Projects per year
Personal profile
Research interests
Chronic viral hepatitis
Evaluation of novel therapeutic agents for chronic viral hepatitis: Clinical trials are examining, for example, several new interferon-free therapies involving combinations of direct acting antiviral agents as well as novel immunological therapies involving HCV-peptide-treated leucocytes. The role of Vitamin D and a range of host genetic markers (such as IL-28B, ITPA) on both treatment outcomes and the severity of liver histology in CHC, and the immunological mechanisms of HCV clearance and effect of HCV on cognitive function in chronically infected patients are also being investigated. Early phase 1 clinical studies are underway to examine novel immune-mediated and anti-viral treatment options for patients with chronic hepatitis B.
Primary liver cancer
Therapeutic approaches to primary liver cancer: We are evaluating novel first- and second-line therapies options in patients with advanced disease as well as comparing the outcomes of local ablation or hepatic resection in those with early stage disease. In addition, large retrospective studies are being performed to determine whether the aetiology of liver cancer (ie. viral versus non-viral) impacts on patient survival.
Fibroscan evaluation
Evaluation of the Fibroscan: Since acquiring the first Fibroscan machine in Australia 4 years ago to assess liver disease via non-invasive measurement of liver stiffness (LSM), several clinical studies have been performed evaluating LSM as a screening and diagnostic tool for liver disease. Patient populations studied include cystic fibrosis, haemophilia, hepatitis C, NAFLD and diabetes. The utility of LSM is also being evaluated as a predictor of outcome of antiviral therapy in patients with hepatitis C, of complications of liver disease in patients with cirrhosis.
Non-alcoholic fatty liver disease
Management of patients with non-alcoholic fatty liver disease (NAFLD): A pilot study is underway examining the therapeutic effect of high dose Vitamin D in NAFLD. Pilot studies are planned in 2013 to evaluate novel therapeutic agents and the institution of a formal lifestyle programme (in conjunction with members of the Dietetics Department).
Evaluating hepatic encephalopathy
Evaluation of the prevalence, clinical significance and management of minimal hepatic encephalopathy in patients with chronic liver disease.
Research area keywords
- hepatology
- Chronic viral hepatitis
- primary liver cancer
- fibroscan evaluation
- non-alcoholic fatty liver disease
Network
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Projects 2019 2024
RECIPE: Randomised controlled trial (RCT) of ROTEM-guided blood component administration versus standard of care in patients with cirrhosis and coagulopathy undergoing invasive procedures.
Majeed, A., Janko, N. E., Roberts, S., Kemp, W., Nandurkar, H. & Gow, P. J.
5/12/19 → 31/08/21
Project: Research
A Phase 3 Double-blinded, Two-arm Study to Evaluate the Safety and Efficacy of Pembrolizumab (MK-3475) versus Placebo as Adjuvant Therapy in Participants with Hepatocellular Carcinoma and Complete Radiological Response after Surgical Resection or Local Ablation
Roberts, S. & Lewis, P.
8/11/19 → 30/06/23
Project: Research
A Phase 3, Multinational, Double-Blind, Randomized, Placebo-Controlled Study of MGL-3196 (resmetirom) in Patients with Non-Alcoholic Steatohepatitis (NASH) and Fibrosis to Resolve NASH and Reduce Progression to Cirrhosis and/or Hepatic Decompensation. Clinical study No. MGL-3196-11.
24/10/19 → 31/12/24
Project: Research
Research Output 1997 2019
4
Citations
(Scopus)
Beneficial response to mycophenolate mofetil by patients with autoimmune hepatitis who have failed standard therapy, is predicted by older age and lower immunoglobulin G and INR levels
Nicoll, A. J., Roberts, S. K., Lim, R., Mitchell, J., Weltman, M., George, J., Wigg, A., Stuart, K., Gow, P., MacQuillan, G., Tse, E., Levy, M., Sood, S., Zekry, A., Cheng, W., Mitchell, J., Skoien, R., Sievert, W., Strasser, S. I., McCaughan, G. W. & 1 others, , 1 May 2019, In : Alimentary Pharmacology and Therapeutics. 49, 10, p. 1314-1322 9 p.Research output: Contribution to journal › Article › Research › peer-review
Declining Mortality of Cirrhotic Variceal Bleeding Requiring Admission to Intensive Care: A Binational Cohort Study
Majeed, A., Majumdar, A., Bailey, M., Kemp, W., Bellomo, R., Pilcher, D. & Roberts, S. K., Oct 2019, In : Critical Care Medicine. 47, 10, p. 1317-1323 7 p.Research output: Contribution to journal › Article › Research › peer-review
3
Citations
(Scopus)
Effect of Body Mass Index, Metabolic Health and Adipose Tissue Inflammation on the Severity of Non-alcoholic Fatty Liver Disease in Bariatric Surgical Patients: a Prospective Study
Ooi, G. J., Burton, P. R., Bayliss, J., Raajendiran, A., Earnest, A., Laurie, C., Kemp, W. W., McLean, C. A., Roberts, S. K., Watt, M. J. & Brown, W. A., Jan 2019, In : Obesity Surgery. 29, 1, p. 99–108 10 p.Research output: Contribution to journal › Article › Research › peer-review
Reply to “Crashing NASH in Patients Listed for Bariatric Surgery”
Ooi, G. J., Burton, P. R., Kemp, W. W., Roberts, S. K. & Brown, W. A., 15 Feb 2019, In : Obesity Surgery. 29, 2, p. 640-641 2 p.Research output: Contribution to journal › Letter › Other › peer-review
1
Citation
(Scopus)
Community-based provision of direct-acting antiviral therapy for hepatitis C: study protocol and challenges of a randomized controlled trial
Wade, A. J., Doyle, J. S., Gane, E., Stedman, C., Draper, B., Iser, D., Roberts, S. K., Kemp, W., Petrie, D., Scott, N., Higgs, P., Agius, P. A., Roney, J., Stothers, L., Thompson, A. J. & Hellard, M. E., 16 Jul 2018, In : Trials. 19, 1, 9 p., 383.Research output: Contribution to journal › Article › Other › peer-review
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