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Research Output 1991 2019

Abstract

A modified ussing chamber model for the evaluation of rhGH transepithelial absorption

McIntosh, K. A., Charman, W. N. & Charman, S. A., 1999, p. S-421 - S-421. 1 p.

Research output: Contribution to conferenceAbstractOther

Development and validation of an in vitro model to measure the intestinal permeability of potential oral formulations of human growth hormone

McIntosh, K. A., Charman, W. N., Milstein, S. & Charman, S. A., 1998, p. 97 - 97. 1 p.

Research output: Contribution to conferenceAbstractOther

In vitro distribution of coenzyme Q10 in plasma lipoproteins

Thomas, B. J., McIntosh, M. P., Kannar, D., Charman, S. A. & Charman, W. N., 1999, p. S-124 - S-124. 1 p.

Research output: Contribution to conferenceAbstractOther

Oral absorptionn of nucleoside analogue prodrugs II.Physio cochemical properties and Invitro intestinal permeabilities

Smith, G. D., Zhou, J., Marcuccio, S., Robertson, A. D., Charman, W. N. & Charman, S. A., 1999, p. S-645 - S-645. 1 p.

Research output: Contribution to conferenceAbstractOther

Oral asorption of nucleoside analogue prodrus I.Invivo bioavailabiliy assessment

Smith, G. D., Bloodworth, T., Marcuccio, S., Robertson, A. D., Charman, W. N. & Charman, S. A., 1999, p. S-641 - S-641. 1 p.

Research output: Contribution to conferenceAbstractOther

Plasma pharmacokinetics and brain penetration of AM36, a novel neuroprotective compound in the rat

Smith, G. D., Robertson, A. D., Charman, W. N. & Charman, S. A., 1998, p. S678 - S678. 1 p.

Research output: Contribution to conferenceAbstractOther

Preliminary stability studies for solution formulations of an investigational protein

Hill, J. M., Radford, A. J. & Charman, S. A., 1997, p. 70 - 70. 1 p.

Research output: Contribution to conferenceAbstractOther

Prodrugs of nucleoside analogues I: Oral bioavailability in the rat

Charman, S. A., Smith, G. D., Robertson, A. D., Bloodworth, T., Marcuccio, S. & Charman, W. N., 1998, p. 94 - 94. 1 p.

Research output: Contribution to conferenceAbstractOther

Prodrugs of nucleoside analogues II: In vitro permeability in excised rat jejunum

Bawden, A., Smith, G. D., Robertson, A. D., Marcuccio, S., Charman, W. N. & Charman, S. A., 1998, p. 95 - 95. 1 p.

Research output: Contribution to conferenceAbstractOther

Relationship between physicochemical properties, in vitro intestinal permeability and oral bioavailability for nucleoside analogue prodrugs

Zhou, J., Smith, G. D. & Charman, S. A., 1999, p. 68 - 68. 1 p.

Research output: Contribution to conferenceAbstractOther

Stability studies for solution formulations of leukemia inhibitory factor (LIF)

Charman, S. A., Hill, J. M. & Radford, A. J., 1998, p. S536 - S536. 1 p.

Research output: Contribution to conferenceAbstractOther

Synthesis, physiochemical and biological evaluation of a novel prodrug for increasing the water solubility of tertiary amine-containing drug

Krise, J. P., Charman, W. N., Charman, S. A. & Stella, V. J., 1997, p. 71 - 71. 1 p.

Research output: Contribution to conferenceAbstractOther

Synthesis and evaluation of a novel prodrug for increasing the water solubility of tertiary amine-containing drugs

Krise, J. P., Charman, W. N., Charman, S. A., Narisawa, S., Zygmunt, J. & Stella, V. J., 1998, p. S99 - S99. 1 p.

Research output: Contribution to conferenceAbstractOther

The D log D parameter as a correlate of the brain penetration of a series novel neuroprotective compounds in the rat

Smith, G. D., Robertson, A. D., Hill, J. M., Charman, W. N. & Charman, S. A., 1998, p. 94 - 94. 1 p.

Research output: Contribution to conferenceAbstractOther

Article
105 Citations (Scopus)

(+)-SJ733, a clinical candidate for malaria that acts through ATP4 to induce rapid host-mediated clearance of Plasmodium

Jimenez-Diaz, M. B., Ebert, D., Salinas, Y., Pradhan, A., Lehane, A. M., Myrand-Lapierre, M-E., O'Loughlin, K. G., Shackleford, D., Justino de Almeida, M., Carrillo, A., Clark, J. A., Dennis, A. S. M., Diep, J., Deng, X., Duffy, S., Endsley, A. N., Fedewa, G., Guiguemde, W. A., Gomez, M. G., Holbrook, G. & 30 others, Horst, J. A., Kim, C. C., Liu, J., Lee, M. C. S., Matheny, A., Martinez, M. S., Miller, G. E., Rodriguez-Alejandre, A., Sanz, L. M., Sigal, M., Spillman, N. J., Stein, P. D., Wang, Z., Zhu, F., Waterson, D., Knapp, S., Shelat, A. A., Avery, V. M., Fidock, D. A., Gamo, F-J., Charman, S. A., Mirsalis, J. C., Ma, H., Ferrer, S. B., Kirk, K., Angulo-Barturen, I., Kyle, D. E., de Risi, J. L., Floyd, D. M. & Guy, R. K., 2014, In : Proceedings of the National Academy of Sciences. 111, 50, p. e5455 - e5462 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
22 Citations (Scopus)

2,4-Diaminothienopyrimidines as orally active antimalarial agents

Cabrera, D. G., Le Manach, C., Douelle, F., Younis, Y., Feng, T-S., Paquet, T., Nchinda, A. T., Street, L. J., Taylor, D., de Kock, C., Wiesner, L., Duffy, S., White, K. L., Zabiulla, M. K., Sambandan, Y., Bashyam, S., Waterson, D., Witty, M. J., Charman, S. A., Avery, V. M. & 2 others, Wittlin, S. & Chibale, K., 2014, In : Journal of Medicinal Chemistry. 57, 3, p. 1014 - 1022 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

2,5-Dimethyl-2,4-hexadiene induced photodechlorination of 9,10-dichloroanthracene

Saltiel, J., Smothers, W. K., Schanze, K. S., Charman, S. A. & Bonneau, R., 2009, In : Photochemical & Photobiological Sciences. 8, 6, p. 856 - 867 12 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

3,3′-Disubstituted 5,5′-Bi(1,2,4-triazine) Derivatives with Potent in Vitro and in Vivo Antimalarial Activity

Xue, L., Shi, D. H., Harjani, J. R., Huang, F., Beveridge, J. G., Dingjan, T., Ban, K., Diab, S., Duffy, S., Lucantoni, L., Fletcher, S., Chiu, F. C. K., Blundell, S., Ellis, K., Ralph, S. A., Wirjanata, G., Teguh, S., Noviyanti, R., Chavchich, M., Creek, D. & 10 others, Price, R. N., Marfurt, J., Charman, S. A., Cuellar, M. E., Strasser, J. M., Dahlin, J. L., Walters, M. A., Edstein, M. D., Avery, V. M. & Baell, J. B., 1 Jan 2019, In : Journal of Medicinal Chemistry. 62, 5, p. 2485-2498 14 p.

Research output: Contribution to journalArticleResearchpeer-review

76 Citations (Scopus)

3,5-Diaryl-2-aminopyridines as a novel class of orally active antimalarials demonstrating single dose cure in mice and clinical candidate potential

Younis, Y., Douelle, F., Feng, T-S., Cabrera, D. G., Le Manach, C., Nchinda, A. T., Duffy, S., White, K. L., Shackleford, D., Morizzi, J., Mannila, J. M., Katneni, K., Bhamidipati, R., Zabiulla, M. K., Joseph, J. T., Bashyam, S., Waterson, D., Witty, M. J., Hardick, D., Wittlin, S. & 3 others, Avery, V. M., Charman, S. A. & Chibale, K., 2012, In : Journal of Medicinal Chemistry. 55, 7, p. 3479 - 3487 9 p.

Research output: Contribution to journalArticleResearchpeer-review

20 Citations (Scopus)

3-(Oxazolo[4,5-b]pyridin-2-yl)anilides as a novel class of potent inhibitors for the kinetoplastid Trypanosoma brucei, the causative agent for human African trypanosomiasis

Ferrins, L., Rahmani, R. S., Sykes, M. L., Jones, A. J., Avery, V. M., Teston, E., Almohaywi, B., Yin, J., Smith, J., Chris, H., White, K. L., Ryan, E., Campbell, M., Charman, S. A., Kaiser, M. & Baell, J. B., 2013, In : European Journal of Medicinal Chemistry. 66, p. 450 - 465 16 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

6-arylpyrazine-2-carboxamides: a new core for Trypanosoma brucei inhibitors

Rahmani, R., Ban, K., Jones, A. J., Ferrins, L., Ganame, D., Sykes, M. L., Avery, V. M., White, K. L., Ryan, E., Kaiser, M., Charman, S. A. & Baell, J. B., 2015, In : Journal of Medicinal Chemistry. 58, 17, p. 6753-6765 13 p.

Research output: Contribution to journalArticleResearchpeer-review

116 Citations (Scopus)

A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria

Phillips, M. A., Lotharius, J., Marsh, K., White, J., Dayan, A., White, K. L., Njoroge, J. W., El Mazouni, F., Lao, Y., Kokkonda, S., Tomchick, D. R., Deng, X., Laird, T., Bhatia, S. N., March, S., Ng, C. L., Fidock, D. A., Wittlin, S., Lafuente-Monasterio, M., Gamo Benito, F. J. & 30 others, Sanz Alonso, L. M., Martinez, M. S., Jimenez-Diaz, M. B., Ferrer Bazaga, S., Angulo-Barturen, I., Haselden, J. N., Louttit, J., Cui, Y., Sridhar, A., Zeeman, A-M., Kocken, C., Sauerwein, R. W., Dechering, K., Avery, V. M., Duffy, S., Delves, M., Sinden, R., Ruecker, A., Wickham, K. S., Rochford, R., Gahagen, J., Iyer, L., Riccio, E., Mirsalis, J., Bathhurst, I., Rueckle, T., Ding, X., Campo, B., Leroy, D. & Charman, S. A., 2015, In : Science Translational Medicine. 7, 296, p. 1-12 12 p.

Research output: Contribution to journalArticleResearchpeer-review

27 Citations (Scopus)

Alteration of the intravenous pharmacokinetics of a synthetic ozonide antimalarial in the presence of a modified cyclodextrin

Charman, S. A., Perry, C. S., Chiu, F. C. K., McIntosh, K. A., Prankerd, R. J. & Charman, W. N., 2006, In : Journal of Pharmaceutical Sciences. 95, 2, p. 256 - 267 12 p.

Research output: Contribution to journalArticleResearchpeer-review

45 Citations (Scopus)

Analogues of fenarimol are potent inhibitors of Trypanosoma cruzi and are efficacious in a murine model of chagas disease

Keenan, M., Abbott, M. J., Alexander, P. W., Armstrong, T., Best, W. M., Berven, B., Botero, A., Chaplin, J. H., Charman, S. A., Chatelain, E., von Geldern, T. W., Kerfoot, M., Khong, A., Nguyen, T. T., McManus, J. D., Morizzi, J., Ryan, E., Scandale, I., Thompson, R. C. A., Wang, S. Z. & 1 others, White, K. L., 2012, In : Journal of Medicinal Chemistry. 55, 9, p. 4189 - 4204 16 p.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

Analysis of bovine immunoglobulin G by capillary gel electrophoresis

Bennett, L. E., Charman, W. N., Williams, D. B. & Charman, S. A., 1994, In : Journal of Pharmaceutical and Biomedical Analysis. 12, 9, p. 1103-1108 6 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

Analysis of pilocarpine and its degradation products by micellar electrokinetic capillary chromatography

Charman, W. N., Humberstone, A. J. & Charman, S. A., 1992, In : Pharmaceutical Research. 9, 9, p. 1219-1223 5 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Analytical methods and stability assessment of liquid yeast derived sucrase

McIntosh, K. A., Charman, S. A., Borgen, L. A. & Charman, W. N., 1998, In : Journal of Pharmaceutical and Biomedical Analysis. p. 1037 - 1045 9 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Analytical methods and stability assessment of liquid yeast derived sucrase

McIntosh, K. A., Charman, S. A., Borgen, L. A. & Charman, W. N., 1 Sep 1998, In : Journal of Pharmaceutical and Biomedical Analysis. 17, 6-7, p. 1037-1045 9 p.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)
161 Citations (Scopus)

A novel multiple-stage antimalarial agent that inhibits protein synthesis

Baragana, B., Hallyburton, I., Lee, M. C. S., Norcross, N. R., Grimaldi, R., Otto, T. D., Proto, W. R., Blagborough, A. M., Meister, S., Wirjanata, G., Ruecker, A., Upton, L. M., Abraham, T. S., Justino de Almeida, M., Pradhan, A., Porzelle, A., Martinez, M. S., Bolscher, J. M., Woodland, A., Norval, S. & 30 others, Zuccotto, F., Thomas, J., Simeons, F., Stojanovski, L., Osuna-Cabello, M., Brock, P. M., Churcher, T. S., Sala, K. A., Zakutansky, S. E., Jimenez-Diaz, M. B., Sanz, L. M., Riley, J., Basak, R., Campbell, M., Avery, V. M., Sauerwein, R. W., Dechering, K. J., Noviyanti, R., Campo, B., Frearson, J. A., Angulo-Barturen, I., Ferrer-Bazaga, S., Gamo, F-J., Wyatt, P. G., Leroy, D., Siegl, P., Delves, M. J., Kyle, D. E., Wittlin, S. & Charman, S. A., 2015, In : Nature. 522, 7556, p. 315-320 6 p.

Research output: Contribution to journalArticleResearchpeer-review

A novel prodrug approach for tertiary amines.3. In vivo evaluation of two N-phosphonocoxymethyl prodrugs in rats and dogs

Krise, J. P., Charman, W. N., Charman, S. A. & Stella, V. J., 1999, In : Journal of Pharmaceutical Sciences. p. 928 - 932 5 p.

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)

A novel prodrug approach for tertiary amines. 3. In vivo evaluation of two N-phosphonooxymethyl prodrugs in rats and dogs

Krise, J. P., Charman, W. N., Charman, S. A. & Stella, V. J., Sep 1999, In : Journal of Pharmaceutical Sciences. 88, 9, p. 928-932 5 p.

Research output: Contribution to journalArticleResearchpeer-review

45 Citations (Scopus)

Antimalarial activity of N-alkyl amine, carboxamide, sulfonamide, and urea derivatives of a dispiro-1,2,4-trioxolane piperidine

Padmanilayam, M., Scorneaux, B., Dong, Y., Chollet, J., Matile, H., Charman, S. A., Creek, D. J., Charman, W. N., Santo Tomas, J., Scheurer, C., Wittlin, S., Brun, R. & Vennerstrom, J., 2006, In : Bioorganic and Medicinal Chemistry Letters. 16, 21, p. 5542 - 5545 4 p.

Research output: Contribution to journalArticleResearchpeer-review

38 Citations (Scopus)

Antimalarial activity of pyrroloiminoquinones from the Australian marine sponge Zyzzya sp.

Davis, R. A., Buchanan, M. S., Duffy, S., Avery, V. M., Charman, S. A., Charman, W. N., White, K. L., Shackleford, D., Edstein, M. D., Andrews, K., Camp, D. G. & Quinn, R. J., 2012, In : Journal of Medicinal Chemistry. 55, 12, p. 5851 - 5858 8 p.

Research output: Contribution to journalArticleResearchpeer-review

57 Citations (Scopus)

Antimalarial efficacy of MMV390048, an inhibitor of Plasmodium phosphatidylinositol 4-kinase

Paquet, T., Le Manach, C., Cabrera, D. G., Younis, Y., Henrich, P. P., Abraham, T. S., Lee, M. C. S., Basak, R., Ghidelli-Disse, S., Lafuente-Monasterio, M. J., Bantscheff, M., Ruecker, A., Blagborough, A. M., Zakutansky, S. E., Zeeman, A-M., White, K. L., Shackleford, D. M., Mannila, J., Morizzi, J., Scheurer, C. & 1 others, Charman, S. A., 26 Apr 2017, In : Science Translational Medicine. 9, 387, 14 p., eaad9735.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

Antimalarial Inhibitors Targeting Serine Hydroxymethyltransferase (SHMT) with in Vivo Efficacy and Analysis of their Binding Mode Based on X-ray Cocrystal Structures

Schwertz, G., Witschel, M. C., Rottmann, M., Bonnert, R., Leartsakulpanich, U., Chitnumsub, P., Jaruwat, A., Ittarat, W., Schäfer, A., Aponte, R. A., Charman, S. A., White, K. L., Kundu, A., Sadhukhan, S., Lloyd, M., Freiberg, G. M., Srikumaran, M., Siggel, M., Zwyssig, A., Chaiyen, P. & 1 others, Diederich, F., 22 Jun 2017, In : Journal of Medicinal Chemistry. 60, 12, p. 4840-4860 21 p.

Research output: Contribution to journalArticleResearchpeer-review

55 Citations (Scopus)

Antimalarial Pyrido[1,2-a]benzimidazoles

Ndakala, A., Gessner, R., Gitari, P., October, N., White, K., Hudson, A., Fakorede, F., Shackleford, D., Kaiser, M., Yates, C., Charman, S. & Chibale, K., 2011, In : Journal of Medicinal Chemistry. 54, p. 4581 - 4589 9 p.

Research output: Contribution to journalArticleResearchpeer-review

29 Citations (Scopus)

Antitrypanosomal activity of fexinidazole metabolites, potential new drug candidates for Chagas disease

Bahia, M. T., Nascimento, A. F. S., Mazzeti, A. L., Marques, L. F., Goncalves, K. R., Mota, L. W. R., Diniz, L. D. F., Caldas, I. S., Talvani, A., Shackleford, D., Koltun, M., Saunders, J., White, K. L., Scandale, I., Charman, S. A. & Chatelain, E., 2014, In : Antimicrobial Agents and Chemotherapy. 58, 8, p. 4362 - 4370 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
37 Citations (Scopus)

A prodrug approach toward cancer-related carbonic anhydrase inhibition

Carroux, C. J., Rankin, G. M., Moeker, J., Bornaghi, L. F., Katneni, K., Morizzi, J., Charman, S. A., Vullo, D., Supuran, C. T. & Poulsen, S-A., 2013, In : Journal of Medicinal Chemistry. 56, 23, p. 9623 - 9634 12 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Assessing drug efficacy against Plasmodium falciparum liver stages in vivo

Flannery, E. L., Foquet, L., Chuenchob, V., Fishbaugher, M., Billman, Z., Navarro, M. J., Betz, W., Olsen, T. M., Lee, J., Camargo, N., Nguyen, T., Schafer, C., Sack, B. K., Wilson, E. M., Saunders, J., Bial, J., Campo, B., Charman, S. A., Murphy, S. C., Phillips, M. A. & 2 others, Kappe, S. H. & Mikolajczak, S. A., 11 Jan 2018, In : JCI Insight. 3, 1, 12 p., e92587.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
25 Citations (Scopus)

Assessing the utility of an anti-malarial pharmacokinetic-pharmacodynamic model for aiding drug clinical development

Zaloumis, S., Humberstone, A. J., Charman, S. A., Price, R. N., Moehrle, J., Gamo-Benito, J., McCaw, J., Jamsen, K., Smith, K. & Simpson, J. A., 2012, In : Malaria Journal. 11, 303, p. 1 - 14 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
24 Citations (Scopus)

A tetraoxane-based antimalarial drug candidate that overcomes PfK13-C580Y dependent artemisinin resistance

O'Neill, P. M., Amewu, R. K., Charman, S. A., Sabbani, S., Gnädig, N. F., Straimer, J., Fidock, D. A., Shore, E. R., Roberts, N. L., Wong, M. H. L., Hong, W. D., Pidathala, C., Riley, C., Murphy, B., Aljayyoussi, G., Gamo, F. J., Sanz, L., Rodrigues, J., Cortes, C. G., Herreros, E. & 2 others, Ryan, E. & Shackleford, D. M., 24 May 2017, In : Nature Communications. 8, 10 p., 15159.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
35 Citations (Scopus)

A triazolopyrimidine-based dihydroorotate dehydrogenase inhibitor with improved drug-like properties for treatment and prevention of malaria

Phillips, M. A., White, K., Kokkonda, S., Deng, X., White, J., El Mazouni, F., Marsh, K., Tomchick, D. R., Manjalanagara, K., Rudra, K. R., Wirjanata, G., Noviyanti, R., Price, R. N., Marfurt, J., Shackleford, D., Chiu, F., Campbell, M., Jimenez-Diaz, M. B., Bazaga, S. F., Angulo-Barturen, I. & 1 others, Charman, S., 9 Dec 2016, In : ACS Infectious Diseases. 2, 12, p. 945-957 13 p.

Research output: Contribution to journalArticleResearchpeer-review

41 Citations (Scopus)

Bioisosteric transformations and permutations in the triazolopyrimidine scaffold to identify the minimum pharmacophore required for inhibitory activity against Plasmodium falciparum dihydroorotate dehydrogenase

Marwaha, A., White, J., El Mazouni, F., Creason, S., Kokkonda, S., Buckner, F. S., Charman, S. A., Phillips, M. & Rathod, P., 2012, In : Journal of Medicinal Chemistry. 55, 17, p. 7425 - 7436 12 p.

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)

Biopharmaceutical characterisation of a low-dose (75 mg) controlled-release aspirin formulation

Charman, W. N., Charman, S. A., Monkhouse, D. C., Frisbee, S. E., Lockhart, E. A., Weisman, S. & Fitzgerald, G. A., 1993, In : British Journal of Clinical Pharmacology. 36, 5, p. 470-473 4 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

Biphasic drug absorption from the epidural space of the dog may limit the utility of a slow release medium molecular weight hyaluronic acid- lidocaine ionic complex formulation

Doherty, M. M., Hughes, P. J., Charman, S. A., Brock, K. V., Korszniak, N. V. & Charman, W. N., 1996, In : Anesthesia and Analgesia. 83, 6, p. 1244-1250 7 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Brain uptake of diazepam and phenytoin in a genetic animal model of absence epilepsy

Nicolazzo, J., Steuten, J. A., Charman, S. A., Taylor, N., Davies, P. & Petrou, S., 2010, In : Clinical and Experimental Pharmacology and Physiology. 37, p. 647 - 649 3 p.

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)

Central nervous system exposure of next generation quinoline methanols is reduced relative to mefloquine after intravenous dosing in mice

Dow, G., Milner, E., Bathurst, I., Bhonsle, J., Caridha, D., Gardner, S., Gerena, L., Kozar, M., Lanteri, C., Mannila, A., McCalmont, W., Moon, J., Read, K., Norval, S., Roncal, N., Shackleford, D., Sousa, J., Steuten, J., White, K., Zeng, Q. & 1 others, Charman, S., 2011, In : Malaria Journal. 10, 150, p. e1 - e11 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
28 Citations (Scopus)

Characterization of the two major CYP450 metabolites of ozonide (1,2,4-trioxolane) OZ277

Zhou, L., Alker, A., Ruf, A., Wang, X., Chiu, F. C. K., Morizzi, J., Charman, S. A., Charman, W. N., Scheurer, C., Wittlin, S., Dong, Y., Hunziker, D. & Vennerstrom, J., 2008, In : Bioorganic and Medicinal Chemistry Letters. 18, 5, p. 1555 - 1558 4 p.

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)

Chemical kinetics and aqueous degradation pathways of a new class of synthetic ozonide antimalarials

Perry, C. S., Charman, S. A., Prankerd, R. J., Chiu, F. C. K., Dong, Y., Vennerstrom, J. L. & Charman, W. N., 2006, In : Journal of Pharmaceutical Sciences. 95, 4, p. 737 - 747 11 p.

Research output: Contribution to journalArticleResearchpeer-review