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Research Output 1991 2019

1991
24 Citations (Scopus)

Presystemic acetylation of platelets by aspirin: Reduction in rate of drug delivery to improve biochemical selectivity for thromboxane A2

Fitzgerald, G. A., Lupinetti, M., Charman, S. A. & Charman, W. N., 1991, In : Journal of Pharmacology and Experimental Therapeutics. 259, 3, p. 1043-1049 7 p.

Research output: Contribution to journalArticleResearchpeer-review

1992
12 Citations (Scopus)

Analysis of pilocarpine and its degradation products by micellar electrokinetic capillary chromatography

Charman, W. N., Humberstone, A. J. & Charman, S. A., 1992, In : Pharmaceutical Research. 9, 9, p. 1219-1223 5 p.

Research output: Contribution to journalArticleResearchpeer-review

362 Citations (Scopus)

Self-Emulsifying Drug Delivery Systems: Formulation and Biopharmaceutic Evaluation of an Investigational Lipophilic Compound

Charman, S. A., Charman, W. N., Rogge, M. C., Wilson, T. D., Dutko, F. J. & Pouton, C. W., 1992, In : Pharmaceutical Research. 9, 1, p. 87-93 7 p.

Research output: Contribution to journalArticleResearchpeer-review

1993
21 Citations (Scopus)

Biopharmaceutical characterisation of a low-dose (75 mg) controlled-release aspirin formulation

Charman, W. N., Charman, S. A., Monkhouse, D. C., Frisbee, S. E., Lockhart, E. A., Weisman, S. & Fitzgerald, G. A., 1993, In : British Journal of Clinical Pharmacology. 36, 5, p. 470-473 4 p.

Research output: Contribution to journalArticleResearchpeer-review

104 Citations (Scopus)

Techniques for Assessing the Effects of Pharmaceutical Excipients on the Aggregation of Porcine Growth Hormone

Charman, S. A., Mason, K. L. & Charman, W. N., 1993, In : Pharmaceutical Research. 10, 7, p. 954-962 9 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Validation of a Peptide Map for Recombinant Porcine Growth Hormone and Application to Stability Assessment

Charman, S. A., McCrossin, L. E. & Charman, W. N., 1993, In : Pharmaceutical Research. 10, 10, p. 1471-1477 7 p.

Research output: Contribution to journalArticleResearchpeer-review

1994
13 Citations (Scopus)

Analysis of bovine immunoglobulin G by capillary gel electrophoresis

Bennett, L. E., Charman, W. N., Williams, D. B. & Charman, S. A., 1994, In : Journal of Pharmaceutical and Biomedical Analysis. 12, 9, p. 1103-1108 6 p.

Research output: Contribution to journalArticleResearchpeer-review

1996
11 Citations (Scopus)

Biphasic drug absorption from the epidural space of the dog may limit the utility of a slow release medium molecular weight hyaluronic acid- lidocaine ionic complex formulation

Doherty, M. M., Hughes, P. J., Charman, S. A., Brock, K. V., Korszniak, N. V. & Charman, W. N., 1996, In : Anesthesia and Analgesia. 83, 6, p. 1244-1250 7 p.

Research output: Contribution to journalArticleResearchpeer-review

26 Citations (Scopus)

Evaluation of emulsifiable glasses for the oral administration of cyclosporin in beagle dogs

Porter, C. J. H., Charman, S. A., Williams, R. D., Bakalova, M. V. & Charman, W. N., 6 Sep 1996, In : International Journal of Pharmaceutics. 141, 1-2, p. 227-237 11 p.

Research output: Contribution to journalArticleResearchpeer-review

113 Citations (Scopus)
9 Citations (Scopus)

Synthesis and evaluation of 5' alkyl ester prodrugs of zidovudine for directed lymphatic delivery

Bibby, D. C., Charman, W. N., Charman, S. A., Iskander, M. N. & Porter, C. J. H., 22 Nov 1996, In : International Journal of Pharmaceutics. 144, 1, p. 61-70 10 p.

Research output: Contribution to journalArticleResearchpeer-review

1997

Overseas Trials

Baines, P. J., Charman, S. A., Clarke, G. M., Roman, R. S. & Walters, S. M., 1997, Drug Products for Clinical Trials : An International Guide to Formulation-Production-Quality Control. New York NY USA: Marcel Dekker, p. 301 - 330 30 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

Preliminary stability studies for solution formulations of an investigational protein

Hill, J. M., Radford, A. J. & Charman, S. A., 1997, p. 70 - 70. 1 p.

Research output: Contribution to conferenceAbstractOther

5 Citations (Scopus)

Protein transport across hydrated hyaluronic acid ester membranes: Evaluation of ribonuclease A as a potentially useful model protein

Simon, L. D., Charman, W. N., Charman, S. A. & Stella, V. J., 1997, In : Journal of Controlled Release. 45, 3, p. 273-285 13 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Synthesis, physiochemical and biological evaluation of a novel prodrug for increasing the water solubility of tertiary amine-containing drug

Krise, J. P., Charman, W. N., Charman, S. A. & Stella, V. J., 1997, p. 71 - 71. 1 p.

Research output: Contribution to conferenceAbstractOther

1998
1 Citation (Scopus)

Analytical methods and stability assessment of liquid yeast derived sucrase

McIntosh, K. A., Charman, S. A., Borgen, L. A. & Charman, W. N., 1 Sep 1998, In : Journal of Pharmaceutical and Biomedical Analysis. 17, 6-7, p. 1037-1045 9 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Analytical methods and stability assessment of liquid yeast derived sucrase

McIntosh, K. A., Charman, S. A., Borgen, L. A. & Charman, W. N., 1998, In : Journal of Pharmaceutical and Biomedical Analysis. p. 1037 - 1045 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Degradation of recombinant porcine growth hormone in the presence of guanidine hydrochloride

McCrossin, L. E., Charman, W. N. & Charman, S. A., 30 Oct 1998, In : International Journal of Pharmaceutics. 173, 1-2, p. 157-170 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Development and validation of an in vitro model to measure the intestinal permeability of potential oral formulations of human growth hormone

McIntosh, K. A., Charman, W. N., Milstein, S. & Charman, S. A., 1998, p. 97 - 97. 1 p.

Research output: Contribution to conferenceAbstractOther

Plasma pharmacokinetics and brain penetration of AM36, a novel neuroprotective compound in the rat

Smith, G. D., Robertson, A. D., Charman, W. N. & Charman, S. A., 1998, p. S678 - S678. 1 p.

Research output: Contribution to conferenceAbstractOther

Prodrugs of nucleoside analogues I: Oral bioavailability in the rat

Charman, S. A., Smith, G. D., Robertson, A. D., Bloodworth, T., Marcuccio, S. & Charman, W. N., 1998, p. 94 - 94. 1 p.

Research output: Contribution to conferenceAbstractOther

Prodrugs of nucleoside analogues II: In vitro permeability in excised rat jejunum

Bawden, A., Smith, G. D., Robertson, A. D., Marcuccio, S., Charman, W. N. & Charman, S. A., 1998, p. 95 - 95. 1 p.

Research output: Contribution to conferenceAbstractOther

Stability studies for solution formulations of leukemia inhibitory factor (LIF)

Charman, S. A., Hill, J. M. & Radford, A. J., 1998, p. S536 - S536. 1 p.

Research output: Contribution to conferenceAbstractOther

Synthesis and evaluation of a novel prodrug for increasing the water solubility of tertiary amine-containing drugs

Krise, J. P., Charman, W. N., Charman, S. A., Narisawa, S., Zygmunt, J. & Stella, V. J., 1998, p. S99 - S99. 1 p.

Research output: Contribution to conferenceAbstractOther

20 Citations (Scopus)

The application of capillary electrophoresis for monitoring effects of excipients on protein conformation

McIntosh, K. A., Charman, W. N. & Charman, S. A., Feb 1998, In : Journal of Pharmaceutical and Biomedical Analysis. 16, 6, p. 1097-1105 9 p.

Research output: Contribution to journalArticleResearchpeer-review

The D log D parameter as a correlate of the brain penetration of a series novel neuroprotective compounds in the rat

Smith, G. D., Robertson, A. D., Hill, J. M., Charman, W. N. & Charman, S. A., 1998, p. 94 - 94. 1 p.

Research output: Contribution to conferenceAbstractOther

1999

A modified ussing chamber model for the evaluation of rhGH transepithelial absorption

McIntosh, K. A., Charman, W. N. & Charman, S. A., 1999, p. S-421 - S-421. 1 p.

Research output: Contribution to conferenceAbstractOther

A novel prodrug approach for tertiary amines.3. In vivo evaluation of two N-phosphonocoxymethyl prodrugs in rats and dogs

Krise, J. P., Charman, W. N., Charman, S. A. & Stella, V. J., 1999, In : Journal of Pharmaceutical Sciences. p. 928 - 932 5 p.

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)

A novel prodrug approach for tertiary amines. 3. In vivo evaluation of two N-phosphonooxymethyl prodrugs in rats and dogs

Krise, J. P., Charman, W. N., Charman, S. A. & Stella, V. J., Sep 1999, In : Journal of Pharmaceutical Sciences. 88, 9, p. 928-932 5 p.

Research output: Contribution to journalArticleResearchpeer-review

41 Citations (Scopus)

Drug delivery: A key factor in realising the full therapeutic potential of drugs

Charman, W. N., Chan, H-K., Finnin, B. C. & Charman, S. A., 1999, In : Drug Development Research. 46, 3-4, p. 316-327 12 p.

Research output: Contribution to journalArticleResearchpeer-review

In vitro distribution of coenzyme Q10 in plasma lipoproteins

Thomas, B. J., McIntosh, M. P., Kannar, D., Charman, S. A. & Charman, W. N., 1999, p. S-124 - S-124. 1 p.

Research output: Contribution to conferenceAbstractOther

7 Citations (Scopus)

Mechanisms controlling diffusion and release of model proteins through and from partially esterified hyaluronic acid membranes

Simon, L. D., Stella, V. J., Charman, W. N. & Charman, S. A., 20 Sep 1999, In : Journal of Controlled Release. 61, 3, p. 267-279 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Oral absorptionn of nucleoside analogue prodrugs II.Physio cochemical properties and Invitro intestinal permeabilities

Smith, G. D., Zhou, J., Marcuccio, S., Robertson, A. D., Charman, W. N. & Charman, S. A., 1999, p. S-645 - S-645. 1 p.

Research output: Contribution to conferenceAbstractOther

Oral asorption of nucleoside analogue prodrus I.Invivo bioavailabiliy assessment

Smith, G. D., Bloodworth, T., Marcuccio, S., Robertson, A. D., Charman, W. N. & Charman, S. A., 1999, p. S-641 - S-641. 1 p.

Research output: Contribution to conferenceAbstractOther

Relationship between physicochemical properties, in vitro intestinal permeability and oral bioavailability for nucleoside analogue prodrugs

Zhou, J., Smith, G. D. & Charman, S. A., 1999, p. 68 - 68. 1 p.

Research output: Contribution to conferenceAbstractOther

Variation in the diffusion and release of ribonuclease through and from esterified hyaluronic acid membranes: Effect of changes in matrix characteristics

Simon, L. D., Stella, V. J., Charman, W. N. & Charman, S. A., 27 Aug 1999, In : Journal of Controlled Release. 61, 1-2, p. 159-164 6 p.

Research output: Contribution to journalArticleResearchpeer-review

2000
168 Citations (Scopus)

Lymphatic transport of proteins after subcutaneous administration

Porter, C. J. H. & Charman, S. A., Mar 2000, In : Journal of Pharmaceutical Sciences. 89, 3, p. 297-310 14 p.

Research output: Contribution to journalArticleResearchpeer-review

70 Citations (Scopus)

Systemic availability and lymphatic transport of human growth hormone administered by subcutaneous injection

Charman, S. A., Segrave, A. M., Edwards, G. A. & Porter, C. J. H., Feb 2000, In : Journal of Pharmaceutical Sciences. 89, 2, p. 168-177 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2001
45 Citations (Scopus)

Lymphatic absorption is a significant contributor to the subcutaneous bioavailability of insulin in a sheep model

Charman, S. A., McLennan, D. N., Edwards, G. & Porter, C. J. H., 2001, In : Pharmaceutical Research. 18, 11, p. 1620-1626 7 p.

Research output: Contribution to journalArticleResearchpeer-review

78 Citations (Scopus)

Lymphatic transport of proteins after s.c. injection: Implications of animal model selection

Porter, C. J. H., Edwards, G. & Charman, S. A., 23 Aug 2001, In : Advanced Drug Delivery Reviews. 50, 1-2, p. 157-171 15 p.

Research output: Contribution to journalArticleResearchpeer-review

2002
22 Citations (Scopus)

Effect of dietary fatty acids on the intestinal permeability of marker drug compounds in excised rat jejunum

Vine, D. F., Charman, S. A., Gibson, P. R., Sinclair, A. J. & Porter, C. J. H., 2002, In : Journal of Pharmacy and Pharmacology. 54, 6, p. 809 - 819 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2003

Oral modified-release delivery systems

Charman, S. A. & Charman, W. N., 2003, Modified-Release Drug Delivery Technology. Rathbone, M. J., Hadgraft, J. & Roberts, M. S. (eds.). 1 ed. USA: Marcel Dekker, p. 1 - 10 10 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

31 Citations (Scopus)

Pharmacokinetic model to describe the lymphatic absorption of r-metHu-Leptin after subcutaneous injection to sheep

McLennan, D. N., Porter, C. J. H., Edwards, G. A., Brumm, M., Martin, S. W. & Charman, S. A., 1 Aug 2003, In : Pharmaceutical Research. 20, 8, p. 1156-1162 7 p.

Research output: Contribution to journalArticleResearchpeer-review

2004
521 Citations (Scopus)

Identification of an antimalarial synthetic trioxolane drug development candidate

Vennerstrom, J. L., Arbe-Barnes, S., Brun, R., Charman, S. A., Chiu, F. C. K., Chollet, J., Dong, Y., Dorn, A., Hunziker, D., Matile, H., McIntosh, K. A., Padmanilayam, M., Santo Tomas, J., Scheurer, C., Scorneaux, B., Tang, Y., Urwyler, H., Wittlin, S. & Charman, W. N., 19 Aug 2004, In : Nature. 430, 7002, p. 900-904 5 p.

Research output: Contribution to journalArticleResearchpeer-review

31 Citations (Scopus)

Pharmacokinetics of recombinant human leukemia inhibitory factor in sheep

Segrave, A. M., Mager, D. E., Charman, S. A., Edwards, G. & Porter, C. J. H., Jun 2004, In : Journal of Pharmacology and Experimental Therapeutics. 309, 3, p. 1085-1092 8 p.

Research output: Contribution to journalArticleResearchpeer-review

2005
34 Citations (Scopus)

Kinetics of iron-mediated artemisinin degradation: effect of solvent composition and iron salt

Creek, D. J., Chiu, F. C. K., Prankerd, R. J., Charman, S. A. & Charman, W. N., 2005, In : Journal of Pharmaceutical Sciences. 94, 8, p. 1820 - 1829 10 p.

Research output: Contribution to journalArticleResearchpeer-review

42 Citations (Scopus)

Lymphatic absorption is the primary contributor to the systemic availability of epoetin alfa following subcutaneous administration to sheep

McLennan, D. N., Porter, C. J. H., Edwards, G. A., Martin, S. W., Heatherington, A. C. & Charman, S. A., 2005, In : Journal of Pharmacology and Experimental Therapeutics. 313, 1, p. 345 - 351 7 p.

Research output: Contribution to journalArticleResearchpeer-review

91 Citations (Scopus)

Spiro and dispiro-1,2,4-trioxolanes as antimalarial peroxides: charting a workable structure-activity relationship using simple prototypes

Dong, Y., Chollet, J., Matile, H., Charman, S. A., Chiu, F. C. K., Charman, W. N., Scorneaux, B., Urwyler, H., Santo Tomas, J., Scheurer, C., Snyder, C., Dorn, A., Wang, X., Karle, J. M., Tang, Y., Wittlin, S., Brun, R. & Vennerstrom, J. L., 2005, In : Journal of Medicinal Chemistry. 48, 15, p. 4953 - 4961 9 p.

Research output: Contribution to journalArticleResearchpeer-review

91 Citations (Scopus)

Subcutaneous drug delivery and the role of the lymphatics

McLennan, D. N., Porter, C. J. H. & Charman, S. A., 2005, In : Drug Discovery Today: Technologies. 2, 1, p. 89-96 8 p.

Research output: Contribution to journalArticleResearchpeer-review