Projects per year
Personal profile
Research interests
Drug Discovery and Development. Drug Metabolism and Pharmacokinetics. Drug Delivery. Drug Discovery for Neglected and Tropical Diseases.
Biography
Susan Charman is Director of the Centre for Drug Candidate Optimisation, and Professor at the Monash Institute of Pharmaceutical Sciences. Her research is focussed on ADME-informed drug candidate optimisation to translate basic biology and chemistry discoveries into new drug candidates. She is particularly interested in the lead optimisation and progression of novel drug candidates for the treatment of neglected and tropical infectious diseases.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research area keywords
- Drug development
- Drug discovery
- Pharmaceutics
- Pharmacokinetics
- Drug Metabolism
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
-
Discovery of New Antimalarials with a Novel Mechanism of Action and Irresistible Target
Giannangelo, C. (Primary Chief Investigator (PCI)), Dillon, A. (Chief Investigator (CI)), Shackleford, D. (Chief Investigator (CI)), Edstein, M. (Chief Investigator (CI)), Creek, D. (Associate Investigator (AI)), Charman, S. (Associate Investigator (AI)), Burrows, J. N. (Associate Investigator (AI)), Stupple, P. (Associate Investigator (AI)), Gilson, P. (Associate Investigator (AI)), Niles, J. (Associate Investigator (AI)), Delves, M. (Associate Investigator (AI)) & Wittlin, S. (Associate Investigator (AI))
1/01/25 → 31/12/27
Project: Research
-
The Australian Centre for Targeted Therapeutics (resubmission)
Silke, J. (Primary Chief Investigator (PCI)), Komander, D. (Chief Investigator (CI)), Lechtenberg, B. (Chief Investigator (CI)), Feltham, R. (Chief Investigator (CI)), Lessene, G. (Chief Investigator (CI)), Haber, M. (Chief Investigator (CI)), Dawson, M. A. (Chief Investigator (CI)) & Charman, S. (Chief Investigator (CI))
1/06/24 → 31/12/25
Project: Research
-
MedChem Australia – catalysing value creation in drug discovery
Stupple, P. (Primary Chief Investigator (PCI)), Charman, S. (Chief Investigator (CI)), Lessene, G. (Chief Investigator (CI)), Kassiou, M. (Chief Investigator (CI)), Mitchell, J. (Chief Investigator (CI)) & Newman, S. (Chief Investigator (CI))
Therapeutic Innovation Australia Limited, Monash University, Walter and Eliza Hall Institute of Medical Research (WEHI), University of Sydney
30/06/23 → 6/12/28
Project: Research
-
Development of a New Class of Formyl Peptide Receptor 1 (FPR1) Biased Agonists for the Treatment of Myocardial Infarction
Ritchie, R. (Primary Chief Investigator (PCI)), Stupple, P. (Chief Investigator (CI)), Qin, C. H. (Chief Investigator (CI)), May, L. (Chief Investigator (CI)), Vecchio, L. (Chief Investigator (CI)), Figtree, G. A. (Chief Investigator (CI)), Shackleford, D. (Chief Investigator (CI)), Chong, J. J. H. (Chief Investigator (CI)), Charman, S. (Associate Investigator (AI)) & McDonald, C. (Associate Investigator (AI))
1/01/23 → 31/12/25
Project: Research
-
Optimization of novel phenotypic screening hits for treatment of malaria
Phillips, M. A. (Primary Chief Investigator (PCI)), Ready, J. M. (Chief Investigator (CI)), Charman, S. (Chief Investigator (CI)), Baniasadi, H. R. (Chief Investigator (CI)), Lemoff, A. (Chief Investigator (CI)), Kittler, R. (Chief Investigator (CI)), Xing, C. (Chief Investigator (CI)) & Laleu, B. (Chief Investigator (CI))
1/04/21 → 31/03/26
Project: Research
-
Activity refinement of aryl amino acetamides that target the P. falciparum STAR-related lipid transfer 1 protein
Nguyen, W., Boulet, C., Dans, M. G., Loi, K., Jarman, K. E., Watson, G. M., Tham, W. H., Fairhurst, K. J., Yeo, T., Fidock, D. A., Wittlin, S., Chowdury, M., de Koning-Ward, T. F., Chen, G., Yan, D., Charman, S. A., Baud, D., Brand, S., Jackson, P. F. & Cowman, A. F. & 2 others, , 15 Apr 2024, In: European Journal of Medicinal Chemistry. 270, 19 p., 116354.Research output: Contribution to journal › Article › Research › peer-review
Open Access5 Citations (Scopus) -
On-target, dual aminopeptidase inhibition provides cross-species antimalarial activity
Edgar, R. C. S., Malcolm, T. R., Siddiqui, G., Giannangelo, C., Counihan, N. A., Challis, M., Duffy, S., Chowdhury, M., Marfurt, J., Dans, M., Wirjanata, G., Noviyanti, R., Daware, K., Suraweera, C. D., Price, R. N., Wittlin, S., Avery, V. M., Drinkwater, N., Charman, S. A. & Creek, D. J. & 3 others, , 12 Jun 2024, In: mBio. 15, 6, 27 p., e0096624.Research output: Contribution to journal › Article › Research › peer-review
Open Access2 Citations (Scopus) -
Antimalarial Dibenzannulated Medium-Ring Keto Lactams
Ren, R., Wang, X., Leas, D. A., Scheurer, C., Hoevel, S., Cal, M., Chen, G., Zhong, L., Katneni, K., Pham, T., Patil, R., Sil, D., Walters, M. J., Schulze, T. T., Neville, A. J., Dong, Y., Wittlin, S., Kaiser, M., Davis, P. H. & Charman, S. A. & 1 others, , 13 Oct 2023, In: ACS Infectious Diseases. 9, 10, p. 1964–1980 17 p.Research output: Contribution to journal › Article › Research › peer-review
2 Citations (Scopus) -
Development and application of a PBPK modeling strategy to support antimalarial drug development
Abla, N., Howgate, E., Rowland-Yeo, K., Dickins, M., Bergagnini-Kolev, M. C., Chen, K. F., McFeely, S., Bonner, J. J., Santos, L. G. A., Gobeau, N., Burt, H., Barter, Z., Jones, H. M., Wesche, D., Charman, S. A., Möhrle, J. J., Burrows, J. N. & Almond, L. M., Sept 2023, In: CPT: Pharmacometrics & Systems Pharmacology. 12, 9, p. 1335-1346 12 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access10 Citations (Scopus) -
Discovery of a highly potent, selective, orally bioavailable inhibitor of KAT6A/B histone acetyltransferases with efficacy against KAT6A-high ER+ breast cancer
Sharma, S., Chung, C. Y., Uryu, S., Petrovic, J., Cao, J., Rickard, A., Nady, N., Greasley, S., Johnson, E., Brodsky, O., Khan, S., Wang, H., Wang, Z., Zhang, Y., Tsaparikos, K., Chen, L., Mazurek, A., Lapek, J., Kung, P. P. & Sutton, S. & 59 others, , 19 Oct 2023, In: Cell Chemical Biology. 30, 10, p. 1191-1210 40 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access26 Citations (Scopus)
Activities
- 6 Patents
-
Medicines for Malaria Venture (MMV) (External organisation)
Susan Ann Charman (Inventor)
19 Jan 2016Activity: Industry, Government and Philanthropy Engagement and Partnerships › Patents › Patent
-
Medicines for Malaria Venture (MMV) (External organisation)
Susan Charman (Inventor)
28 Jul 2015Activity: Industry, Government and Philanthropy Engagement and Partnerships › Patents › Patent
-
Medicines for Malaria Venture (MMV) (External organisation)
Charman, S. A. (Inventor)
16 Jun 2015Activity: Industry, Government and Philanthropy Engagement and Partnerships › Patents › Patent
-
Medicines for Malaria Venture (MMV) (External organisation)
Susan Ann Charman (Inventor)
18 Nov 2015Activity: Industry, Government and Philanthropy Engagement and Partnerships › Patents › Patent
-
Medicines for Malaria Venture (MMV) (External organisation)
Susan Ann Charman (Inventor)
22 Dec 2015Activity: Industry, Government and Philanthropy Engagement and Partnerships › Patents › Patent
Equipment
-
Centre for Drug Candidate Optimisation
Charman, S. (Other)
Pharmacy and Pharmaceutical Sciences Faculty OfficeFacility/equipment: Facility