1990 …2024

Research output per year

If you made any changes in Pure these will be visible here soon.

Personal profile

Research interests

Chronic viral hepatitis

Evaluation of novel therapeutic agents for chronic viral hepatitis: Clinical trials are examining, for example, several new interferon-free therapies involving combinations of direct acting antiviral agents as well as novel immunological therapies involving HCV-peptide-treated leucocytes. The role of Vitamin D and a range of host genetic markers (such as IL-28B, ITPA) on both treatment outcomes and the severity of liver histology in CHC, and the immunological mechanisms of HCV clearance and effect of HCV on cognitive function in chronically infected patients are also being investigated. Early phase 1 clinical studies are underway to examine novel immune-mediated and anti-viral treatment options for patients with chronic hepatitis B.

Primary liver cancer

Therapeutic approaches to primary liver cancer: We are evaluating novel first- and second-line therapies options in patients with advanced disease as well as comparing the outcomes of local ablation or hepatic resection in those with early stage disease. In addition, large retrospective studies are being performed to determine whether the aetiology of liver cancer (ie. viral versus non-viral) impacts on patient survival.

Fibroscan evaluation

Evaluation of the Fibroscan: Since acquiring the first Fibroscan machine in Australia 4 years ago to assess liver disease via non-invasive measurement of liver stiffness (LSM), several clinical studies have been performed evaluating LSM as a screening and diagnostic tool for liver disease. Patient populations studied include cystic fibrosis, haemophilia, hepatitis C, NAFLD and diabetes. The utility of LSM is also being evaluated as a predictor of outcome of antiviral therapy in patients with hepatitis C, of complications of liver disease in patients with cirrhosis.

Non-alcoholic fatty liver disease

Management of patients with non-alcoholic fatty liver disease (NAFLD): A pilot study is underway examining the therapeutic effect of high dose Vitamin D in NAFLD. Pilot studies are planned in 2013 to evaluate novel therapeutic agents and the institution of a formal lifestyle programme (in conjunction with members of the Dietetics Department).

Evaluating hepatic encephalopathy

Evaluation of the prevalence, clinical significance and management of minimal hepatic encephalopathy in patients with chronic liver disease.

Research area keywords

  • hepatology
  • Chronic viral hepatitis
  • primary liver cancer
  • fibroscan evaluation
  • non-alcoholic fatty liver disease

Network Recent external collaboration on country level. Dive into details by clicking on the dots.


Research Output

An Unusual Cause of Lower Gastrointestinal Bleeding

Vaz, K., Clements, W. & Roberts, S. K., Mar 2020, In : Gastroenterology. 158, 4, p. 834-835 2 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

Open Access

Fast computation of desired thermal dose: application to focused ultrasound-induced lesion planning

Zhang, J., Bui, N-D., Cheung, W., Roberts, S. K. & Chauhan, S., 4 Feb 2020, In : Numerical Heat Transfer Part A-Applications. 77, 6, p. 666-682 17 p.

Research output: Contribution to journalArticleResearchpeer-review

Beneficial response to mycophenolate mofetil by patients with autoimmune hepatitis who have failed standard therapy, is predicted by older age and lower immunoglobulin G and INR levels

Nicoll, A. J., Roberts, S. K., Lim, R., Mitchell, J., Weltman, M., George, J., Wigg, A., Stuart, K., Gow, P., MacQuillan, G., Tse, E., Levy, M., Sood, S., Zekry, A., Cheng, W., Mitchell, J., Skoien, R., Sievert, W., Strasser, S. I., McCaughan, G. W. & 1 others, on behalf of the ALA Clinical Research Network, Gastroenterological Society of Australia, 1 May 2019, In : Alimentary Pharmacology and Therapeutics. 49, 10, p. 1314-1322 9 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Declining Mortality of Cirrhotic Variceal Bleeding Requiring Admission to Intensive Care: A Binational Cohort Study

Majeed, A., Majumdar, A., Bailey, M., Kemp, W., Bellomo, R., Pilcher, D. & Roberts, S. K., Oct 2019, In : Critical Care Medicine. 47, 10, p. 1317-1323 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Effect of Body Mass Index, Metabolic Health and Adipose Tissue Inflammation on the Severity of Non-alcoholic Fatty Liver Disease in Bariatric Surgical Patients: a Prospective Study

Ooi, G. J., Burton, P. R., Bayliss, J., Raajendiran, A., Earnest, A., Laurie, C., Kemp, W. W., McLean, C. A., Roberts, S. K., Watt, M. J. & Brown, W. A., Jan 2019, In : Obesity Surgery. 29, 1, p. 99–108 10 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)