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Susan Charman

Professor

 https://orcid.org/0000-0003-1753-8213
1991 …2020

Research output per year

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Personal profile

Research interests

Drug Discovery and Development. Drug Metabolism and Pharmacokinetics.  Drug Delivery. Drug Discovery for Neglected and Tropical Diseases.

Biography

Susan Charman is Director of the Centre for Drug Candidate Optimisation, and Professor at the Monash Institute of Pharmaceutical Sciences. Her research is focussed on ADME-informed drug candidate optimisation to translate basic biology and chemistry discoveries into new drug candidates. She is particularly interested in the lead optimisation and progression of novel drug candidates for the treatment of neglected and tropical infectious diseases.

Research area keywords

  • Drug development
  • Drug discovery
  • Pharmaceutics
  • Pharmacokinetics
  • Drug Metabolism

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Projects

Multidisciplinary catalyst to discover and progress novel antimalarial drugs

Charman, S., Creek, D., de Koning-Ward, T. F., Gilson, P., McGowan, S. & Scammells, P.

National Health & Medical Research Council (NHMRC)

1/01/20 → 31/12/24

Project: Research

Novel TB Drug Candidates via the Inhibition of Lipid I Biosynthesis

Payne, R., Britton, W., Crick, D., Charman, S. & West, N.

National Health & Medical Research Council (NHMRC)

1/01/18 → 31/12/20

Project: Research

Targeting trypanosomatid deoxyhypusine synthase

Phillips, M., Charman, S., DeBrabender, J. & Posner, B.

National Institutes of Health (NIH US) United States

5/12/18 → 30/11/19

Project: Research

Novel peptide inhibitors of the potassium voltage-gated channel Kv1.3 as therapeutics for autoimmune diseases

Norton, R. & Charman, S.

23/10/18 → 23/10/19

Project: Research

Lead optimization of DHODH inhibitors for malaria

Phillips, M. A., Rathod, P. & Charman, S.

1/08/18 → 31/03/19

Project: Research

Research Output

An in vitro toolbox to accelerate anti-malarial drug discovery and development

Charman, S. A., Andreu, A., Barker, H., Blundell, S., Campbell, A., Campbell, M., Chen, G., Chiu, F. C. K., Crighton, E., Katneni, K., Morizzi, J., Patil, R., Pham, T., Ryan, E., Saunders, J., Shackleford, D. M., White, K. L., Almond, L., Dickins, M., Smith, D. A. & 3 others, Moehrle, J. J., Burrows, J. N. & Abla, N., 2 Jan 2020, In : Malaria Journal. 19, 1, 27 p., 1.

Research output: Contribution to journal › Article › Research › peer-review

Open Access
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1 Citation (Scopus)

3,3′-Disubstituted 5,5′-Bi(1,2,4-triazine) Derivatives with Potent in Vitro and in Vivo Antimalarial Activity

Xue, L., Shi, D. H., Harjani, J. R., Huang, F., Beveridge, J. G., Dingjan, T., Ban, K., Diab, S., Duffy, S., Lucantoni, L., Fletcher, S., Chiu, F. C. K., Blundell, S., Ellis, K., Ralph, S. A., Wirjanata, G., Teguh, S., Noviyanti, R., Chavchich, M., Creek, D. & 10 others, Price, R. N., Marfurt, J., Charman, S. A., Cuellar, M. E., Strasser, J. M., Dahlin, J. L., Walters, M. A., Edstein, M. D., Avery, V. M. & Baell, J. B., 1 Jan 2019, In : Journal of Medicinal Chemistry. 62, 5, p. 2485-2498 14 p.

Research output: Contribution to journal › Article › Research › peer-review

1 Citation (Scopus)

Discovery of benzoylsulfonohydrazides as potent inhibitors of the histone acetyltransferase KAT6A

Leaver, D. J., Cleary, B., Nguyen, N., Priebbenow, D., Lagiakos, H. R., Sanchez, J., Xue, L., Huang, F., Sun, Y., Mujumdar, P., Mudududdla, R., Varghese, S., Teguh, S., Charman, S. A., White, K. L., Katneni, K., Cuellar, M., Strasser, J. M., Dahlin, J. L., Walters, M. A. & 10 others, Street, I. P., Monahan, B. J., Jarman, K. E., Sabroux, H. J., Falk, H., Chung, M. C., Hermans, S. J., Parker, M. W., Thomas, T. & Baell, J. B., 8 Aug 2019, In : Journal of Medicinal Chemistry. 62, 15, p. 7146-7159 14 p.

Research output: Contribution to journal › Article › Research › peer-review

5 Citations (Scopus)

Evaluation of 4-amino 2-anilinoquinazolines against Plasmodium and other apicomplexan parasites in vitro and in a P. Falciparum Humanized NOD-scid IL2R null Mouse Model of Malaria

Gilson, P. R., Nguyen, W., Poole, W. A., Teixeira, J. E., Thompson, J. K., Guo, K., Stewart, R. J., Ashton, T. D., White, K. L., Sanz, L. M., Gamo, F. J., Charman, S. A., Wittlin, S., Duffy, J., Tonkin, C. J., Tham, W. H., Crabb, B. S., Cooke, B. M., Huston, C. D., Cowman, A. F. & 1 others, Sleebs, B. E., 1 Mar 2019, In : Antimicrobial Agents and Chemotherapy. 63, 3, 15 p., e01804-18.

Research output: Contribution to journal › Article › Research › peer-review

Falcipain Inhibitors Based on the Natural Product Gallinamide A Are Potent in Vitro and in Vivo Antimalarials

Stoye, A., Juillard, A., Tang, A. H., Legac, J., Gut, J., White, K. L., Charman, S. A., Rosenthal, P. J., Grau, G. E. R., Hunt, N. H. & Payne, R. J., 13 Jun 2019, In : Journal of Medicinal Chemistry. 62, 11, p. 5562-5578 17 p.

Research output: Contribution to journal › Article › Research › peer-review

6 Citations (Scopus)