Projects per year
Personal profile
Research interests
Drug Discovery and Development. Drug Metabolism and Pharmacokinetics. Drug Delivery. Drug Discovery for Neglected and Tropical Diseases.
Biography
Susan Charman is Director of the Centre for Drug Candidate Optimisation, and Professor at the Monash Institute of Pharmaceutical Sciences. Her research is focussed on ADME-informed drug candidate optimisation to translate basic biology and chemistry discoveries into new drug candidates. She is particularly interested in the lead optimisation and progression of novel drug candidates for the treatment of neglected and tropical infectious diseases.
Keywords
- Drug development
- Drug discovery
- Pharmaceutics
- Pharmacokinetics
- Drug Metabolism
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Projects 2008 2021
Collaborative Study Agreement with Epichem for lead optimisation studies
20/05/19 → 31/12/20
Project: Research
Targeting trypanosomatid deoxyhypusine synthase
Phillips, M., Charman, S., DeBrabender, J. & Posner, B.
National Institutes of Health (NIH US)
5/12/18 → 30/11/19
Project: Research
Novel peptide inhibitors of the potassium voltage-gated channel Kv1.3 as therapeutics for autoimmune diseases
23/10/18 → 23/10/19
Project: Research
Male contraception through pharmacological blockade of sperm transport
Ventura, S., Baell, J., Charman, S. & Sexton, P.
1/08/18 → 31/05/20
Project: Research
Research Output 1991 2019
3,3′-Disubstituted 5,5′-Bi(1,2,4-triazine) Derivatives with Potent in Vitro and in Vivo Antimalarial Activity
Xue, L., Shi, D. H., Harjani, J. R., Huang, F., Beveridge, J. G., Dingjan, T., Ban, K., Diab, S., Duffy, S., Lucantoni, L., Fletcher, S., Chiu, F. C. K., Blundell, S., Ellis, K., Ralph, S. A., Wirjanata, G., Teguh, S., Noviyanti, R., Chavchich, M., Creek, D. & 10 others, 1 Jan 2019, In : Journal of Medicinal Chemistry. 62, 5, p. 2485-2498 14 p.Research output: Contribution to journal › Article › Research › peer-review
Evaluation of 4-amino 2-anilinoquinazolines against Plasmodium and other apicomplexan parasites in vitro and in a P. Falciparum Humanized NOD-scid IL2R null Mouse Model of Malaria
Gilson, P. R., Nguyen, W., Poole, W. A., Teixeira, J. E., Thompson, J. K., Guo, K., Stewart, R. J., Ashton, T. D., White, K. L., Sanz, L. M., Gamo, F. J., Charman, S. A., Wittlin, S., Duffy, J., Tonkin, C. J., Tham, W. H., Crabb, B. S., Cooke, B. M., Huston, C. D., Cowman, A. F. & 1 others, 1 Mar 2019, In : Antimicrobial Agents and Chemotherapy. 63, 3, 15 p., e01804-18.Research output: Contribution to journal › Article › Research › peer-review
Falcipain Inhibitors Based on the Natural Product Gallinamide A Are Potent in Vitro and in Vivo Antimalarials
Stoye, A., Juillard, A., Tang, A. H., Legac, J., Gut, J., White, K. L., Charman, S. A., Rosenthal, P. J., Grau, G. E. R., Hunt, N. H. & Payne, R. J., 13 Jun 2019, In : Journal of Medicinal Chemistry. 62, 11, p. 5562-5578 17 p.Research output: Contribution to journal › Article › Research › peer-review
Inhibition of cytomegalovirus replication with extended-half-life synthetic ozonides
Wang, Y., Mukhopadhyay, R., Roy, S., Kapoor, A., Su, Y. P., Charman, S. A., Chen, G., Wu, J., Wang, X., Vennerstrom, J. L. & Arav-Boger, R., 1 Jan 2019, In : Antimicrobial Agents and Chemotherapy. 63, 1, 14 p., e01735-18.Research output: Contribution to journal › Article › Research › peer-review
Assessing drug efficacy against Plasmodium falciparum liver stages in vivo
Flannery, E. L., Foquet, L., Chuenchob, V., Fishbaugher, M., Billman, Z., Navarro, M. J., Betz, W., Olsen, T. M., Lee, J., Camargo, N., Nguyen, T., Schafer, C., Sack, B. K., Wilson, E. M., Saunders, J., Bial, J., Campo, B., Charman, S. A., Murphy, S. C., Phillips, M. A. & 2 others, 11 Jan 2018, In : JCI Insight. 3, 1, 12 p., e92587.Research output: Contribution to journal › Article › Research › peer-review
Open Access
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