1980 …2018

Research output per year

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Article
2018

Evidence that TLR4 Is Not a Receptor for Saturated Fatty Acids but Mediates Lipid-Induced Inflammation by Reprogramming Macrophage Metabolism

Lancaster, G. I., Langley, K. G., Berglund, N. A., Kammoun, H. L., Reibe, S., Estevez, E., Weir, J., Mellett, N. A., Pernes, G., Conway, J. R. W., Lee, M. K. S., Timpson, P., Murphy, A. J., Masters, S. L., Gerondakis, S., Bartonicek, N., Kaczorowski, D. C., Dinger, M. E., Meikle, P. J., Bond, P. J. & 1 others, Febbraio, M. A., 1 May 2018, In : Cell Metabolism. 27, 5, p. 1096-1110 16 p.

Research output: Contribution to journalArticleResearchpeer-review

66 Citations (Scopus)

Loss of NF-κB1 Causes Gastric Cancer with Aberrant Inflammation and Expression of Immune Checkpoint Regulators in a STAT-1-Dependent Manner

O'Reilly, L. A., Putoczki, T. L., Mielke, L. A., Low, J. T., Lin, A., Preaudet, A., Herold, M. J., Yaprianto, K., Tai, L., Kueh, A., Pacini, G., Ferrero, R. L., Gugasyan, R., Hu, Y., Christie, M., Wilcox, S., Grumont, R., Griffin, M. D. W., O'Connor, L., Smyth, G. K. & 4 others, Ernst, M., Waring, P., Gerondakis, S. & Strasser, A., 20 Mar 2018, In : Immunity. 48, 3, p. 570-583 14 p.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)
2017

Foxp3+ Tregs are recruited to the retina to repair pathological angiogenesis

Deliyanti, D., Talia, D. M., Zhu, T., Maxwell, M. J., Agrotis, A., Jerome, J. R., Hargreaves, E. M., Gerondakis, S., Hibbs, M. L., Mackay, F. & Wilkinson-Berka, J. L., 1 Dec 2017, In : Nature Communications. 8, 1, 12 p., 748.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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16 Citations (Scopus)

The bacterial peptidoglycan-sensing molecules NOD1 and NOD2 promote CD8+ thymocyte selection

Martinic, M. M., Caminschi, I., O'Keeffe, M., Thinnes, T. C., Grumont, R., Gerondakis, S., McKay, D. B., Nemazee, D. & Gavin, A. L., 1 Apr 2017, In : Journal of Immunology. 198, 7, p. 2649-2660 12 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)
2016

Impact of loss of NF-κB1, NF-κB2 or c-REL on SLE-like autoimmune disease and lymphadenopathy in Faslpr/lpr mutant mice

Low, JT., Hughes, P., Lin, A., Siebenlist, U., Jain, R., Yaprianto, K., Gray, DHD., Gerondakis, S., Strasser, A. & O'Reilly, LA., 2016, In : Immunology and Cell Biology. 94, 1, p. 66-78 13 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

NFκB1 is essential to prevent the development of multiorgan autoimmunity by limiting IL-6 production in follicular B cells

de Valle, E., Grigoriadis, G., O'Rielly, L. A., Willis, S. N., Maxwell, M. J., Corcoran, L. M., Tsantikos, E., Cornish, J. K. S., Fairfax, K. A., Vasanthakumar, A., Febbraio, M. A., Hibbs, M. L., Pellegrini, M., Banerjee, A., Hodgkin, P. D., Kallies, A., Mackay, F., Strasser, A., Gerondakis, S. & Gugasyan, R., 4 Apr 2016, In : The Journal of Experimental Medicine. 213, 4, p. 621-641 21 p., PMC4821646.

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)

The NF-κB transcription factor RelA is required for the tolerogenic function of Foxp3+ regulatory T cells

Messina, N., Fulford, T., O'Reilly, L., Loh, W. X., Motyer, J. M., Ellis, D., McLean, C., Naeem, H., Lin, A., Gugasyan, R., Slattery, R. M., Grumont, R. J. & Gerondakis, S., Jun 2016, In : Journal of Autoimmunity. 70, p. 52-62 11 p.

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)
2015

BTB-ZF transcriptional regulator PLZF modifies chromatin to restrain inflammatory signaling programs

Sadler, A. J., Rossello, F. J., Yu, L., Deane, J. A., Yuan, X-L., Wang, D., Irving, A. T., Liaskos, M., Gantier, M. P. M., Ying, H., Yim, H. C. H., Hartland, E. L., Notini, A. J., De Boer, C. M., White, S., Mansell, A. S., Liu, J-P., Watkins, D. N., Gerondakis, S. D., Williams, B. R. G. & 1 others, Xu, D., 2015, In : Proceedings of the National Academy of Sciences. 112, 5, p. 1535 - 1540 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
34 Citations (Scopus)

Loss of c-REL but not NF-{kappa}B2 prevents autoimmune disease driven by FasL mutation

O'Reilly, L. A., Hughes, P. D., Lin, A., Waring, P. M., Siebenlist, U., Jain, R., Gray, D. H. D., Gerondakis, S. D. & Strasser, A., 2015, In : Cell Death and Differentiation. 22, 5, p. 767 - 778 12 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

MYB elongation is regulated by the nucleic acid binding of NF?B p50 to the intronic stem-loop region

Pereira, L. A., Hugo, H. J., Malaterre, J., Xu, H., Sonza, S., Cures, A., Purcell, D. F. J., Ramsland, P. A., Gerondakis, S. D., Gonda, T. J. & Ramsay, R. G., 2015, In : PLoS ONE. 10, 4 (Art. No: e0122919), p. 1 - 25 25 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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6 Citations (Scopus)

NF-κB1, NF-κB2 and c-Rel differentially regulate susceptibility to colitis-associated adenoma development in C57BL/6 mice

Burkitt, M. D., Hanedi, A. F., Duckworth, C. A., Williams, J. M., Tang, J. M., O'Reilly, L. A., Putoczki, T. L., Gerondakis, S., Dimaline, R., Caamano, J. H. & Mark Pritchard, D., 1 Jul 2015, In : Journal of Pathology. 236, 3, p. 326-336 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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18 Citations (Scopus)

The acetyltransferase HAT1 moderates the NF-?B response by regulating the transcription factor PLZF

Sadler, A. J., Suliman, B. A., Yu, L., Yuan, X-L., Wang, D., Irving, A. T., Sarvestani, S., Banerjee, A., Mansell, A. S., Liu, J-P., Gerondakis, S. D., Williams, B. R. G. & Xu, D., 2015, In : Nature Communications. 6, 13 (Art. ID: 6795), p. 1 - 11 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
28 Citations (Scopus)
2014

c-Rel regulates Ezh2 expression in activated lymphocytes and malignant lymphoid cells

Wenhao, N., Lim, J., Grumont, R. J., Gerondakis, S. D. & I-Hsin, S., 2014, In : Journal of Biological Chemistry. 289, 46, p. 31693 - 31707 15 p.

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)

NF-{kappa}B control of T cell development

Gerondakis, S. D., Fulford, T., Messina, N. L. & Grumont, R. J., 2014, In : Nature Immunology. 15, 1, p. 15 - 25 11 p.

Research output: Contribution to journalArticleResearchpeer-review

108 Citations (Scopus)

The dual-specificity phosphatase 2 (DUSP2) does not regulate obesity-associated inflammation or insulin resistance in mice

Lancaster, G. I., Kraakman, M. J., Kammoun, H. L., Langley, K. G., Estevez, E., Banerjee, A., Grumont, R. J., Febbraio, M. A. & Gerondakis, S. D., 2014, In : PLoS ONE. 9, 11, 8 p., e111524.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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3 Citations (Scopus)
2013

Foxo-mediated Bim transcription is dispensable for the apoptosis of hematopoietic cells that is mediated by this BH3-only protein

Herold, M., Rohrbeck, L., Lang, M., Grumont, R. J., Gerondakis, S. D., Tai, L., Bouillet, P., Kaufmann, T. & Strasser, A., 2013, In : EMBO Reports. 14, 11, p. 992 - 998 7 p.

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)

MEK inhibitors as a chemotherapeutic intervention in multiple myeloma

Leow, C. C-Y., Gerondakis, S. D. & Spencer, A., 2013, In : Blood Cancer Journal. 3, p. 1 - 8 8 p., e105.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
34 Citations (Scopus)

The TACI receptor regulates T-cell-independent marginal zone B cell responses through innate activation-induced cell death

Figgett, W. A., Fairfax, K., Vincent, F., Le Page, M., Katik, I., Deliyanti, D., Quah, P. S., Verma, P., Grumont, R. J., Gerondakis, S. D., Hertzog, P. J., O'Reilly, L. A., Strasser, A. & Mackay-Fisson, F., 2013, In : Immunity. 39, 3, p. 573 - 583 11 p.

Research output: Contribution to journalArticleResearchpeer-review

30 Citations (Scopus)
2012

Combined loss of cRel/p50 subunits of NF-?B leads to impaired innate host response in sepsis

Courtine, E., Cognard, N., Mazzolini, J., Antona, M., Pene, F., Fitting, C., Jacques, S., Rousseau, C., Niedergang, F., Gerondakis, S. D., Chiche, J-D., Ouaaz, F. & Mira, J-P., 2012, In : Innate Immunity. 18, 5, p. 753 - 763 11 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

c-Rel: shaping CD4 regulatory T cell development in unexpected ways

Gerondakis, S. D., Fulford, T. & Grumont, R. J., Sep 2012, In : Transcription (Austin). 3, 5, p. 245 - 249 5 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

NF-k(kappa)B subunit specificity in hemopoiesis.

Gerondakis, S. D., Banerjee, A., Grigoriadis, G., Vasanthakumar, A., Gugasyan, R., Sidwell, T. & Grumont, R. J., 2012, In : Immunological Reviews. 246, 1, p. 272 - 285 14 p.

Research output: Contribution to journalArticleResearchpeer-review

36 Citations (Scopus)

The NF-[kappa]B1 transcription factor prevents the intrathymic development of CD8 T cells with memory properties

Gugasyan, R., Horat, E., Kinkel, S., Ross, F., Grigoriadis, G., Gray, D., O'Keeffe, M., Berzins, S., Belz, G., Grumont, R., Banerjee, A., Strasser, A., Godfrey, D., Tsichlis, P. & Gerondakis, S., 2012, In : EMBO Journal. 31, 3, p. 692 - 706 15 p.

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)

Tumor progression locus 2 (Tpl2) deficiency does not protect against obesity-induced metabolic disease

Lancaster, G. I., Kowalski, G., Estevez, E., Kraakman, M. J., Grigoriadis, G., Febbraio, M. A., Gerondakis, S. D. & Banerjee, A., 2012, In : PLoS ONE. 7, 6, 7 p., e39100.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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6 Citations (Scopus)
2011

C-rel controls multiple discrete steps in the thymic development of Foxp3+ CD4 regulatory T cells

Grigoriadis, G., Vasanthakumar, A., Banerjee, A., Grumont, R. J., Overall, S., Gleeson, P. A., Shannon, M. & Gerondakis, S., 2011, In : PLoS ONE. 6, 10, 10 p., e26851.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
22 Citations (Scopus)

Critical role of cRel subunit of NF-kB in sepsis survival

Courtine, E., Pene, F., Cagnard, N., Toubiana, J., Fitting, C., Brocheton, J., Rousseau, C., Gerondakis, S., Chiche, J-D., Ouaaz, F. & Mira, J-P., 2011, In : Infection and Immunity. 79, 5, p. 1848 - 1854 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
22 Citations (Scopus)

Differentiation of inflammatory dendritic cells is mediated by NF-κB1-dependent GM-CSF production in CD4 T cells

Campbell, I. K., van Nieuwenhuijze, A., Segura, E., O'Donnell, K., Coghill, E., Hommel, M., Gerondakis, S., Villadangos, J. A. & Wicks, I. P., 1 May 2011, In : Journal of Immunology. 186, 9, p. 5468-5477 10 p.

Research output: Contribution to journalArticleResearchpeer-review

58 Citations (Scopus)

Distinct roles in NKT cell maturation and function for the different transcription factors in the classical NF-I?B pathway

Stankovic, S., Gugasyan, R., Kyparissoudis, K., Grumont, R., Banerjee, A., Tsichlis, P., Gerondakis, S. & Godfrey, D., 2011, In : Immunology and Cell Biology. 89, 2, p. 294 - 303 10 p.

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)

Immunotherapy with costimulatory dendritic cells to control autoimmune inflammation

O'Sullivan, B. J., Pai, S., Street, S., An, X., MacDonald, K. P. A., Wong, M., Strutton, G., Gerondakis, S., Steptoe, R. J., De St Groth, B. F., Hill, G. R. & Thomas, R., 15 Oct 2011, In : Journal of Immunology. 187, 8, p. 4018-4030 13 p.

Research output: Contribution to journalArticleResearchpeer-review

27 Citations (Scopus)

The c-Rel transcription factor in development and disease

Gilmore, T. & Gerondakis, S., 2011, In : Genes & Cancer. 2, 7, p. 695 - 711 17 p.

Research output: Contribution to journalArticleResearchpeer-review

65 Citations (Scopus)

The NF-kappaB transcription factor c-Rel is required for Th17 effector cell development in experimental autoimmune encephalomyelitis

Chen, G., Hardy, K., Pagler, E., Ma, L., Lee, S., Gerondakis, S., Daley, S. & Shannon, M., 2011, In : Journal of Immunology. 187, 9, p. 4483 - 4491 9 p.

Research output: Contribution to journalArticleResearchpeer-review

49 Citations (Scopus)
2010

c-Rel phenocopies PKCθ but not Bcl-10 in regulating CD8+ T-cell activation versus tolerance

Deenick, E. K., Po, L., Chapatte, L., Murakami, K., Lu, Y. C., Elford, A. R., Saibil, S. D., Ruland, J., Gerondakis, S., Mak, T. W. & Ohashi, P. S., 1 Mar 2010, In : European Journal of Immunology. 40, 3, p. 867-877 11 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)
2009

c-Rel is required for the development of thymic Foxp3+ CD4 regulatory T cells

Isomura, I., Palmer, S., Grumont, R. J., Bunting, K., Hoyne, G. F., Wilkinson, N., Banerjee, A., Proietto, A. I., Gugasyan, R., Wu, L., McNally, A., Steptoe, R. J., Thomas, R., Shannon, M. F. & Gerondakis, S. D., 2009, In : The Journal of Experimental Medicine. 206, 13, p. 3001 - 3014 14 p.

Research output: Contribution to journalArticleResearchpeer-review

153 Citations (Scopus)

Differential role for c-Rel and C/EBPβ/δ in TLR-mediated induction of proinflammatory cytokines

Lu, Y. C., Kim, I., Lye, E., Shen, F., Suzuki, N., Suzuki, S., Gerondakis, S., Akira, S., Gaffen, S. L., Yeh, W. C. & Ohashi, P. S., 1 Jun 2009, In : Journal of Immunology. 182, 11, p. 7212-7221 10 p.

Research output: Contribution to journalArticleResearchpeer-review

77 Citations (Scopus)

Fatal Hepatitis Mediated by Tumor Necrosis Factor TNFα Requires Caspase-8 and Involves the BH3-Only Proteins Bid and Bim

Kaufmann, T., Jost, P. J., Pellegrini, M., Puthalakath, H., Gugasyan, R., Gerondakis, S., Cretney, E., Smyth, M. J., Silke, J., Hakem, R., Bouillet, P., Mak, T. W., Dixit, V. M. & Strasser, A., 16 Jan 2009, In : Immunity. 30, 1, p. 56-66 11 p.

Research output: Contribution to journalArticleResearchpeer-review

94 Citations (Scopus)

Illumina WG-6 BeadChip strips should be normalized separately

Shi, W., Banerjee, A., Ritchie, M. E., Gerondakis, S. & Smyth, G. K., 11 Nov 2009, In : BMC Bioinformatics. 10, 372.

Research output: Contribution to journalArticleResearchpeer-review

19 Citations (Scopus)
2008

Glucocorticoid-induced TNF receptor expression by T cells is reciprocally regulated by NF-κB and NFAT

Zhan, Y., Gerondakis, S., Coghill, E., Bourges, D., Xu, Y., Brady, J. L. & Lew, A. M., 1 Dec 2008, In : Journal of Immunology. 181, 8, p. 5405-5413 9 p.

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)

NFAT but not NF-{kappa}B is critical for transcriptional induction of the prosurvival gene A1 after IgE receptor activation in mast cells

Ullerås, E., Karlberg, M., Westerberg, C. M., Alfredsson, J., Gerondakis, S., Strasser, A. & Nilsson, G., 15 Mar 2008, In : Blood. 111, 6, p. 3081-3089 9 p.

Research output: Contribution to journalArticleResearchpeer-review

24 Citations (Scopus)

NF-kappaB1 and c-Rel cooperate to promote the survival of TLR4-activated B cells by neutralizing Bim via distinct mechanisms

Banerjee, A., Grumont, R. J., Gugasyan, R., White, C. L., Strasser, A. & Gerondakis, S. D., 2008, In : Blood. 112, 13, p. 5063 - 5073 11 p.

Research output: Contribution to journalArticleResearchpeer-review

34 Citations (Scopus)

The nuclear factor-κB and p53 pathways function independently in primary cells and transformed fibroblasts responding to genotoxic damage

Nesic, D., Grumont, R. & Gerondakis, S., 1 Jul 2008, In : Molecular Cancer Research. 6, 7, p. 1193-1203 11 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)
2007

CD4+ and CD8+ T cell survival is regulated differentially by protein kinase Cθ c-Rel, and protein kinase B

Saibil, S. D., Jones, R. G., Deenick, E. K., Liadis, N., Elford, A. R., Vainberg, M. G., Baerg, H., Woodgett, J. A., Gerondakis, S. & Ohashi, P. S., 1 Mar 2007, In : Journal of Immunology. 178, 5, p. 2932-2939 8 p.

Research output: Contribution to journalArticleResearchpeer-review

36 Citations (Scopus)

Tissue-specific effects of the nuclear factor κB subunit p50 on myocardial ischemia-reperfusion injury

Frantz, S., Tillmanns, J., Kuhlencordt, P. J., Schmidt, I., Adamek, A., Dienesch, C., Thum, T., Gerondakis, S., Ertl, G. & Bauersachs, J., 1 Jan 2007, In : American Journal of Pathology. 171, 2, p. 507-512 6 p.

Research output: Contribution to journalArticleResearchpeer-review

59 Citations (Scopus)
2006

Absence of NF-κB subunit p50 improves heart failure after myocardial infarction

Frantz, S., Hu, K., Bayer, B., Gerondakis, S., Strotmann, J., Adamek, A., Ertl, G. & Bauersachs, J., 1 Jan 2006, In : FASEB Journal. 20, 11

Research output: Contribution to journalArticleResearchpeer-review

105 Citations (Scopus)
116 Citations (Scopus)

Positive regulation of immune cell function and inflammatory responses by phosphatase PAC-1

Jeffrey, K. L., Brummer, T., Rolph, M. S., Liu, S. M., Callejas, N. A., Grumont, R. J., Gillieron, C., Mackay-Fisson, F., Grey, S., Camps, M., Rommel, C., Gerondakis, S. D. & Mackay, C. R., 2006, In : Nature Immunology. 7, 3, p. 274 - 283 10 p.

Research output: Contribution to journalArticleResearchpeer-review

167 Citations (Scopus)
2005

A c-Rel subdomain responsible for enhanced DNA-binding affinity and selective gene activation

Sanjabi, S., Williams, K. J., Saccani, S., Zhou, L., Hoffmann, A., Ghosh, G., Gerondakis, S., Natoli, G. & Smale, S. T., 15 Sep 2005, In : Genes and Development. 19, 18, p. 2138-2151 14 p.

Research output: Contribution to journalArticleResearchpeer-review

83 Citations (Scopus)

Distinct roles for the NF-κB1 and c-Rel transcription factors in the differentiation and survival of plasmacytoid and conventional dendritic cells activated by TLR-9 signals

O'Keeffe, M., Grumont, R. J., Hochrein, H., Fuchsberger, M., Gugasyan, R., Vremec, D., Shortman, K. & Gerondakis, S., 15 Nov 2005, In : Blood. 106, 10, p. 3457-3464 8 p.

Research output: Contribution to journalArticleResearchpeer-review

60 Citations (Scopus)

Histone dynamics on the interleukin-2 gene in response to T-cell activation

Chen, X., Wang, J., Woltring, D., Gerondakis, S. & Shannon, M. F., 1 Apr 2005, In : Molecular and Cellular Biology. 25, 8, p. 3209-3219 11 p.

Research output: Contribution to journalArticleResearchpeer-review

84 Citations (Scopus)

NF-κB couples protein kinase B/Akt signaling to distinct survival pathways and the regulation of lymphocyte homeostasis in vivo

Jones, R. G., Saibil, S. D., Pun, J. M., Elford, A. R., Bonnard, M., Pellegrini, M., Arya, S., Parsons, M. E., Krawczyk, C. M., Gerondakis, S., Yeh, W. C., Woodgett, J. M., Boothby, M. R. & Ohashi, P. S., 15 Sep 2005, In : Journal of Immunology. 175, 6, p. 3790-3799 10 p.

Research output: Contribution to journalArticleResearchpeer-review

34 Citations (Scopus)
2004

Apaf-1 and caspase-9 do not act as tumor suppressors in myc-induced lymphomagenesis or mouse embryo fibroblast transformation

Scott, C. L., Schuler, M., Marsden, V. S., Egle, A., Pellegrini, M., Nesic, D., Gerondakis, S., Nutt, S. L., Green, D. R. & Strasser, A., 1 Jan 2004, In : Journal of Cell Biology. 164, 1, p. 89-96 8 p.

Research output: Contribution to journalArticleResearchpeer-review

57 Citations (Scopus)

The mitogen-induced increase in T cell size involves PKC and NFAT activation of Rel/NF-κB-dependent c-myc expression

Grumont, R., Lock, P., Mollinari, M., Shannon, F. M., Moore, A. & Gerondakis, S., 1 Jul 2004, In : Immunity. 21, 1, p. 19-30 12 p.

Research output: Contribution to journalArticleResearchpeer-review

61 Citations (Scopus)