Projects per year
Personal profile
Research interests
Drug Discovery and Development. Drug Metabolism and Pharmacokinetics. Drug Delivery. Drug Discovery for Neglected and Tropical Diseases.
Biography
Susan Charman is Director of the Centre for Drug Candidate Optimisation, and Professor at the Monash Institute of Pharmaceutical Sciences. Her research is focussed on ADME-informed drug candidate optimisation to translate basic biology and chemistry discoveries into new drug candidates. She is particularly interested in the lead optimisation and progression of novel drug candidates for the treatment of neglected and tropical infectious diseases.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research area keywords
- Drug development
- Drug discovery
- Pharmaceutics
- Pharmacokinetics
- Drug Metabolism
Network
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Collaborative Study Program Agreement with The University of Auckland (Wilson) for Lead Optimisation Studies
30/03/23 → 31/12/23
Project: Research
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Optimization of novel phenotypic screening hits for treatment of malaria
Phillips, M. A., Ready, J. M., Charman, S., Baniasadi, H. R., Lemoff, A., Kittler, R., Xing, C. & Laleu, B.
1/04/21 → 31/03/26
Project: Research
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Multidisciplinary catalyst to discover and progress novel antimalarial drugs
Charman, S., Creek, D., de Koning-Ward, T. F., Gilson, P., McGowan, S. & Scammells, P.
National Health and Medical Research Council (NHMRC) (Australia)
1/01/20 → 31/12/24
Project: Research
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Targeting trypanosomatid deoxyhypusine synthase
Phillips, M., Charman, S., DeBrabander, J. & Posner, B.
NIH - National Institutes of Health (United States of America)
5/12/18 → 30/11/19
Project: Research
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Novel peptide inhibitors of the potassium voltage-gated channel Kv1.3 as therapeutics for autoimmune diseases
23/10/18 → 23/10/19
Project: Research
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In Vitro and In Vivo Antischistosomal Activity Profiling and Pharmacokinetics of Ozonide Carboxylic Acids
Biendl, S., Häberli, C., Chen, G., Wang, W., Zhong, L., Saunders, J., Pham, T., Wang, X., Wu, J., Charman, S. A., Vennerstrom, J. L. & Keiser, J., 16 Feb 2023, In: ACS Infectious Diseases. 9, 3, p. 643-652 10 p.Research output: Contribution to journal › Article › Research › peer-review
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Insights Into Drug Repurposing, as Well as Specificity and Compound Properties of Piperidine-Based SARS-CoV-2 PLpro Inhibitors
Calleja, D. J., Kuchel, N., Lu, B. G. C., Birkinshaw, R. W., Klemm, T., Doerflinger, M., Cooney, J. P., Mackiewicz, L., Au, A. E., Yap, Y. Q., Blackmore, T. R., Katneni, K., Crighton, E., Newman, J., Jarman, K. E., Call, M. J., Lechtenberg, B. C., Czabotar, P. E., Pellegrini, M., Charman, S. A., & 5 others, 12 Apr 2022, In: Frontiers in Chemistry. 10, 21 p., 861209.Research output: Contribution to journal › Article › Research › peer-review
Open Access1 Citation (Scopus) -
Metabolic, Pharmacokinetic, and Activity Profile of the Liver Stage Antimalarial (RC-12)
Dong, Y., Sonawane, Y., Maher, S. P., Zeeman, A. M., Chaumeau, V., Vantaux, A., Cooper, C. A., Chiu, F. C. K., Ryan, E., McLaren, J., Chen, G., Wittlin, S., Witkowski, B., Nosten, F., Sriraghavan, K., Kyle, D. E., Kocken, C. H. M., Charman, S. A. & Vennerstrom, J. L., 30 Mar 2022, In: ACS Omega. 7, 14, p. 12401–12411 11 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access -
Preclinical Activity and Pharmacokinetic/Pharmacodynamic Relationship for a Series of Novel Benzenesulfonamide Perforin Inhibitors
Gartlan, K. H., Jaiswal, J. K., Bull, M. R., Akhlaghi, H., Sutton, V. R., Alexander, K. A., Chang, K., Hill, G. R., Miller, C. K., O'Connor, P. D., Jose, J., Trapani, J. A., Charman, S. A., Spicer, J. A. & Jamieson, S. M. F., 10 Jun 2022, In: ACS Pharmacology & Translational Science. 5, 6, p. 429-439 11 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access1 Citation (Scopus) -
Repurposed dihydroorotate dehydrogenase inhibitors with efficacy against drug-resistant Acinetobacter baumannii
Russo, T. A., Umland, T. C., Deng, X., Mazouni, F. E., Kokkonda, S., Olson, R., Carlino-MacDonald, U., Beanan, J., Alvarado, C. L., Tomchick, D. R., Hutson, A., Chen, H., Posner, B., Rathod, P. K., Charman, S. A. & Phillips, M. A., 13 Dec 2022, In: Proceedings of the National Academy of Sciences of the United States of America. 119, 51, 10 p., e2213116119.Research output: Contribution to journal › Article › Research › peer-review
Activities
- 6 Patents
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Medicines for Malaria Venture (MMV) (External organisation)
Susan Ann Charman (Inventor)
19 Jan 2016Activity: Industry, Government and Philanthropy Engagement and Partnerships › Patents › Patent
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Medicines for Malaria Venture (MMV) (External organisation)
Susan Ann Charman (Inventor)
16 Jun 2015Activity: Industry, Government and Philanthropy Engagement and Partnerships › Patents › Patent
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Medicines for Malaria Venture (MMV) (External organisation)
Susan Charman (Inventor)
28 Jul 2015Activity: Industry, Government and Philanthropy Engagement and Partnerships › Patents › Patent
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Medicines for Malaria Venture (MMV) (External organisation)
Susan Ann Charman (Inventor)
18 Nov 2015Activity: Industry, Government and Philanthropy Engagement and Partnerships › Patents › Patent
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Medicines for Malaria Venture (MMV) (External organisation)
Susan Ann Charman (Inventor)
22 Dec 2015Activity: Industry, Government and Philanthropy Engagement and Partnerships › Patents › Patent
Equipment
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Centre for Drug Candidate Optimisation
Susan Charman (Other)
Pharmacy and Pharmaceutical Sciences Faculty OfficeFacility/equipment: Facility