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Personal profile

Research interests

Drug Discovery and Development. Drug Metabolism and Pharmacokinetics.  Drug Delivery. Drug Discovery for Neglected and Tropical Diseases.


Susan Charman is Director of the Centre for Drug Candidate Optimisation, and Professor at the Monash Institute of Pharmaceutical Sciences. Her research is focussed on ADME-informed drug candidate optimisation to translate basic biology and chemistry discoveries into new drug candidates. She is particularly interested in the lead optimisation and progression of novel drug candidates for the treatment of neglected and tropical infectious diseases.


  • Drug development
  • Drug discovery
  • Pharmaceutics
  • Pharmacokinetics
  • Drug Metabolism

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Projects 2008 2020

Research Output 1991 2018

Erratum for Brunschwig et al., "UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria"

Brunschwig, C., Lawrence, N., Taylor, D., Abay, E., Njoroge, M., Basarab, G. S., Le Manach, C., Paquet, T., Gonzàlez Cabrera, D., Nchinda, A. T., de Kock, C., Wiesner, L., Denti, P., Waterson, D., Blasco, B., Leroy, D., Witty, M. J., Donini, C., Duffy, J., Wittlin, S. & 28 othersWhite, K. L., Charman, S. A., Jiménez-Díaz, M. B., Angulo-Barturen, I., Herreros, E., Gamo, F. J., Rochford, R., Mancama, D., Coetzer, T. L., van der Watt, M. E., Reader, J., Birkholtz, L. M., Marsh, K. C., Solapure, S. M., Burke, J. E., McPhail, J. A., Vanaerschot, M., Fidock, D. A., Fish, P. V., Siegl, P., Smith, D. A., Wirjanata, G., Noviyanti, R., Price, R. N., Marfurt, J., Silue, K. D., Street, L. J. & Chibale, K., 1 Nov 2018, In : Antimicrobial Agents and Chemotherapy. 62, 11

Research output: Contribution to journalComment / DebateOtherpeer-review

Open Access

Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth

Baell, J. B., Leaver, D. J., Hermans, S. J., Kelly, G. L., Brennan, M. S., Downer, N. L., Nguyen, N., Wichmann, J., McRae, H. M., Yang, Y., Cleary, B., Lagiakos, H. R., Mieruszynski, S., Pacini, G., Vanyai, H. K., Bergamasco, M. I., May, R. E., Davey, B. K., Morgan, K. J., Sealey, A. J. & 32 othersWang, B., Zamudio, N., Wilcox, S., Garnham, A. L., Sheikh, B. N., Aubrey, B. J., Doggett, K., Chung, M. C., de Silva, M., Bentley, J., Pilling, P., Hattarki, M., Dolezal, O., Dennis, M. L., Falk, H., Ren, B., Charman, S. A., White, K. L., Rautela, J., Newbold, A., Hawkins, E. D., Johnstone, R. W., Huntington, N. D., Peat, T. S., Heath, J. K., Strasser, A., Parker, M. W., Smyth, G. K., Street, I. P., Monahan, B. J., Voss, A. K. & Thomas, T., 9 Aug 2018, In : Nature. 560, 7717, p. 253-257 5 p.

Research output: Contribution to journalLetterResearchpeer-review

Open Access

Novel Toxoplasma gondii inhibitor chemotypes

Sanford, A. G., Schulze, T. T., Potluri, L. P., Hemsley, R. M., Larson, J. J., Judge, A. K., Zach, S. J., Wang, X., Charman, S. A., Vennerstrom, J. L. & Davis, P. H., 1 Apr 2018, In : Parasitology International. 67, 2, p. 107-111 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Parasite-mediated degradation of synthetic ozonide antimalarials impacts in vitro antimalarial activity

Giannangelo, C., Stingelin, L., Yang, T., Tilley, L., Charman, S. A. & Creek, D. J., 1 Mar 2018, In : Antimicrobial Agents and Chemotherapy. 62, 3, 14 p., e01566-17.

Research output: Contribution to journalArticleResearchpeer-review

Progress in antischistosomal N,N′-diaryl urea SAR

Wu, J., Wang, C., Leas, D., Vargas, M., White, K. L., Shackleford, D. M., Chen, G., Sanford, A. G., Hemsley, R. M., Davis, P. H., Dong, Y., Charman, S. A., Keiser, J. & Vennerstrom, J. L., 1 Feb 2018, In : Bioorganic and Medicinal Chemistry Letters. 28, 3, p. 244-248 5 p.

Research output: Contribution to journalArticleResearchpeer-review