• 23 Innovation Walk

    3800 Clayton

    Australia

Accepting PhD Students

20092019
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Personal profile

Biography

Steven is a molecular immunologist dissecting the exquisite assembly and function of antiviral immune systems and host-virus interplay to develop new antiviral technologies and lead collaborative, international research efforts.

Steven's work investigates the molecular mechanisms that control the innate immune system and methods by which viruses manipulate these mechanisms to facilitate their replication. By targeting multifunctional host proteins, viruses can factorially enhance their replication by favourably manipulating multiple host cell processes at once. Drawing upon a wide range of techniques in molecular biology, cell biology, virology and structural biology, Steven's vision is to leverage such evolutionary ‘strengths’ of viruses against them, to design new kinds of antiviral therapies that are effective yet resilient against virus escape.

Research interests

RIG-I-like receptors (RLRs), NOD-like receptors (NLRs), and Toll-like receptors (TLRs) sense virus components inside infected cells to trigger an antiviral state. In turn, viruses subvert immune and other host cell processes in order to replicate.

Steven's primary research interests include innate immune signalling and viral immune evasion, post-translational regulation of RNA-binding proteins and immune receptors, post-transcriptional regulation of RNA and translating biomedical research into new technologies and treatments.

Steven is a specialist in recombinant protein expression, purification and biochemical characterisation, molecular biology and cloning techniques, confocal microscopy and cell and virus culture.

Monash teaching commitment

Steven has trained hundreds of students across 20 units in the principles and applications of biochemistry and molecular biology in the study and treatment of human disease. Steven has also directly supervised one BCH3990 final year biochemistry research student.

Education/Academic qualification

Biochemistry & Molecular Biology, PhD, MONASH UNIVERSITY

Biochemistry, B.Sc(Honours First Class), MONASH UNIVERSITY

Chemistry, Immunology, B.Sc, MONASH UNIVERSITY

Philosophy, Dip.A, MONASH UNIVERSITY

Keywords

  • molecular immunology
  • nuclear transport
  • virology
  • post-translational modifications
  • innate immunity
  • host-pathogen interactions

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 2009 2019

Recognition by host nuclear transport proteins drives disorder-to-order transition in Hendra virus v

Atkinson, S. C., Audsley, M. D., Lieu, K. G., Marsh, G. A., Thomas, D. R., Heaton, S. M., Paxman, J. J., Wagstaff, K. M., Buckle, A. M., Moseley, G. W., Jans, D. A. & Borg, N. A., 10 Jan 2018, In : Scientific Reports. 8, 1, 17 p., 358.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Dynamic nucleolar targeting of dengue virus polymerase NS5 in response to extracellular pH

Fraser, J. E., Rawlinson, S. M., Heaton, S. M. & Jans, D. A., Jun 2016, In : Journal of Virology. 90, 12, p. 5797-5807 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Ubiquitin in the activation and attenuation of innate antiviral immunity

Heaton, S. M., Borg, N. A. & Dixit, V. M., 11 Jan 2016, In : Journal of Experimental Medicine. 213, 1, p. 1-13 13 p.

Research output: Contribution to journalReview ArticleOtherpeer-review

Ivermectin is a specific inhibitor of importin alpha/beta-mediated nuclear import able to inhibit replication of HIV-1 and dengue virus

Wagstaff, K. M., Sivakumaran, H., Heaton, S. M., Harrich, D. & Jans, D. A., 2012, In : Biochemical Journal. 443, 3, p. 851 - 856 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Prizes

AIFII Travel Fellow

Steven Heaton (Recipient), 4 Sep 2018

Prize: Competitive Fellowships

MPG Best Poster Award

Steven Heaton (Recipient), 12 Jul 2018

Prize: Prize (including medals and awards)

ASMR Best Poster Award

Steven Heaton (Recipient), 1 Jun 2018

Prize: Prize (including medals and awards)

The Cutting Edge

Steven Heaton (Recipient), 10 May 2018

Prize: Prize (including medals and awards)

Sparrho Early Career Researcher Prize

Steven Heaton (Recipient), 9 Sep 2017

Prize: Prize (including medals and awards)

Activities 2010 2019

Inaugural Charles Cole Minisymposium

Steven Heaton (Invited speaker)
7 Dec 2018

Activity: Participating in or organising an event typesContribution to conference

meRNA Symposium

Steven Heaton (Speaker)
3 Dec 2018

Activity: Participating in or organising an event typesContribution to conference

ANZSCDB Victoria Annual Meeting

Steven Heaton (Speaker)
30 Nov 2018

Activity: Participating in or organising an event typesContribution to conference

ComBio 2018

Steven Heaton (Speaker)
23 Sep 201826 Sep 2018

Activity: Participating in or organising an event typesContribution to conference

Awaji International Forum on Infection and Immunity (AIFII) 2018

Steven Heaton (Invited speaker)
4 Sep 20187 Sep 2018

Activity: Participating in or organising an event typesContribution to conference

Press / Media

Monash University Student Wins Early Career Researcher Prize

Steven Heaton

16/10/175/12/17

5 items of media coverage, 1 media contribution

Press/Media: Research