Projects per year
Personal profile
Research interests
Drug Discovery and Development. Drug Metabolism and Pharmacokinetics. Drug Delivery. Drug Discovery for Neglected and Tropical Diseases.
Biography
Susan Charman is Director of the Centre for Drug Candidate Optimisation, and Professor at the Monash Institute of Pharmaceutical Sciences. Her research is focussed on ADME-informed drug candidate optimisation to translate basic biology and chemistry discoveries into new drug candidates. She is particularly interested in the lead optimisation and progression of novel drug candidates for the treatment of neglected and tropical infectious diseases.
Keywords
- Drug development
- Drug discovery
- Pharmaceutics
- Pharmacokinetics
- Drug Metabolism
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Projects 2008 2020
Male contraception through pharmacological blockade of sperm transport
Ventura, S., Baell, J. B., Charman, S. A. & Sexton, P.
1/08/18 → 31/05/20
Project: Research
Novel TB Drug Candidates via the Inhibition of Lipid I Biosynthesis
Payne, R., Britton, W., Crick, D., Charman, S. A. & West, N.
National Health & Medical Research Council (NHMRC)
1/01/18 → 31/12/20
Project: Research
A Safe, Orally Administered Agent for Dengue
Jans, D. A., Charman, S. A., Dow, G., Low, J., Porter, C. J., Vasudevan, S. & Wagstaff, K. M.
National Health & Medical Research Council (NHMRC)
1/01/17 → 31/12/19
Project: Research
Defining the mechanisms of action for ozonide antimalarials
Creek, D. J., Charman, S. A. & Edgington-Mitchell, L.
National Health & Medical Research Council (NHMRC)
1/01/17 → 31/12/19
Project: Research
Optimization of Antischistosomal Chemotypes
Vennerstrom, J., Keiser, J. & Charman, S. A.
National Institutes of Health (NIH US)
1/04/15 → 31/03/20
Project: Research
Research Output 1991 2018
Novel Toxoplasma gondii inhibitor chemotypes
Sanford, A. G., Schulze, T. T., Potluri, L. P., Hemsley, R. M., Larson, J. J., Judge, A. K., Zach, S. J., Wang, X., Charman, S. A., Vennerstrom, J. L. & Davis, P. H. 1 Apr 2018 In : Parasitology International. 67, 2, p. 107-111 5 p.Research output: Contribution to journal › Article › Research › peer-review
Parasite-mediated degradation of synthetic ozonide antimalarials impacts in vitro antimalarial activity
Giannangelo, C., Stingelin, L., Yang, T., Tilley, L., Charman, S. A. & Creek, D. J. 1 Mar 2018 In : Antimicrobial Agents and Chemotherapy. 62, 3, 14 p., e01566-17Research output: Contribution to journal › Article › Research › peer-review
Progress in antischistosomal N,N′-diaryl urea SAR
Wu, J., Wang, C., Leas, D., Vargas, M., White, K. L., Shackleford, D. M., Chen, G., Sanford, A. G., Hemsley, R. M., Davis, P. H., Dong, Y., Charman, S. A., Keiser, J. & Vennerstrom, J. L. 1 Feb 2018 In : Bioorganic and Medicinal Chemistry Letters. 28, 3, p. 244-248 5 p.Research output: Contribution to journal › Article › Research › peer-review
Antimalarial efficacy of MMV390048, an inhibitor of Plasmodium phosphatidylinositol 4-kinase
Paquet, T. , Le Manach, C. , Cabrera, D. G. , Younis, Y. , Henrich, P. P. , Abraham, T. S. , Lee, M. C. S. , Basak, R. , Ghidelli-Disse, S. , Lafuente-Monasterio, M. J. , Bantscheff, M. , Ruecker, A. , Blagborough, A. M. , Zakutansky, S. E. , Zeeman, A-M. , White, K. L. , Shackleford, D. M. , Mannila, J. , Morizzi, J. , Scheurer, C. & 1 others 26 Apr 2017 In : Science Translational Medicine. 9, 387, 14 p., eaad9735Research output: Contribution to journal › Article › Research › peer-review
Antimalarial Inhibitors Targeting Serine Hydroxymethyltransferase (SHMT) with in Vivo Efficacy and Analysis of their Binding Mode Based on X-ray Cocrystal Structures
Schwertz, G. , Witschel, M. C. , Rottmann, M. , Bonnert, R. , Leartsakulpanich, U. , Chitnumsub, P. , Jaruwat, A. , Ittarat, W. , Schäfer, A. , Aponte, R. A. , Charman, S. A. , White, K. L. , Kundu, A. , Sadhukhan, S. , Lloyd, M. , Freiberg, G. M. , Srikumaran, M. , Siggel, M. , Zwyssig, A. , Chaiyen, P. & 1 others 22 Jun 2017 In : Journal of Medicinal Chemistry. 60, 12, p. 4840-4860 21 p.Research output: Contribution to journal › Article › Research › peer-review