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Research Output 1991 2019

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105 Citations (Scopus)

(+)-SJ733, a clinical candidate for malaria that acts through ATP4 to induce rapid host-mediated clearance of Plasmodium

Jimenez-Diaz, M. B., Ebert, D., Salinas, Y., Pradhan, A., Lehane, A. M., Myrand-Lapierre, M-E., O'Loughlin, K. G., Shackleford, D., Justino de Almeida, M., Carrillo, A., Clark, J. A., Dennis, A. S. M., Diep, J., Deng, X., Duffy, S., Endsley, A. N., Fedewa, G., Guiguemde, W. A., Gomez, M. G., Holbrook, G. & 30 others, Horst, J. A., Kim, C. C., Liu, J., Lee, M. C. S., Matheny, A., Martinez, M. S., Miller, G. E., Rodriguez-Alejandre, A., Sanz, L. M., Sigal, M., Spillman, N. J., Stein, P. D., Wang, Z., Zhu, F., Waterson, D., Knapp, S., Shelat, A. A., Avery, V. M., Fidock, D. A., Gamo, F-J., Charman, S. A., Mirsalis, J. C., Ma, H., Ferrer, S. B., Kirk, K., Angulo-Barturen, I., Kyle, D. E., de Risi, J. L., Floyd, D. M. & Guy, R. K., 2014, In : Proceedings of the National Academy of Sciences. 111, 50, p. e5455 - e5462 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
22 Citations (Scopus)

2,4-Diaminothienopyrimidines as orally active antimalarial agents

Cabrera, D. G., Le Manach, C., Douelle, F., Younis, Y., Feng, T-S., Paquet, T., Nchinda, A. T., Street, L. J., Taylor, D., de Kock, C., Wiesner, L., Duffy, S., White, K. L., Zabiulla, M. K., Sambandan, Y., Bashyam, S., Waterson, D., Witty, M. J., Charman, S. A., Avery, V. M. & 2 others, Wittlin, S. & Chibale, K., 2014, In : Journal of Medicinal Chemistry. 57, 3, p. 1014 - 1022 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

2,5-Dimethyl-2,4-hexadiene induced photodechlorination of 9,10-dichloroanthracene

Saltiel, J., Smothers, W. K., Schanze, K. S., Charman, S. A. & Bonneau, R., 2009, In : Photochemical & Photobiological Sciences. 8, 6, p. 856 - 867 12 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

3,3′-Disubstituted 5,5′-Bi(1,2,4-triazine) Derivatives with Potent in Vitro and in Vivo Antimalarial Activity

Xue, L., Shi, D. H., Harjani, J. R., Huang, F., Beveridge, J. G., Dingjan, T., Ban, K., Diab, S., Duffy, S., Lucantoni, L., Fletcher, S., Chiu, F. C. K., Blundell, S., Ellis, K., Ralph, S. A., Wirjanata, G., Teguh, S., Noviyanti, R., Chavchich, M., Creek, D. & 10 others, Price, R. N., Marfurt, J., Charman, S. A., Cuellar, M. E., Strasser, J. M., Dahlin, J. L., Walters, M. A., Edstein, M. D., Avery, V. M. & Baell, J. B., 1 Jan 2019, In : Journal of Medicinal Chemistry. 62, 5, p. 2485-2498 14 p.

Research output: Contribution to journalArticleResearchpeer-review

77 Citations (Scopus)

3,5-Diaryl-2-aminopyridines as a novel class of orally active antimalarials demonstrating single dose cure in mice and clinical candidate potential

Younis, Y., Douelle, F., Feng, T-S., Cabrera, D. G., Le Manach, C., Nchinda, A. T., Duffy, S., White, K. L., Shackleford, D., Morizzi, J., Mannila, J. M., Katneni, K., Bhamidipati, R., Zabiulla, M. K., Joseph, J. T., Bashyam, S., Waterson, D., Witty, M. J., Hardick, D., Wittlin, S. & 3 others, Avery, V. M., Charman, S. A. & Chibale, K., 2012, In : Journal of Medicinal Chemistry. 55, 7, p. 3479 - 3487 9 p.

Research output: Contribution to journalArticleResearchpeer-review

20 Citations (Scopus)

3-(Oxazolo[4,5-b]pyridin-2-yl)anilides as a novel class of potent inhibitors for the kinetoplastid Trypanosoma brucei, the causative agent for human African trypanosomiasis

Ferrins, L., Rahmani, R. S., Sykes, M. L., Jones, A. J., Avery, V. M., Teston, E., Almohaywi, B., Yin, J., Smith, J., Chris, H., White, K. L., Ryan, E., Campbell, M., Charman, S. A., Kaiser, M. & Baell, J. B., 2013, In : European Journal of Medicinal Chemistry. 66, p. 450 - 465 16 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

6-arylpyrazine-2-carboxamides: a new core for Trypanosoma brucei inhibitors

Rahmani, R., Ban, K., Jones, A. J., Ferrins, L., Ganame, D., Sykes, M. L., Avery, V. M., White, K. L., Ryan, E., Kaiser, M., Charman, S. A. & Baell, J. B., 2015, In : Journal of Medicinal Chemistry. 58, 17, p. 6753-6765 13 p.

Research output: Contribution to journalArticleResearchpeer-review

119 Citations (Scopus)

A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria

Phillips, M. A., Lotharius, J., Marsh, K., White, J., Dayan, A., White, K. L., Njoroge, J. W., El Mazouni, F., Lao, Y., Kokkonda, S., Tomchick, D. R., Deng, X., Laird, T., Bhatia, S. N., March, S., Ng, C. L., Fidock, D. A., Wittlin, S., Lafuente-Monasterio, M., Gamo Benito, F. J. & 30 others, Sanz Alonso, L. M., Martinez, M. S., Jimenez-Diaz, M. B., Ferrer Bazaga, S., Angulo-Barturen, I., Haselden, J. N., Louttit, J., Cui, Y., Sridhar, A., Zeeman, A-M., Kocken, C., Sauerwein, R. W., Dechering, K., Avery, V. M., Duffy, S., Delves, M., Sinden, R., Ruecker, A., Wickham, K. S., Rochford, R., Gahagen, J., Iyer, L., Riccio, E., Mirsalis, J., Bathhurst, I., Rueckle, T., Ding, X., Campo, B., Leroy, D. & Charman, S. A., 2015, In : Science Translational Medicine. 7, 296, p. 1-12 12 p.

Research output: Contribution to journalArticleResearchpeer-review

27 Citations (Scopus)

Alteration of the intravenous pharmacokinetics of a synthetic ozonide antimalarial in the presence of a modified cyclodextrin

Charman, S. A., Perry, C. S., Chiu, F. C. K., McIntosh, K. A., Prankerd, R. J. & Charman, W. N., 2006, In : Journal of Pharmaceutical Sciences. 95, 2, p. 256 - 267 12 p.

Research output: Contribution to journalArticleResearchpeer-review

45 Citations (Scopus)

Analogues of fenarimol are potent inhibitors of Trypanosoma cruzi and are efficacious in a murine model of chagas disease

Keenan, M., Abbott, M. J., Alexander, P. W., Armstrong, T., Best, W. M., Berven, B., Botero, A., Chaplin, J. H., Charman, S. A., Chatelain, E., von Geldern, T. W., Kerfoot, M., Khong, A., Nguyen, T. T., McManus, J. D., Morizzi, J., Ryan, E., Scandale, I., Thompson, R. C. A., Wang, S. Z. & 1 others, White, K. L., 2012, In : Journal of Medicinal Chemistry. 55, 9, p. 4189 - 4204 16 p.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

Analysis of bovine immunoglobulin G by capillary gel electrophoresis

Bennett, L. E., Charman, W. N., Williams, D. B. & Charman, S. A., 1994, In : Journal of Pharmaceutical and Biomedical Analysis. 12, 9, p. 1103-1108 6 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

Analysis of pilocarpine and its degradation products by micellar electrokinetic capillary chromatography

Charman, W. N., Humberstone, A. J. & Charman, S. A., 1992, In : Pharmaceutical Research. 9, 9, p. 1219-1223 5 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Analytical methods and stability assessment of liquid yeast derived sucrase

McIntosh, K. A., Charman, S. A., Borgen, L. A. & Charman, W. N., 1998, In : Journal of Pharmaceutical and Biomedical Analysis. p. 1037 - 1045 9 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Analytical methods and stability assessment of liquid yeast derived sucrase

McIntosh, K. A., Charman, S. A., Borgen, L. A. & Charman, W. N., 1 Sep 1998, In : Journal of Pharmaceutical and Biomedical Analysis. 17, 6-7, p. 1037-1045 9 p.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)
167 Citations (Scopus)

A novel multiple-stage antimalarial agent that inhibits protein synthesis

Baragana, B., Hallyburton, I., Lee, M. C. S., Norcross, N. R., Grimaldi, R., Otto, T. D., Proto, W. R., Blagborough, A. M., Meister, S., Wirjanata, G., Ruecker, A., Upton, L. M., Abraham, T. S., Justino de Almeida, M., Pradhan, A., Porzelle, A., Martinez, M. S., Bolscher, J. M., Woodland, A., Norval, S. & 30 others, Zuccotto, F., Thomas, J., Simeons, F., Stojanovski, L., Osuna-Cabello, M., Brock, P. M., Churcher, T. S., Sala, K. A., Zakutansky, S. E., Jimenez-Diaz, M. B., Sanz, L. M., Riley, J., Basak, R., Campbell, M., Avery, V. M., Sauerwein, R. W., Dechering, K. J., Noviyanti, R., Campo, B., Frearson, J. A., Angulo-Barturen, I., Ferrer-Bazaga, S., Gamo, F-J., Wyatt, P. G., Leroy, D., Siegl, P., Delves, M. J., Kyle, D. E., Wittlin, S. & Charman, S. A., 2015, In : Nature. 522, 7556, p. 315-320 6 p.

Research output: Contribution to journalArticleResearchpeer-review

A novel prodrug approach for tertiary amines.3. In vivo evaluation of two N-phosphonocoxymethyl prodrugs in rats and dogs

Krise, J. P., Charman, W. N., Charman, S. A. & Stella, V. J., 1999, In : Journal of Pharmaceutical Sciences. p. 928 - 932 5 p.

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)

A novel prodrug approach for tertiary amines. 3. In vivo evaluation of two N-phosphonooxymethyl prodrugs in rats and dogs

Krise, J. P., Charman, W. N., Charman, S. A. & Stella, V. J., Sep 1999, In : Journal of Pharmaceutical Sciences. 88, 9, p. 928-932 5 p.

Research output: Contribution to journalArticleResearchpeer-review

46 Citations (Scopus)

Antimalarial activity of N-alkyl amine, carboxamide, sulfonamide, and urea derivatives of a dispiro-1,2,4-trioxolane piperidine

Padmanilayam, M., Scorneaux, B., Dong, Y., Chollet, J., Matile, H., Charman, S. A., Creek, D. J., Charman, W. N., Santo Tomas, J., Scheurer, C., Wittlin, S., Brun, R. & Vennerstrom, J., 2006, In : Bioorganic and Medicinal Chemistry Letters. 16, 21, p. 5542 - 5545 4 p.

Research output: Contribution to journalArticleResearchpeer-review

39 Citations (Scopus)

Antimalarial activity of pyrroloiminoquinones from the Australian marine sponge Zyzzya sp.

Davis, R. A., Buchanan, M. S., Duffy, S., Avery, V. M., Charman, S. A., Charman, W. N., White, K. L., Shackleford, D., Edstein, M. D., Andrews, K., Camp, D. G. & Quinn, R. J., 2012, In : Journal of Medicinal Chemistry. 55, 12, p. 5851 - 5858 8 p.

Research output: Contribution to journalArticleResearchpeer-review

59 Citations (Scopus)

Antimalarial efficacy of MMV390048, an inhibitor of Plasmodium phosphatidylinositol 4-kinase

Paquet, T., Le Manach, C., Cabrera, D. G., Younis, Y., Henrich, P. P., Abraham, T. S., Lee, M. C. S., Basak, R., Ghidelli-Disse, S., Lafuente-Monasterio, M. J., Bantscheff, M., Ruecker, A., Blagborough, A. M., Zakutansky, S. E., Zeeman, A-M., White, K. L., Shackleford, D. M., Mannila, J., Morizzi, J., Scheurer, C. & 1 others, Charman, S. A., 26 Apr 2017, In : Science Translational Medicine. 9, 387, 14 p., eaad9735.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

Antimalarial Inhibitors Targeting Serine Hydroxymethyltransferase (SHMT) with in Vivo Efficacy and Analysis of their Binding Mode Based on X-ray Cocrystal Structures

Schwertz, G., Witschel, M. C., Rottmann, M., Bonnert, R., Leartsakulpanich, U., Chitnumsub, P., Jaruwat, A., Ittarat, W., Schäfer, A., Aponte, R. A., Charman, S. A., White, K. L., Kundu, A., Sadhukhan, S., Lloyd, M., Freiberg, G. M., Srikumaran, M., Siggel, M., Zwyssig, A., Chaiyen, P. & 1 others, Diederich, F., 22 Jun 2017, In : Journal of Medicinal Chemistry. 60, 12, p. 4840-4860 21 p.

Research output: Contribution to journalArticleResearchpeer-review

55 Citations (Scopus)

Antimalarial Pyrido[1,2-a]benzimidazoles

Ndakala, A., Gessner, R., Gitari, P., October, N., White, K., Hudson, A., Fakorede, F., Shackleford, D., Kaiser, M., Yates, C., Charman, S. & Chibale, K., 2011, In : Journal of Medicinal Chemistry. 54, p. 4581 - 4589 9 p.

Research output: Contribution to journalArticleResearchpeer-review

31 Citations (Scopus)

Antitrypanosomal activity of fexinidazole metabolites, potential new drug candidates for Chagas disease

Bahia, M. T., Nascimento, A. F. S., Mazzeti, A. L., Marques, L. F., Goncalves, K. R., Mota, L. W. R., Diniz, L. D. F., Caldas, I. S., Talvani, A., Shackleford, D., Koltun, M., Saunders, J., White, K. L., Scandale, I., Charman, S. A. & Chatelain, E., 2014, In : Antimicrobial Agents and Chemotherapy. 58, 8, p. 4362 - 4370 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
37 Citations (Scopus)

A prodrug approach toward cancer-related carbonic anhydrase inhibition

Carroux, C. J., Rankin, G. M., Moeker, J., Bornaghi, L. F., Katneni, K., Morizzi, J., Charman, S. A., Vullo, D., Supuran, C. T. & Poulsen, S-A., 2013, In : Journal of Medicinal Chemistry. 56, 23, p. 9623 - 9634 12 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Assessing drug efficacy against Plasmodium falciparum liver stages in vivo

Flannery, E. L., Foquet, L., Chuenchob, V., Fishbaugher, M., Billman, Z., Navarro, M. J., Betz, W., Olsen, T. M., Lee, J., Camargo, N., Nguyen, T., Schafer, C., Sack, B. K., Wilson, E. M., Saunders, J., Bial, J., Campo, B., Charman, S. A., Murphy, S. C., Phillips, M. A. & 2 others, Kappe, S. H. & Mikolajczak, S. A., 11 Jan 2018, In : JCI Insight. 3, 1, 12 p., e92587.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
25 Citations (Scopus)

Assessing the utility of an anti-malarial pharmacokinetic-pharmacodynamic model for aiding drug clinical development

Zaloumis, S., Humberstone, A. J., Charman, S. A., Price, R. N., Moehrle, J., Gamo-Benito, J., McCaw, J., Jamsen, K., Smith, K. & Simpson, J. A., 2012, In : Malaria Journal. 11, 303, p. 1 - 14 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
24 Citations (Scopus)

A tetraoxane-based antimalarial drug candidate that overcomes PfK13-C580Y dependent artemisinin resistance

O'Neill, P. M., Amewu, R. K., Charman, S. A., Sabbani, S., Gnädig, N. F., Straimer, J., Fidock, D. A., Shore, E. R., Roberts, N. L., Wong, M. H. L., Hong, W. D., Pidathala, C., Riley, C., Murphy, B., Aljayyoussi, G., Gamo, F. J., Sanz, L., Rodrigues, J., Cortes, C. G., Herreros, E. & 2 others, Ryan, E. & Shackleford, D. M., 24 May 2017, In : Nature Communications. 8, 10 p., 15159.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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35 Citations (Scopus)

A triazolopyrimidine-based dihydroorotate dehydrogenase inhibitor with improved drug-like properties for treatment and prevention of malaria

Phillips, M. A., White, K., Kokkonda, S., Deng, X., White, J., El Mazouni, F., Marsh, K., Tomchick, D. R., Manjalanagara, K., Rudra, K. R., Wirjanata, G., Noviyanti, R., Price, R. N., Marfurt, J., Shackleford, D., Chiu, F., Campbell, M., Jimenez-Diaz, M. B., Bazaga, S. F., Angulo-Barturen, I. & 1 others, Charman, S., 9 Dec 2016, In : ACS Infectious Diseases. 2, 12, p. 945-957 13 p.

Research output: Contribution to journalArticleResearchpeer-review

41 Citations (Scopus)

Bioisosteric transformations and permutations in the triazolopyrimidine scaffold to identify the minimum pharmacophore required for inhibitory activity against Plasmodium falciparum dihydroorotate dehydrogenase

Marwaha, A., White, J., El Mazouni, F., Creason, S., Kokkonda, S., Buckner, F. S., Charman, S. A., Phillips, M. & Rathod, P., 2012, In : Journal of Medicinal Chemistry. 55, 17, p. 7425 - 7436 12 p.

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)

Biopharmaceutical characterisation of a low-dose (75 mg) controlled-release aspirin formulation

Charman, W. N., Charman, S. A., Monkhouse, D. C., Frisbee, S. E., Lockhart, E. A., Weisman, S. & Fitzgerald, G. A., 1993, In : British Journal of Clinical Pharmacology. 36, 5, p. 470-473 4 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

Biphasic drug absorption from the epidural space of the dog may limit the utility of a slow release medium molecular weight hyaluronic acid- lidocaine ionic complex formulation

Doherty, M. M., Hughes, P. J., Charman, S. A., Brock, K. V., Korszniak, N. V. & Charman, W. N., 1996, In : Anesthesia and Analgesia. 83, 6, p. 1244-1250 7 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Brain uptake of diazepam and phenytoin in a genetic animal model of absence epilepsy

Nicolazzo, J., Steuten, J. A., Charman, S. A., Taylor, N., Davies, P. & Petrou, S., 2010, In : Clinical and Experimental Pharmacology and Physiology. 37, p. 647 - 649 3 p.

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)

Central nervous system exposure of next generation quinoline methanols is reduced relative to mefloquine after intravenous dosing in mice

Dow, G., Milner, E., Bathurst, I., Bhonsle, J., Caridha, D., Gardner, S., Gerena, L., Kozar, M., Lanteri, C., Mannila, A., McCalmont, W., Moon, J., Read, K., Norval, S., Roncal, N., Shackleford, D., Sousa, J., Steuten, J., White, K., Zeng, Q. & 1 others, Charman, S., 2011, In : Malaria Journal. 10, 150, p. e1 - e11 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
28 Citations (Scopus)

Characterization of the two major CYP450 metabolites of ozonide (1,2,4-trioxolane) OZ277

Zhou, L., Alker, A., Ruf, A., Wang, X., Chiu, F. C. K., Morizzi, J., Charman, S. A., Charman, W. N., Scheurer, C., Wittlin, S., Dong, Y., Hunziker, D. & Vennerstrom, J., 2008, In : Bioorganic and Medicinal Chemistry Letters. 18, 5, p. 1555 - 1558 4 p.

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)

Chemical kinetics and aqueous degradation pathways of a new class of synthetic ozonide antimalarials

Perry, C. S., Charman, S. A., Prankerd, R. J., Chiu, F. C. K., Dong, Y., Vennerstrom, J. L. & Charman, W. N., 2006, In : Journal of Pharmaceutical Sciences. 95, 4, p. 737 - 747 11 p.

Research output: Contribution to journalArticleResearchpeer-review

49 Citations (Scopus)

Comparative antimalarial activities and ADME profiles of ozonides (1,2,4-trioxolanes) OZ277, OZ439, and their 1,2-dioxolane, 1,2,4-trioxane, and 1,2,4,5-tetraoxane isosteres

Wang, X., Dong, Y., Wittlin, S., Charman, S. A., Chiu, F. C. K., Chollet, J., Katneni, K., Mannila, J. M., Morizzi, J., Ryan, E., Scheurer, C., Steuten, J. A., Santo Tomas, J., Snyder, C. & Vennerstrom, J., 2013, In : Journal of Medicinal Chemistry. 56, 6, p. 2547 - 2555 9 p.

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)

Comparative antimalarial activities of six pairs of 1,2,4,5-tetraoxanes (peroxide dimers) and 1,2,4,5,7,8-hexaoxonanes (peroxide trimers)

Dong, Y., Creek, D. J., Chollet, J., Matile, H., Charman, S. A., Wittlin, S., Woods, J. H. & Vennerstrom, J., 2007, In : Antimicrobial Agents and Chemotherapy. 51, 8, p. 3033 - 3035 3 p.

Research output: Contribution to journalArticleResearchpeer-review

24 Citations (Scopus)

Comparison of the exposure time dependence of the activities of synthetic ozonide antimalarials and dihydroartemisinin against K13 wild-type and mutant Plasmodium falciparum strains

Yang, T., Xie, S. C., Cao, P., Giannangelo, C., McCaw, J., Creek, D. J., Charman, S. A., Klonis, N. & Tilley, L., 1 Aug 2016, In : Antimicrobial Agents and Chemotherapy. 60, 8, p. 4501-4510 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
53 Citations (Scopus)

Complexes of Trypanosoma cruzi sterol 14a-demethylase (CYP51) with two pyridine-based drug candidates for Chagas disease: Structural basis for pathogen selectivity

Hargrove, T. Y., Wawrzak, Z., Alexander, P. W., Chaplin, J. H., Keenan, M., Charman, S. A., Perez, C., Waterman, M., Chatelain, E. & Lepesheva, G. I., 2013, In : Journal of Biological Chemistry. 288, 44, p. 31602 - 31615 14 p.

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)

Computational prediction of CNS drug exposure based on a novel in vivo dataset

Bergstrom, C. A. S., Charman, S. A. & Nicolazzo, J., 2012, In : Pharmaceutical Research. 29, 11, p. 3131 - 3142 12 p.

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)

CYT997: a novel orally active tubulin polymerization inhibitor with potent cytotoxic and vascular disrupting activity in vitro and in vivo

Burns, C., Fantino, E., Phillips, I. D., Su, S., Harte, M., Bukczynska, P. E., Frazzetto, M., Joffe, M., Kruszelnicki, I., Wang, B., Wang, Y., Wilson, N., Dilley, R. J., Wan, S. S., Charman, S. A., Shackleford, D., Fida, R., Malcontenti-Wilson, C. & Wilks, A. F., 2009, In : Molecular Cancer Therapeutics. 8, 11, p. 3036 - 3045 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Degradation of recombinant porcine growth hormone in the presence of guanidine hydrochloride

McCrossin, L. E., Charman, W. N. & Charman, S. A., 30 Oct 1998, In : International Journal of Pharmaceutics. 173, 1-2, p. 157-170 14 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Derivatives of a benzoquinone acyl hydrazone with activity against Toxoplasma gondii

Sanford, A. G., Schulze, T. T., Potluri, L. P., Watson, G. F., Darner, E. B., Zach, S. J., Hemsley, R. M., Wallick, A. I., Warner, R. C., Charman, S. A., Wang, X., Vennerstrom, J. L. & Davis, P. H., 1 Dec 2018, In : International Journal for Parasitology: Drugs and Drug Resistance. 8, 3, p. 488-492 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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20 Citations (Scopus)

Design, structure-activity relationship and in vivo efficacy of piperazine analogues of fenarimol as inhibitors of Trypanosoma cruzi

Keenan, M., Alexander, P. W., Diao, H., Best, W. M., Khong, A., Kerfoot, M., Thompson, R. C. A., White, K. L., Shackleford, D., Ryan, E., Gregg, A. D., Charman, S. A., von Geldern, T. W., Scandale, I. & Chatelain, E., 2013, In : Bioorganic & Medicinal Chemistry. 21, 7, p. 1756 - 1763 8 p.

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)

Development of diaminoquinazoline histone lysine methyltransferase inhibitors as potent blood-stage antimalarial compounds

Sundriyal, S., Malmquist, N. A., Caron, J., Blundell, S., Liu, F., Chen, X., Srimongkolpithak, N., Jin, JI., Charman, S. A., Scherf, A. & Fuchter, M. J., 2014, In : ChemMedChem. 9, 10, p. 2360 - 2373 14 p.

Research output: Contribution to journalArticleResearchpeer-review

62 Citations (Scopus)

Discovery, synthesis, and optimization of antimalarial 4(1H)-quinolone-3-diarylethers

Nilsen, A., Miley, G. P., Forquer, I. P., Mather, M. W., Katneni, K., Li, Y., Pou, S., Pershing, A. M., Stickles, A. M., Ryan, E., Kelly, J. X., Doggett, J. S., White, K. L., Hinrichs, D. J., Winter, R. W., Charman, S. A., Zakharov, L. N., Bathurst, I. C., Burrows, J., Vaidya, A. B. & 1 others, Riscoe, M. K., 2014, In : Journal of Medicinal Chemistry. 57, 9, p. 3818 - 3834 17 p.

Research output: Contribution to journalArticleResearchpeer-review

33 Citations (Scopus)

Discovery and structure-activity relationships of pyrrolone antimalarials

Murugesan, D., Mital, A., Kaiser, M., Shackleford, D., Morizzi, J., Katneni, K., Campbell, M., Hudson, A., Charman, S. A., Yeates, C. & Gilbert, I. H., 2013, In : Journal of Medicinal Chemistry. 56, 7, p. 2975 - 2990 16 p.

Research output: Contribution to journalArticleResearchpeer-review

104 Citations (Scopus)

Discovery of 7-hydroxy-6-methoxy-2-methyl-3-(3,4,5-trimethoxybenzoyl)benzo[b]furan (BNC105), a tubulin polymerization inhibitor with potent antiproliferative and tumor vascular disrupting properties

Flynn, B., Gurmit, G., Grobelny, D., Chaplin, J., Paul, D., Leske, A., Lavranos, T., Chalmers, D., Charman, S., Kostewicz, E., Shackleford, D., Morizzi, J., Hamel, E., Jung, K. & Kremmidiotis, G., 2011, In : Journal of Medicinal Chemistry. 54, 17, p. 6014 - 6027 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Discovery of benzoylsulfonohydrazides as potent inhibitors of the histone acetyltransferase KAT6A

Leaver, D. J., Cleary, B., Nguyen, N., Priebbenow, D., Lagiakos, H. R., Sanchez, J., Xue, L., Huang, F., Sun, Y., Mujumdar, P., Mudududdla, R., Varghese, S., Teguh, S., Charman, S. A., White, K. L., Katneni, K., Cuellar, M., Strasser, J. M., Dahlin, J. L., Walters, M. A. & 10 others, Street, I. P., Monahan, B. J., Jarman, K. E., Sabroux, H. J., Falk, H., Chung, M. C., Hermans, S. J., Parker, M. W., Thomas, T. & Baell, J. B., 8 Aug 2019, In : Journal of Medicinal Chemistry. 62, 15, p. 7146-7159 14 p.

Research output: Contribution to journalArticleResearchpeer-review