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Research Output 1991 2019

1999

A novel prodrug approach for tertiary amines.3. In vivo evaluation of two N-phosphonocoxymethyl prodrugs in rats and dogs

Krise, J. P., Charman, W. N., Charman, S. A. & Stella, V. J., 1999, In : Journal of Pharmaceutical Sciences. p. 928 - 932 5 p.

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)

A novel prodrug approach for tertiary amines. 3. In vivo evaluation of two N-phosphonooxymethyl prodrugs in rats and dogs

Krise, J. P., Charman, W. N., Charman, S. A. & Stella, V. J., Sep 1999, In : Journal of Pharmaceutical Sciences. 88, 9, p. 928-932 5 p.

Research output: Contribution to journalArticleResearchpeer-review

41 Citations (Scopus)

Drug delivery: A key factor in realising the full therapeutic potential of drugs

Charman, W. N., Chan, H-K., Finnin, B. C. & Charman, S. A., 1999, In : Drug Development Research. 46, 3-4, p. 316-327 12 p.

Research output: Contribution to journalArticleResearchpeer-review

In vitro distribution of coenzyme Q10 in plasma lipoproteins

Thomas, B. J., McIntosh, M. P., Kannar, D., Charman, S. A. & Charman, W. N., 1999, p. S-124 - S-124. 1 p.

Research output: Contribution to conferenceAbstractOther

7 Citations (Scopus)

Mechanisms controlling diffusion and release of model proteins through and from partially esterified hyaluronic acid membranes

Simon, L. D., Stella, V. J., Charman, W. N. & Charman, S. A., 20 Sep 1999, In : Journal of Controlled Release. 61, 3, p. 267-279 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Oral absorptionn of nucleoside analogue prodrugs II.Physio cochemical properties and Invitro intestinal permeabilities

Smith, G. D., Zhou, J., Marcuccio, S., Robertson, A. D., Charman, W. N. & Charman, S. A., 1999, p. S-645 - S-645. 1 p.

Research output: Contribution to conferenceAbstractOther

Oral asorption of nucleoside analogue prodrus I.Invivo bioavailabiliy assessment

Smith, G. D., Bloodworth, T., Marcuccio, S., Robertson, A. D., Charman, W. N. & Charman, S. A., 1999, p. S-641 - S-641. 1 p.

Research output: Contribution to conferenceAbstractOther

Relationship between physicochemical properties, in vitro intestinal permeability and oral bioavailability for nucleoside analogue prodrugs

Zhou, J., Smith, G. D. & Charman, S. A., 1999, p. 68 - 68. 1 p.

Research output: Contribution to conferenceAbstractOther

Variation in the diffusion and release of ribonuclease through and from esterified hyaluronic acid membranes: Effect of changes in matrix characteristics

Simon, L. D., Stella, V. J., Charman, W. N. & Charman, S. A., 27 Aug 1999, In : Journal of Controlled Release. 61, 1-2, p. 159-164 6 p.

Research output: Contribution to journalArticleResearchpeer-review

1998
1 Citation (Scopus)

Analytical methods and stability assessment of liquid yeast derived sucrase

McIntosh, K. A., Charman, S. A., Borgen, L. A. & Charman, W. N., 1 Sep 1998, In : Journal of Pharmaceutical and Biomedical Analysis. 17, 6-7, p. 1037-1045 9 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Analytical methods and stability assessment of liquid yeast derived sucrase

McIntosh, K. A., Charman, S. A., Borgen, L. A. & Charman, W. N., 1998, In : Journal of Pharmaceutical and Biomedical Analysis. p. 1037 - 1045 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Degradation of recombinant porcine growth hormone in the presence of guanidine hydrochloride

McCrossin, L. E., Charman, W. N. & Charman, S. A., 30 Oct 1998, In : International Journal of Pharmaceutics. 173, 1-2, p. 157-170 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Development and validation of an in vitro model to measure the intestinal permeability of potential oral formulations of human growth hormone

McIntosh, K. A., Charman, W. N., Milstein, S. & Charman, S. A., 1998, p. 97 - 97. 1 p.

Research output: Contribution to conferenceAbstractOther

Plasma pharmacokinetics and brain penetration of AM36, a novel neuroprotective compound in the rat

Smith, G. D., Robertson, A. D., Charman, W. N. & Charman, S. A., 1998, p. S678 - S678. 1 p.

Research output: Contribution to conferenceAbstractOther

Prodrugs of nucleoside analogues I: Oral bioavailability in the rat

Charman, S. A., Smith, G. D., Robertson, A. D., Bloodworth, T., Marcuccio, S. & Charman, W. N., 1998, p. 94 - 94. 1 p.

Research output: Contribution to conferenceAbstractOther

Prodrugs of nucleoside analogues II: In vitro permeability in excised rat jejunum

Bawden, A., Smith, G. D., Robertson, A. D., Marcuccio, S., Charman, W. N. & Charman, S. A., 1998, p. 95 - 95. 1 p.

Research output: Contribution to conferenceAbstractOther

Stability studies for solution formulations of leukemia inhibitory factor (LIF)

Charman, S. A., Hill, J. M. & Radford, A. J., 1998, p. S536 - S536. 1 p.

Research output: Contribution to conferenceAbstractOther

Synthesis and evaluation of a novel prodrug for increasing the water solubility of tertiary amine-containing drugs

Krise, J. P., Charman, W. N., Charman, S. A., Narisawa, S., Zygmunt, J. & Stella, V. J., 1998, p. S99 - S99. 1 p.

Research output: Contribution to conferenceAbstractOther

20 Citations (Scopus)

The application of capillary electrophoresis for monitoring effects of excipients on protein conformation

McIntosh, K. A., Charman, W. N. & Charman, S. A., Feb 1998, In : Journal of Pharmaceutical and Biomedical Analysis. 16, 6, p. 1097-1105 9 p.

Research output: Contribution to journalArticleResearchpeer-review

The D log D parameter as a correlate of the brain penetration of a series novel neuroprotective compounds in the rat

Smith, G. D., Robertson, A. D., Hill, J. M., Charman, W. N. & Charman, S. A., 1998, p. 94 - 94. 1 p.

Research output: Contribution to conferenceAbstractOther

1997

Overseas Trials

Baines, P. J., Charman, S. A., Clarke, G. M., Roman, R. S. & Walters, S. M., 1997, Drug Products for Clinical Trials : An International Guide to Formulation-Production-Quality Control. New York NY USA: Marcel Dekker, p. 301 - 330 30 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

Preliminary stability studies for solution formulations of an investigational protein

Hill, J. M., Radford, A. J. & Charman, S. A., 1997, p. 70 - 70. 1 p.

Research output: Contribution to conferenceAbstractOther

5 Citations (Scopus)

Protein transport across hydrated hyaluronic acid ester membranes: Evaluation of ribonuclease A as a potentially useful model protein

Simon, L. D., Charman, W. N., Charman, S. A. & Stella, V. J., 1997, In : Journal of Controlled Release. 45, 3, p. 273-285 13 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Synthesis, physiochemical and biological evaluation of a novel prodrug for increasing the water solubility of tertiary amine-containing drug

Krise, J. P., Charman, W. N., Charman, S. A. & Stella, V. J., 1997, p. 71 - 71. 1 p.

Research output: Contribution to conferenceAbstractOther

1996
11 Citations (Scopus)

Biphasic drug absorption from the epidural space of the dog may limit the utility of a slow release medium molecular weight hyaluronic acid- lidocaine ionic complex formulation

Doherty, M. M., Hughes, P. J., Charman, S. A., Brock, K. V., Korszniak, N. V. & Charman, W. N., 1996, In : Anesthesia and Analgesia. 83, 6, p. 1244-1250 7 p.

Research output: Contribution to journalArticleResearchpeer-review

26 Citations (Scopus)

Evaluation of emulsifiable glasses for the oral administration of cyclosporin in beagle dogs

Porter, C. J. H., Charman, S. A., Williams, R. D., Bakalova, M. V. & Charman, W. N., 6 Sep 1996, In : International Journal of Pharmaceutics. 141, 1-2, p. 227-237 11 p.

Research output: Contribution to journalArticleResearchpeer-review

113 Citations (Scopus)
9 Citations (Scopus)

Synthesis and evaluation of 5' alkyl ester prodrugs of zidovudine for directed lymphatic delivery

Bibby, D. C., Charman, W. N., Charman, S. A., Iskander, M. N. & Porter, C. J. H., 22 Nov 1996, In : International Journal of Pharmaceutics. 144, 1, p. 61-70 10 p.

Research output: Contribution to journalArticleResearchpeer-review

1994
13 Citations (Scopus)

Analysis of bovine immunoglobulin G by capillary gel electrophoresis

Bennett, L. E., Charman, W. N., Williams, D. B. & Charman, S. A., 1994, In : Journal of Pharmaceutical and Biomedical Analysis. 12, 9, p. 1103-1108 6 p.

Research output: Contribution to journalArticleResearchpeer-review

1993
21 Citations (Scopus)

Biopharmaceutical characterisation of a low-dose (75 mg) controlled-release aspirin formulation

Charman, W. N., Charman, S. A., Monkhouse, D. C., Frisbee, S. E., Lockhart, E. A., Weisman, S. & Fitzgerald, G. A., 1993, In : British Journal of Clinical Pharmacology. 36, 5, p. 470-473 4 p.

Research output: Contribution to journalArticleResearchpeer-review

104 Citations (Scopus)

Techniques for Assessing the Effects of Pharmaceutical Excipients on the Aggregation of Porcine Growth Hormone

Charman, S. A., Mason, K. L. & Charman, W. N., 1993, In : Pharmaceutical Research. 10, 7, p. 954-962 9 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Validation of a Peptide Map for Recombinant Porcine Growth Hormone and Application to Stability Assessment

Charman, S. A., McCrossin, L. E. & Charman, W. N., 1993, In : Pharmaceutical Research. 10, 10, p. 1471-1477 7 p.

Research output: Contribution to journalArticleResearchpeer-review

1992
12 Citations (Scopus)

Analysis of pilocarpine and its degradation products by micellar electrokinetic capillary chromatography

Charman, W. N., Humberstone, A. J. & Charman, S. A., 1992, In : Pharmaceutical Research. 9, 9, p. 1219-1223 5 p.

Research output: Contribution to journalArticleResearchpeer-review

362 Citations (Scopus)

Self-Emulsifying Drug Delivery Systems: Formulation and Biopharmaceutic Evaluation of an Investigational Lipophilic Compound

Charman, S. A., Charman, W. N., Rogge, M. C., Wilson, T. D., Dutko, F. J. & Pouton, C. W., 1992, In : Pharmaceutical Research. 9, 1, p. 87-93 7 p.

Research output: Contribution to journalArticleResearchpeer-review

1991
24 Citations (Scopus)

Presystemic acetylation of platelets by aspirin: Reduction in rate of drug delivery to improve biochemical selectivity for thromboxane A2

Fitzgerald, G. A., Lupinetti, M., Charman, S. A. & Charman, W. N., 1991, In : Journal of Pharmacology and Experimental Therapeutics. 259, 3, p. 1043-1049 7 p.

Research output: Contribution to journalArticleResearchpeer-review