Projects per year
Personal profile
Research interests
Chronic viral hepatitis
Evaluation of novel therapeutic agents for chronic viral hepatitis: Clinical trials are examining, for example, several new interferon-free therapies involving combinations of direct acting antiviral agents as well as novel immunological therapies involving HCV-peptide-treated leucocytes. The role of Vitamin D and a range of host genetic markers (such as IL-28B, ITPA) on both treatment outcomes and the severity of liver histology in CHC, and the immunological mechanisms of HCV clearance and effect of HCV on cognitive function in chronically infected patients are also being investigated. Early phase 1 clinical studies are underway to examine novel immune-mediated and anti-viral treatment options for patients with chronic hepatitis B.
Primary liver cancer
Therapeutic approaches to primary liver cancer: We are evaluating novel first- and second-line therapies options in patients with advanced disease as well as comparing the outcomes of local ablation or hepatic resection in those with early stage disease. In addition, large retrospective studies are being performed to determine whether the aetiology of liver cancer (ie. viral versus non-viral) impacts on patient survival.
Fibroscan evaluation
Evaluation of the Fibroscan: Since acquiring the first Fibroscan machine in Australia 4 years ago to assess liver disease via non-invasive measurement of liver stiffness (LSM), several clinical studies have been performed evaluating LSM as a screening and diagnostic tool for liver disease. Patient populations studied include cystic fibrosis, haemophilia, hepatitis C, NAFLD and diabetes. The utility of LSM is also being evaluated as a predictor of outcome of antiviral therapy in patients with hepatitis C, of complications of liver disease in patients with cirrhosis.
Non-alcoholic fatty liver disease
Management of patients with non-alcoholic fatty liver disease (NAFLD): A pilot study is underway examining the therapeutic effect of high dose Vitamin D in NAFLD. Pilot studies are planned in 2013 to evaluate novel therapeutic agents and the institution of a formal lifestyle programme (in conjunction with members of the Dietetics Department).
Evaluating hepatic encephalopathy
Evaluation of the prevalence, clinical significance and management of minimal hepatic encephalopathy in patients with chronic liver disease.
Research area keywords
- hepatology
- Chronic viral hepatitis
- primary liver cancer
- fibroscan evaluation
- non-alcoholic fatty liver disease
Network
Projects
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A randomized, double-blind, dose-ranging, placebo-controlled, Phase 2a evaluation of the safety, tolerability, and pharmacokinetics of PLN 74809 in participants with primary sclerosing cholangitis (PSC) and suspected liver fibrosis (INTEGRIS-PSC).
Roberts, S., Adams, L. A., George, J., Strasser, S. I., Thompson, A. J. V. & Lynch, K.
1/10/20 → 1/11/23
Project: Research
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A Phase 2a, Multicenter, Single-Blind, Placebo-Controlled, Multiple Cohort Study Evaluating ABI-H2158-Containing Regimens in Chronic Hepatitis B Infection.
Roberts, S. & Mitchell, J. L.
15/08/20 → 15/08/22
Project: Research
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A Phase 3 Multicenter, Randomized, Double-blinded, Active-controlled, Clinical Study to Evaluate the Safety and Efficacy of Lenvatinib (E7080/MK-7902) with Pembrolizumab (MK-3475) in Combination with Transarterial Chemoembolization (TACE) Versus TACE in Participants with Incurable/Non-metastatic Hepatocellular Carcinoma (LEAP-012).
Roberts, S. & Lewis, P.
5/06/20 → 31/12/23
Project: Research
Research output
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An Unusual Cause of Lower Gastrointestinal Bleeding
Vaz, K., Clements, W. & Roberts, S. K., Mar 2020, In : Gastroenterology. 158, 4, p. 834-835 2 p.Research output: Contribution to journal › Comment / Debate › Other › peer-review
Open Access -
Balloon-occluded retrograde transvenous obliteration (BRTO) of gastric varices using foam sclerosant and a reduced balloon inflation time: Feasibility and efficacy
Clements, W., Barrett, R., Roberts, S. K., Majeed, A., Kemp, W. & Moriarty, H. K., Aug 2020, In : Journal of Medical Imaging and Radiation Oncology. 64, 4, p. 490-495 6 p.Research output: Contribution to journal › Article › Research › peer-review
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Embolisation of Parastomal Varices Using Balloon-Occluded Retrograde Transvenous Obliteration (BRTO)
Clements, W., Roberts, S. K. & Moriarty, H. K., Aug 2020, In : CardioVascular and Interventional Radiology. 43, 8, p. 1246-1248 3 p.Research output: Contribution to journal › Letter › Other › peer-review
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Evaluation of the histological variability of core and wedge biopsies in nonalcoholic fatty liver disease in bariatric surgical patients
Ooi, G. J., Clouston, A., Johari, Y., Kemp, W. W., Roberts, S. K., Brown, W. A. & Burton, P. R., 13 Mar 2020, (Accepted/In press) In : Surgical Endoscopy. 9 p.Research output: Contribution to journal › Article › Research › peer-review
4 Citations (Scopus) -
Fast computation of desired thermal dose: application to focused ultrasound-induced lesion planning
Zhang, J., Bui, N-D., Cheung, W., Roberts, S. K. & Chauhan, S., 4 Feb 2020, In : Numerical Heat Transfer, Part A: Applications. 77, 6, p. 666-682 17 p.Research output: Contribution to journal › Article › Research › peer-review
1 Citation (Scopus)