutka, T., Li, Y., Wirjanata, G., Ryan, E., Duffy, S., Kelly, J. X., Sebayang, B. F., Zeeman, A-M. & 21 others, Noviyanti, R., Sinden, R. E., Kocken, C. H. M., Price, R. N., Avery, V. M., Angulo-Barturen, I., Jimenez-Diaz, M. B., Ferrer, S. B., Herreros, E., Sanz, L. M., Gamo, F-J., Bathurst, I. C., Burrows, J., Siegl, P., Guy, R. K., Winter, R. W., Vaidya, A. B., Charman, S. A., Kyle, D. E., Manetsch, R. & Risco, M. K., 2013, In : Science Translational Medicine. 5, 177, p. 1 - 13 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Selection and optimization of hits from a high-throughput phenotypic screen against Trypanosoma cruzi

Keenan, M., Alexander, P. W., Chaplin, J. H., Abbott, M. J., Diao, H., Wang, S. Z., Best, W. M., Perez, C., Cornwall, S. MJ., Keatley, S. K., Thompson, R. C. A., Charman, S. A., White, K. L., Ryan, E., Chen, G., Ioset, J. R., von Geldern, T. W. & Chatelain, E., 2013, In : Future Medicinal Chemistry. 5, 15, p. 1733 - 1752 20 p.

Research output: Contribution to journalArticleResearchpeer-review

Strategies to address low drug solubility in discovery and development

Williams, H. D., Trevaskis, N., Charman, S. A., Shanker, R., Charman, W. N., Pouton, C. W. & Porter, C. J., 2013, In : Pharmacological Reviews. 65, 1, p. 315 - 499 185 p.

Research output: Contribution to journalArticleResearchpeer-review

Structure-activity-relationship studies around the 2-amino group and pyridine core of antimalarial 3,5-diarylaminopyridines lead to a novel series of pyrazine analogues with oral in vivo activity

Younis, Y., Douelle, F., Cabrera, D. G., Le Manach, C., Nchinda, A. T., Paquet, T., Street, L. J., White, K. L., Zabiulla, M. K., Joseph, J. T., Bashyam, S., Waterson, D., Witty, M. J., Wittlin, S., Charman, S. A. & Chibale, K., 2013, In : Journal of Medicinal Chemistry. 56, 21, p. 8860 - 8871 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Structure-activity relationship studies of pyrrolone antimalarial agents

Murugesan, D., Kaiser, M., White, K. L., Norval, S., Riley, J., Wyatt, P. G., Charman, S. A., Read, K. D., Yeates, C. & Gilbert, I. H., 2013, In : ChemMedChem. 8, 9, p. 1537 - 1544 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Synthesis of acylated glycoconjugates as templates to investigate in vitro biopharmaceutical properties

Carroux, C. J., Moeker, J., Motte, J., Lopez, M., Bornaghi, L. F., Katneni, K., Ryan, E., Morizzi, J., Shackleford, D., Charman, S. A. & Poulsen, S-A., 2013, In : Bioorganic and Medicinal Chemistry Letters. 23, 2, p. 455 - 459 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Two analogues of fenarimol show curative activity in an experimental model of chagas disease

Keenan, M., Chaplin, J. H., Alexander, P. W., Abbott, M. J., Best, W. M., Khong, A., Botero, A., Perez, C., Cornwall, S., Thompson, R. C. A., White, K. L., Shackleford, D., Koltun, M., Chiu, F. C. K., Morizzi, J., Ryan, E., Campbell, M., von Geldern, T. W., Scandale, I., Chatelain, E. & 1 others, Charman, S. A., 2013, In : Journal of Medicinal Chemistry. 56, 24, p. 10158 - 10170 13 p.

Research output: Contribution to journalArticleResearchpeer-review

2012

3,5-Diaryl-2-aminopyridines as a novel class of orally active antimalarials demonstrating single dose cure in mice and clinical candidate potential

Younis, Y., Douelle, F., Feng, T-S., Cabrera, D. G., Le Manach, C., Nchinda, A. T., Duffy, S., White, K. L., Shackleford, D., Morizzi, J., Mannila, J. M., Katneni, K., Bhamidipati, R., Zabiulla, M. K., Joseph, J. T., Bashyam, S., Waterson, D., Witty, M. J., Hardick, D., Wittlin, S. & 3 others, Avery, V. M., Charman, S. A. & Chibale, K., 2012, In : Journal of Medicinal Chemistry. 55, 7, p. 3479 - 3487 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Analogues of fenarimol are potent inhibitors of Trypanosoma cruzi and are efficacious in a murine model of chagas disease

Keenan, M., Abbott, M. J., Alexander, P. W., Armstrong, T., Best, W. M., Berven, B., Botero, A., Chaplin, J. H., Charman, S. A., Chatelain, E., von Geldern, T. W., Kerfoot, M., Khong, A., Nguyen, T. T., McManus, J. D., Morizzi, J., Ryan, E., Scandale, I., Thompson, R. C. A., Wang, S. Z. & 1 others, White, K. L., 2012, In : Journal of Medicinal Chemistry. 55, 9, p. 4189 - 4204 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Antimalarial activity of pyrroloiminoquinones from the Australian marine sponge Zyzzya sp.

Davis, R. A., Buchanan, M. S., Duffy, S., Avery, V. M., Charman, S. A., Charman, W. N., White, K. L., Shackleford, D., Edstein, M. D., Andrews, K., Camp, D. G. & Quinn, R. J., 2012, In : Journal of Medicinal Chemistry. 55, 12, p. 5851 - 5858 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Assessing the utility of an anti-malarial pharmacokinetic-pharmacodynamic model for aiding drug clinical development

Zaloumis, S., Humberstone, A. J., Charman, S. A., Price, R. N., Moehrle, J., Gamo-Benito, J., McCaw, J., Jamsen, K., Smith, K. & Simpson, J. A., 2012, In : Malaria Journal. 11, 303, p. 1 - 14 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Bioisosteric transformations and permutations in the triazolopyrimidine scaffold to identify the minimum pharmacophore required for inhibitory activity against Plasmodium falciparum dihydroorotate dehydrogenase

Marwaha, A., White, J., El Mazouni, F., Creason, S., Kokkonda, S., Buckner, F. S., Charman, S. A., Phillips, M. & Rathod, P., 2012, In : Journal of Medicinal Chemistry. 55, 17, p. 7425 - 7436 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Computational prediction of CNS drug exposure based on a novel in vivo dataset

Bergstrom, C. A. S., Charman, S. A. & Nicolazzo, J., 2012, In : Pharmaceutical Research. 29, 11, p. 3131 - 3142 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Endochin-like quinolones are highly efficacious against acute and latent experimental toxoplasmosis

Doggett, J. S., Nilsen, A., Forquer, I., Wegmann, K. W., Jones-Brando, L., Yolken, R. H., Bordon, C., Charman, S. A., Katneni, K., Schultz, T., Burrows, J., Hinrichs, D. J., Meunier, B., Carruthers, V. B. & Risco, M. K., 2012, In : Proceedings of the National Academy of Sciences. 109, 39, p. 15936 - 15941 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Malarial dihydrofolate reductase as a paradigm for drug development against a resistance-compromised target

Yuthavong, Y., Tarnchompoo, B., Vilaivan, T., Chitnumsub, P., Kamchonwongpaisan, S., Charman, S. A., McLennan, D. N., White, K. L., Vivas, L., Bongard, E., Thongphanchang, C., Taweechai, S., Vanichtanankul, J., Rattanajak, R., Arwon, U., Fantauzzi, P., Yuvaniyama, J., Charman, W. N. & Matthews, D., 2012, In : Proceedings of the National Academy of Sciences. 109, 42, p. 16823 - 16828 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Metallocene-based inhibitors of cancer-associated carbonic anhydrase enzymes IX and XII

Salmon, A. J., Williams, M. L., Wu, Q. K., Morizzi, J., Gregg, D. J., Charman, S. A., Vullo, D., Supuran, C. T. & Poulsen, S-A., 2012, In : Journal of Medicinal Chemistry. 55, 11, p. 5506 - 5517 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Pharmacological characterization, structural studies, and in vivo activities of anti-chagas disease lead compounds derived from tipifarnib

Buckner, F. S., Bahia, M. T., Suryadevara, P. K., White, K. L., Shackleford, D., Chennamaneni, N. K., Hulverson, M. A., Laydbak, J. U., Chatelain, E., Scandale, I., Verlinde, C. L. M. J., Charman, S. A., Lepesheva, G. I. & Gelb, M. H., 2012, In : Antimicrobial Agents and Chemotherapy. 56, 9, p. 4914 - 4921 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Probing a potential in vivo drug-excipient interaction: Temporal effects of a modified beta-cyclodextrin on the intravenous pharmacokinetics of a model high-affinity drug ligand

Mannila, A. H., Morizzi, J., Nguyen, T. T., Charman, S. A., McIntosh, M. P. & Shackleford, D., 2012, In : Journal of Pharmaceutical Sciences. 101, 9, p. 3381 - 3389 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Structure-activity relationship studies of orally active antimalarial 3,5-substituted 2-aminopyridines

Cabrera, D. G., Douelle, F., Younis, Y., Feng, T-S., Le Manach, C., Nchinda, A. T., Street, L. J., Scheurer, C., Kamber, J., White, K. L., Montagnat, O. D., Ryan, E., Katneni, K., Zabiulla, M. K., Joseph, J. T., Bashyam, S., Waterson, D., Witty, M. J., Charman, S. A., Wittlin, S. & 1 others, Chibale, K., 2012, In : Journal of Medicinal Chemistry. 55, 24, p. 11022 - 11030 9 p.

Research output: Contribution to journalArticleResearchpeer-review

The involvement of a Na+ - and Cl- -dependent transporter in the brain uptake of amantadine and rimantadine

Kooijmans, S. A. A., Senyschyn, D., Mezhiselvam, M. M., Morizzi, J., Charman, S. A., Weksler, B., Romero, I-A., Couraud, P. & Nicolazzo, J., 2012, In : Molecular Pharmaceutics. 9, p. 883 - 893 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2011

Antimalarial Pyrido[1,2-a]benzimidazoles

Ndakala, A., Gessner, R., Gitari, P., October, N., White, K., Hudson, A., Fakorede, F., Shackleford, D., Kaiser, M., Yates, C., Charman, S. & Chibale, K., 2011, In : Journal of Medicinal Chemistry. 54, p. 4581 - 4589 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Central nervous system exposure of next generation quinoline methanols is reduced relative to mefloquine after intravenous dosing in mice

Dow, G., Milner, E., Bathurst, I., Bhonsle, J., Caridha, D., Gardner, S., Gerena, L., Kozar, M., Lanteri, C., Mannila, A., McCalmont, W., Moon, J., Read, K., Norval, S., Roncal, N., Shackleford, D., Sousa, J., Steuten, J., White, K., Zeng, Q. & 1 others, Charman, S., 2011, In : Malaria Journal. 10, 150, p. e1 - e11 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Discovery of 7-hydroxy-6-methoxy-2-methyl-3-(3,4,5-trimethoxybenzoyl)benzo[b]furan (BNC105), a tubulin polymerization inhibitor with potent antiproliferative and tumor vascular disrupting properties

Flynn, B., Gurmit, G., Grobelny, D., Chaplin, J., Paul, D., Leske, A., Lavranos, T., Chalmers, D., Charman, S., Kostewicz, E., Shackleford, D., Morizzi, J., Hamel, E., Jung, K. & Kremmidiotis, G., 2011, In : Journal of Medicinal Chemistry. 54, 17, p. 6014 - 6027 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Lead optimization of aryl and aralkyl amine-based triazolopyrimidine inhibitors of plasmodium falciparum dihydroorotate dehydrogenase with antimalarial activity in mice

Gujjar, R., El Mazouni, F., White, K., White, J., Creason, S., Shackleford, D., Deng, X., Charman, W., Bathurst, I., Burrows, J., Floyd, D., Matthews, D., Buckner, F., Charman, S., Phillips, M. & Rathod, P., 2011, In : Journal of Medicinal Chemistry. 54, p. 3935 - 3949 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Novel orally active antimalarial thiazoles

Cabera, D., Douelle, F., Feng, T-S., Nchinda, A., Younis, Y., White, K., Wu, Q., Ryan, E., Burrows, J., Waterson, D., Witty, M., Wittlin, S., Charman, S. & Chibale, K., 2011, In : Journal of Medicinal Chemistry. 54, p. 7713 - 7719 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Structure-guided lead optimization of triazolopyrimidine-ring substituents identifies potent Plasmodium falciparum dihydroorotate dehydrogenase inhibitors with clinical candidate potential

Coteron, J., Marco, M., Esquivias, J., Deng, X., White, K., White, J., Koltun, M., El Mazouni, F., Kokkonda, S., Katneni, K., Bhamidipati, R., Shackleford, D., Angulo-Barturen, I., Ferrer, S., Jimenez-Diaz, M. B., Gamo, F-J., Goldsmith, E., Charman, W., Bathurst, I., Floyd, D. & 5 others, Matthews, D., Burrows, J., Rathod, P., Charman, S. & Phillips, M., 2011, In : Journal of Medicinal Chemistry. 54, 15, p. 5540 - 5561 22 p.

Research output: Contribution to journalArticleResearchpeer-review

Synthetic ozonide drug candidate OZ439 offers new hope for a single-dose cure of uncomplicated malaria

Charman, S., Arbe-Barnes, S., Bathurst, I., Brun, R., Campbell, M., Charman, W., Chiu, F., Chollet, J., Craft, C., Creek, D., Dong, Y., Matile, H., Maurer, M., Morizzi, J., Nguyen, T., Papastogiannidis, P., Scheurer, C., Shackleford, D., Sriraghavan, K., Stingelin, L. & 7 others, Tang, Y., Urwyler, H., Wang, X., White, K., Wittlin, S., Zhou, L. & Vennerstrom, J., 2011, In : Proceedings of the National Academy of Sciences. 108, 11, p. 4400 - 4405 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
2010

Brain uptake of diazepam and phenytoin in a genetic animal model of absence epilepsy

Nicolazzo, J., Steuten, J. A., Charman, S. A., Taylor, N., Davies, P. & Petrou, S., 2010, In : Clinical and Experimental Pharmacology and Physiology. 37, p. 647 - 649 3 p.

Research output: Contribution to journalArticleResearchpeer-review

Discovery of novel benzo[ a ]phenoxazine SSJ-183 as a drug candidate for malaria

Ge, J-F., Arai, C., Yang, M., Bakar, A., Lu, J., Ismail, N. S. M., Wittlin, S., Kaiser, M., Brun, R., Charman, S. A., Nguyen, T., Morizzi, J., Itoh, I. & Ihara, M., 2010, In : A C S Medicinal Chemistry Letters. 1, 7, p. 360 - 364 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Preclinical comparison of intravenous melphalan pharmacokinetics administered in formulations containing either (SBE)7m-beta-cyclodextrin or a co-solvent system

Koltun, M., Morizzi, J., Katneni, K., Charman, S. A., Shackleford, D. & McIntosh, M. P., 2010, In : Biopharmaceutics and Drug Disposition. 31, 8-9, p. 450 - 454 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Sulfonamide linked neoglycoconjugates-A new class of inhibitors for cancer-associated carbonic anhydrases

Lopez, M., Bornaghi, L. F., Innocenti, A., Vullo, D., Charman, S. A., Supuran, C. T. & Poulsen, S-A., 2010, In : Journal of Medicinal Chemistry. 53, p. 2913 - 2926 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Synthesis and Biological Evaluation of Polysulfated Oligosaccharide Glycosides as Inhibitors of Angiogenesis and Tumor Growth

Johnstone, K. D., Karoli, T., Liu, L., Dredge, K., Copeman, E., Li, C. P., Davis, K., Hammond, E., Bytheway, I., Kostewicz, E. S., Chiu, F. C. K., Shackleford, D., Charman, S. A., Charman, W. N., Harenberg, J., Gonda, T. & Ferro, V., 2010, In : Journal of Medicinal Chemistry. 53, 4, p. 1686 - 1699 14 p.

Research output: Contribution to journalArticleResearchpeer-review

The comparative antimalarial properties of weak base and neutral synthetic ozonides

Tang, Y., Wittlin, S., Charman, S. A., Chollet, J., Chiu, F. C. K., Morizzi, J., Johnson, L., Santo Tomas, J., Scheurer, C., Snyder, C., Zhou, L., Dong, Y., Charman, W. N., Matile, H., Urwyler, H., Dorn, A. & Vennerstrom, J., 2010, In : Bioorganic and Medicinal Chemistry Letters. 20, 2, p. 563 - 566 4 p.

Research output: Contribution to journalArticleResearchpeer-review

The structure - activity relationship of the antimalarial ozonide arterolane (OZ277)

Dong, Y., Wittlin, S., Sriraghavan, K., Chollet, J., Charman, S. A., Charman, W. N., Scheurer, C., Urwyler, H., Santo Tomas, J., Snyder, C., Creek, D. J., Morizzi, J., Koltun, M., Matile, H., Wang, X., Padmanilayam, M., Tang, Y., Dorn, A., Brun, R. & Vennerstrom, J., 2010, In : Journal of Medicinal Chemistry. 53, p. 481 - 491 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2009

2,5-Dimethyl-2,4-hexadiene induced photodechlorination of 9,10-dichloroanthracene

Saltiel, J., Smothers, W. K., Schanze, K. S., Charman, S. A. & Bonneau, R., 2009, In : Photochemical & Photobiological Sciences. 8, 6, p. 856 - 867 12 p.

Research output: Contribution to journalArticleResearchpeer-review

CYT997: a novel orally active tubulin polymerization inhibitor with potent cytotoxic and vascular disrupting activity in vitro and in vivo

Burns, C., Fantino, E., Phillips, I. D., Su, S., Harte, M., Bukczynska, P. E., Frazzetto, M., Joffe, M., Kruszelnicki, I., Wang, B., Wang, Y., Wilson, N., Dilley, R. J., Wan, S. S., Charman, S. A., Shackleford, D., Fida, R., Malcontenti-Wilson, C. & Wilks, A. F., 2009, In : Molecular Cancer Therapeutics. 8, 11, p. 3036 - 3045 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Discovery of CYT997: a structurally novel orally active microtubule targeting agent

Burns, C., Harte, M., Bu, X., Fantino, E., Joffe, M., Sikanyika, H., Su, S., Tranberg, C. E., Wilson, N., Charman, S. A., Shackleford, D. & Wilks, A. F., 2009, In : Bioorganic and Medicinal Chemistry Letters. 19, 16, p. 4639 - 4642 4 p.

Research output: Contribution to journalArticleResearchpeer-review