Susan Charman

Professor

Professor, Centre for Drug Candidate Optimisation

https://orcid.org/0000-0003-1753-8213

EmailSusan.Charman@monash.edu

Research activity per year

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Personal profile

Research interests

Drug Discovery and Development. Drug Metabolism and Pharmacokinetics. Drug Delivery. Drug Discovery for Neglected and Tropical Diseases.

Biography

Susan Charman is Director of the Centre for Drug Candidate Optimisation, and Professor at the Monash Institute of Pharmaceutical Sciences. Her research is focussed on ADME-informed drug candidate optimisation to translate basic biology and chemistry discoveries into new drug candidates. She is particularly interested in the lead optimisation and progression of novel drug candidates for the treatment of neglected and tropical infectious diseases.

Research area keywords

Drug development
Drug discovery
Pharmaceutics
Pharmacokinetics
Drug Metabolism

Network

Recent external collaboration on country level. Dive into details by clicking on the dots or

1 Active
24 Finished

Multidisciplinary catalyst to discover and progress novel antimalarial drugs
Charman, S., Creek, D., de Koning-Ward, T. F., Gilson, P., McGowan, S. & Scammells, P.
National Health and Medical Research Council (NHMRC) (Australia)
1/01/20 → 31/12/24
Project: Research
Targeting trypanosomatid deoxyhypusine synthase
Phillips, M., Charman, S., DeBrabender, J. & Posner, B.
National Institutes of Health (United States)
5/12/18 → 30/11/19
Project: Research
Novel peptide inhibitors of the potassium voltage-gated channel Kv1.3 as therapeutics for autoimmune diseases
Norton, R. & Charman, S.
23/10/18 → 23/10/19
Project: Research
Male contraception through pharmacological blockade of sperm transport
Ventura, S., Baell, J., Charman, S. & Sexton, P.
Male Contraceptive Initiative
1/08/18 → 31/05/20
Project: Research
Lead optimization of DHODH inhibitors for malaria
Phillips, M. A., Rathod, P. & Charman, S.
1/08/18 → 31/03/19
Project: Research

171 Article
14 Abstract
6 Chapter (Book)
2 Comment / Debate
More
- 2 Review Article
- 1 Letter

An in vitro toolbox to accelerate anti-malarial drug discovery and development
Charman, S. A., Andreu, A., Barker, H., Blundell, S., Campbell, A., Campbell, M., Chen, G., Chiu, F. C. K., Crighton, E., Katneni, K., Morizzi, J., Patil, R., Pham, T., Ryan, E., Saunders, J., Shackleford, D. M., White, K. L., Almond, L., Dickins, M., Smith, D. A. & 3 others, Moehrle, J. J., Burrows, J. N. & Abla, N., 2 Jan 2020, In : Malaria Journal. 19, 1, 27 p., 1.
Research output: Contribution to journal › Article › Research › peer-review

Open Access
File

7 Citations (Scopus)
Discovery of Acylsulfonohydrazide-Derived Inhibitors of the Lysine Acetyltransferase, KAT6A, as Potent Senescence-Inducing Anti-Cancer Agents
Priebbenow, D. L., Leaver, D. J., Nguyen, N., Cleary, B., Lagiakos, H. R., Sanchez, J., Xue, L., Huang, F., Sun, Y., Mujumdar, P., Mudududdla, R., Varghese, S., Teguh, S., Charman, S. A., White, K. L., Shackleford, D. M., Katneni, K., Cuellar, M., Strasser, J. M., Dahlin, J. L. & 13 others, Walters, M. A., Street, I. P., Monahan, B. J., Jarman, K. E., Jousset Sabroux, H., Falk, H., Chung, M. C., Hermans, S. J., Downer, N. L., Parker, M. W., Voss, A. K., Thomas, T. & Baell, J. B., 14 May 2020, In : Journal of Medicinal Chemistry. 63, 9, p. 4655-4684 30 p.
Research output: Contribution to journal › Article › Research › peer-review

1 Citation (Scopus)
Efficacy, metabolism and pharmacokinetics of Ro 15-5458, a forgotten schistosomicidal 9-acridanone hydrazone
Probst, A., Häberli, C., Siegel, D., Huang, J., Vigneron, S., Ta, A. P., Skinner, D. E., El-Sakkary, N., Momper, J. D., Gangoiti, J., Dong, Y., Vennerstrom, J. L., Charman, S. A., Caffrey, C. R. & Keiser, J., 1 Oct 2020, In : Journal of Antimicrobial Chemotherapy. 75, 10, p. 2925-2932 8 p.
Research output: Contribution to journal › Article › Research › peer-review
Intestinal Lymph Flow, and Lipid and Drug Transport Scale Allometrically From Pre-clinical Species to Humans
Trevaskis, N. L., Lee, G., Escott, A., Phang, K. L., Hong, J., Cao, E., Katneni, K., Charman, S. A., Han, S., Charman, W. N., Phillips, A. R. J., Windsor, J. A. & Porter, C. J. H., 21 May 2020, In : Frontiers in Physiology. 11, 11 p., 458.
Research output: Contribution to journal › Article › Research › peer-review

Open Access
File

2 Citations (Scopus)
Lead Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series for the Treatment of Malaria
Kokkonda, S., Deng, X., White, K. L., El Mazouni, F., White, J., Shackleford, D. M., Katneni, K., Chiu, F. C. K., Barker, H., McLaren, J., Crighton, E., Chen, G., Angulo-Barturen, I., Jimenez-Diaz, M. B., Ferrer, S., Huertas-Valentin, L., Martinez-Martinez, M. S., Lafuente-Monasterio, M. J., Chittimalla, R., Shahi, S. P. & 9 others, Wittlin, S., Waterson, D., Burrows, J. N., Matthews, D., Tomchick, D., Rathod, P. K., Palmer, M. J., Charman, S. A. & Phillips, M. A., 14 May 2020, In : Journal of Medicinal Chemistry. 63, 9, p. 4929-4956 28 p.
Research output: Contribution to journal › Article › Research › peer-review

1 Citation (Scopus)