Projects per year
Personal profile
Research interests
Drug Discovery and Development. Drug Metabolism and Pharmacokinetics. Drug Delivery. Drug Discovery for Neglected and Tropical Diseases.
Biography
Susan Charman is Director of the Centre for Drug Candidate Optimisation, and Professor at the Monash Institute of Pharmaceutical Sciences. Her research is focussed on ADME-informed drug candidate optimisation to translate basic biology and chemistry discoveries into new drug candidates. She is particularly interested in the lead optimisation and progression of novel drug candidates for the treatment of neglected and tropical infectious diseases.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research area keywords
- Drug development
- Drug discovery
- Pharmaceutics
- Pharmacokinetics
- Drug Metabolism
Network
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Optimization of novel phenotypic screening hits for treatment of malaria
Phillips, M. A., Ready, J. M., Charman, S., Baniasadi, H. R., Lemoff, A., Kittler, R., Xing, C. & Laleu, B.
1/04/21 → 31/03/26
Project: Research
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Multidisciplinary catalyst to discover and progress novel antimalarial drugs
Charman, S., Creek, D., de Koning-Ward, T. F., Gilson, P., McGowan, S. & Scammells, P.
National Health and Medical Research Council (NHMRC) (Australia)
1/01/20 → 31/12/24
Project: Research
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Targeting trypanosomatid deoxyhypusine synthase
Phillips, M., Charman, S., DeBrabander, J. & Posner, B.
National Institutes of Health (United States)
5/12/18 → 30/11/19
Project: Research
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Novel peptide inhibitors of the potassium voltage-gated channel Kv1.3 as therapeutics for autoimmune diseases
23/10/18 → 23/10/19
Project: Research
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Male contraception through pharmacological blockade of sperm transport
Ventura, S., Baell, J., Charman, S. & Sexton, P.
1/08/18 → 31/05/20
Project: Research
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Cytochrome P450-Mediated Metabolism and CYP Inhibition for the Synthetic Peroxide Antimalarial OZ439
Shackleford, D. M., Chiu, F. C. K., Katneni, K., Blundell, S., McLaren, J., Wang, X., Zhou, L., Sriraghavan, K., Alker, A. M., Hunziker, D., Scheurer, C., Zhao, Q., Dong, Y., Möhrle, J. J., Abla, N., Matile, H., Wittlin, S., Vennerstrom, J. L. & Charman, S. A., 8 Jun 2021, In: ACS Infectious Diseases. 7, 7, p. 1885–1893 9 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access1 Citation (Scopus) -
Discovery of Potent and Fast-Acting Antimalarial Bis-1,2,4-triazines
Priebbenow, D. L., Mathiew, M., Shi, D. H., Harjani, J. R., Beveridge, J. G., Chavchich, M., Edstein, M. D., Duffy, S., Avery, V. M., Jacobs, R. T., Brand, S., Shackleford, D. M., Wang, W., Zhong, L., Lee, G., Tay, E., Barker, H., Crighton, E., White, K. L., Charman, S. A. & 3 others, , 8 Apr 2021, In: Journal of Medicinal Chemistry. 64, 7, p. 4150-4162 13 p.Research output: Contribution to journal › Article › Research › peer-review
2 Citations (Scopus) -
Effects of backbone cyclization on the pharmacokinetics and drug efficiency of the orally active analgesic conotoxin cVc1.1
Poth, A. G., Chiu, F. C. K., Stalmans, S., Hamilton, B. R., Huang, Y. H., Shackleford, D. M., Patil, R., Le, T. T., Kan, M. W., Durek, T., Wynendaele, E., De Spiegeleer, B., Powell, A. K., Venter, D. J., Clark, R. J., Charman, S. A. & Craik, D. J., Jun 2021, In: Medicine in Drug Discovery. 10, 10 p., 100087.Research output: Contribution to journal › Article › Research › peer-review
Open Access2 Citations (Scopus) -
Novel Antimalarial Tetrazoles and Amides Active against the Hemoglobin Degradation Pathway in Plasmodium falciparum
Lawong, A., Gahalawat, S., Okombo, J., Striepen, J., Yeo, T., Mok, S., Deni, I., Bridgford, J. L., Niederstrasser, H., Zhou, A., Posner, B., Wittlin, S., Gamo, F. J., Crespo, B., Churchyard, A., Baum, J., Mittal, N., Winzeler, E., Laleu, B., Palmer, M. J. & 4 others, , 11 Mar 2021, In: Journal of Medicinal Chemistry. 64, 5, p. 2739-2761 23 p.Research output: Contribution to journal › Article › Research › peer-review
1 Citation (Scopus) -
Potent Antimalarials with Development Potential Identified by Structure-Guided Computational Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series
Palmer, M. J., Deng, X., Watts, S., Krilov, G., Gerasyuto, A., Kokkonda, S., El Mazouni, F., White, J., White, K. L., Striepen, J., Bath, J., Schindler, K. A., Yeo, T., Shackleford, D. M., Mok, S., Deni, I., Lawong, A., Huang, A., Chen, G., Wang, W. & 24 others, , 13 May 2021, In: Journal of Medicinal Chemistry. 64, 9, p. 6085-6136 52 p.Research output: Contribution to journal › Article › Research › peer-review
1 Citation (Scopus)
Activities
- 6 Patents
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Medicines for Malaria Venture (MMV) (External organisation)
Susan Ann Charman (Inventor)
19 Jan 2016Activity: Industry, Government and Philanthropy Engagement and Partnerships › Patents › Patent
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Medicines for Malaria Venture (MMV) (External organisation)
Susan Ann Charman (Inventor)
18 Nov 2015Activity: Industry, Government and Philanthropy Engagement and Partnerships › Patents › Patent
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Medicines for Malaria Venture (MMV) (External organisation)
Susan Ann Charman (Inventor)
22 Dec 2015Activity: Industry, Government and Philanthropy Engagement and Partnerships › Patents › Patent
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Medicines for Malaria Venture (MMV) (External organisation)
Susan Charman (Inventor)
28 Jul 2015Activity: Industry, Government and Philanthropy Engagement and Partnerships › Patents › Patent
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Medicines for Malaria Venture (MMV) (External organisation)
Susan Ann Charman (Inventor)
16 Jun 2015Activity: Industry, Government and Philanthropy Engagement and Partnerships › Patents › Patent